{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:21:37Z","timestamp":1789827697234,"version":"4.0.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Lung transplantation (LTx) remains the only efficient treatment for selected patients with end-stage pulmonary disease. The age limit for the acceptance of donor organs in LTx is still a matter of debate. We here analyze the impact of donor organ age and the underlying pulmonary disease on short- and long-term outcome and survival after LTx.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Donor and recipient characteristics of LTx recipients at our institution between 03\/2003 and 12\/2021 were analyzed. Statistical analysis was performed using SPSS and GraphPad software.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In 230 patients analyzed, donor age\u2009\u2265\u200955 years was associated with a higher incidence of severe primary graft dysfunction (PGD2\/3) (46% vs. 31%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03) and reduced long-term survival after LTx (1-, 5- and 10-year survival: 75%, 54%, 37% vs. 84%, 76%, 69%, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). Notably, this was only significant in recipients with idiopathic pulmonary fibrosis (IPF) (PGD: 65%, vs. 37%, <jats:italic>p<\/jats:italic>\u2009=\u20090.016; 1-, 5-, and 10-year survival: 62%, 38%, 16% vs. 80%, 76%, 70%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0002 respectively). In patients with chronic obstructive pulmonary disease (COPD), donor age had no impact on the incidence of PGD2\/3 or survival (21% vs. 27%, <jats:italic>p<\/jats:italic>\u2009=\u20090.60 and 68% vs. 72%; <jats:italic>p<\/jats:italic>\u2009=\u20090.90 respectively). Moreover, we found higher <jats:italic>Torque-teno<\/jats:italic> virus (TTV)-DNA levels after LTx in patients with IPF compared to COPD (X<jats:sup>2<\/jats:sup>\u2009=\u20094.57, <jats:italic>p<\/jats:italic>\u2009=\u20090.033). Donor age\u2009\u2265\u200955 is an independent risk factor for reduced survival in the whole cohort and patients with IPF specifically.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In recipients with IPF, donor organ age\u2009\u2265\u200955 years was associated with a higher incidence of PGD2\/3 and reduced survival after LTx. The underlying pulmonary disease may thus be a relevant factor for postoperative graft function and survival.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration number DKRS<\/jats:title>\n                <jats:p>DRKS00033312.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-024-03317-x","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T17:02:32Z","timestamp":1728493352000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Donor age over 55 is associated with worse outcome in lung transplant recipients with idiopathic pulmonary fibrosis"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-5214","authenticated-orcid":false,"given":"Isabelle","family":"Moneke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ecem Deniz","family":"Ogutur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya","family":"Kornyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"F\u00e4hndrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schibilsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Bierbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Czerny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana","family":"Stolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernward","family":"Passlick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Jungraithmayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern Christian","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"issue":"3","key":"3317_CR1","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/MOT.0000000000000753","volume":"25","author":"S Bos","year":"2020","unstructured":"Bos S, Vos R, Van Raemdonck DE, Verleden GM. 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