{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:08:25Z","timestamp":1792757305671,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100017689","name":"Guangdong Provincial People\u2019s Hospital","doi-asserted-by":"crossref","award":["8227010402"],"award-info":[{"award-number":["8227010402"]}],"id":[{"id":"10.13039\/501100017689","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"DOI":"10.1186\/s12890-025-03480-9","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T09:28:32Z","timestamp":1741426112000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Determinative sleep traits associated with dyslipidemia in obstructive sleep apnea patients"],"prefix":"10.1186","volume":"25","author":[{"given":"Longlong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"issue":"1","key":"3480_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","volume":"41","author":"F Mach","year":"2020","unstructured":"Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, et al. 2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111\u201388. https:\/\/doi.org\/10.1093\/eurheartj\/ehz455.","journal-title":"Eur Heart J"},{"issue":"6","key":"3480_CR2","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1378\/chest.12-1652","volume":"143","author":"W Trzepizur","year":"2013","unstructured":"Trzepizur W, Le Vaillant M, Meslier N, Pigeanne T, Masson P, Humeau MP, et al. Independent association between nocturnal intermittent hypoxemia and metabolic dyslipidemia. Chest. 2013;143(6):1584\u20139. https:\/\/doi.org\/10.1378\/chest.12-1652.","journal-title":"Chest"},{"issue":"5","key":"3480_CR3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.5664\/jcsm.3690","volume":"10","author":"R Nadeem","year":"2014","unstructured":"Nadeem R, Singh M, Nida M, Waheed I, Khan A, Ahmed S, et al. Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis. J Clin Sleep Med. 2014;10(5):475\u201389. https:\/\/doi.org\/10.5664\/jcsm.3690.","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"3480_CR4","doi-asserted-by":"publisher","first-page":"zsy236","DOI":"10.1093\/sleep\/zsy236","volume":"42","author":"D Barros","year":"2019","unstructured":"Barros D, Garc\u00eda-R\u00edo F. Obstructive sleep apnea and dyslipidemia: from animal models to clinical evidence. Sleep. 2019;42(3):zsy236. https:\/\/doi.org\/10.1093\/sleep\/zsy236.","journal-title":"Sleep"},{"key":"3480_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.sleep.2021.05.012","volume":"84","author":"E Mart\u00ednez-Cer\u00f3n","year":"2021","unstructured":"Mart\u00ednez-Cer\u00f3n E, Casitas R, Galera R, S\u00e1nchez-S\u00e1nchez B, Zamarr\u00f3n E, Garcia-Sanchez A, et al. Contribution of sleep characteristics to the association between obstructive sleep apnea and dyslipidemia. Sleep Med. 2021;84:63\u201372. https:\/\/doi.org\/10.1016\/j.sleep.2021.05.012.","journal-title":"Sleep Med"},{"issue":"2","key":"3480_CR6","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.atherosclerosis.2014.03.034","volume":"234","author":"H Xu","year":"2014","unstructured":"Xu H, Yi H, Guan J, Yin S. Effect of continuous positive airway pressure on lipid profile in patients with obstructive sleep apnea syndrome: a meta-analysis of randomized controlled trials. Atherosclerosis. 2014;234(2):446\u201353. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2014.03.034.","journal-title":"Atherosclerosis"},{"issue":"3","key":"3480_CR7","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3390\/jcm11030596","volume":"11","author":"B Chen","year":"2022","unstructured":"Chen B, Guo M, Peker Y, Salord N, Drager LF, Lorenzi-Filho G, et al. Effect of continuous positive Airway pressure on lipid profiles in obstructive sleep apnea: a Meta-analysis. J Clin Med. 2022;11(3):596. https:\/\/doi.org\/10.3390\/jcm11030596.","journal-title":"J Clin Med"},{"issue":"6","key":"3480_CR8","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.arbres.2023.03.012","volume":"59","author":"F Cattazzo","year":"2023","unstructured":"Cattazzo F, Pengo MF, Giontella A, Soranna D, Bilo G, Zambon A, et al. Effect of continuous positive Airway pressure on glucose and lipid profiles in patients with obstructive sleep apnoea: a systematic review and Meta-analysis of Randomized controlled trials. Arch Bronconeumol. 2023;59(6):370\u20136. https:\/\/doi.org\/10.1016\/j.arbres.2023.03.012.","journal-title":"Arch Bronconeumol"},{"issue":"5","key":"3480_CR9","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.chest.2021.12.669","volume":"161","author":"SQC Giamp\u00e1","year":"2022","unstructured":"Giamp\u00e1 SQC, Furlan SF, Freitas LS, Macedo TA, Lebkuchen A, Cardozo KHM, et al. Effects of CPAP on metabolic syndrome in patients with OSA: a Randomized Trial. Chest. 2022;161(5):1370\u201381. https:\/\/doi.org\/10.1016\/j.chest.2021.12.669.","journal-title":"Chest"},{"issue":"42","key":"3480_CR10","doi-asserted-by":"publisher","first-page":"e31258","DOI":"10.1097\/MD.0000000000031258","volume":"101","author":"Y Xu","year":"2022","unstructured":"Xu Y, Wu H, Lu X. Influence of continuous positive airway pressure on lipid profiles of obstructive sleep apnea: a systematic review and meta-analysis. Med (Baltim). 2022;101(42):e31258. https:\/\/doi.org\/10.1097\/MD.0000000000031258.","journal-title":"Med (Baltim)"},{"issue":"2","key":"3480_CR11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jsmc.2019.02.003","volume":"14","author":"HE Gunn","year":"2019","unstructured":"Gunn HE, Tutek J, Buysse DJ. Brief behavioral treatment of Insomnia. Sleep Med Clin. 2019;14(2):235\u201343. https:\/\/doi.org\/10.1016\/j.jsmc.2019.02.003.","journal-title":"Sleep Med Clin"},{"issue":"12","key":"3480_CR12","first-page":"1077","volume":"20","author":"SF Quan","year":"1997","unstructured":"Quan SF, Howard BV, Iber C, Kiley JP, Nieto FJ, O\u2019Connor GT, et al. The Sleep Heart Health Study: design, rationale, and methods. Sleep. 1997;20(12):1077\u201385.","journal-title":"Sleep"},{"issue":"9","key":"3480_CR13","doi-asserted-by":"publisher","first-page":"zsae132","DOI":"10.1093\/sleep\/zsae132","volume":"47","author":"L Wang","year":"2024","unstructured":"Wang L, Ou Q, Shan G, Zhan W, Huang J, Lin Q, et al. Community-based Intervention for Obstructive Sleep Apnea in the General Population: a Randomized Controlled Trial. Sleep. 2024;47(9):zsae132. https:\/\/doi.org\/10.1093\/sleep\/zsae132.","journal-title":"Sleep"},{"issue":"6","key":"3480_CR14","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540\u20135. https:\/\/doi.org\/10.1093\/sleep\/14.6.540.","journal-title":"Sleep"},{"issue":"19","key":"3480_CR15","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1001\/jama.299.19.2287","volume":"299","author":"P Holvoet","year":"2008","unstructured":"Holvoet P, Lee DH, Steffes M, Gross M, Jacobs DR Jr. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA. 2008;299(19):2287\u201393. https:\/\/doi.org\/10.1001\/jama.299.19.2287.","journal-title":"JAMA"},{"issue":"1","key":"3480_CR16","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12944-020-01354-z","volume":"19","author":"M Rezaei","year":"2020","unstructured":"Rezaei M, Fakhri N, Pasdar Y, Moradinazar M, Najafi F. Modeling the risk factors for dyslipidemia and blood lipid indices: Ravansar cohort study. Lipids Health Dis. 2020;19(1):176. https:\/\/doi.org\/10.1186\/s12944-020-01354-z.","journal-title":"Lipids Health Dis"},{"key":"3480_CR17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.trsl.2021.12.008","volume":"243","author":"IH Seo","year":"2022","unstructured":"Seo IH, Son DH, Lee HS, Lee YJ. Non-HDL cholesterol as a predictor for incident type 2 diabetes in community-dwelling adults: longitudinal findings over 12 years. Transl Res. 2022;243:52\u20139. https:\/\/doi.org\/10.1016\/j.trsl.2021.12.008.","journal-title":"Transl Res"},{"issue":"10215","key":"3480_CR18","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1016\/S0140-6736(19)32519-X","volume":"394","author":"FJ Brunner","year":"2019","unstructured":"Brunner FJ, Waldeyer C, Ojeda F, Salomaa V, Kee F, Sans S, et al. Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the multinational Cardiovascular Risk Consortium. Lancet. 2019;394(10215):2173\u201383. https:\/\/doi.org\/10.1016\/S0140-6736(19)32519-X.","journal-title":"Lancet"},{"issue":"1","key":"3480_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12933-023-02103-z","volume":"23","author":"M Li","year":"2024","unstructured":"Li M, Zhang W, Zhang M, Li L, Wang D, Yan G, et al. Nonlinear relationship between untraditional lipid parameters and the risk of prediabetes: a large retrospective study based on Chinese adults. Cardiovasc Diabetol. 2024;23(1):12. https:\/\/doi.org\/10.1186\/s12933-023-02103-z.","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"3480_CR20","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s12933-023-01934-0","volume":"22","author":"X Zheng","year":"2023","unstructured":"Zheng X, Zhang X, Han Y, Hu H, Cao C. Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults. Cardiovasc Diabetol. 2023;22(1):205. https:\/\/doi.org\/10.1186\/s12933-023-01934-0.","journal-title":"Cardiovasc Diabetol"},{"issue":"12","key":"3480_CR21","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1111\/dom.15264","volume":"25","author":"J Brandts","year":"2023","unstructured":"Brandts J, Tittel SR, Bramlage P, Danne T, Brix JM, Zimny S, et al. Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in type 1 diabetes and type 2 diabetes: lipid goal attainment in a large german-austrian diabetes registry. Diabetes Obes Metab. 2023;25(12):3700\u20138. https:\/\/doi.org\/10.1111\/dom.15264.","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"3480_CR22","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s12967-022-03470-z","volume":"20","author":"G Sheng","year":"2022","unstructured":"Sheng G, Kuang M, Yang R, Zhong Y, Zhang S, Zou Y. Evaluation of the value of conventional and unconventional lipid parameters for predicting the risk of diabetes in a non-diabetic population. J Transl Med. 2022;20(1):266. https:\/\/doi.org\/10.1186\/s12967-022-03470-z.","journal-title":"J Transl Med"},{"issue":"11","key":"3480_CR23","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1001\/jama.2022.1816","volume":"327","author":"AM Lipsky","year":"2022","unstructured":"Lipsky AM, Greenland S. Causal Directed Acyclic Graphs. JAMA. 2022;327(11):1083\u20134. https:\/\/doi.org\/10.1001\/jama.2022.1816.","journal-title":"JAMA"},{"issue":"7","key":"3480_CR24","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1093\/aje\/kwac041","volume":"191","author":"MP Fox","year":"2022","unstructured":"Fox MP, Nianogo R, Rudolph JE, Howe CJ. Illustrating how to simulate Data from Directed Acyclic Graphs to understand epidemiologic concepts. Am J Epidemiol. 2022;191(7):1300\u20136. https:\/\/doi.org\/10.1093\/aje\/kwac041.","journal-title":"Am J Epidemiol"},{"issue":"2","key":"3480_CR25","doi-asserted-by":"publisher","first-page":"e126","DOI":"10.1097\/SLA.0000000000003562","volume":"274","author":"R Mao","year":"2021","unstructured":"Mao R, Li K, Cai JQ, Luo S, Turner M, Blazer D, et al. Adjuvant chemotherapy Versus Observation following resection for patients with nonmetastatic poorly differentiated colorectal neuroendocrine carcinomas. Ann Surg. 2021;274(2):e126\u201333. https:\/\/doi.org\/10.1097\/SLA.0000000000003562.","journal-title":"Ann Surg"},{"issue":"9","key":"3480_CR26","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1002\/sim.3841","volume":"29","author":"L Desquilbet","year":"2010","unstructured":"Desquilbet L, Mariotti F. Dose-response analyses using restricted cubic spline functions in public health research. Stat Med. 2010;29(9):1037\u201357. https:\/\/doi.org\/10.1002\/sim.3841.","journal-title":"Stat Med"},{"issue":"16","key":"3480_CR27","doi-asserted-by":"publisher","first-page":"8761","DOI":"10.1021\/acs.jmedchem.9b01101","volume":"63","author":"R Rodr\u00edguez-P\u00e9rez","year":"2020","unstructured":"Rodr\u00edguez-P\u00e9rez R, Bajorath J. Interpretation of compound activity predictions from Complex Machine Learning models using local approximations and Shapley Values. J Med Chem. 2020;63(16):8761\u201377. https:\/\/doi.org\/10.1021\/acs.jmedchem.9b01101.","journal-title":"J Med Chem"},{"issue":"2","key":"3480_CR28","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/jch.13473","volume":"21","author":"X Zhao","year":"2019","unstructured":"Zhao X, Li X, Xu H, Qian Y, Fang F, Yi H, et al. Relationships between cardiometabolic disorders and obstructive sleep apnea: implications for cardiovascular disease risk. J Clin Hypertens (Greenwich). 2019;21(2):280\u201390. https:\/\/doi.org\/10.1111\/jch.13473.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"3480_CR29","doi-asserted-by":"publisher","first-page":"1359108","DOI":"10.3389\/fgene.2024.1359108","volume":"15","author":"PY Hong","year":"2024","unstructured":"Hong PY, Liu D, Liu A, Su X, Zhang XB, Zeng YM. Assessing causality between obstructive sleep apnea with the dyslipidemia and osteoporosis: a mendelian randomization study. Front Genet. 2024;15:1359108. https:\/\/doi.org\/10.3389\/fgene.2024.1359108.","journal-title":"Front Genet"},{"issue":"6","key":"3480_CR30","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.chest.2018.12.003","volume":"155","author":"LF Drager","year":"2019","unstructured":"Drager LF, Santos RB, Silva WA, Parise BK, Giatti S, Aielo AN, et al. OSA, short sleep duration, and their interactions with sleepiness and cardiometabolic risk factors in adults: the ELSA-Brasil Study. Chest. 2019;155(6):1190\u20138. https:\/\/doi.org\/10.1016\/j.chest.2018.12.003.","journal-title":"Chest"},{"key":"3480_CR31","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1186\/1471-2458-14-1050","volume":"14","author":"Y Zhan","year":"2014","unstructured":"Zhan Y, Zhang F, Lu L, Wang J, Sun Y, Ding R, et al. Prevalence of dyslipidemia and its association with insomnia in a community based population in China. BMC Public Health. 2014;14:1050. https:\/\/doi.org\/10.1186\/1471-2458-14-1050.","journal-title":"BMC Public Health"},{"issue":"11","key":"3480_CR32","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.3390\/biomedicines10112754","volume":"10","author":"M Meszaros","year":"2022","unstructured":"Meszaros M, Bikov A. Obstructive sleep apnoea and lipid metabolism: the Summary of evidence and future perspectives in the pathophysiology of OSA-Associated Dyslipidaemia. Biomedicines. 2022;10(11):2754. https:\/\/doi.org\/10.3390\/biomedicines10112754.","journal-title":"Biomedicines"},{"issue":"24","key":"3480_CR33","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1056\/NEJMoa1306187","volume":"370","author":"JA Chirinos","year":"2014","unstructured":"Chirinos JA, Gurubhagavatula I, Teff K, Rader DJ, Wadden TA, Townsend R, et al. CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med. 2014;370(24):2265\u201375. https:\/\/doi.org\/10.1056\/NEJMoa1306187.","journal-title":"N Engl J Med"},{"issue":"5","key":"3480_CR34","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1164\/rccm.202107-1761OC","volume":"205","author":"B Lechat","year":"2022","unstructured":"Lechat B, Naik G, Reynolds A, Aishah A, Scott H, Loffler KA, et al. Multinight Prevalence, variability, and Diagnostic Misclassification of Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2022;205(5):563\u20139. https:\/\/doi.org\/10.1164\/rccm.202107-1761OC.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"3480_CR35","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.chest.2023.01.027","volume":"164","author":"B Lechat","year":"2023","unstructured":"Lechat B, Nguyen DP, Reynolds A, Loffler K, Escourrou P, McEvoy RD, et al. Single-night diagnosis of Sleep Apnea contributes to Inconsistent Cardiovascular Outcome findings. Chest. 2023;164(1):231\u201340. https:\/\/doi.org\/10.1016\/j.chest.2023.01.027.","journal-title":"Chest"},{"issue":"12","key":"3480_CR36","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1111\/resp.13372","volume":"23","author":"C G\u00fcnd\u00fcz","year":"2018","unstructured":"G\u00fcnd\u00fcz C, Basoglu OK, Hedner J, Zou D, Bonsignore MR, Hein H, et al. Obstructive sleep apnoea independently predicts lipid levels: data from the European Sleep Apnea Database. Respirology. 2018;23(12):1180\u20139. https:\/\/doi.org\/10.1111\/resp.13372.","journal-title":"Respirology"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-025-03480-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-025-03480-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-025-03480-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T09:28:38Z","timestamp":1741426118000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-025-03480-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,8]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3480"],"URL":"https:\/\/doi.org\/10.1186\/s12890-025-03480-9","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,8]]},"assertion":[{"value":"20 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Participants in the SHHS study gave written informed consent, and the study protocols were approved by the ethical review boards at the respective institutions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"105"}}