{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:45:20Z","timestamp":1759178720929,"version":"3.37.3"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Interstitial lung diseases (ILDs) are diverse pulmonary disorders marked by diffuse lung inflammation and fibrosis. The variability in characteristics and treatment approaches complicates diagnosis and management. In advanced cases requiring transplantation, determining indications and selecting suitable candidates presents additional challenges.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Of all patients with non-IPF ILD between December 2016 to December 2022 were analyzed retrospectively. Patients were categorized into two groups: transplanted patients and deceased patients on the waiting list. Clinical data and survival outcomes were compared between groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 43 patients, 20 underwent lung transplantation while 23 died awaiting transplantation. Waiting list mortality was 53.4%, with median waiting times similar between groups (3 months for transplant patients and 6 months for those on the waiting list). There were no significant differences between groups in age, gender, height, BMI, 6-minute walk test (6MWT), or forced vital capacity (FVC). The prevalence of pulmonary hypertension (PH) was 76.7% in right heart catheterizations, similar in both groups. One single and 19 bilateral lung transplants were performed. Overall, 13 of the 20 patients survived to discharge from the hospital. One-year mortality was 7\/20 (35%). The median follow-up was 34 months, with a 1-year conditional survival of 90.9% at 3 years and 70.7% at 5 years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study underscores the importance of further research into non-IPF ILDs. Lung transplantation remains a viable option that can significantly enhance both the quality and longevity of life for patients with advanced ILD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-024-03291-4","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T12:02:08Z","timestamp":1727870528000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Expanding horizons: lung transplantation for non-IPF interstitial lung diseases"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-3330","authenticated-orcid":false,"given":"Sevinc","family":"Citak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-9118","authenticated-orcid":false,"given":"Ertan","family":"Saribas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-2865","authenticated-orcid":false,"given":"Ayse Nigar","family":"Halis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5423-1941","authenticated-orcid":false,"given":"Fatma Feyza","family":"Alkilic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-4057","authenticated-orcid":false,"given":"Murat Ersin","family":"Cardak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-7498","authenticated-orcid":false,"given":"Mustafa","family":"Vayvada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-7878","authenticated-orcid":false,"given":"Ahmet Erdal","family":"Tasci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"issue":"4","key":"3291_CR1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1136\/thoraxjnl-2020-215681","volume":"77","author":"M Chizinga","year":"2022","unstructured":"Chizinga M, Machuca TN, Shahmohammadi A, et al. Lung transplantation for acute exacerbation of interstitial lung disease. Thorax. 2022;77(4):364\u20139.","journal-title":"Thorax"},{"key":"3291_CR2","doi-asserted-by":"publisher","first-page":"14054","DOI":"10.1038\/npjpcrm.2014.54","volume":"24","author":"JD Zibrak","year":"2014","unstructured":"Zibrak JD, Price D. Interstitial lung disease: raising the index of suspicion in primary care. NPJ Prim Care Respir Med. 2014;24:14054.","journal-title":"NPJ Prim Care Respir Med"},{"issue":"161","key":"3291_CR3","doi-asserted-by":"publisher","first-page":"210017","DOI":"10.1183\/16000617.0017-2021","volume":"30","author":"SG Kapnadak","year":"2021","unstructured":"Kapnadak SG, Raghu G. Lung transplantation for interstitial lung disease. 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This study was conducted according to the Helsinki principles, patients signed informed consent for participation, and nothing invasive of patients\u2019 privacy was done. The study was a human organ\/tissue transplant study, as it involved lung transplantation for patients with interstitial lung diseases other than IPF. We confirm that organs\/tissues were not taken from prisoners. Each organ\/tissue was taken from volunteer donors. And when these donors became brain dead, Written informed consent was also obtained from their first-degree relatives. And also, written informed consent was obtained for publication of this original article and all accompanying images from all patients who underwent transplantation and from whom that tissue\/organ was taken.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"482"}}