{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:58:23Z","timestamp":1791845903273,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-NHLHCRF-LX-01"],"award-info":[{"award-number":["2022-NHLHCRF-LX-01"]}]},{"name":"the Elite Medical Professionals Project of China-Japan Friendship Hospital","award":["ZRJY2021- BJ08"],"award-info":[{"award-number":["ZRJY2021- BJ08"]}]},{"name":"the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2020-PT320-001"],"award-info":[{"award-number":["2020-PT320-001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Sarcopenia and obesity are two abnormal body composition phenotypes, and sarcopenic obesity (SO) is characterized by both low skeletal muscle mass (sarcopenia) and high adiposity (obesity). SO negatively influences the clinical status of patients with chronic obstructive pulmonary disease (COPD). However, the studies exploring the prevalence and clinical effects of SO in COPD patients are limited. Our study aimed to elucidate the prevalence and impact of SO on COPD patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this cross-sectional study, the pulmonary function, St. George\u2019s Respiratory Questionnaire, exercise tolerance, body composition, and serum levels of resistin and TNF-\u03b1 were assessed in 198 COPD patients. The clinical value of serum resistin and TNF-\u03b1 for predicting SO in patients with COPD was evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the 198 patients with COPD, the prevalence rates of sarcopenia, obesity, and SO in COPD patients were 27.27%, 29.8%, and 9.6%, respectively. Patients with SO experienced more severe symptoms of dyspnea and worse health related quality of life. The expression of resistin increased in patients with SO compared to other patients. The AUC value of serum resistin level for predicting SO was 0.870 (95% CI: 0.799\u20130.940). BMI (OR: 1.474, 95% CI: 1.124\u20131.934) and resistin (OR: 1.001, 95% CI: 1.000-1.002) levels were independent risk factors of SO in patients with COPD in Multivariate analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The prevalence rates of SO in COPD patients was 9.6%. COPD accompanied by SO is significantly associated with worse pulmonary function and poor physical performance. Serum resistin may be a potential adjunct for predicting SO in COPD patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-023-02702-2","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T12:02:21Z","timestamp":1697630541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical impacts of sarcopenic obesity on chronic obstructive pulmonary disease: a cross-sectional study"],"prefix":"10.1186","volume":"23","author":[{"given":"Zilin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiding","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrui","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaye","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"2702_CR1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. Global Strategy For Prevention, Diagnosis and Management Of COPD: 2023 Report. Available from: http:\/\/www.goldcopd.org."},{"issue":"9859","key":"2702_CR2","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","volume":"380","author":"R Lozano","year":"2012","unstructured":"Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of Disease Study 2010. Lancet. 2012;380(9859):2095\u2013128.","journal-title":"Lancet"},{"key":"2702_CR3","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.pharmthera.2019.02.013","volume":"198","author":"SMH Chan","year":"2019","unstructured":"Chan SMH, Selemidis S, Bozinovski S, Vlahos R. Pathobiological mechanisms underlying metabolic syndrome (MetS) in Chronic Obstructive Pulmonary Disease (COPD): clinical significance and therapeutic strategies. Pharmacol Ther. 2019;198:160\u201388.","journal-title":"Pharmacol Ther"},{"issue":"5","key":"2702_CR4","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/jcsm.12600","volume":"11","author":"W Sep\u00falveda-Loyola","year":"2020","unstructured":"Sep\u00falveda-Loyola W, Osadnik C, Phu S, Morita AA, Duque G, Probst VS. Diagnosis, prevalence, and clinical impact of Sarcopenia in COPD: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2020;11(5):1164\u201376.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2702_CR5","doi-asserted-by":"crossref","unstructured":"Sayer AA, Cruz-Jentoft A. Sarcopenia definition, diagnosis and treatment: consensus is growing. Age Ageing. 2022;51(10).","DOI":"10.1093\/ageing\/afac220"},{"issue":"5","key":"2702_CR6","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.chest.2016.12.006","volume":"151","author":"JA Hwang","year":"2017","unstructured":"Hwang JA, Kim YS, Leem AY, Park MS, Kim SK, Chang J, et al. Clinical implications of Sarcopenia on decreased bone density in men with COPD. Chest. 2017;151(5):1018\u201327.","journal-title":"Chest"},{"issue":"3","key":"2702_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1136\/thoraxjnl-2014-206440","volume":"70","author":"SE Jones","year":"2015","unstructured":"Jones SE, Maddocks M, Kon SSC, Canavan JL, Nolan CM, Clark AL, et al. Sarcopenia in COPD: prevalence, clinical correlates and response to pulmonary rehabilitation. Thorax. 2015;70(3):213\u20138.","journal-title":"Thorax"},{"key":"2702_CR8","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2147\/COPD.S126192","volume":"12","author":"JH Park","year":"2017","unstructured":"Park JH, Lee JK, Heo EY, Kim DK, Chung HS. The effect of obesity on patients with mild Chronic Obstructive Pulmonary Disease: results from KNHANES 2010 to 2012. Int J Chron Obstruct Pulmon Dis. 2017;12:757\u201363.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"11","key":"2702_CR9","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.120.316101","volume":"126","author":"ME Pich\u00e9","year":"2020","unstructured":"Pich\u00e9 ME, Tchernof A, Despr\u00e9s JP. Obesity phenotypes, Diabetes, and Cardiovascular Diseases. Circ Res. 2020;126(11):1477\u2013500.","journal-title":"Circ Res"},{"issue":"12","key":"2702_CR10","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1136\/thx.2007.086827","volume":"63","author":"FME Franssen","year":"2008","unstructured":"Franssen FME, O\u2019Donnell DE, Goossens GH, Blaak EE, Schols AMWJ. Obesity and the lung: 5 \u00b7 obesity and COPD. Thorax. 2008;63(12):1110\u20137.","journal-title":"Thorax"},{"issue":"1","key":"2702_CR11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.chest.2016.08.1432","volume":"151","author":"AA Lambert","year":"2017","unstructured":"Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, et al. Obesity is Associated with increased morbidity in moderate to severe COPD. Chest. 2017;151(1):68\u201377.","journal-title":"Chest"},{"issue":"7","key":"2702_CR12","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.1016\/j.clnu.2021.06.009","volume":"40","author":"Q Gao","year":"2021","unstructured":"Gao Q, Mei F, Shang Y, Hu K, Chen F, Zhao L, et al. Global prevalence of sarcopenic obesity in older adults: a systematic review and meta-analysis. Clin Nutr. 2021;40(7):4633\u201341.","journal-title":"Clin Nutr"},{"issue":"4","key":"2702_CR13","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s13679-019-00359-9","volume":"8","author":"C Koliaki","year":"2019","unstructured":"Koliaki C, Liatis S, Dalamaga M, Kokkinos A. Sarcopenic obesity: epidemiologic evidence, pathophysiology, and therapeutic perspectives. Curr Obes Rep. 2019;8(4):458\u201371.","journal-title":"Curr Obes Rep"},{"issue":"22","key":"2702_CR14","doi-asserted-by":"publisher","first-page":"5049","DOI":"10.1016\/j.febslet.2005.08.011","volume":"579","author":"R Palanivel","year":"2005","unstructured":"Palanivel R, Sweeney G. Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Lett. 2005;579(22):5049\u201354.","journal-title":"FEBS Lett"},{"issue":"9","key":"2702_CR15","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.4049\/jimmunol.174.9.5789","volume":"174","author":"M Bokarewa","year":"2005","unstructured":"Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J Immunol. 2005;174(9):5789\u201395.","journal-title":"J Immunol"},{"key":"2702_CR16","doi-asserted-by":"crossref","unstructured":"Chen N, Zhou L, Zhang Z, Xu J, Wan Z, Qin L. Resistin induces lipolysis and suppresses adiponectin secretion in cultured human visceral adipose tissue. Regul Pept. 2014:49\u201354.","DOI":"10.1016\/j.regpep.2014.10.001"},{"issue":"3","key":"2702_CR17","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1002\/jcsm.12417","volume":"10","author":"CW Li","year":"2019","unstructured":"Li CW, Yu K, Shyh-Chang N, Li GX, Jiang LJ, Yu SL, et al. Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. J Cachexia Sarcopenia Muscle. 2019;10(3):586\u2013600.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"7","key":"2702_CR18","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1136\/thx.54.7.581","volume":"54","author":"JC Bestall","year":"1999","unstructured":"Bestall JC, Paul EA, Garrod R, Garnham R, Jones PW, Wedzicha JA. Usefulness of the Medical Research Council (MRC) Dyspnoea scale as a measure of disability in patients with Chronic Obstructive Pulmonary Disease. Thorax. 1999;54(7):581\u20136.","journal-title":"Thorax"},{"issue":"3","key":"2702_CR19","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1183\/09031936.00102509","volume":"34","author":"PW Jones","year":"2009","unstructured":"Jones PW, Harding G, Berry P, Wiklund I, Chen WH, Kline Leidy N. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009;34(3):648\u201354.","journal-title":"Eur Respir J"},{"key":"2702_CR20","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.2147\/COPD.S173509","volume":"13","author":"Q Zhang","year":"2018","unstructured":"Zhang Q, Li YX, Li XL, Yin Y, Li RL, Qiao X, et al. A comparative study of the five-repetition sit-to-stand test and the 30-second sit-to-stand test to assess exercise tolerance in COPD patients. Int J Chron Obstruct Pulmon Dis. 2018;13:2833\u20139.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2702_CR21","unstructured":"World Health Organization. Regional Office for the Western P. The Asia-Pacific perspective: redefining obesity and its treatment: Sydney : Health Communications Australia; 2000 2000."},{"issue":"5","key":"2702_CR22","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.clnu.2022.03.017","volume":"41","author":"Y Someya","year":"2022","unstructured":"Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, et al. Sarcopenic obesity is associated with cognitive impairment in community-dwelling older adults: the Bunkyo Health Study. Clin Nutr. 2022;41(5):1046\u201351.","journal-title":"Clin Nutr"},{"issue":"8","key":"2702_CR23","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1016\/j.clnu.2019.11.024","volume":"39","author":"LM Donini","year":"2020","unstructured":"Donini LM, Busetto L, Bauer JM, Bischoff S, Boirie Y, Cederholm T, et al. Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review. Clin Nutr. 2020;39(8):2368\u201388.","journal-title":"Clin Nutr"},{"key":"2702_CR24","doi-asserted-by":"publisher","first-page":"921399","DOI":"10.3389\/fnut.2022.921399","volume":"9","author":"J Gao","year":"2022","unstructured":"Gao J, Deng M, Li Y, Yin Y, Zhou X, Zhang Q, et al. Resistin as a systemic inflammation-related biomarker for Sarcopenia in patients with Chronic Obstructive Pulmonary Disease. Front Nutr. 2022;9:921399.","journal-title":"Front Nutr"},{"issue":"8","key":"2702_CR25","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.jamda.2016.03.020","volume":"17","author":"P Joppa","year":"2016","unstructured":"Joppa P, Tkacova R, Franssen FM, Hanson C, Rennard SI, Silverman EK, et al. Sarcopenic Obesity, functional outcomes, and systemic inflammation in patients with Chronic Obstructive Pulmonary Disease. J Am Med Dir Assoc. 2016;17(8):712\u20138.","journal-title":"J Am Med Dir Assoc"},{"issue":"10","key":"2702_CR26","doi-asserted-by":"publisher","first-page":"e110448","DOI":"10.1371\/journal.pone.0110448","volume":"9","author":"HK Koo","year":"2014","unstructured":"Koo HK, Park JH, Park HK, Jung H, Lee SS. Conflicting role of Sarcopenia and obesity in male patients with Chronic Obstructive Pulmonary Disease: Korean National Health and Nutrition Examination Survey. PLoS ONE. 2014;9(10):e110448.","journal-title":"PLoS ONE"},{"issue":"10","key":"2702_CR27","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41569-021-00541-4","volume":"18","author":"A Pirillo","year":"2021","unstructured":"Pirillo A, Casula M, Olmastroni E, Norata GD, Catapano AL. Global epidemiology of dyslipidaemias. Nat Rev Cardiol. 2021;18(10):689\u2013700.","journal-title":"Nat Rev Cardiol"},{"key":"2702_CR28","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.foodres.2018.07.002","volume":"113","author":"G Jamar","year":"2018","unstructured":"Jamar G, Santamarina AB, Dias GC, Masquio DCL, de Rosso VV, Pisani LP. Relationship between fatty acids intake and Clostridium coccoides in obese individuals with metabolic syndrome. Food Res Int. 2018;113:86\u201392.","journal-title":"Food Res Int"},{"key":"2702_CR29","doi-asserted-by":"crossref","unstructured":"Ma\u0219taleru A, Cojocariu AS, Oancea A, Leon-Constantin MM, Roca M, Zota IM et al. Eating habits in patients with familial hypercholesterolemia from North-Eastern Romania. Nutrients. 2022;14(15).","DOI":"10.3390\/nu14153124"},{"issue":"2","key":"2702_CR30","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/jcsm.12901","volume":"13","author":"CW Li","year":"2022","unstructured":"Li CW, Yu K, Shyh-Chang N, Jiang Z, Liu T, Ma S, et al. Pathogenesis of Sarcopenia and the relationship with fat mass: descriptive review. J Cachexia Sarcopenia Muscle. 2022;13(2):781\u201394.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"10","key":"2702_CR31","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1164\/rccm.200904-0530OC","volume":"180","author":"J Ora","year":"2009","unstructured":"Ora J, Laveneziana P, Ofir D, Deesomchok A, Webb KA, O\u2019Donnell DE. Combined effects of obesity and Chronic Obstructive Pulmonary Disease on dyspnea and exercise tolerance. Am J Respir Crit Care Med. 2009;180(10):964\u201371.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"2702_CR32","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1152\/japplphysiol.01131.2010","volume":"111","author":"J Ora","year":"2011","unstructured":"Ora J, Laveneziana P, Wadell K, Preston M, Webb KA, O\u2019Donnell DE. Effect of obesity on respiratory mechanics during rest and exercise in COPD. J Appl Physiol (1985). 2011;111(1):10\u20139.","journal-title":"J Appl Physiol (1985)"},{"issue":"2","key":"2702_CR33","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1183\/09031936.00197314","volume":"46","author":"C van de Bool","year":"2015","unstructured":"van de Bool C, Rutten EP, Franssen FM, Wouters EF, Schols AM. Antagonistic implications of Sarcopenia and abdominal obesity on physical performance in COPD. Eur Respir J. 2015;46(2):336\u201345.","journal-title":"Eur Respir J"},{"issue":"6","key":"2702_CR34","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s00421-008-0758-y","volume":"103","author":"CL Lafortuna","year":"2008","unstructured":"Lafortuna CL, Agosti F, Galli R, Busti C, Lazzer S, Sartorio A. The energetic and cardiovascular response to treadmill walking and cycle ergometer exercise in obese women. Eur J Appl Physiol. 2008;103(6):707\u201317.","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"2702_CR35","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1183\/09031936.00128008","volume":"33","author":"PJ Barnes","year":"2009","unstructured":"Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J. 2009;33(5):1165\u201385.","journal-title":"Eur Respir J"},{"key":"2702_CR36","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.arr.2016.09.008","volume":"35","author":"A Kalinkovich","year":"2017","unstructured":"Kalinkovich A, Livshits G. Sarcopenic obesity or obese sarcopenia: a cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev. 2017;35:200\u201321.","journal-title":"Ageing Res Rev"},{"issue":"3","key":"2702_CR37","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1152\/japplphysiol.00898.2007","volume":"104","author":"BJ Hardin","year":"2008","unstructured":"Hardin BJ, Campbell KS, Smith JD, Arbogast S, Smith J, Moylan JS, et al. TNF-\u03b1 acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle. J Appl Physiol. 2008;104(3):694\u20139.","journal-title":"J Appl Physiol"},{"issue":"6","key":"2702_CR38","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.cmet.2006.11.005","volume":"4","author":"GR Steinberg","year":"2006","unstructured":"Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, et al. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab. 2006;4(6):465\u201374.","journal-title":"Cell Metab"},{"issue":"2","key":"2702_CR39","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/jcsm.12144","volume":"8","author":"C Lipina","year":"2017","unstructured":"Lipina C, Hundal HS. Lipid modulation of skeletal muscle mass and function. J Cachexia Sarcopenia Muscle. 2017;8(2):190\u2013201.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"2702_CR40","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1182\/blood-2011-04-325225","volume":"119","author":"BB Aggarwal","year":"2012","unstructured":"Aggarwal BB, Gupta SC, Kim JH. Historical perspectives on Tumor necrosis factor and its superfamily: 25 years later, a golden journey. Blood. 2012;119(3):651\u201365.","journal-title":"Blood"},{"issue":"3","key":"2702_CR41","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1462-8902.2004.00334.x","volume":"6","author":"R Rea","year":"2004","unstructured":"Rea R, Donnelly R. Resistin: an adipocyte-derived hormone. Has it a role in Diabetes and obesity? Diabetes Obes Metab. 2004;6(3):163\u201370.","journal-title":"Diabetes Obes Metab"},{"key":"2702_CR42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12970-016-0118-y","volume":"13","author":"P Bond","year":"2016","unstructured":"Bond P. Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance. J Int Soc Sports Nutr. 2016;13:8.","journal-title":"J Int Soc Sports Nutr"},{"key":"2702_CR43","doi-asserted-by":"publisher","first-page":"804632","DOI":"10.1155\/2013\/804632","volume":"2013","author":"CH Sheng","year":"2013","unstructured":"Sheng CH, Du ZW, Song Y, Wu XD, Zhang YC, Wu M, et al. Human resistin inhibits myogenic differentiation and induces insulin resistance in myocytes. Biomed Res Int. 2013;2013:804632.","journal-title":"Biomed Res Int"},{"issue":"1","key":"2702_CR44","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1371\/journal.pone.0000031","volume":"1","author":"I Nagaev","year":"2006","unstructured":"Nagaev I, Bokarewa M, Tarkowski A, Smith U. Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes. PLoS ONE. 2006;1(1):e31.","journal-title":"PLoS ONE"},{"issue":"2","key":"2702_CR45","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s00223-019-00623-z","volume":"106","author":"SE Lee","year":"2020","unstructured":"Lee SE, Park JH, Kim KA, Kang YS, Choi HS. Association between Sarcopenic Obesity and pulmonary function in Korean Elderly: results from the Korean National Health and Nutrition Examination Survey. Calcif Tissue Int. 2020;106(2):124\u201330.","journal-title":"Calcif Tissue Int"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-023-02702-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-023-02702-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-023-02702-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T06:05:34Z","timestamp":1700287534000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-023-02702-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2702"],"URL":"https:\/\/doi.org\/10.1186\/s12890-023-02702-2","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]},"assertion":[{"value":"4 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures involving human participants were performed in accordance with the Declaration of Helsinki. The study was approved by the Institutional Review Board (or Ethics Committee) of Research Ethics Committee of the First Hospital of China Medical University (No. 2018-144-2), and written informed consents were obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"394"}}