{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:51:18Z","timestamp":1760986278730,"version":"3.37.3"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Natural Science Foundation of Chongqing, China","award":["CSTB2022NSCQ-MSX1150"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX1150"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2022CDJYGRH-001"],"award-info":[{"award-number":["2022CDJYGRH-001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing Professional Talents Plan","award":["cstc2022ycjh-bgzxm0048"],"award-info":[{"award-number":["cstc2022ycjh-bgzxm0048"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The diagnostic complexities that arise in radiographic distinction between ectopic pleural thymoma and other thoracic neoplasms are substantial, with instances of co-occurring T-cell lymphocytosis and osseous metastasis being exceedingly rare.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 51-year-old woman was admitted to our hospital with dyspnea and chest pain. Upon imaging examination, she was found to have diffuse and nodular pleural thickening on the left side, collapse of the left lung and a compression in the second thoracic vertebrae. All lesions showed significant <jats:sup>18<\/jats:sup>F-FDG uptake on <jats:sup>18<\/jats:sup>F-FDG PET\/CT examination. Furthermore, she exhibited T-cell lymphocytosis in her peripheral blood, lymph nodes, and bone marrow. After ruling out malignant pleural mesothelioma (MPM), lung cancer with pleural metastasis, and T-cell lymphoma, the definitive diagnosis asserted was ectopic pleural thymoma with T-cell lymphocytosis and bone metastasis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Physicians need to expand their knowledge of the imaging features of ectopic pleural thymoma. Cases with T-cell lymphocytosis may exhibit increased aggressiveness and prone to bone metastasis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-024-03090-x","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T10:02:57Z","timestamp":1718359377000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ectopic pleural thymoma with T-cell lymphocytosis and bone metastasis: a case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zailin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"3090_CR1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/annonc\/mdl406","volume":"18","author":"M Morales","year":"2007","unstructured":"Morales M, Trujillo M, del Carmen Maeso M, et al. Thymoma and progressive T-cell lymphocytosis. Ann Oncol. 2007;18:603\u20134. https:\/\/doi.org\/10.1093\/annonc\/mdl406","journal-title":"Ann Oncol"},{"key":"3090_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.20517\/2394-4722.2021.203","volume":"8","author":"S Suster","year":"2022","unstructured":"Suster S. The WHO 2021 thymoma classification: a work in progress. J Cancer Metastasis Treat. 2022;8:7. https:\/\/doi.org\/10.20517\/2394-4722.2021.203","journal-title":"J Cancer Metastasis Treat"},{"key":"3090_CR3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00428-016-1967-0","volume":"469","author":"A Weissferdt","year":"2016","unstructured":"Weissferdt A, Moran CA. The spectrum of ectopic thymomas. Virchows Arch. 2016;469:245\u20134. https:\/\/doi.org\/10.1007\/s00428-016-1967-0","journal-title":"Virchows Arch"},{"key":"3090_CR4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.clinimag.2019.10.017","volume":"60","author":"Q Zhou","year":"2020","unstructured":"Zhou Q, Han L, Ke X, et al. Ectopic thymoma: retrospective analysis of eight cases with clinical features and computed tomography findings. Clin Imaging. 2020;60:153\u20139. https:\/\/doi.org\/10.1016\/j.clinimag.2019.10.017","journal-title":"Clin Imaging"},{"key":"3090_CR5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12893-016-0171-0","volume":"16","author":"L Zhao","year":"2016","unstructured":"Zhao L, Zhou X, Li Z, et al. Bone metastasis of malignant thymomas associated with peripheral T-cell lymphocytosis. BMC Surg. 2016;16:58. https:\/\/doi.org\/10.1186\/s12893-016-0171-0","journal-title":"BMC Surg"},{"key":"3090_CR6","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1148\/rg.346130089","volume":"34","author":"LT Nickell","year":"2014","unstructured":"Nickell LT, Lichtenberger JP, Khorashadi L, et al. Multimodality imaging for characterization, classification, and staging of malignant pleural mesothelioma. Radiographics. 2014;34:1692\u2013706. https:\/\/doi.org\/10.1148\/rg.346130089","journal-title":"Radiographics"},{"key":"3090_CR7","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.radcr.2021.12.019","volume":"17","author":"NE Bouardi","year":"2022","unstructured":"Bouardi NE, Haloua M, Lamrani YA, et al. Pleural thymoma: a rare cause of pleural mass. About one case. Radiol case Rep. 2022;17:794\u20137. https:\/\/doi.org\/10.1016\/j.radcr.2021.12.019","journal-title":"Radiol case Rep"},{"key":"3090_CR8","doi-asserted-by":"publisher","first-page":"e12901","DOI":"10.7759\/cureus.12901","volume":"13","author":"FA Shah","year":"2021","unstructured":"Shah FA, Greene N, Purut C. Thymoma presenting as a pleural-based Mass. Cureus. 2021;13:e12901. https:\/\/doi.org\/10.7759\/cureus.12901","journal-title":"Cureus"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03090-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-024-03090-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03090-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T10:05:01Z","timestamp":1718359501000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-024-03090-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3090"],"URL":"https:\/\/doi.org\/10.1186\/s12890-024-03090-x","relation":{},"ISSN":["1471-2466"],"issn-type":[{"type":"electronic","value":"1471-2466"}],"subject":[],"published":{"date-parts":[[2024,6,14]]},"assertion":[{"value":"27 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The patient was treated ethically in accordance with the declaration of Helsinki. The patient has signed written informed consent for publication of this case report and all the accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"280"}}