{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:35:15Z","timestamp":1793824515641,"version":"4.6.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"DOI":"10.1186\/s12890-024-03259-4","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:04:10Z","timestamp":1725879850000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The relationship between lung CT features and serum cryptococcal antigen titers in localized pulmonary cryptococcosis patients"],"prefix":"10.1186","volume":"24","author":[{"given":"Chunmei","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"issue":"5","key":"3259_CR1","doi-asserted-by":"publisher","first-page":"476","DOI":"10.7883\/yoken.JJID.2022.141","volume":"75","author":"Z Mo","year":"2022","unstructured":"Mo Z, Li C, Liang Z, Cui J, Yu L, Chen L. Clinical analysis of non-AIDS patients with pulmonary cryptococcosis and the change in their clinical features over 30 years in a tertiary hospital in Beijing, China. Jpn J Infect Dis. 2022;75(5):476\u201383.","journal-title":"Jpn J Infect Dis"},{"issue":"1","key":"3259_CR2","doi-asserted-by":"publisher","first-page":"5712","DOI":"10.1038\/s41598-022-09794-6","volume":"12","author":"DX Wang","year":"2022","unstructured":"Wang DX, Zhang Q, Wen QT, Ding GX, Wang YG, Du FX, Zhang TY, Zheng XY, Cong HY, Du YL, et al. Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients. Sci Rep. 2022;12(1):5712.","journal-title":"Sci Rep"},{"issue":"1","key":"3259_CR3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s11684-017-0601-0","volume":"12","author":"M Chen","year":"2018","unstructured":"Chen M, Xu Y, Hong N, Yang Y, Lei W, Du L, Zhao J, Lei X, Xiong L, Cai L, et al. Epidemiology of fungal infections in China. Front Med. 2018;12(1):58\u201375.","journal-title":"Front Med"},{"issue":"12","key":"3259_CR4","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"B De Pauw","year":"2008","unstructured":"De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, Pappas PG, Maertens J, Lortholary O, Kauffman CA, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group. Clin Infect Dis. 2008;46(12):1813\u201321.","journal-title":"Clin Infect Dis"},{"key":"3259_CR5","first-page":"321","volume":"05","author":"Zhejiang Medical Association Societ","year":"2017","unstructured":"Zhejiang Medical Association Society of Respiratory Diseases. Expert consensus on diagnosis and treatment of pulmonary cryptococcosis. Chin J Clin Infect Dis. 2017;05:321\u20136.","journal-title":"Chin J Clin Infect Dis."},{"issue":"2","key":"3259_CR6","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1128\/JCM.02223-15","volume":"54","author":"A Jitmuang","year":"2016","unstructured":"Jitmuang A, Panackal AA, Williamson PR, Bennett JE, Dekker JP, Zelazny AM, Diekema DJ. Performance of the cryptococcal antigen lateral flow assay in non-HIV-related cryptococcosis. J Clin Microbiol. 2016;54(2):460\u20133.","journal-title":"J Clin Microbiol"},{"issue":"18","key":"3259_CR7","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.4103\/0366-6999.240815","volume":"131","author":"T Zhu","year":"2018","unstructured":"Zhu T, Luo WT, et al. Extent of lung involvement and serum cryptococcal antigen test in non-human immunodeficiency virus adult patients with pulmonary cryptococcosis. Chin Med J. 2018;131(18):2210\u20135.","journal-title":"Chin Med J"},{"issue":"37","key":"3259_CR8","doi-asserted-by":"publisher","first-page":"e30572","DOI":"10.1097\/MD.0000000000030572","volume":"101","author":"Q Hu","year":"2022","unstructured":"Hu Q, Li X, Zhou X, Zhao C, Zheng C, Xu L, Zhou Z. Clinical utility of cryptococcal antigen detection in transthoracic needle aspirate by lateral flow assay for diagnosing non-HIV pulmonary cryptococcosis: a multicenter retrospective study. Medicine. 2022;101(37):e30572.","journal-title":"Medicine"},{"issue":"8","key":"3259_CR9","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1128\/JCM.00751-17","volume":"55","author":"M Dubbels","year":"2017","unstructured":"Dubbels M, Granger D, Theel ES, Gilligan P. Low Cryptococcus antigen titers as determined by lateral flow assay should be interpreted cautiously in patients without prior diagnosis of cryptococcal infection. J Clin Microbiol. 2017;55(8):2472\u20139.","journal-title":"J Clin Microbiol"},{"key":"3259_CR10","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.2147\/IDR.S178391","volume":"11","author":"Y Zhou","year":"2018","unstructured":"Zhou Y, Lin PC, Ye JR, Su SS, Dong L, Wu Q, Xu HY, Xie YP, Li YP. The performance of serum cryptococcal capsular polysaccharide antigen test, histopathology and culture of the lung tissue for diagnosis of pulmonary cryptococcosis in patients without HIV infection. Infect Drug Resist. 2018;11:2483\u201390.","journal-title":"Infect Drug Resist"},{"key":"3259_CR11","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1056\/NEJMicm2109090","volume":"385","author":"L Akintilo","year":"2021","unstructured":"Akintilo L, Femia A. Disseminated Cryptococcosis. N Engl J Med. 2021;385:1699.","journal-title":"N Engl J Med"},{"issue":"1","key":"3259_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jmii.2021.08.006","volume":"55","author":"C Wang","year":"2022","unstructured":"Wang C, Li R, Ma C, Du J, Gu L. Early diagnosis of disseminated cryptococcosis by cryptococcal antigen lateral-flow assay. J Microbiol Immunol Infect. 2022;55(1):177\u20139.","journal-title":"J Microbiol Immunol Infect"},{"issue":"1","key":"3259_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jiac.2014.08.025","volume":"21","author":"S Kohno","year":"2015","unstructured":"Kohno S, Kakeya H, Izumikawa K, Miyazaki T, Yamamoto Y, Yanagihara K, Mitsutake K, Miyazaki Y, Maesaki S, Yasuoka A, et al. Clinical features of pulmonary cryptococcosis in non-HIV patients in Japan. J Infect Chemother. 2015;21(1):23\u201330.","journal-title":"J Infect Chemother"},{"key":"3259_CR14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fcimb.2020.00170","volume":"10","author":"M Xu","year":"2020","unstructured":"Xu M, Peng Z, Xu C, Chen Y, Cheng J, Chi Y, Wei H, Chen W, Hu Z. Underlying cryptococcal diseases and the correlation with serum cryptococcal antigen titers in hospitalized HIV-infected patients screened positive for cryptococcal antigenemia. Front Cell Infect Microbiol. 2020;10:170.","journal-title":"Front Cell Infect Microbiol"},{"issue":"02","key":"3259_CR15","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1093\/cid\/ciz193","volume":"70","author":"K Marr","year":"2020","unstructured":"Marr K, Sun Y, et al. A multicenter, longitudinal cohort study of cryptococcosis in human immunodeficiency virus-negative people in the United States. Clin Infect Dis. 2020;70(02):252\u201361.","journal-title":"Clin Infect Dis"},{"issue":"10","key":"3259_CR16","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1111\/myc.12966","volume":"62","author":"X Hou","year":"2019","unstructured":"Hou X, Kou L, Han X, Zhu R, Song L, Liu T. Pulmonary cryptococcosis characteristics in immunocompetent patients-a 20-year clinical retrospective analysis in China. Mycoses. 2019;62(10):937\u201344.","journal-title":"Mycoses"},{"issue":"2","key":"3259_CR17","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1128\/JCM.02635-15","volume":"54","author":"DY Thomaz","year":"2016","unstructured":"Thomaz DY, Grenfell RC, Vidal MS, Giudice MC, Del Negro GM, Juliano L, Benard G, de Almeida Junior JN. Does the capsule interfere with performance of matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of Cryptococcus neoformans and Cryptococcus gattii? J Clin Microbiol. 2016;54(2):474\u20137.","journal-title":"J Clin Microbiol"},{"issue":"1","key":"3259_CR18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12879-023-08131-0","volume":"23","author":"Y Yan","year":"2023","unstructured":"Yan Y, Wu Y, Wang Q, Zhu X, Li H, Jiang H. Lesion size as a prognostic factor in the antifungal treatment of pulmonary cryptococcosis: a retrospective study with chest CT pictorial review of 2-year follow up. BMC Infect Dis. 2023;23(1):153.","journal-title":"BMC Infect Dis"},{"issue":"2","key":"3259_CR19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jmii.2021.05.002","volume":"55","author":"Z Li","year":"2022","unstructured":"Li Z, Wang M, Zeng P, Chen Z, Zhan Y, Li S, Lin Y, Cheng J, Ye F. Examination of a Chinese-made cryptococcal glucuronoxylomannan antigen test in serum and bronchoalveolar lavage fluid for diagnosing pulmonary cryptococcosis in HIV-negative patients. J Microbiol Immunol Infect. 2022;55(2):307\u201313.","journal-title":"J Microbiol Immunol Infect"},{"issue":"11","key":"3259_CR20","doi-asserted-by":"publisher","first-page":"e49541","DOI":"10.1371\/journal.pone.0049541","volume":"7","author":"BJ McMullan","year":"2012","unstructured":"McMullan BJ, Halliday C, Sorrell TC, Judd D, Sleiman S, Marriott D, Olma T, Chen SC. Clinical utility of the cryptococcal antigen lateral flow assay in a diagnostic mycology laboratory. PLoS ONE. 2012;7(11):e49541.","journal-title":"PLoS ONE"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03259-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-024-03259-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03259-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:04:37Z","timestamp":1725879877000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-024-03259-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3259"],"URL":"https:\/\/doi.org\/10.1186\/s12890-024-03259-4","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,9]]},"assertion":[{"value":"1 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Research Ethics Commission of the First Affiliated Hospital of Xiamen University, China (approved NO. 2021 -67). The need for participants' informed consent was waived because of the retrospective nature of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"441"}}