{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:27:12Z","timestamp":1719966432914},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82173182"],"award-info":[{"award-number":["82173182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Immunoglobulin light chain (AL) amyloidosis presents a clinical spectrum characterized by diverse manifestations and involvement of multiple organs, posing a significant diagnostic challenge for physicians.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>We present a case of a patient admitted to our hospital due to recurrent cough and sputum, which was initially diagnosed as refractory tuberculosis. Throughout his hospitalization, the patient experienced distressing symptoms, including uncontrollable chest tightness, hypotension, and fever. Noteworthy observations included a persistent elevation in cardiac biomarkers, indicative of cardiac damage. Bronchoalveolar lavage revealed the presence of various pathogenic microorganisms, while bone marrow flow cytometry demonstrated the existence of clonal plasma cells. Additionally, the urine free light chain assay detected the presence of M protein, and the positive congo red staining of the abdominal wall fat biopsy confirmed amyloid deposition in the tissues. Taking into account the patient\u2019s clinical presentation and the examination findings, we reached a conclusive diagnosis of immunoglobulin light chain (AL) amyloidosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This case serves as a reminder for physicians to consider rare diseases like AL amyloidosis when patients present with symptoms involving multiple organ systems such as heart, lung and kidney that are unresponsive to conventional treatment options.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-024-03127-1","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T20:41:48Z","timestamp":1719952908000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A patient with AL amyloidosis presenting with refractory tuberculosis, chest tightness and hypotension: case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Jun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Fahim Fathima","family":"Farhath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huohuan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linhui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"3127_CR1","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.jacc.2016.06.053","volume":"68","author":"RH Falk","year":"2016","unstructured":"Falk RH, Alexander KM, Liao R, Dorbala S. AL (Light-Chain) Cardiac Amyloidosis: a review of diagnosis and therapy. J Am Coll Cardiol. 2016;68:1323\u201341.","journal-title":"J Am Coll Cardiol"},{"key":"3127_CR2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41572-018-0034-3","volume":"4","author":"G Merlini","year":"2018","unstructured":"Merlini G, Dispenzieri A, Sanchorawala V, et al. Systemic immunoglobulin light chain amyloidosis. Nat Reviews Disease Primers. 2018;4:38.","journal-title":"Nat Reviews Disease Primers"},{"key":"3127_CR3","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1182\/blood.V79.7.1817.1817","volume":"79","author":"RA Kyle","year":"1992","unstructured":"Kyle RA, Linos A, Beard CM, et al. Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. 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JAMA. 2020;324:79\u201389.","journal-title":"JAMA"},{"key":"3127_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.6004\/jnccn.2022.7077","volume":"21","author":"S Zanwar","year":"2023","unstructured":"Zanwar S, Gertz MA, Muchtar E. Immunoglobulin light chain amyloidosis: diagnosis and Risk Assessment. J Natl Compr Cancer Network: JNCCN. 2023;21:83\u201390.","journal-title":"J Natl Compr Cancer Network: JNCCN"},{"key":"3127_CR8","first-page":"199","volume":"42","author":"HL Miao","year":"2021","unstructured":"Miao HL, Shen KN, Su W, et al. [Clinical presentation and prognosis in patients with light-chain amyloidosis with an ultra-high level of serum free light-chain]. Zhonghua xue ye xue Za Zhi\u2009=\u2009Zhonghua. Xueyexue Zazhi. 2021;42:199\u2013204.","journal-title":"Xueyexue Zazhi"},{"key":"3127_CR9","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s00392-019-01490-2","volume":"109","author":"F Escher","year":"2020","unstructured":"Escher F, Senoner M, Doerler J, et al. When and how do patients with cardiac amyloidosis die? Clin Res Cardiology: Official J German Cardiac Soc. 2020;109:78\u201388.","journal-title":"Clin Res Cardiology: Official J German Cardiac Soc"},{"key":"3127_CR10","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.jaccao.2022.08.009","volume":"4","author":"AD Wechalekar","year":"2022","unstructured":"Wechalekar AD, Fontana M, Quarta CC, Liedtke M. AL Amyloidosis for cardiologists: awareness, diagnosis, and future prospects: JACC: CardioOncology State-of-the-art review. 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Abdominal fat pad excisional biopsy for the diagnosis and typing of systemic amyloidosis. Hum Pathol. 2018;72:71\u20139.","journal-title":"Hum Pathol"},{"key":"3127_CR14","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1016\/S0140-6736(15)01274-X","volume":"387","author":"AD Wechalekar","year":"2016","unstructured":"Wechalekar AD, Gillmore JD, Hawkins PN. Systemic amyloidosis. 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