{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T01:04:20Z","timestamp":1778115860872,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Grant-in-Aid for scientific research from the Japan Society for the Promotion of Science","award":["21K11960"],"award-info":[{"award-number":["21K11960"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"DOI":"10.1186\/s12890-024-03456-1","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T06:18:01Z","timestamp":1735193881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and efficacy of transbronchial cryobiopsy for elderly lung cancer patients"],"prefix":"10.1186","volume":"24","author":[{"given":"Kumiko","family":"Yamatsuta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Okachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Kako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Ina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Oya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naozumi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Imaizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"issue":"3","key":"3456_CR1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1093\/annonc\/mdu268","volume":"26","author":"R Blanco","year":"2015","unstructured":"Blanco R, Maestu I, de la Torre MG, Cassinello A, Nu\u00f1ez I. A review of the management of elderly patients with non-small-cell lung cancer. Ann Oncol. 2015;26(3):451\u201363.","journal-title":"Ann Oncol"},{"issue":"3","key":"3456_CR2","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1183\/09031936.00033011","volume":"39","author":"J Hetzel","year":"2012","unstructured":"Hetzel J, Eberhardt R, Herth FJ, Petermann C, Reichle G, Freitag L, et al. Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial. Eur Respir J. 2012;39(3):685\u201390.","journal-title":"Eur Respir J"},{"issue":"4","key":"3456_CR3","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1016\/j.chest.2021.04.063","volume":"160","author":"FJ Herth","year":"2021","unstructured":"Herth FJ, Mayer M, Thiboutot J, Kapp CM, Sun J, Zhang X, et al. Safety and performance of Transbronchial Cryobiopsy for Parenchymal Lung lesions. Chest. 2021;160(4):1512\u20139.","journal-title":"Chest"},{"issue":"3","key":"3456_CR4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.resinv.2013.09.003","volume":"52","author":"T Ogawa","year":"2014","unstructured":"Ogawa T, Imaizumi K, Hashimoto I, Shindo Y, Imai N, Uozu S, et al. Prospective analysis of efficacy and safety of an individualized-midazolam-dosing protocol for sedation during prolonged bronchoscopy. Respir Investig. 2014;52(3):153\u20139.","journal-title":"Respir Investig"},{"issue":"2","key":"3456_CR5","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.chest.2020.02.025","volume":"158","author":"T Souma","year":"2020","unstructured":"Souma T, Minezawa T, Yatsuya H, Okamura T, Yamatsuta K, Morikawa S, et al. Risk factors of Infectious complications after Endobronchial Ultrasound-guided Transbronchial Biopsy. Chest. 2020;158(2):797\u2013807.","journal-title":"Chest"},{"issue":"2","key":"3456_CR6","doi-asserted-by":"publisher","first-page":"00008","DOI":"10.1183\/23120541.00008-2020","volume":"6","author":"M Inomata","year":"2020","unstructured":"Inomata M, Kuse N, Awano N, Tone M, Yoshimura H, Jo T, et al. Prospective multicentre study on the safety and utility of transbronchial lung cryobiopsy with endobronchial balloon. ERJ Open Res. 2020;6(2):00008\u20132020.","journal-title":"ERJ Open Res"},{"issue":"1","key":"3456_CR7","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1186\/s12890-024-03279-0","volume":"24","author":"SS Kho","year":"2024","unstructured":"Kho SS, Tan SH, Chan SK, Chai CS, Tie ST. Bronchial branch tracing navigation in ultrathin bronchoscopy-guided radial endobronchial ultrasound for peripheral pulmonary nodule. BMC Pulm Med. 2024;24(1):466.","journal-title":"BMC Pulm Med"},{"issue":"13","key":"3456_CR8","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.2169\/internalmedicine.55.6341","volume":"55","author":"S Okachi","year":"2016","unstructured":"Okachi S, Imai N, Imaizumi K, Iwano S, Ando M, Hase T, et al. Factors affecting the Diagnostic yield of Transbronchial Biopsy using Endobronchial Ultrasonography with a Guide Sheath in Peripheral Lung Cancer. Intern Med. 2016;55(13):1705\u201312.","journal-title":"Intern Med"},{"issue":"1","key":"3456_CR9","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12890-021-01817-8","volume":"22","author":"T Nakai","year":"2022","unstructured":"Nakai T, Watanabe T, Kaimi Y, Ogawa K, Matsumoto Y, Sawa K, et al. Safety profile and risk factors for bleeding in transbronchial cryobiopsy using a two-scope technique for peripheral pulmonary lesions. BMC Pulm Med. 2022;22(1):20.","journal-title":"BMC Pulm Med"},{"issue":"5","key":"3456_CR10","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/j.chest.2021.05.015","volume":"160","author":"Y Matsumoto","year":"2021","unstructured":"Matsumoto Y, Nakai T, Tanaka M, Imabayashi T, Tsuchida T, Ohe Y. Diagnostic outcomes and Safety of Cryobiopsy added to conventional sampling methods: an observational study. Chest. 2021;160(5):1890\u2013901.","journal-title":"Chest"},{"issue":"1","key":"3456_CR11","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.chest.2020.01.036","volume":"158","author":"EE Folch","year":"2020","unstructured":"Folch EE, Mahajan AK, Oberg CL, Maldonado F, Toloza E, Krimsky WS, et al. Standardized definitions of bleeding after Transbronchial Lung Biopsy: a Delphi Consensus Statement from the Nashville Working Group. Chest. 2020;158(1):393\u2013400.","journal-title":"Chest"},{"issue":"3","key":"3456_CR12","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/j.1440-1843.2011.02123.x","volume":"17","author":"F Asano","year":"2012","unstructured":"Asano F, Aoe M, Ohsaki Y, Okada Y, Sasada S, Sato S, et al. Deaths and complications associated with respiratory endoscopy: a survey by the Japan Society for Respiratory Endoscopy in 2010. Respirology. 2012;17(3):478\u201385.","journal-title":"Respirology"},{"issue":"3","key":"3456_CR13","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/jgs.13999","volume":"64","author":"T Haga","year":"2016","unstructured":"Haga T, Cho K, Nakagawa A, Takagiwa J, Arakawa S, Sakamoto Y, et al. Complications of fiberoptic bronchoscopy in very Elderly adults. J Am Geriatr Soc. 2016;64(3):676\u20137.","journal-title":"J Am Geriatr Soc"},{"issue":"Suppl 1","key":"3456_CR14","doi-asserted-by":"publisher","first-page":"i1","DOI":"10.1136\/thoraxjnl-2013-203618","volume":"68","author":"IA Du Rand","year":"2013","unstructured":"Du Rand IA, Blaikley J, Booton R, Chaudhuri N, Gupta V, Khalid S, British Thoracic Society Bronchoscopy Guideline Group, et al. British thoracic society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE. Thorax. 2013;68(Suppl 1):i1\u201344.","journal-title":"Thorax"},{"issue":"2","key":"3456_CR15","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/00128594-200304000-00005","volume":"10","author":"PF Allan","year":"2003","unstructured":"Allan PF, MD, US Air Force, Ouellette, Colonel Daniel MD, US Army. Bronchoscopic procedures in octogenarians: a case-control analysis. J Bronchol. 2003;10(2):112\u20137.","journal-title":"J Bronchol"},{"issue":"4","key":"3456_CR16","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1111\/ggi.12043","volume":"13","author":"S Okachi","year":"2013","unstructured":"Okachi S, Imai N, Imaizumi K, Hase T, Shindo Y, Sakamoto K, et al. Endobronchial ultrasound transbronchial needle aspiration in older people. Geriatr Gerontol Int. 2013;13(4):986\u201392.","journal-title":"Geriatr Gerontol Int"},{"issue":"2","key":"3456_CR17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s41999-018-0033-7","volume":"9","author":"S Okachi","year":"2018","unstructured":"Okachi S, Imaizumi K, Imai N, Shimizu T, Hase T, Morise M, et al. Safety and efficacy of diagnostic flexible bronchoscopy in very old patients with lung cancer. Eur Geriatr Med. 2018;9(2):255\u201362.","journal-title":"Eur Geriatr Med"},{"issue":"4","key":"3456_CR18","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/LBR.0000000000000511","volume":"25","author":"CW McLaughlin","year":"2018","unstructured":"McLaughlin CW, Skabelund AJ, Easterling ER, Morris MJ. The Safety and Utility of Fiberoptic Bronchoscopy in the very Elderly. J Bronchol Interv Pulmonol. 2018;25(4):300\u20134.","journal-title":"J Bronchol Interv Pulmonol"},{"issue":"1","key":"3456_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/ggi.14313","volume":"22","author":"M Mineshita","year":"2022","unstructured":"Mineshita M, Morikawa K, Furuya N, Kida H, Nishine H, Handa H, et al. Flexible bronchoscopy for lung cancer diagnosis in patients aged\u2009\u2265\u200985 years. Geriatr Gerontol Int. 2022;22(1):32\u20135.","journal-title":"Geriatr Gerontol Int"},{"issue":"1","key":"3456_CR20","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s12871-023-02241-7","volume":"23","author":"M Tun\u00e7","year":"2023","unstructured":"Tun\u00e7 M, Sazak H, \u00d6zt\u00fcrk A, Y\u0131lmaz A, Alag\u00f6z A. Safety of geriatric patients undergoing endobronchial ultrasound-guided transbronchial needle aspiration with deep sedation: a retrospective study. BMC Anesthesiol. 2023;23(1):276.","journal-title":"BMC Anesthesiol"},{"issue":"7","key":"3456_CR21","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1111\/cas.14489","volume":"111","author":"H Udagawa","year":"2020","unstructured":"Udagawa H, Kirita K, Naito T, Nomura S, Ishibashi M, Matsuzawa R, et al. Feasibility and utility of transbronchial cryobiopsy in precision medicine for lung cancer: prospective single-arm study. Cancer Sci. 2020;111(7):2488\u201398.","journal-title":"Cancer Sci"},{"issue":"4","key":"3456_CR22","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/resp.14680","volume":"29","author":"MH Kim","year":"2024","unstructured":"Kim MH, Kim SH, Lee G, Mok J, Lee MK, Song JS, et al. Next-generation sequencing using tissue specimen collected with a 1.1\u00a0mm-diameter cryoprobe in patients with lung cancer. Respirology. 2024;29(4):333\u20139.","journal-title":"Respirology"},{"issue":"5","key":"3456_CR23","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00408-024-00713-2","volume":"202","author":"Y Bian","year":"2024","unstructured":"Bian Y, Deng M, Gao Q, Zhou G, Tong R, Zhao L, et al. The diagnostic efficiency and safety of Transbronchial Lung Cryobiopsy using 1.1-mm cryoprobe in diagnosing interstitial lung disease. Lung. 2024;202(5):615\u201323.","journal-title":"Lung"},{"issue":"3","key":"3456_CR24","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.jgo.2018.09.005","volume":"10","author":"M Radovic","year":"2019","unstructured":"Radovic M, Kanesvaran R, Rittmeyer A, Fr\u00fch M, Minervini F, Glatzer M, et al. Multidisciplinary treatment of lung cancer in older patients: a review. J Geriatr Oncol. 2019;10(3):405\u201310.","journal-title":"J Geriatr Oncol"},{"key":"3456_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.lungcan.2022.07.006","volume":"171","author":"J Lindqvist","year":"2022","unstructured":"Lindqvist J, Jekunen A, Sihvo E, Johansson M, Anders\u00e9n H. Effect of adherence to treatment guidelines on overall survival in elderly non-small-cell lung cancer patients. Lung Cancer. 2022;171:9\u201317.","journal-title":"Lung Cancer"},{"issue":"7","key":"3456_CR26","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1093\/annonc\/mdu022","volume":"25","author":"AG Pallis","year":"2014","unstructured":"Pallis AG, Gridelli C, Wedding U, Faivre-Finn C, Veronesi G, Jaklitsch M, et al. Management of elderly patients with NSCLC; updated expert\u2019s opinion paper: EORTC Elderly Task Force, Lung Cancer Group and International Society for Geriatric Oncology. Ann Oncol. 2014;25(7):1270\u201383.","journal-title":"Ann Oncol"},{"issue":"9","key":"3456_CR27","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1097\/JTO.0b013e318260de8b","volume":"7","author":"M Maemondo","year":"2012","unstructured":"Maemondo M, Minegishi Y, Inoue A, Kobayashi K, Harada M, Okinaga S, et al. First-line gefitinib in patients aged 75 or older with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations: NEJ 003 study. J Thorac Oncol. 2012;7(9):1417\u201322.","journal-title":"J Thorac Oncol"},{"issue":"10","key":"3456_CR28","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1111\/ggi.14243","volume":"21","author":"Y Tsubata","year":"2021","unstructured":"Tsubata Y, Masuda T, Hamai K, Taniwaki M, Tanino A, Hotta T, et al. Efficacy of erlotinib and its effects on the quality of life of older patients with epidermal growth factor receptor-mutant non-small cell lung cancer: a prospective, multicenter, dose-modification study. Geriatr Gerontol Int. 2021;21(10):881\u20136.","journal-title":"Geriatr Gerontol Int"},{"issue":"10","key":"3456_CR29","doi-asserted-by":"publisher","first-page":"11525","DOI":"10.1002\/cam4.5889","volume":"12","author":"D Morinaga","year":"2023","unstructured":"Morinaga D, Asahina H, Ito S, Honjo O, Tanaka H, Honda R, Hokkaido Lung Cancer Clinical Study Group Trial, et al. Real-world data on the efficacy and safety of immune-checkpoint inhibitors in elderly patients with non-small cell lung cancer. Cancer Med. 2023;12(10):11525\u201341.","journal-title":"Cancer Med"},{"key":"3456_CR30","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s11748-020-01426-y","volume":"69","author":"H Ichinokawa","year":"2021","unstructured":"Ichinokawa H, Takamochi K, Fukui M, Hattori A, Matsunaga T, Suzuki K. Surgical results and prognosis of lung cancer in elderly Japanese patients aged over 85 years: comparison with patients aged 80\u201384 years. Gen Thorac Cardiovasc Surg. 2021;69:67\u201375.","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"3456_CR31","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jgo.2016.11.003","volume":"8","author":"KS Kass","year":"2017","unstructured":"Kass KS, Velez-Cubian FO, Zhang WW, et al. Effect of advanced age on peri-operative outcomes after robotic-assisted pulmonary lobectomy: retrospective analysis of 287 consecutive cases. J Geriatr Oncol. 2017;8:102\u20137.","journal-title":"J Geriatr Oncol"},{"issue":"10","key":"3456_CR32","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/S1470-2045(21)00401-0","volume":"22","author":"JY Chang","year":"2021","unstructured":"Chang JY, Mehran RJ, Feng L, Verma V, Liao Z, Welsh JW, STARS Lung Cancer Trials Group, et al. Stereotactic ablative radiotherapy for operable stage I non-small-cell lung cancer (revised STARS): long-term results of a single-arm, prospective trial with prespecified comparison to surgery. Lancet Oncol. 2021;22(10):1448\u201357.","journal-title":"Lancet Oncol"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03456-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-024-03456-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-024-03456-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T07:04:34Z","timestamp":1735196674000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-024-03456-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3456"],"URL":"https:\/\/doi.org\/10.1186\/s12890-024-03456-1","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"31 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our institutional review board approved this study (approval number: HM23-206). Given that this study is a retrospective observational study, informed consent was not required. However, information related to the study was disclosed, and patients were given the opportunity to opt-out from participation, in accordance with institutional guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Patients were given the opportunity to opt-out from publication, in accordance with institutional guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"632"}}