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We assessed the capability of objective cough measurement to predict the success of the spontaneous breathing trial (SBT) and extubation. Intra- and inter-observer reproducibility of the cough test and was evaluated using the intraclass correlation coefficient (ICC) and Cohen\u2019s weighted kappa. We used receiver operating characteristic curves (ROC-curve) to evaluate the predictive ability of objective cough measurement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We recruited 367 subjects who were receiving invasive mechanical ventilation. A total of 451 objective cough measurements and 456 SBTs were conducted. A significant association was found between objective cough measurement and successful SBT (OR: 1.68; 95% CI 1.48\u20131.90; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). The predictive capability of the objective cough test for SBT success had a ROC-curve of 0.58 (95% CI: 0.56\u20130.61). Objective cough measurement to predict successful extubation had a ROC-curve of 0.61 (95% CI: 0.56\u20130.66). The intraobserver reproducibility exhibited an ICC of 0.94 (95% CI: 0.89\u20130.96; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while the interobserver reproducibility demonstrated an ICC of 0.72 (95% CI: 0.51\u20130.85; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The intraobserver agreement, assessed using Cohen\u2019s weighted kappa was 0.94 (95% CI: 0.93\u20130.99; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), whereas the interobserver agreement was 0.84 (95% CI: 0.67\u2009\u2212\u20090.10; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The objective measurement of cough using the method employed in our study demonstrates nearly perfect intra-observer reproducibility and agreement. However, its ability to predict success or failure in the weaning process is limited.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-024-03033-6","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T14:02:31Z","timestamp":1714658551000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing the reproducibility and predictive value of objective cough measurement for successful withdrawal of invasive ventilatory support in adult patients"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-6007","authenticated-orcid":false,"given":"Fabio","family":"Var\u00f3n-Vega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Giraldo-Cadavid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Tuta-Quintero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Crevoisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana C.","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Poveda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cucunubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Monedero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"issue":"1","key":"3033_CR1","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/s13054-021-03686-3","volume":"25","author":"P Pelosi","year":"2021","unstructured":"Pelosi P, Ball L, Barbas CSV, Bellomo R, Burns KEA, Einav S, et al. 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