{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:23:08Z","timestamp":1780089788750,"version":"3.54.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"DOI":"10.1186\/s12890-025-03590-4","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T07:18:42Z","timestamp":1742973522000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["FDG-avid pulmonary mucous gland adenoma mimicking lung cancer on 18\u00a0F-FDG PET\/CT: a rare case report and literature review"],"prefix":"10.1186","volume":"25","author":[{"given":"Chen","family":"Xiaomei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Jiahui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Fangbiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Chunhui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"issue":"1","key":"3590_CR1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00427013","volume":"383","author":"H Spencer","year":"1979","unstructured":"Spencer H. Bronchial mucous gland tumours. Virchows Arch Pathol Anat Histol. 1979;383(1):101\u201315.","journal-title":"Virchows Arch Pathol Anat Histol"},{"issue":"8","key":"3590_CR2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/00000478-199508000-00003","volume":"19","author":"DM England","year":"1995","unstructured":"England DM, Hochholzer L. Truly benignbronchial adenoma. Report of 10 cases of mucous gland adenoma with immunohistochemical and ultrastructural findings. Am J Surg Pathol. 1995;19(8):887\u201399.","journal-title":"Am J Surg Pathol"},{"key":"3590_CR3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/ajcp\/26.2.151","volume":"26","author":"RA Gilman","year":"1956","unstructured":"Gilman RA, Klassen KP, Scarpelli DG. Mucous gland adenoma of bronchus; report of a case with histochemical study of secretion. Am J Clin Pathol. 1956;26:151\u20134.","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"3590_CR4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/icvts\/ivr104","volume":"14","author":"S Couraud","year":"2012","unstructured":"Couraud S, Isaac S, Guibert B, Souquet PJ. Bronchial mucous gland adenoma revealed following acute pneumonia. Interact Cardiovasc Thorac Surg. 2012;14(3):347\u20139.","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"9","key":"3590_CR5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1080\/02770900701645371","volume":"44","author":"B Milenkovic","year":"2007","unstructured":"Milenkovic B, Stojsic J, Mandaric D, et al. Mucous gland adenoma simulating bronchial asthma: case report and literature review. J Asthma. 2007;44(9):789\u201393.","journal-title":"J Asthma"},{"issue":"3","key":"3590_CR6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4103\/0970-2113.135776","volume":"31","author":"R Kumari","year":"2014","unstructured":"Kumari R, Nandita B, Kumar KR. Bronchial mucous gland adenoma presenting as massive hemoptysis: A diagnostic dilemma. Lung India. 2014;31(3):274\u20136.","journal-title":"J] Lung India"},{"issue":"5","key":"3590_CR7","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/00004728-199909000-00023","volume":"23","author":"JW Kwon","year":"1999","unstructured":"Kwon JW, Goo JM, Seo JB, et al. Mucous gland adenoma of the bronchus: CT findings in two patients. J Comput Assist Tomogr. 1999;23(5):758\u201360.","journal-title":"J Comput Assist Tomogr"},{"issue":"3","key":"3590_CR8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4103\/0970-2113.135776","volume":"31","author":"RK Badyal","year":"2014","unstructured":"Badyal RK, Kakkar N, Vasishta RK, et al. Bronchial mucous gland adenoma presenting as massive hemoptysis: A diagnostic dilemma.. Lung India. 2014;31(3):274\u20136.","journal-title":"Lung India"},{"issue":"3","key":"3590_CR9","doi-asserted-by":"crossref","first-page":"e9597","DOI":"10.1097\/MD.0000000000009597","volume":"97","author":"X-T Zhang","year":"2018","unstructured":"Zhang X-T, Yang M, Liu X-F, et al. Peripheral mucous gland adenoma of the lung with parenchymal involvement and smooth muscle in the stroma: A rare case report. Literature Rev Med (Baltimore). 2018;97(3):e9597.","journal-title":"Literature Rev Med (Baltimore)"},{"key":"3590_CR10","doi-asserted-by":"crossref","unstructured":"Ahmet Ulu\u015fan et al. Zeynep, Bayramo\u011flu,Maruf, \u015eanl\u0131. A rare case of peripherally located non-bronchial pulmonary mucous gland adenoma..Turk Gogus Kalp Damar Cerrahisi Derg, 2018, 26(4):664-7.","DOI":"10.5606\/tgkdc.dergisi.2018.15357"},{"issue":"1","key":"3590_CR11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11748-021-01705-2","volume":"70","author":"H Komatsu","year":"2022","unstructured":"Komatsu H, Izumi N, Tsukioka T, Inoue H, Ito R, Matsuda Y, Nishiyama N. Peripheral pulmonary mucous gland adenoma with a cavity mimicking lung cancer. Gen Thorac Cardiovasc Surg. 2022;70(1):92\u20135.","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"3590_CR12","first-page":"426","volume":"47","author":"Y Hashimoto","year":"2006","unstructured":"Hashimoto Y, Tsuijkawa T, Kondo C, et al. Accuracy of PET for diagnosis of solid pulmonary lesions with 18FDG uptake below the standardized uptake value of 2.5. J Nucl Med. 2006;47:426\u201331.","journal-title":"J Nucl Med"},{"key":"3590_CR13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00408-013-9500-6","volume":"191","author":"YT Sim","year":"2013","unstructured":"Sim YT, Goh YG, Dempsey MF, et al. PET-CT evaluation of solitary pulmonary nodules: correlation with maximum standardized uptake value and pathology. Lung. 2013;191:625\u201332.","journal-title":"Lung"},{"key":"3590_CR14","doi-asserted-by":"crossref","unstructured":"Jaehyuk C et al. Jae Seon, Eo,Kwang Ho, In. 18F-FDG PET\/CT of Bronchial Mucous Gland Adenoma..Clin Nucl Med, 2015, 41(2):e118-9.","DOI":"10.1097\/RLU.0000000000000921"},{"key":"3590_CR15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.rmr.2016.07.008","volume":"34","author":"C Vergnen\u00e8gre","year":"2017","unstructured":"Vergnen\u00e8gre C, Hureaux J, Morvant B, et al. [A bronchial mucous gland adenoma resected by endoscopic procedure]. Rev Mal Respir. 2017;34:253\u20136.","journal-title":"[J] Rev Mal Respir"},{"key":"3590_CR16","doi-asserted-by":"crossref","unstructured":"Michael P, Zaleski,Neda KCA. Moran,Mucous gland adenoma: the spectrum of growth patterns and the diagnostic Challenges..Adv Anat pathol, 2020, 27:371\u20139.","DOI":"10.1097\/PAP.0000000000000283"},{"issue":"3","key":"3590_CR17","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1139\/bcb-2016-0197","volume":"95","author":"A Giatromanolaki","year":"2017","unstructured":"Giatromanolaki A, Liousia M, Arelaki S, Kalamida D, Pouliliou S, Mitrakas A, Tsolou A, Sivridis E, Koukourakis M. Differential effect of hypoxia and acidity on lung cancer cell and fibroblast metabolism. Biochem Cell Biol. 2017;95(3):428\u201336.","journal-title":"Biochem Cell Biol"},{"key":"3590_CR18","doi-asserted-by":"crossref","unstructured":"Mathew B, Purandare NC, Shah S, Puranik A, Agrawal A, Rangarajan V. Lung masses of unusual histologies mimicking malignancy: flurodeoxyglucose positron emission tomography-Computed tomography appearance. Indian J Nucl Med. 2019 Oct-Dec;34(4):295\u2013301.","DOI":"10.4103\/ijnm.IJNM_116_19"},{"key":"3590_CR19","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.4076\/1752-1947-3-8581","volume":"3","author":"SA Raza","year":"2009","unstructured":"Raza SA, Alexakis C, Creagh M, Lawrence DR, Wood M. Primary pulmonary mucinous cystadenocarcinoma presenting as a complex bronchocele: a case report. J Med Case Rep. 2009;3:8581.","journal-title":"J Med Case Rep"},{"issue":"3","key":"3590_CR20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13139-016-0402-4","volume":"51","author":"A Kalkanis","year":"2017","unstructured":"Kalkanis A, Palaiodimos L, Klinaki I, Karantanis D, Kalkanis D. 18F-FDG PET\/CT imaging of pulmonary mucinous cystadenocarcinoma with signet ring cells. Nucl Med Mol Imaging. 2017;51(3):277\u201380.","journal-title":"Nucl Med Mol Imaging"},{"issue":"4","key":"3590_CR21","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2214\/ajr.174.4.1741005","volume":"174","author":"KL Berger","year":"2000","unstructured":"Berger KL, Nicholson SA, Dehdashti F, Siegel BA. FDG PET evaluation of mucinous neoplasms: correlation of FDG uptake with histopathologic features. AJR Am J Roentgenol. 2000;174(4):1005\u20138.","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"3590_CR22","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.athoracsur.2014.10.065","volume":"99","author":"H Watanabe","year":"2015","unstructured":"Watanabe H, Saito H, Yokose T, Sakuma Y, Murakami S, Kondo T, Oshita F, Ito H, Nakayama H, Yamada K, Iwazaki M. Relation between thin-section computed tomography and clinical findings of mucinous adenocarcinoma. Ann Thorac Surg. 2015;99(3):975\u201381.","journal-title":"Ann Thorac Surg"},{"key":"3590_CR23","doi-asserted-by":"crossref","first-page":"109874","DOI":"10.1016\/j.ejrad.2021.109874","volume":"142","author":"D Caruso","year":"2021","unstructured":"Caruso D, Zerunian M, Daffina J, Polici M, Polidori T, Tipaldi MA, Ronconi E, Pucciarelli F, Lucertini E, Rossi M, Laghi A. Radiomics and functional imaging in lung cancer: the importance of radiological heterogeneity beyond FDG PET\/CT and lung biopsy. Eur J Radiol. 2021;142:109874.","journal-title":"Eur J Radiol"},{"issue":"3","key":"3590_CR24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2478\/raon-2021-0024","volume":"55","author":"A Marin","year":"2021","unstructured":"Marin A, Murchison JT, Skwarski KM, Tavares AAS, Fletcher A, Wallace WA, Salapura V, van Beek EJR, Mirsadraee S. Can dynamic imaging, using 18F-FDG PET\/CT and CT perfusion differentiate between benign and malignant pulmonary nodules? Radiol Oncol. 2021;55(3):259\u201367.","journal-title":"Radiol Oncol"},{"key":"3590_CR25","doi-asserted-by":"crossref","first-page":"105627","DOI":"10.1016\/j.humpath.2024.105627","volume":"151","author":"V Rerkpichaisuth","year":"2024","unstructured":"Rerkpichaisuth V, Lau RP, Meyerson C, Fishbein GA. The utility of the lineage specific immunohistochemical stains SATB2, CDX2, and Villin, and the mucin glycoproteins MUC2, MUC5AC, and MUC6 to distinguish pulmonary invasive mucinous adenocarcinoma from metastatic colorectal carcinoma. Hum Pathol. 2024;151:105627.","journal-title":"Hum Pathol"},{"key":"3590_CR26","first-page":"239173","volume":"2013","author":"G Karpathiou","year":"2013","unstructured":"Karpathiou G, Sivridis E, Mikroulis D, et al. Pulmonary mucus gland adenomas: are they always of endobronchial localization? Case Rep Pathol. 2013;2013:239173.","journal-title":"Case Rep Pathol"},{"key":"3590_CR27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/MD.0000000000009218","volume":"97","author":"XT Zhang","year":"2018","unstructured":"Zhang XT, Yang M, Liu XF, et al. Peripheral mucous gland adenoma of the lung with intraparenchymal involvement and smooth muscle in the stroma. Medicine. 2018;97:3.","journal-title":"Medicine"},{"key":"3590_CR28","doi-asserted-by":"crossref","unstructured":"Ryuji K, Junichi M, Yasuo I et al. A bronchial mucous gland adenoma harboring GNAS R201C mutation..Diagn cytopathol, 2020, 49: e203\u20136.","DOI":"10.1002\/dc.24674"},{"key":"3590_CR29","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.athoracsur.2011.06.053","volume":"92","author":"M Natsumi","year":"2011","unstructured":"Natsumi M, Naoya Y, Tetsuhiko G, et al. Bronchoplastic operation using a continuous anastomosis for mucous gland adenoma. Ann Thorac Surg. 2011;92:2272\u20134.","journal-title":"J] Ann Thorac Surg"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-025-03590-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-025-03590-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-025-03590-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T07:20:04Z","timestamp":1742973604000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-025-03590-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3590"],"URL":"https:\/\/doi.org\/10.1186\/s12890-025-03590-4","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"assertion":[{"value":"15 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report was reviewed and approved by the Clinical College, Lishui Central Hospital Institutional Review Board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient signed informed consent for publication of this case report and any associated images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"137"}}