{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:37:48Z","timestamp":1792701468855,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>The evaluation of the asthmatic patient is usually based on clinical and functional parameters that do not necessarily evidence the degree of airway inflammation. The aim of this study was to analyze whether clinical scores (CS) correlate with spirometry (S), impulse oscillometry (IO) and FeNO, in severe asthmatic children.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material and methods<\/jats:title>\n                <jats:p>A multicentric, prospective, cross-sectional study was conducted over a 12-month period. All SA patients (6\u201318 years old) followed-up in the Pulmonology Department were recruited. CS, FeNO measurements, IO and S were consecutively performed on the same day. Asthma control was ascertained using ACT and GINAq. A cut-off value of \u2265\u200925 parts per billion (ppb) was used to define airway inflammation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eighty-one patients were included. ACT: 75% (n 61) were controlled; GINAq: 44.5% (n 36) were controlled; 39.5% (n 32) were partly controlled, and 16% (n 13) were uncontrolled. FeNO had a median value of 24 ppb (IQR 14\u201341); FeNO\u2009\u2265\u200925 ppb was observed in 49% of patients (n 39). ROC AUC for FeNO vs. ACT was 0.71 (95%CI 0.57\u20130.86), PPV 0.47, NPV 0.87, SE 0.61, SP 0.80; FeNO vs. GINAq was ROC AUC 0.69 (95%CI 0.54\u20130.85), PPV 0.34, NPV 0.91, SE 0.62, SP 0.77; Youden cut-off FeNO\u2009&gt;\u200939 ppb for both CS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In severe asthmatic children, current symptoms control as evidenced by ACT and GINA correlates with low FeNO values. Clinical scores showed good correlation with airway inflammation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-024-03058-x","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T10:03:48Z","timestamp":1717668228000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Childhood severe asthma: relationship among asthma control scores, FeNO, spirometry and impulse oscillometry"],"prefix":"10.1186","volume":"24","author":[{"given":"Gabriela","family":"Pel\u00e1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Giubergia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Lucero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Aguerre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Casta\u00f1os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"issue":"10258","key":"3058_CR1","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","volume":"396","author":"GBD2019 DandIC","year":"2020","unstructured":"GBD2019DandIC. Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the global burden of Disease Study 2019. Lancet. 2020;396(10258):1204\u201322. https:\/\/doi.org\/10.1016\/S0140-6736(20)30925-9. Erratum in: Lancet. 2020;396(10262):1562. PMID: 33069326; PMCID: PMC7567026.","journal-title":"Lancet"},{"key":"3058_CR2","doi-asserted-by":"publisher","unstructured":"Brusselle GG, Koppelman GH. Biologic Therapies for Severe Asthma. N Engl J Med. 2022;386(2):157\u2013171. https:\/\/doi.org\/10.1056\/NEJMra2032506. PMID: 35020986.","DOI":"10.1056\/NEJMra2032506"},{"key":"3058_CR3","unstructured":"\u200bGlobal Initiative for Asthma. Global Strategy for Asthma Management and Prevention,2023. Available from: www.ginasthma.org."},{"key":"3058_CR4","doi-asserted-by":"crossref","unstructured":"Giubergia V, Ramirez Far\u00edas MJ, P\u00e9rez V, Gonz\u00e1lez A, Crespi N, Fridman N, Casta\u00f1os C. Asma grave en pediatr\u00eda: resultados de la implementaci\u00f3n de un protocolo especial de atenci\u00f3n. Arch Argent Pediatr. 2018 Abr 1;116(2):105\u2013111.","DOI":"10.5546\/aap.2018.105"},{"key":"3058_CR5","doi-asserted-by":"publisher","unstructured":"Salviano LDDS, Taglia-Ferre KD, Lisboa S, Costa ACCD, Campos HDS, March MFP. Association between Fraction of Exhaled Nitric Oxide and Spirometry data and Clinical Control of Asthma in Children and Adolescents. Rev Paul Pediatr. 2018;36(1):8. https:\/\/doi.org\/10.1590\/1984-0462\/;2018;36;1;00015. PMID: 29412429; PMCID: PMC5849379.","DOI":"10.1590\/1984-0462\/;2018;36;1;00015"},{"key":"3058_CR6","doi-asserted-by":"publisher","unstructured":"Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor DR, American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011 Sep 1;184(5):602\u2009\u2013\u200915. https:\/\/doi.org\/10.1164\/rccm.9120-11ST. PMID: 21885636; PMCID: PMC4408724.","DOI":"10.1164\/rccm.9120-11ST"},{"issue":"5","key":"3058_CR7","doi-asserted-by":"publisher","first-page":"382","DOI":"10.5546\/aap.2012.382","volume":"110","author":"V Giubergia","year":"2012","unstructured":"Giubergia V, Fridman N, Gonz\u00e1lez Pena H. Evaluaci\u00f3n Del impacto de un programa de atenci\u00f3n de ni\u00f1os con asma grave. Arch Argent Pediatr. 2012;110(5):382\u20137.","journal-title":"Arch Argent Pediatr"},{"issue":"4","key":"3058_CR8","first-page":"S123","volume":"119","author":"Comit\u00e9 Nacional de Neumonolog\u00eda","year":"2021","unstructured":"Comit\u00e9 Nacional de Neumonolog\u00eda. Comit\u00e9 Nacional De Alergia, Comit\u00e9 Nacional De Emergencia Y Cuidados Cr\u00edticos, Comit\u00e9 Nacional De Familia Y Salud Mental. Gu\u00eda de diagn\u00f3stico y tratamiento: asma bronquial en ni\u00f1os\u2009\u2265\u20096 a\u00f1os. Actualizaci\u00f3n 2021. Arch Argent Pediatr. 2021;119(4):S123\u201358.","journal-title":"Arch Argent Pediatr"},{"key":"3058_CR9","doi-asserted-by":"publisher","unstructured":"American Thoracic Society; European Respiratory Society. ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005;171(8):912\u2009\u2013\u200930. https:\/\/doi.org\/10.1164\/rccm.200406-710ST. PMID: 15817806.","DOI":"10.1164\/rccm.200406-710ST"},{"issue":"10","key":"3058_CR10","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1002\/ppul.23426","volume":"51","author":"B Thomas","year":"2016","unstructured":"Thomas B, Chay OM, Allen JC Jr, Chiang AS, Pugalenthi A, Goh A, Wong P, Teo AH, Tan SG, Teoh OH. Concordance between bronchial hyperresponsiveness, fractional exhaled nitric oxide, and asthma control in children. Pediatr Pulmonol. 2016;51(10):1004\u20139. Epub 2016 Apr 13. PMID: 27074221.","journal-title":"Pediatr Pulmonol"},{"key":"3058_CR11","doi-asserted-by":"publisher","unstructured":"Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, Van der Grinten CP, Gustafsson P et al. ; ATS\/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005;26(2):319\u2009\u2013\u200938. https:\/\/doi.org\/10.1183\/09031936.05.00034805. PMID: 16055882.","DOI":"10.1183\/09031936.05.00034805"},{"key":"3058_CR12","doi-asserted-by":"publisher","unstructured":"Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CP, Gustafsson P, Hankinson J et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948\u2009\u2013\u200968. https:\/\/doi.org\/10.1183\/09031936.05.00035205. PMID: 16264058.","DOI":"10.1183\/09031936.05.00035205"},{"issue":"8","key":"3058_CR13","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","volume":"200","author":"BL Graham","year":"2019","unstructured":"Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, Hallstrand TS, Kaminsky DA, McCarthy K, McCormack MC. Et. Al. Standardization of Spirometry 2019 Update. An official American Thoracic Society and European Respiratory Society Technical Statement. Am J Respir Crit Care Med. 2019;200(8):e70\u201388. https:\/\/doi.org\/10.1164\/rccm.201908-1590ST. PMID: 31613151; PMCID: PMC6794117.","journal-title":"Am J Respir Crit Care Med"},{"key":"3058_CR14","doi-asserted-by":"publisher","unstructured":"Oostveen E, MacLeod D, Lorino H, Farr\u00e9 R, Hantos Z, Desager K, Marchal F, ERS Task Force on Respiratory Impedance Measurements. The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J. 2003;22(6):1026-41. https:\/\/doi.org\/10.1183\/09031936.03.00089403. PMID: 14680096.","DOI":"10.1183\/09031936.03.00089403"},{"key":"3058_CR15","first-page":"72","volume":"31","author":"HJ Smith","year":"2005","unstructured":"Smith HJ, Reinhold P, Goldman MD. Forced oscillation technique and impulse oscillometry. Eur Respir Monograph. 2005;31:10: 72\u2013105.","journal-title":"Eur Respir Monograph"},{"key":"3058_CR16","doi-asserted-by":"publisher","unstructured":"King GG, Bates J, Berger KI, Calverley P, de Melo PL, Dellac\u00e0 RL, Farr\u00e9 R, Hall GL, Ioan I, Irvin CG et al. Technical standards for respiratory oscillometry. Eur Respir J. 2020;55(2):1900753. https:\/\/doi.org\/10.1183\/13993003.00753-2019. PMID: 31772002.","DOI":"10.1183\/13993003.00753-2019"},{"key":"3058_CR17","doi-asserted-by":"publisher","unstructured":"Vega JM, Badia X, Badiola C, L\u00f3pez-Vi\u00f1a A, Olagu\u00edbel JM, Picado C, Sastre J, Dal-R\u00e9 R. Covalair Investigator Group. Validation of the Spanish version of the Asthma Control Test (ACT). J Asthma. 2007;44(10):867\u2009\u2013\u200972. https:\/\/doi.org\/10.1080\/02770900701752615. PMID: 18097865.","DOI":"10.1080\/02770900701752615"},{"issue":"1","key":"3058_CR18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jaci.2010.08.042","volume":"127","author":"EO Meltzer","year":"2011","unstructured":"Meltzer EO, Busse WW, Wenzel SE, Belozeroff V, Weng HH, Feng J, Chon Y, Chiou CF, Globe D, Lin SL. Use of the Asthma Control Questionnaire to predict future risk of asthma exacerbation. J Allergy Clin Immunol. 2011;127(1):167\u201372. Epub 2010 Nov 18. PMID: 21093024.","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"3058_CR19","doi-asserted-by":"publisher","first-page":"e97","DOI":"10.1164\/rccm.202109-2093ST","volume":"204","author":"SB Khatri","year":"2021","unstructured":"Khatri SB, Iaccarino JM, Barochia A, Soghier I, Akuthota P, Brady A, Covar RA, Debley JS, Diamant Z, Fitzpatrick AM. American Thoracic Society Assembly on Allergy, Immunology, and inflammation. Use of Fractional exhaled nitric oxide to Guide the treatment of Asthma: an official American thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2021;204(10):e97\u2013109. https:\/\/doi.org\/10.1164\/rccm.202109-2093ST. PMID: 34779751; PMCID: PMC8759314.","journal-title":"Am J Respir Crit Care Med"},{"key":"3058_CR20","doi-asserted-by":"publisher","first-page":"691425","DOI":"10.1155\/2010\/691425","volume":"2010","author":"M Verini","year":"2010","unstructured":"Verini M, Consilvio NP, Di Pillo S, Cingolani A, Spagnuolo C, Rapino D, Scaparrotta A, Chiarelli F. FeNO as a marker of Airways inflammation: the possible implications in Childhood Asthma Management. J Allergy (Cairo). 2010;2010:691425. https:\/\/doi.org\/10.1155\/2010\/691425. Epub 2010 May 18. PMID: 20948878; PMCID: PMC2948939.","journal-title":"J Allergy (Cairo)"},{"issue":"3","key":"3058_CR21","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1164\/rccm.201212-2156LE","volume":"188","author":"L Fleming","year":"2013","unstructured":"Fleming L, Tsartsali L, Wilson N, Regamey N, Bush A. Longitudinal relationship between sputum eosinophils and exhaled nitric oxide in children with asthma. Am J Respir Crit Care Med. 2013;188(3):400\u20132. https:\/\/doi.org\/10.1164\/rccm.201212-2156LE. PMID: 23905533; PMCID: PMC3778731.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"3058_CR22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/ppul.21529","volume":"47","author":"V Waibel","year":"2012","unstructured":"Waibel V, Ulmer H, Horak E. Assessing asthma control: symptom scores, GINA levels of asthma control, lung function, and exhaled nitric oxide. Pediatr Pulmonol. 2012;47(2):113\u20138. https:\/\/doi.org\/10.1002\/ppul.21529. Epub 2011 Aug 24. PMID: 22241569.","journal-title":"Pediatr Pulmonol"},{"key":"3058_CR23","doi-asserted-by":"publisher","unstructured":"Tibosch M, de Ridder J, Landstra A, Hugen C, Brouwer M, Gerrits P, van Gent R, Roukema J, Verhaak C, Merkus P. Four of a kind: asthma control, FEV1, FeNO, and psychosocial problems in adolescents. Pediatr Pulmonol. 2012;47(10):933\u2009\u2013\u200940. https:\/\/doi.org\/10.1002\/ppul.22514. Epub 2012 Feb 10. PMID: 22328345.","DOI":"10.1002\/ppul.22514"},{"key":"3058_CR24","doi-asserted-by":"publisher","first-page":"117727191982655","DOI":"10.1177\/1177271919826550","volume":"14","author":"FC de Abreu","year":"2019","unstructured":"de Abreu FC, da Silva J\u00fanior JLR, Rabahi MF. The Fraction exhaled nitric oxide as a biomarker of Asthma Control. Biomark Insights. 2019;14:1177271919826550. https:\/\/doi.org\/10.1177\/1177271919826550. PMID: 30728712; PMCID: PMC6357290.","journal-title":"Biomark Insights"},{"key":"3058_CR25","doi-asserted-by":"publisher","unstructured":"Ricciardolo FL, Sorbello V, Bellezza Fontana R, Schiavetti I, Ciprandi G. Exhaled nitric oxide in relation to asthma control: a real-life survey. Allergol Immunopathol (Madr). 2016 May-Jun;44(3):197\u2013205. https:\/\/doi.org\/10.1016\/j.aller.2015.05.012. Epub 2015 Nov 14. PMID: 26589339.","DOI":"10.1016\/j.aller.2015.05.012"},{"issue":"1","key":"3058_CR26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1136\/thoraxjnl-2012-201861","volume":"68","author":"F Volbeda","year":"2013","unstructured":"Volbeda F, Broekema M, Lodewijk ME, Hylkema MN, Reddel HK, Timens W, Postma DS, ten Hacken NH. Clinical control of asthma associates with measures of airway inflammation. Thorax. 2013;68(1):19\u201324. https:\/\/doi.org\/10.1136\/thoraxjnl-2012-201861. Epub 2012 Oct 6. PMID: 23042704.","journal-title":"Thorax"},{"issue":"6","key":"3058_CR27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1136\/thoraxjnl-2014-206161","volume":"70","author":"S Voorend-van Bergen","year":"2015","unstructured":"Voorend-van Bergen S, Vaessen-Verberne AA, Brackel HJ, Landstra AM, van den Berg NJ, Hop WC, de Jongste JC, Merkus PJ, Pijnenburg MW. Monitoring strategies in children with asthma: a randomised controlled trial. Thorax. 2015;70(6):543\u201350. https:\/\/doi.org\/10.1136\/thoraxjnl-2014-206161. Epub 2015 Mar 30. PMID: 25825006.","journal-title":"Thorax"},{"key":"3058_CR28","doi-asserted-by":"publisher","unstructured":"Rodrigues AM, Roncada C, Santos G, Heinzmann-Filho JP, de Souza RG, Vargas MH, Pinto LA, Jones MH, Stein RT, Pitrez PM. Clinical characteristics of children and adolescents with severe therapy-resistant asthma in Brazil. J Bras Pneumol. 2015 Jul-Aug;41(4):343\u201350. https:\/\/doi.org\/10.1590\/S1806-37132015000004462. PMID: 26398754; PMCID: PMC4635954.","DOI":"10.1590\/S1806-37132015000004462"},{"key":"3058_CR29","doi-asserted-by":"publisher","unstructured":"Payne DN, Rogers AV, Adelroth E, Bandi V, Guntupalli KK, Bush A, Jeffery PK. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med. 2003;167(1):78\u201382. https:\/\/doi.org\/10.1164\/rccm.200205-414OC. PMID: 12502479.","DOI":"10.1164\/rccm.200205-414OC"},{"key":"3058_CR30","doi-asserted-by":"publisher","unstructured":"Chan R, Lipworth BJ. Determinants of asthma control and exacerbations in moderate to severe asthma. J Allergy Clin Immunol Pract. 2022;10(10):2758\u20132760.e1. https:\/\/doi.org\/10.1016\/j.jaip.2022.06.042. Epub 2022 Jul 5. PMID: 35803537.","DOI":"10.1016\/j.jaip.2022.06.042"},{"issue":"3","key":"3058_CR31","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00408-022-00542-1","volume":"200","author":"R Chan","year":"2022","unstructured":"Chan R, Lipworth B. Forced vital capacity and low frequency Reactance Area measurements are Associated with Asthma Control and exacerbations. Lung. 2022;200(3):301\u20133. https:\/\/doi.org\/10.1007\/s00408-022-00542-1. Epub 2022 Jun 3. PMID: 35662363; PMCID: PMC9205791.","journal-title":"Lung"},{"key":"3058_CR32","doi-asserted-by":"publisher","unstructured":"Chan R, Lipworth BJ. Combining low-frequency oscillometry and spirometry measurements in relation to asthma control and exacerbations in moderate-to-severe asthma. J Allergy Clin Immunol Pract. 2022;10(7):1910\u20131912.e1. https:\/\/doi.org\/10.1016\/j.jaip.2022.03.023. Epub 2022 Apr 8. PMID: 35398555.","DOI":"10.1016\/j.jaip.2022.03.023"},{"key":"3058_CR33","doi-asserted-by":"publisher","unstructured":"Jenkins HA, Cherniack R, Szefler SJ, Covar R, Gelfand EW, Spahn JD. A comparison of the clinical characteristics of children and adults with severe asthma. Chest. 2003;124(4):1318-24. https:\/\/doi.org\/10.1378\/chest.124.4.1318. PMID: 14555561.","DOI":"10.1378\/chest.124.4.1318"},{"issue":"3","key":"3058_CR34","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/j.1651-2227.2009.01625.x","volume":"99","author":"AM Lang","year":"2010","unstructured":"Lang AM, Konradsen J, Carlsen KH, Sachs-Olsen C, Mowinckel P, Hedlin G, L\u00f8drup Carlsen KC. Identifying problematic severe asthma in the individual child\u2013does lung function matter? Acta Paediatr. 2010;99(3):404\u201310. https:\/\/doi.org\/10.1111\/j.1651-2227.2009.01625.x. Epub 2009 Dec 22. PMID: 20040073.","journal-title":"Acta Paediatr"},{"key":"3058_CR35","first-page":"29","volume":"28","author":"G Alberto Vidal","year":"2012","unstructured":"Alberto Vidal G. Ana Mar\u00eda Escobar C. Y Mar\u00eda Eugenia Medina R. correlation and agreement between the instruments of asthma control in children. Rev Chil Enf Respir. 2012;28:29\u201334.","journal-title":"Rev Chil Enf Respir"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03058-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-024-03058-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03058-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T10:04:11Z","timestamp":1717668251000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-024-03058-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3058"],"URL":"https:\/\/doi.org\/10.1186\/s12890-024-03058-x","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]},"assertion":[{"value":"26 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All parents signed a written informed consent. The study was approved by the Garrahan\u00b4s Hospital Ethics Committee (Ref Proj 1022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"270"}}