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The RC time can be obtained using either a simplified empirical approach or a semilogarithmic equation. Although direct curve-fit analysis is a feasible and ostensibly reference approach for RC analysis, it remains largely unexplored. We aimed to study the relationship between various RC methods in different states of pulmonary hemodynamics.<\/jats:p><jats:p><jats:bold>Methods\u00a0<\/jats:bold>In total, 182 patients underwent clinically indicated right heart catheterization. The pressure curves were exported and processed using the MATLAB software. We calculated the RC time using the empirical method (RC<jats:sub>EST<\/jats:sub>), semilogarithmic approach (RC<jats:sub>SL<\/jats:sub>), and direct measurement of curve fit (RC<jats:sub>FIT<\/jats:sub>).<\/jats:p><jats:p><jats:bold>Results\u00a0<\/jats:bold>Among 182 patients, 137 had pulmonary hypertension due to left heart disease (PH-LHD), 35 had pulmonary arterial hypertension (PAH), and 10 demonstrated normal hemodynamics (non-PH). RC<jats:sub>EST<\/jats:sub> consistently overestimated the RC<jats:sub>FIT<\/jats:sub> and RC<jats:sub>SL<\/jats:sub> measurements by a mean of 75%. With all three methods, the RC values were longer in the PAH (RC<jats:sub>FIT<\/jats:sub>\u2009=\u20090.36\u2009\u00b1\u20090.14\u00a0s) than in the PH-LHD (0.27\u2009\u00b1\u20090.1\u00a0s) and non-PH (0.27\u2009\u00b1\u20090.09\u00a0s) groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Although the RC<jats:sub>SL<\/jats:sub> and RC<jats:sub>FIT<\/jats:sub> values were similar among the three subgroups, they exhibited broad limits of agreement. Finally, the RC<jats:sub>EST<\/jats:sub> demonstrated a strong discriminatory ability (AUC\u2009=\u20090.86, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, CI\u2009=\u20090.79\u20130.93) in identifying PAH.<\/jats:p><jats:p><jats:bold>Conclusion\u00a0<\/jats:bold>RC time in PAH patients was substantially prolonged compared to that in PH-LHD and non-PH patients. The use of the empirical formula yielded systematic RC overestimation. In contrast, the semilogarithmic analysis provided reliable RC estimates, particularly for group comparisons.<\/jats:p>","DOI":"10.1186\/s12890-024-03107-5","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T02:01:34Z","timestamp":1719280894000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Insights into RC time curve fit analysis of pulmonary artery pressure decay"],"prefix":"10.1186","volume":"24","author":[{"given":"Aristomenis","family":"Manouras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars H.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3 Ilona","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"3107_CR1","doi-asserted-by":"publisher","first-page":"H1731","DOI":"10.1152\/ajpheart.00336.2006","volume":"291","author":"JW Lankhaar","year":"2006","unstructured":"Lankhaar JW, Westerhof N, Faes TJ, et al. 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