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We aimed to determine whether\u00a0in utero exposure to an acute, high-intensity air pollution episode impaired lung function 7-years later.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>We conducted a prospective cohort study of children who lived in the vicinity of a coalmine fire. Respiratory function was measured using the forced oscillation technique (FOT). Z-scores for resistance at 5\u00a0Hz (R<jats:sub>5<\/jats:sub>), reactance at 5\u00a0Hz (X<jats:sub>5<\/jats:sub>) and area under the reactance curve (AX) were calculated. Two sets of analyses were conducted to address two separate questions: (1) whether mine fire exposure (a binary indicator; conceived after the mine fire vs in utero exposed) was associated with\u00a0the respiratory Z-scores; (2) whether there was any dose\u2013response relationship between fire-related PM<jats:sub>2.5<\/jats:sub> exposure and respiratory outcomes among those exposed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Acceptable lung function measurements were obtained from 79 children; 25 unexposed and 54 exposed in utero. Median (interquartile range) for daily average and peak PM<jats:sub>2.5<\/jats:sub> for the exposed children were 4.2 (2.6 \u2013 14.2) and 88 (52\u2014225) \u00b5g\/m<jats:sup>3<\/jats:sup> respectively. There were no detectable differences in Z-scores between unexposed and exposed children. There were no associations between respiratory Z-scores and in utero exposure to PM<jats:sub>2.5<\/jats:sub> (daily average or peak).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>There was no detectable effect of in utero exposure to PM<jats:sub>2.5<\/jats:sub> from a local coalmine fire on post-natal lung function 7-years later. However, statistical power was limited.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-023-02414-7","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T10:02:31Z","timestamp":1681466551000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["No association between in utero exposure to emissions from a coalmine fire and post-natal lung function"],"prefix":"10.1186","volume":"23","author":[{"given":"Emily J.","family":"Hemstock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Foong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham L.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamali C.","family":"Dharmage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant J.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fay H.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme R.","family":"Zosky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"2414_CR1","first-page":"2018","volume-title":"version 2","author":"WHO. 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Additional approval was received from the Human Research Ethics Committees of Monash University, Monash Health and the University of Melbourne.All parents and caregivers of the participants provided signed informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No conflicts of interest to declare for the following authors: EH, RF, GH, AW, SD, MD, GW, CG, FJ or GZ. MA reports a relationship with Pfizer Global Research and Development that includes: funding grants. MA reports a relationship with Boehringer Ingelheim GmbH that includes: funding grants. MA reports a relationship with Sanofi Australia that includes: consulting or advisory, funding grants, and travel reimbursement. MA reports a relationship with GlaxoSmithKline that includes: funding grants and speaking and lecture fees.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"120"}}