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We aim to investigate the clinical impact of BEC on patients with acute bronchiectasis exacerbation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1332 adult patients diagnosed with acute exacerbation of bronchiectasis from January 2012 to December 2020 were included in this retrospective study. A propensity-matched analysis was performed by matching age, sex and comorbidities in patients with high eosinophil count (\u2265\u2009300 cell\/\u00b5L) and low eosinophil count (&lt;\u2009300 cell\/\u00b5L). Clinical characteristics, length of hospital stay (LOS), hospitalization cost and inflammatory markers were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eosinophilic bronchiectasis occurred in approximately 11.7% of all patients. 156 propensity score\u2013matched pairs were identified with and without high eosinophil count. Eosinophilic bronchiectasis presented with a longer LOS [9.0 (6.0\u201312.5) vs. 5.0 (4.0\u20136.0) days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001] and more hospitalization cost [15,011(9,753\u201327,404) vs. 9,109(6,402\u201312,287) RMB,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001] compared to those in non-eosinophilic bronchiectasis. The median white blood cell (WBC), lymphocyte, platelet\u00a0(PLT) and C-reactive protein (CRP) levels in eosinophilic bronchiectasis were significantly increased. Multivariate logistic regression analysis confirmed that the high levels of eosinophil count (OR\u2009=\u200913.95,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), worse FEV1% predicted (OR\u2009=\u20097.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0003) and PLT (OR\u2009=\u20091.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035) were independent prognostic factors for length of hospital (LOS) greater than 7\u00a0days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eosinophilic bronchiectasis patients had longer length of hospital stay and more hospitalization cost compared to those in non-eosinophilic bronchiectasis group, which might be associated with the stronger inflammatory reaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12890-024-02912-2","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T07:02:21Z","timestamp":1708930941000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Eosinophilic bronchiectasis increases length and cost of hospitalization: a retrospective analysis in a hospital of southern China from 2012 to 2020"],"prefix":"10.1186","volume":"24","author":[{"given":"Chengcheng","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"issue":"2","key":"2912_CR1","doi-asserted-by":"publisher","first-page":"2002990","DOI":"10.1183\/13993003.02990-2020","volume":"58","author":"AB Chang","year":"2021","unstructured":"Chang AB, Fortescue R, Grimwood K, et al. 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