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Patients with pulmonary metastases, and a subgroup with metastases from colorectal or renal cell carcinoma, or sarcoma (termed subgroup) which are considered more radioresistant, were analyzed. Single-arm pooled analyses, univariable, and multivariable random-effects meta-regressions were conducted to compare LTP and OS between IGTA and SBRT treated patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Analyses included 3,264 IGTA and 5,486 SBRT patients. IGTA patients with pulmonary metastases had higher LTP than SBRT patients at one year, 13% and 9% respectively. At two years, the LTP for IGTA patients was 14% compared to 16% for SBRT patients. Three-year LTP remained lower for IGTA patients compared to SBRT patients (14% and 22% respectively). In the subgroup, SBRT patients had higher LTP than IGTA patients across all timepoints. OS was similar across analyses\/subgroups in the single-arm pooled analyses. The multivariable analyses showed that SBRT was associated with significantly lower OS at one year; however nonsignificant differences were observed at years two and three.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>In patients with pulmonary metastases, IGTA had lower LTP than SBRT at later timepoints. 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Calvin Ng: Receives grants or contracts from: Johnson and Johnson, Inc., Medtronic, Inc., Siemens Healthineer, LLC; Receives consulting fees from: Johnson and Johnson, Inc., Medtronic, Inc.; Receives payment for manuscript writing or speaker events: Johnson and Johnson, Inc.; Participates on a data safety monitoring board or advisory board for Johnson and Johnson, Inc. Nicole Ferko, Andrada Naghi, George Wright, Di Wang, and Alyshia Laidlaw have no competing interests to disclose. Iftekhar Kalsekar, Tony Amos, Balaji Laxmanan, Sudip K. Ghosh, and Meijia Zhou have stock or stock options and are employees of Johnson and Johnson, Inc. Philippe Szapary is an employee of Johnson and Johnson, Inc. Michael Pritchett: Receives grants or contracts from: Johnson and Johnson, Inc., Medtronic, Inc., Intuitive, Inc., BodyVision, Inc., Biodesix, Inc., Philips; Receives consulting fees from: Johnson and Johnson, Inc., Medtronic, Inc., Intuitive, Inc., BodyVision, Inc., Biodesix, Inc., Philips, Noah Medical, Inc., AstraZeneca, PLC; Receives payment for manuscript writing or speaker events: Johnson and Johnson, Inc., Intuitive, Inc., BodyVision, Inc., Biodesix, Inc., AstraZeneca, PLC; Participates on a data safety monitoring board or advisory board for AstraZeneca, PLC and Pfizer, Inc.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"188"}}