{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:19:33Z","timestamp":1792718373410,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"DOI":"10.1186\/s12890-024-03264-7","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T10:53:37Z","timestamp":1733396017000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluating the diagnostic and prognostic utility of serial KL-6 measurements in connective tissue disease patients at risk for interstitial lung disease: correlations with pulmonary function tests and high-resolution computed tomography"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1108-9461","authenticated-orcid":false,"given":"Jorge","family":"\u00c1lvarez Troncoso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Porto Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Fern\u00e1ndez Velilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"G\u00f3mez Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Soto Ab\u00e1nades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mart\u00ednez Robles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-8262","authenticated-orcid":false,"given":"Raquel","family":"Sorriguieta Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"R\u00edos Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"3264_CR1","doi-asserted-by":"publisher","unstructured":"Oliveira DS, Ara\u00fajo Filho J de A, Paiva AFL, Ikari ES, Chate RC, Nomura CH. Idiopathic interstitial pneumonias: Review of the latest American Thoracic Society\/European Respiratory Society classification. Radiologia Brasileira. 2018;51(5):321\u2013327. \nhttps:\/\/doi.org\/10.1590\/0100-3984.2016.0134.","DOI":"10.1590\/0100-3984.2016.0134"},{"issue":"5","key":"3264_CR2","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1053\/j.semdp.2018.08.001","volume":"35","author":"M Mlika","year":"2018","unstructured":"Mlika M, Braham E, Mezni F. Interstitial lung disease: Elementary lesions and diagnosis. Semin Diagn Pathol. 2018;35(5):288\u201396. https:\/\/doi.org\/10.1053\/j.semdp.2018.08.001.","journal-title":"Semin Diagn Pathol"},{"key":"3264_CR3","doi-asserted-by":"publisher","unstructured":"Ruaro B, Matucci Cerinic M, Salton F, Baratella E, Confalonieri M, Hughes M. Editorial: Pulmonary fibrosis: One manifestation, various diseases. Front Pharmacol. 2022;13:1027332. Published 2022 Oct 17. \nhttps:\/\/doi.org\/10.3389\/fphar.2022.1027332.","DOI":"10.3389\/fphar.2022.1027332"},{"issue":"3","key":"3264_CR4","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.3390\/ijms24032405","volume":"24","author":"G Cerro Chiang","year":"2023","unstructured":"Cerro Chiang G, Parimon T. Understanding Interstitial Lung Diseases Associated with Connective Tissue Disease (CTD-ILD): Genetics, Cellular Pathophysiology, and Biologic Drivers. Int J Mol Sci. 2023;24(3):2405. https:\/\/doi.org\/10.3390\/ijms24032405.","journal-title":"Int J Mol Sci"},{"key":"3264_CR5","doi-asserted-by":"publisher","unstructured":"Mathai SC, Danoff SK. Management of interstitial lung disease associated with connective tissue disease. BMJ. Published online February 24, 2016:h6819. \nhttps:\/\/doi.org\/10.1136\/bmj.h6819.","DOI":"10.1136\/bmj.h6819"},{"issue":"4","key":"3264_CR6","doi-asserted-by":"publisher","first-page":"326","DOI":"10.36141\/svdld.v34i4.5894","volume":"34","author":"S Geerts","year":"2017","unstructured":"Geerts S, Wuyts W, Langhe ED, Lenaerts J, Yserbyt J. Connective tissue disease associated interstitial pneumonia: a challenge for both rheumatologists and pulmonologists. Sarcoidosis, Vasculitis and Diffuse Lung Diseases. 2017;34(4):326\u201335. https:\/\/doi.org\/10.36141\/svdld.v34i4.5894.","journal-title":"Sarcoidosis, Vasculitis and Diffuse Lung Diseases"},{"issue":"3","key":"3264_CR7","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.ccm.2019.05.008","volume":"40","author":"D Antin-Ozerkis","year":"2019","unstructured":"Antin-Ozerkis D, Hinchcliff M. Connective Tissue disease-associated interstitial lung disease. Clin Chest Med. 2019;40(3):617\u201336. https:\/\/doi.org\/10.1016\/j.ccm.2019.05.008.","journal-title":"Clin Chest Med"},{"issue":"19","key":"3264_CR8","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1001\/jama.2024.3669","volume":"331","author":"TM Maher","year":"2024","unstructured":"Maher TM. Interstitial Lung Disease: A Review. JAMA. 2024;331(19):1655\u201365. https:\/\/doi.org\/10.1001\/jama.2024.3669.","journal-title":"JAMA"},{"key":"3264_CR9","doi-asserted-by":"publisher","unstructured":"Takei R, Matsuda T, Fukihara J, et al. Changes in patient-reported outcomes in patients with non-idiopathic pulmonary fibrosis fibrotic interstitial lung disease and progressive pulmonary fibrosis. Front Med (Lausanne). 2023;10:1067149. Published 2023 Jun 30. \nhttps:\/\/doi.org\/10.3389\/fmed.2023.1067149.","DOI":"10.3389\/fmed.2023.1067149"},{"issue":"5","key":"3264_CR10","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/acr2.11253","volume":"3","author":"FV Castelino","year":"2021","unstructured":"Castelino FV, Moua T. Detection and management of interstitial lung diseases associated with connective tissue diseases. ACR Open Rheumatol. 2021;3(5):295\u2013304. https:\/\/doi.org\/10.1002\/acr2.11253.","journal-title":"ACR Open Rheumatol"},{"issue":"16","key":"3264_CR11","doi-asserted-by":"publisher","first-page":"e19493","DOI":"10.1097\/md.0000000000019493","volume":"99","author":"H Zhang","year":"2020","unstructured":"Zhang H, Chen L, Wu L, et al. Diagnostic and prognostic predictive values of circulating KL-6 for interstitial lung disease. Medicine. 2020;99(16):e19493. https:\/\/doi.org\/10.1097\/md.0000000000019493.","journal-title":"Medicine"},{"key":"3264_CR12","doi-asserted-by":"publisher","unstructured":"Zhang T, Shen P, Duan C, Gao L. KL-6 as an immunological biomarker predicts the severity, progression, acute exacerbation, and poor outcomes of interstitial lung disease: a systematic review and meta-analysis. Front Immunol. 2021;12. https:\/\/doi.org\/10.3389\/fimmu.2021.745233","DOI":"10.3389\/fimmu.2021.745233"},{"issue":"4","key":"3264_CR13","doi-asserted-by":"publisher","first-page":"e2022035","DOI":"10.36141\/svdld.v39i4.11344","volume":"39","author":"E Demird\u00f6\u011fen","year":"2022","unstructured":"Demird\u00f6\u011fen E, Dilekta\u015fl\u0131 AG, \u00d6zt\u00fcrk NAA, et al. Serum Krebs von den Lungen-6: promising biomarker to differentiate CPFE from IPF. Sarcoidosis Vasc Diffuse Lung Dis. 2022;39(4):e2022035\u2013e2022035. https:\/\/doi.org\/10.36141\/svdld.v39i4.11344.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"3264_CR14","doi-asserted-by":"publisher","unstructured":"Lee JS, Lee EY, Ha YJ, Kang EH, Lee YJ, Song YW. Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease. Arthritis Research & Therapy. 2019;21(1). \nhttps:\/\/doi.org\/10.1186\/s13075-019-1835-9.","DOI":"10.1186\/s13075-019-1835-9"},{"issue":"8","key":"3264_CR15","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2217\/bmm-2019-0545","volume":"14","author":"M d\u2019Alessandro","year":"2020","unstructured":"d\u2019Alessandro M, Bergantini L, Cameli P, et al. Krebs von den Lungen-6 as a biomarker for disease severity assessment in interstitial lung disease: a comprehensive review. Biomark Med. 2020;14(8):665\u201374. https:\/\/doi.org\/10.2217\/bmm-2019-0545.","journal-title":"Biomark Med"},{"key":"3264_CR16","doi-asserted-by":"publisher","unstructured":"Wang Y, Chen S, Zheng S, et al. The role of lung ultrasound B-lines and serum KL-6 in the screening and follow-up of rheumatoid arthritis patients for an identification of interstitial lung disease: review of the literature, proposal for a preliminary algorithm, and clinical application to cases. Arthritis Res Ther. 2021;23(1). \nhttps:\/\/doi.org\/10.1186\/s13075-021-02586-9.","DOI":"10.1186\/s13075-021-02586-9"},{"issue":"8","key":"3264_CR17","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1159\/000531945","volume":"102","author":"C Lederer","year":"2023","unstructured":"Lederer C, Mayer K, Somogyi V, et al. Krebs von den Lungen-6 as a Potential Predictive Biomarker in Fibrosing Interstitial Lung Diseases. Respiration. 2023;102(8):591\u2013600. https:\/\/doi.org\/10.1159\/000531945.","journal-title":"Respiration"},{"key":"3264_CR18","doi-asserted-by":"publisher","unstructured":"Sieiro Santos C, Antol\u00edn SC, Lorenzo JD la C, et al. KL6 and IL-18 levels are negatively correlated with respiratory function tests and ILD extent assessed on HRCT in patients with systemic sclerosis-related interstitial lung disease (SSc-ILD). Semin Arthritis Rheum. 2024;65:152366. \nhttps:\/\/doi.org\/10.1016\/j.semarthrit.2024.152366.","DOI":"10.1016\/j.semarthrit.2024.152366"},{"issue":"3","key":"3264_CR19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/crj.12341","volume":"11","author":"Y Hu","year":"2015","unstructured":"Hu Y, Wang L, Jin Y, et al. Serum Krebs von den Lungen-6 level as a diagnostic biomarker for interstitial lung disease in Chinese patients. Clin Respir J. 2015;11(3):337\u201345. https:\/\/doi.org\/10.1111\/crj.12341.","journal-title":"Clin Respir J"},{"issue":"23","key":"3264_CR20","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.2169\/internalmedicine.50.5866","volume":"50","author":"S Doishita","year":"2011","unstructured":"Doishita S, Inokuma S, Asashima H, et al. Serum KL-6 level as an indicator of active or inactive interstitial pneumonitis associated with connective tissue diseases. Intern Med. 2011;50(23):2889\u201392. https:\/\/doi.org\/10.2169\/internalmedicine.50.5866.","journal-title":"Intern Med"},{"key":"3264_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/9099802","volume":"2021","author":"Y Tagami","year":"2021","unstructured":"Tagami Y, Hara Y, Murohashi K, et al. Comparison of Clinical Features between the High and Low Serum KL-6 Patients with Acute Exacerbation of Interstitial Lung Diseases. Can Respir J. 2021;2021:1\u20139. https:\/\/doi.org\/10.1155\/2021\/9099802.","journal-title":"Can Respir J"},{"issue":"4","key":"3264_CR22","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3109\/bf03041350","volume":"9","author":"T Oyama","year":"1999","unstructured":"Oyama T, Kohno N, Yokoyama A, et al. High serum KL-6 levels predict the deterioration of pulmonary function in patients with rheumatoid arthritis. Japanese J Rheumatol. 1999;9(4):373\u201380. https:\/\/doi.org\/10.3109\/bf03041350.","journal-title":"Japanese J Rheumatol"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03264-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-024-03264-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03264-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T11:04:25Z","timestamp":1733396665000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-024-03264-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3264"],"URL":"https:\/\/doi.org\/10.1186\/s12890-024-03264-7","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]},"assertion":[{"value":"19 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Commission of the Hospital Universitario La Paz (Approval Number: PI-5929). All participants provided informed consent to participate in the study. The authors have reviewed and accepted the journal\u2019s instructions for authors and comply with all conditions therein.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable as this manuscript does not contain any individual person\u2019s data in any form (including individual details, images, or videos).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"603"}}