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They hold potential in aiding the recognition of gastroesophageal reflux-induced chronic cough (GERC). Our study aims to investigate their diagnostic value in GERC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study included patients suspected GERC. General information and relevant laboratory examinations were collected, and final diagnosis were determined following guidelines for chronic cough. The parameters of multichannel intraluminal impedance-pH monitoring (MII-pH) in patients were analyzed and compared to explore their diagnostic value in GERC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 186 patients were enrolled in this study. The diagnostic value of PSPWI for GERC was significant, with the area under the working curve (AUC) of 0.757 and a cutoff value of 39.4%, which was not statistically different from that of acid exposure time (AET) (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). The combined diagnostic value of AET\u2009&gt;\u20094.4% and PSPWI\u2009&lt;\u200939.4% was superior to using AET\u2009&gt;\u20094.4% alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, MNBI and distal MNBI also contributed to the diagnosis of GERC, with AUC values of 0.639 and 0.624, respectively. AET\u2009&gt;\u20094.4% or PSPWI\u2009&lt;\u200939.4% is associated with a 44% reduction in missed diagnoses of non-acid GERC compared to AET\u2009&gt;\u20096.0% or symptom association probability (SAP)\u2009\u2265\u200995%, and may be more favorable for identifying GERC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The diagnostic value of PSPWI for GERC is comparable to that of AET. Combining PSPWI\u2009&lt;\u200939.4% or AET\u2009&gt;\u20094.4% can improve the diagnostic efficiency by reducing the risk of missed diagnoses in cases where non-acid reflux is predominant. Distal MNBI and MNBI can serve as secondary reference indices in the diagnosis of GERC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-024-03080-z","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T13:08:55Z","timestamp":1717592935000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["How to diagnose GERC more effectively: reflections on post-reflux swallow-induced peristaltic wave index and mean nocturnal baseline impedance"],"prefix":"10.1186","volume":"24","author":[{"given":"Bingxian","family":"Sha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyangzi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"issue":"1 Suppl","key":"3080_CR1","doi-asserted-by":"publisher","first-page":"s1","DOI":"10.1378\/chest.129.1_suppl.1S","volume":"129","author":"RS Irwin","year":"2006","unstructured":"Irwin RS, Baumann MH, Bolser DC, Boulet LP, Braman SS, Brightling CE, et al. 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