{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:00:09Z","timestamp":1778122809882,"version":"3.51.4"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"DOI":"10.1186\/s12890-024-03227-y","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T09:13:13Z","timestamp":1724922793000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Utility of exhaled nitric oxide to guide mild asthma treatment in atopic patients and its correlation with asthma control test score: a randomized controlled trial"],"prefix":"10.1186","volume":"24","author":[{"given":"Edwin","family":"Pesantes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana","family":"Hernando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Lores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"C\u00e1mara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u00edas","family":"Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Lores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"3227_CR1","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2020. Available from: www.ginasthma.org."},{"key":"3227_CR2","unstructured":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica. GEMA5.0 . Gu\u00eda Espa\u00f1ola Para El Manejo Del Asma.; 2020."},{"issue":"6885","key":"3227_CR3","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.jaci.2020.10.003.2020","volume":"306","author":"National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group","year":"2020","unstructured":"National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. 2020 Focused Updates to the Asthma Management Guidelines. J Allergy Clin Immunol. 2020;306(6885):1132. https:\/\/doi.org\/10.1016\/j.jaci.2020.10.003.2020.","journal-title":"J Allergy Clin Immunol."},{"issue":"1","key":"3227_CR4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jaci.2008.09.049","volume":"123","author":"Z Mikhak","year":"2010","unstructured":"Mikhak Z, Fukui M, Farsidjani A, Medoff BD, Tager AM, Luster AD. Contribution of CCR4 and CCR8 to antigen-specific Th2 cell trafficking in allergic pulmonary inflammation. J Allergy Clin Immunol. 2010;123(1):67\u201373.","journal-title":"J Allergy Clin Immunol"},{"key":"3227_CR5","doi-asserted-by":"publisher","first-page":"6531","DOI":"10.4049\/jimmunol.175.10.6531","volume":"175","author":"L Xue","year":"2005","unstructured":"Xue L, Gyles SL, Wettey FR, et al. Prostaglandin D2 Causes Preferential Induction of Proinflammatory Th2 Cytokine Production through an Action on Chemoattractant Receptor-Like Molecule Expressed on Th2 Cells. J Immunol. 2005;175:6531\u20136.","journal-title":"J Immunol"},{"issue":"4","key":"3227_CR6","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1183\/20734735.0268-2019","volume":"15","author":"SW Turner","year":"2019","unstructured":"Turner SW, Chang AB, Yang IA. Clinical utility of exhaled nitric oxide fraction in the management of asthma and COPD. Breathe. 2019;15(4):306\u201316. https:\/\/doi.org\/10.1183\/20734735.0268-2019.","journal-title":"Breathe"},{"key":"3227_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1183\/13993003.01633-2019","volume":"55","author":"A Menzies-Gow","year":"2020","unstructured":"Menzies-Gow A, Mansur AH, Brightling CE. Clinical utility of fractional exhaled nitric oxide in severe asthma management. Eur Respir J. 2020;55:1\u201331. https:\/\/doi.org\/10.1183\/13993003.01633-2019.","journal-title":"Eur Respir J"},{"key":"3227_CR8","doi-asserted-by":"crossref","unstructured":"Wang Z, Pianosi P, Keogh K, et al. The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017. Report No.: 17(18)-EHC030-EF. PMID: 29533572.","DOI":"10.23970\/AHRQEPCCER197"},{"issue":"5","key":"3227_CR9","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1164\/rccm.9120-11ST","volume":"184","author":"RA Dweik","year":"2011","unstructured":"Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: Interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184(5):602\u201315. https:\/\/doi.org\/10.1164\/rccm.9120-11ST.","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"3227_CR10","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.jaip.2013.07.013","volume":"1","author":"J Syk","year":"2013","unstructured":"Syk J, Malinovschi A, Johansson G, et al. Anti-inflammatory treatment of atopic asthma guided by exhaled nitric oxide: A randomized, controlled trial. J Allergy Clin Immunol Pract. 2013;1(6):639\u2013648.e8. https:\/\/doi.org\/10.1016\/j.jaip.2013.07.013.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"10","key":"3227_CR11","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1001\/2012.jama.10893","volume":"308","author":"WJ Calhoun","year":"2012","unstructured":"Calhoun WJ, Bill T, King TS, et al. Comparison of Physician-, Biomarker-and Symptom-Based Strategies for Adjustment of Inhaled Corticosteroid Therapy in Adults with asthma. JAMA. 2012;308(10):987\u201397.","journal-title":"JAMA"},{"issue":"3","key":"3227_CR12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1164\/rccm.200610-1427OC","volume":"176","author":"DE Shaw","year":"2007","unstructured":"Shaw DE, Berry MA, Thomas M, et al. The use of exhaled nitric oxide to guide asthma management: A randomized controlled trial. Am J Respir Crit Care Med. 2007;176(3):231\u20137. https:\/\/doi.org\/10.1164\/rccm.200610-1427OC.","journal-title":"Am J Respir Crit Care Med"},{"issue":"8 I","key":"3227_CR13","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1164\/ajrccm.164.8.2101145","volume":"164","author":"DNR Payne","year":"2001","unstructured":"Payne DNR, Adcock IM, Wilson NM, Oates T, Scallan M, Bush A. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med. 2001;164(8 I):1376\u201381. https:\/\/doi.org\/10.1164\/ajrccm.164.8.2101145.","journal-title":"Am J Respir Crit Care Med."},{"issue":"5","key":"3227_CR14","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1136\/thorax.57.5.383","volume":"57","author":"TJ Warke","year":"2002","unstructured":"Warke TJ, Fitch PS, Brown V, et al. Exhaled nitric oxide correlates with airway eosinophils in childhood asthma. Thorax. 2002;57(5):383\u20137.","journal-title":"Thorax"},{"key":"3227_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1136\/thx.53.2.91","volume":"53","author":"A Jatakanon","year":"1998","unstructured":"Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax. 1998;53:91\u20135.","journal-title":"Thorax"},{"issue":"5","key":"3227_CR16","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.jaci.2003.08.014","volume":"112","author":"RC Strunk","year":"2003","unstructured":"Strunk RC, Szefler SJ, Phillips BR, et al. Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J Allergy Clin Immunol. 2003;112(5):883\u201392. https:\/\/doi.org\/10.1016\/j.jaci.2003.08.014.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"3227_CR17","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S1081-1206(10)60199-8","volume":"101","author":"B Khalili","year":"2008","unstructured":"Khalili B, Boggs PB, Shi R, Bahna SL. Discrepancy between clinical asthma control assessment tools and fractional exhaled nitric oxide. Ann Allergy, Asthma Immunol. 2008;101(2):124\u20139. https:\/\/doi.org\/10.1016\/S1081-1206(10)60199-8.","journal-title":"Ann Allergy, Asthma Immunol"},{"issue":"2","key":"3227_CR18","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1398-9995.2006.01250.x","volume":"62","author":"G Senna","year":"2007","unstructured":"Senna G, Passalacqua G, Schiappoli M, Lombardi C, Wilcock L. Correlation among FEV1, nitric oxide and asthma control test in newly diagnosed asthma. Allergy Eur J Allergy Clin Immunol. 2007;62(2):207\u20138. https:\/\/doi.org\/10.1111\/j.1398-9995.2006.01250.x.","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"issue":"6","key":"3227_CR19","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/S1081-1206(10)60223-2","volume":"101","author":"T Shirai","year":"2008","unstructured":"Shirai T, Furuhashi K, Suda T, Chida K. Relationship of the asthma control test with pulmonary function and exhaled nitric oxide. Ann Allergy, Asthma Immunol. 2008;101(6):608\u201313. https:\/\/doi.org\/10.1016\/S1081-1206(10)60223-2.","journal-title":"Ann Allergy, Asthma Immunol"},{"issue":"6","key":"3227_CR20","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1136\/thx.2010.153411","volume":"66","author":"S Hashimoto","year":"2011","unstructured":"Hashimoto S, Ten Brinke A, Roldaan AC, et al. Internet-based tapering of oral corticosteroids in severe asthma: A pragmatic randomised controlled trial. Thorax. 2011;66(6):514\u201320. https:\/\/doi.org\/10.1136\/thx.2010.153411.","journal-title":"Thorax"},{"issue":"3","key":"3227_CR21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1177\/1721727X1201000314","volume":"10","author":"M Malerba","year":"2012","unstructured":"Malerba M, Ragnoli B, Radaeli A, Ricciardolo FLM. Long-term adjustment of stable asthma treatment with fractional exhaled nitric oxide and sputum eosinophils. Eur J Inflamm. 2012;10(3):383\u201392. https:\/\/doi.org\/10.1177\/1721727X1201000314.","journal-title":"Eur J Inflamm"},{"issue":"1","key":"3227_CR22","doi-asserted-by":"publisher","first-page":"91","DOI":"10.2332\/allergolint.12-OA-0444","volume":"62","author":"M Hojo","year":"2013","unstructured":"Hojo M, Mizutani T, Iikura M, Hirano S, Kobayashi N, Sugiyama H. Asthma control can be maintained after fixed-dose, budesonide\/ formoterol combination inhaler therapy is stepped down from medium to low dose. Allergol Int. 2013;62(1):91\u20138. https:\/\/doi.org\/10.2332\/allergolint.12-OA-0444.","journal-title":"Allergol Int"},{"issue":"7","key":"3227_CR23","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3109\/02770903.2013.795588","volume":"50","author":"Y Obase","year":"2013","unstructured":"Obase Y, Ikeda M, Kurose K, et al. Step-down of budesonide\/formoterol in early stages of asthma treatment leads to insufficient anti-inflammatory effect. J Asthma. 2013;50(7):718\u201321. https:\/\/doi.org\/10.3109\/02770903.2013.795588.","journal-title":"J Asthma"},{"issue":"21","key":"3227_CR24","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1056\/NEJMoa043596","volume":"352","author":"AD Smith","year":"2005","unstructured":"Smith AD, Cowan J, Brassett K, Herbison G, Taylor DR. Use of Exhaled Nitric Oxide Measurements to Guide Treatment in Chronic Asthma. N Engl J Med. 2005;352(21):2163\u201373.","journal-title":"N Engl J Med"},{"issue":"3","key":"3227_CR25","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2332\/allergolint.13-OA-0543","volume":"62","author":"A Hayata","year":"2013","unstructured":"Hayata A, Matsunaga K, Hirano T, et al. Stratifying a risk for an increased variation of airway caliber among the clinically stable asthma. Allergol Int. 2013;62(3):343\u20139. https:\/\/doi.org\/10.2332\/allergolint.13-OA-0543.","journal-title":"Allergol Int"},{"key":"3227_CR26","unstructured":"British Thoracic Society, Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. 2016. Available from: https:\/\/www.brit-thoracic.org.uk\/quality-improvement\/guidelines\/asthma\/. Accessed 28 May 2022."},{"key":"3227_CR27","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.rmed.2019.07.010","volume":"155","author":"CRW Kuo","year":"2019","unstructured":"Kuo CRW, Spears M, Haughney J, et al. Scottish consensus statement on the role of FeNO in adult asthma. Respir Med. 2019;155:54\u20137. https:\/\/doi.org\/10.1016\/j.rmed.2019.07.010.","journal-title":"Respir Med"},{"key":"3227_CR28","unstructured":"National Institute for Health and Care Excellence. Asthma: Diagnosis and Monitoring of Asthma in Adults, Children and Young People.; 2017."},{"issue":"4","key":"3227_CR29","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jaci.2009.06.053","volume":"124","author":"M Schatz","year":"2009","unstructured":"Schatz M, Kosinski M, Yarlas AS, et al. The minimally important difference of the Asthma Control Test. J Allergy Clin Immunol. 2009;124(4):719\u2013723.e1. https:\/\/doi.org\/10.1016\/j.jaci.2009.06.053.","journal-title":"J Allergy Clin Immunol"},{"key":"3227_CR30","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1080\/02770900701752615","volume":"44","author":"JM Vega","year":"2007","unstructured":"Vega JM, Badia X, Badiola C, et al. Validation of the Spanish Version of the Asthma Control Test ( ACT ). J Asthma. 2007;44:867\u201372. https:\/\/doi.org\/10.1080\/02770900701752615.","journal-title":"J Asthma"},{"key":"3227_CR31","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.jaci.2012.08.023","volume":"131","author":"CE Jia","year":"2013","unstructured":"Jia CE, Zhang HP, Lv Y, et al. The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control\u202f: Systematic review and meta-analysis. J Allergy Clin Immunol. 2013;131:695\u2013703. https:\/\/doi.org\/10.1016\/j.jaci.2012.08.023.","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"3227_CR32","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","volume":"171","author":"The American Thoracic Society (ATS) and the European Respiratory Society (ERS)","year":"2005","unstructured":"The American Thoracic Society (ATS) and the European Respiratory Society (ERS). ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005;171(8):912\u201330. https:\/\/doi.org\/10.1164\/rccm.200406-710ST.","journal-title":"Am J Respir Crit Care Med."},{"issue":"4","key":"3227_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1183\/13993003.00965-2016","volume":"49","author":"I Horv\u00e1th","year":"2017","unstructured":"Horv\u00e1th I, Barnes PJ, Loukides S, et al. A european respiratory society technical standard: Exhaled biomarkers in lung disease. Eur Respir J. 2017;49(4):1\u201326. https:\/\/doi.org\/10.1183\/13993003.00965-2016.","journal-title":"Eur Respir J"},{"issue":"5","key":"3227_CR34","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1183\/09031936.05.00035205","volume":"26","author":"R Pellegrino","year":"2005","unstructured":"Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948\u201368. https:\/\/doi.org\/10.1183\/09031936.05.00035205.","journal-title":"Eur Respir J"},{"issue":"5","key":"3227_CR35","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1183\/09031936.06.00040506","volume":"28","author":"ALP Albuquerque","year":"2006","unstructured":"Albuquerque ALP, Nery LE, Villa\u00e7a DS, et al. Inspiratory fraction and exercise impairment in COPD patients GOLD stages II-III. Eur Respir J. 2006;28(5):939\u201344. https:\/\/doi.org\/10.1183\/09031936.06.00040506.","journal-title":"Eur Respir J"},{"issue":"10","key":"3227_CR36","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.3346\/jkms.2015.30.10.1459","volume":"30","author":"TR Shin","year":"2015","unstructured":"Shin TR, Oh YM, Park JH, et al. The prognostic value of residual volume\/total lung capacity in patients with chronic obstructive pulmonary disease. J Korean Med Sci. 2015;30(10):1459\u201365. https:\/\/doi.org\/10.3346\/jkms.2015.30.10.1459.","journal-title":"J Korean Med Sci"},{"issue":"9643","key":"3227_CR37","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/S0140-6736(08)61448-8","volume":"372","author":"SJ Szefler","year":"2008","unstructured":"Szefler SJ, Mitchell H, Sorkness CA, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008;372(9643):1065\u201372. https:\/\/doi.org\/10.1016\/S0140-6736(08)61448-8.","journal-title":"Lancet"},{"issue":"1","key":"3227_CR38","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1399-3038.2005.00220.x","volume":"16","author":"M Barreto","year":"2005","unstructured":"Barreto M, Villa MP, Monti F, et al. Additive effect of eosinophilia and atopy on exhaled nitric oxide levels in children with or without a history of respiratory symptoms. Pediatr Allergy Immunol. 2005;16(1):52\u20138. https:\/\/doi.org\/10.1111\/j.1399-3038.2005.00220.x.","journal-title":"Pediatr Allergy Immunol"},{"issue":"5","key":"3227_CR39","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1378\/chest.130.5.1319","volume":"130","author":"AC Olin","year":"2006","unstructured":"Olin AC, Rosengren A, Thelle DS, Lissner L, Bake B, Tor\u00e9n K. Height, age, and atopy are associated with fraction of exhaled nitric oxide in a large adult general population sample. Chest. 2006;130(5):1319\u201325. https:\/\/doi.org\/10.1378\/chest.130.5.1319.","journal-title":"Chest"},{"issue":"9","key":"3227_CR40","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1046\/j.1365-2222.1999.00661.x","volume":"29","author":"I Horv\u00e1th","year":"1999","unstructured":"Horv\u00e1th I, Barnes PJ. Exhaled monoxides in asymptomatic atopic subjects. Clin Exp Allergy. 1999;29(9):1276\u201380. https:\/\/doi.org\/10.1046\/j.1365-2222.1999.00661.x.","journal-title":"Clin Exp Allergy"},{"issue":"2","key":"3227_CR41","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/j.1365-2222.2004.01888.x","volume":"34","author":"AC Olin","year":"2004","unstructured":"Olin AC, Alving K, Tor\u00e9n K. Exhaled nitric oxide: Relation to sensitization and respiratory symptoms. Clin Exp Allergy. 2004;34(2):221\u20136. https:\/\/doi.org\/10.1111\/j.1365-2222.2004.01888.x.","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"3227_CR42","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.anai.2021.03.031","volume":"127","author":"JH Kim","year":"2021","unstructured":"Kim JH, Jin J, Park SY, et al. Discontinuation of inhaled corticosteroids in patients with controlled asthma: The DISCO (Discontinuation of Inhaled Steroid in Controlled asthmatics Over 6 months) study. Ann Allergy, Asthma Immunol. 2021;127(1):123\u2013130.e1. https:\/\/doi.org\/10.1016\/j.anai.2021.03.031.","journal-title":"Ann Allergy, Asthma Immunol"},{"issue":"3","key":"3227_CR43","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1752-699X.2008.00124.x","volume":"3","author":"J Syk","year":"2009","unstructured":"Syk J, Und\u00e9n AL, Alving K. Relationship between exhaled nitric oxide and IgE sensitisation in patients with asthma: Influence of steroid treatment. Clin Respir J. 2009;3(3):143\u201351. https:\/\/doi.org\/10.1111\/j.1752-699X.2008.00124.x.","journal-title":"Clin Respir J"},{"issue":"3","key":"3227_CR44","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.jaci.2014.07.016","volume":"135","author":"PJ Honkoop","year":"2015","unstructured":"Honkoop PJ, Loijmans RJB, Termeer EH, et al. Symptom- and fraction of exhaled nitric oxide-driven strategies for asthma control: A cluster-randomized trial in primary care. J Allergy Clin Immunol. 2015;135(3):682\u2013688.e11. https:\/\/doi.org\/10.1016\/j.jaci.2014.07.016.","journal-title":"J Allergy Clin Immunol"},{"key":"3227_CR45","doi-asserted-by":"publisher","unstructured":"Petsky HL, Kew KM, Turner C, Chang AB. Exhaled nitric oxide levels to guide treatment for adults with asthma. Cochrane Database Syst Rev. 2016;2016(9). \nhttps:\/\/doi.org\/10.1002\/14651858.CD011440.pub2","DOI":"10.1002\/14651858.CD011440.pub2"},{"issue":"12","key":"3227_CR46","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1136\/thoraxjnl-2018-211540","volume":"73","author":"HL Petsky","year":"2018","unstructured":"Petsky HL, Cates CJ, Kew KM, Chang AB. Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): A systematic review and meta-analysis. Thorax. 2018;73(12):1110\u20139. https:\/\/doi.org\/10.1136\/thoraxjnl-2018-211540.","journal-title":"Thorax"},{"key":"3227_CR47","doi-asserted-by":"publisher","unstructured":"Wang K, Verbakel JY, Oke J, et al. Using fractional exhaled nitric oxide to guide step-down treatment decisions in patients with asthma: A systematic review and individual patient data meta-analysis. Eur Respir J. 2020;55(5). https:\/\/doi.org\/10.1183\/13993003.02150-2019","DOI":"10.1183\/13993003.02150-2019"},{"key":"3227_CR48","doi-asserted-by":"publisher","unstructured":"Hamid QA. Peripheral inflammation is more important than central inflammation. Respir Med. 1997;91(SUPPL. A):9\u201310. https:\/\/doi.org\/10.1016\/S0954-6111(97)90097-4","DOI":"10.1016\/S0954-6111(97)90097-4"},{"issue":"1","key":"3227_CR49","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ccm.2005.11.001","volume":"27","author":"DJ Slade","year":"2006","unstructured":"Slade DJ, Kraft M. Airway remodeling from bench to bedside: Current perspectives. Clin Chest Med. 2006;27(1):71\u201385. https:\/\/doi.org\/10.1016\/j.ccm.2005.11.001.","journal-title":"Clin Chest Med"},{"key":"3227_CR50","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.rmed.2017.01.011","volume":"124","author":"A Tiwari","year":"2017","unstructured":"Tiwari A, Rahman K, Abejie B, Jain VV, Vempilly JJ. Longer duration of asthma is significantly associated with increased RV\/TLC ratio. Respir Med. 2017;124:44\u20138. https:\/\/doi.org\/10.1016\/j.rmed.2017.01.011.","journal-title":"Respir Med"},{"issue":"6","key":"3227_CR51","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3109\/02770903.2013.789058","volume":"50","author":"VV Jain","year":"2013","unstructured":"Jain VV, Abejie B, Bashir MH, Tyner T, Vempilly J. Lung volume abnormalities and its correlation to spirometric and demographic variables in adult asthma. J Asthma. 2013;50(6):600\u20135. https:\/\/doi.org\/10.3109\/02770903.2013.789058.","journal-title":"J Asthma"},{"issue":"11","key":"3227_CR52","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.rmed.2013.08.009","volume":"107","author":"T Perez","year":"2013","unstructured":"Perez T, Chanez P, Dusser D, Devillier P. Small airway impairment in moderate to severe asthmatics without significant proximal airway obstruction. Respir Med. 2013;107(11):1667\u201374. https:\/\/doi.org\/10.1016\/j.rmed.2013.08.009.","journal-title":"Respir Med"},{"issue":"3","key":"3227_CR53","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1183\/09031936.03.00261903","volume":"22","author":"B Abraham","year":"2003","unstructured":"Abraham B, Ant\u00f3 JM, Barreiro E, et al. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J. 2003;22(3):470\u20137. https:\/\/doi.org\/10.1183\/09031936.03.00261903.","journal-title":"Eur Respir J"},{"issue":"2","key":"3227_CR54","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1159\/000242113","volume":"80","author":"T Takeda","year":"2010","unstructured":"Takeda T, Oga T, Niimi A, et al. Relationship between small airway function and health status, dyspnea and disease control in asthma. Respiration. 2010;80(2):120\u20136. https:\/\/doi.org\/10.1159\/000242113.","journal-title":"Respiration"},{"issue":"4","key":"3227_CR55","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1378\/chest.124.4.1325","volume":"124","author":"L Prieto","year":"2003","unstructured":"Prieto L, Bruno L, Guti\u00e9rrez V, et al. Airway Responsiveness to Adenosine 5\u2032-Monophosphate and Exhaled Nitric Oxide Measurements: Predictive Value as Markers for Reducing the Dose of Inhaled Corticosteroids in Asthmatic Subjects. Chest. 2003;124(4):1325\u201333. https:\/\/doi.org\/10.1378\/chest.124.4.1325.","journal-title":"Chest"},{"issue":"3","key":"3227_CR56","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1053\/rmed.2001.1248","volume":"96","author":"AS Jang","year":"2002","unstructured":"Jang AS, Choi IS. Relationship between the perception of dyspnoea and airway inflammatory markers. Respir Med. 2002;96(3):150\u20134. https:\/\/doi.org\/10.1053\/rmed.2001.1248.","journal-title":"Respir Med"},{"issue":"9","key":"3227_CR57","doi-asserted-by":"publisher","first-page":"955","DOI":"10.3109\/02770900903265804","volume":"46","author":"JA Bernstein","year":"2009","unstructured":"Bernstein JA, Davis B, Alvarez-Puebla MJ, Levin L, Olaguibel JM. Is exhaled nitric oxide a useful adjunctive test for assessing asthma? J Asthma. 2009;46(9):955\u201360. https:\/\/doi.org\/10.3109\/02770900903265804.","journal-title":"J Asthma"},{"issue":"7","key":"3227_CR58","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.arbres.2010.04.003","volume":"46","author":"FJ Alvarez-Guti\u00e9rrez","year":"2010","unstructured":"Alvarez-Guti\u00e9rrez FJ, Medina-Gallardo JF, P\u00e9rez-Navarro P, et al. Relaci\u00f3n del test de control del asma (ACT) con la funci\u00f3n pulmonar, niveles de \u00f3xido n\u00edtrico exhalado y grados de control seg\u00fan la Iniciativa Global para el Asma (GINA). Arch Bronconeumol. 2010;46(7):370\u20137. https:\/\/doi.org\/10.1016\/j.arbres.2010.04.003.","journal-title":"Arch Bronconeumol"},{"issue":"9","key":"3227_CR59","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3109\/02770903.2011.611958","volume":"48","author":"D Papakosta","year":"2011","unstructured":"Papakosta D, Latsios D, Manika K, Porpodis K, Kontakioti E, Gioulekas D. Asthma control test is correlated to Fev1 and nitric oxide in Greek asthmatic patients: Influence of treatment. J Asthma. 2011;48(9):901\u20136. https:\/\/doi.org\/10.3109\/02770903.2011.611958.","journal-title":"J Asthma"},{"issue":"2","key":"3227_CR60","doi-asserted-by":"publisher","first-page":"132","DOI":"10.4103\/0970-2113.201322","volume":"34","author":"V Kavitha","year":"2017","unstructured":"Kavitha V, Mohan A, Madan K, Hadda V, Khilnani G, Guleria R. Fractional exhaled nitric oxide is a useful adjunctive modality for monitoring bronchial asthma. Lung India. 2017;34(2):132\u20137. https:\/\/doi.org\/10.4103\/0970-2113.201322.","journal-title":"Lung India"},{"key":"3227_CR61","doi-asserted-by":"publisher","unstructured":"Gemicioglu B, Musellim B, Dogan I, Guven K. Fractional Exhaled Nitric Oxide (FeNo) in Different Asthma Phenotypes. Allergy Rhinol. 2014;5(3):ar.2014.5.0099. https:\/\/doi.org\/10.2500\/ar.2014.5.0099","DOI":"10.2500\/ar.2014.5.0099"},{"issue":"5","key":"3227_CR62","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.21037\/jtd.2020.04.01","volume":"12","author":"VN Nguyen","year":"2020","unstructured":"Nguyen VN, Chavannes NH. Correlation between fractional exhaled nitric oxide and Asthma Control Test score and spirometry parameters in on-treatmentasthmatics in Ho Chi Minh City. J Thorac Dis. 2020;12(5):2197\u2013209. https:\/\/doi.org\/10.21037\/jtd.2020.04.01.","journal-title":"J Thorac Dis"},{"key":"3227_CR63","doi-asserted-by":"publisher","unstructured":"Han CH, Park Y Il, Kwak HJ, et al. Relationship between exhaled nitric oxide and levels of asthma control in asthma patients treated with inhaled corticosteroid. Tuberc Respir Dis (Seoul). 2011;71(2):106\u2013113.\u00a0https:\/\/doi.org\/10.4046\/trd.2011.71.2.106","DOI":"10.4046\/trd.2011.71.2.106"},{"issue":"4","key":"3227_CR64","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.mjafi.2021.01.018","volume":"78","author":"CDS Katoch","year":"2022","unstructured":"Katoch CDS, Vasan AS, Pathak K. Correlation of fraction of exhaled nitric oxide with asthma control test and asthma severity in diagnosed cases of asthma. Med J Armed Forces India. 2022;78(4):443\u20137. https:\/\/doi.org\/10.1016\/j.mjafi.2021.01.018.","journal-title":"Med J Armed Forces India"},{"key":"3227_CR65","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2147\/JAA.S107773","volume":"9","author":"H Nguyen-Thi-Bich","year":"2016","unstructured":"Nguyen-Thi-Bich H, Duong-Thi-Ly H, Thom VT, et al. Study of the correlations between fractional exhaled nitric oxide in exhaled breath and atopic status, blood eosinophils, FCER2 mutation, and asthma control in Vietnamese children. J Asthma Allergy. 2016;9:163\u201370. https:\/\/doi.org\/10.2147\/JAA.S107773.","journal-title":"J Asthma Allergy"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03227-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-024-03227-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03227-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T09:13:28Z","timestamp":1724922808000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-024-03227-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3227"],"URL":"https:\/\/doi.org\/10.1186\/s12890-024-03227-y","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"assertion":[{"value":"1 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Ethics Committee for Clinical Research of Fundaci\u00f3n Sant Joan de D\u00e9u (Barcelona, Spain) (N.E. 2012\u2013000372-42\u2014C.I. AC-06\u201312). Informed consent was obtained from all participants involved in the study or their legal guardians, and gave their voluntary consent to participate.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"421"}}