{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:07:22Z","timestamp":1788217642721,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High-flow nasal cannula (HFNC) is often used in pediatric populations with respiratory distress. In adults, the respiratory-rate oxygenation (ROX) index is used as a predictor of HFNC therapy; however, children have age-associated differences in respiratory rate, thus may not be applicable to children. This study aims to find the reliability of ROX index and modified P-ROX index as predictors of HFNC therapy failure in pediatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects in this analytical cross-sectional study were taken from January 2023 until November 2023 in Cipto Mangunkusumo Hospital. Inclusion criteria are children aged 1\u00a0month to 18\u00a0years with respiratory distress and got HFNC therapy. Receiver operating characteristics (ROC) analysis was used to find mP-ROX index cutoff value as a predictor of HFNC failure. The area under curve (AUC) score of mP-ROX index was assessed at different time point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 102 patients, with 70% of the population with pneumonia, were included in this study. There are significant differences in the ROX index between the successful and failed HFNC group therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). This study suggests that mP-ROX index is not useful as predictor of HFNC therapy in pediatrics. While ROX index\u2009&lt;\u20095.52 at 60\u00a0min and\u2009&lt;\u20095.68 at 90\u00a0min after HFNC initiation have a sensitivity of 90% and specificity of 71%, sensitivity of 78% and specificity of 76%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>mP-ROX index is not useful as a predictor of HFNC therapy in pediatrics. Meanwhile, ROX index at 60\u00a0min and 90\u00a0min after initiation of HFNC is useful as a predictor of HFNC failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12890-024-03029-2","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T08:02:02Z","timestamp":1714636922000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Respiratory Rate Oxygenation (ROX) index as predictor of high flow nasal cannula in pediatric patients in pediatric intensive care unit"],"prefix":"10.1186","volume":"24","author":[{"given":"Irene","family":"Yuniar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonius Hocky","family":"Pudjiadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rismala","family":"Dewi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogi","family":"Prawira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niken Wahyu","family":"Puspaningtyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tartila","family":"Tartila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharfina","family":"Fulki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"3029_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3345\/kjp.2019.00626","volume":"63","author":"JW Kwon","year":"2020","unstructured":"Kwon JW. High-flow nasal cannula oxygen therapy in children: a clinical review. Clin Exp Pediatr. 2020;63:3\u20137.","journal-title":"Clin Exp Pediatr"},{"key":"3029_CR2","doi-asserted-by":"crossref","unstructured":"Chang CC, Lin YC, Chen TC, Lin JJ, Hsia SH, Chan OW, et al. High-Flow Nasal Cannula Therapy in Children With Acute Respiratory Distress With Hypoxia in A Pediatric Intensive Care Unit\u2013A Single Center Experience. Frontiers in Pediatrics. 2021;9. Available from: https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.664180. Cited 2024 Jan 26","DOI":"10.3389\/fped.2021.664180"},{"key":"3029_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13613-014-0029-5","volume":"4","author":"C Mil\u00e9si","year":"2014","unstructured":"Mil\u00e9si C, Boubal M, Jacquot A, Baleine J, Durand S, Odena MP, et al. High-flow nasal cannula: recommendations for daily practice in pediatrics. 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