{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:32:26Z","timestamp":1778394746262,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12891-016-1044-5","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T01:51:23Z","timestamp":1462326683000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The influence of calcitonin gene-related peptide on markers of bone metabolism in MG-63 osteoblast-like cells co-cultured with THP-1 macrophage-like cells under virtually osteolytic conditions"],"prefix":"10.1186","volume":"17","author":[{"given":"Heidrun","family":"Jablonski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Rekasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,4]]},"reference":[{"issue":"24","key":"1044_CR1","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/S0142-9612(98)00140-9","volume":"19","author":"TR Green","year":"1998","unstructured":"Green TR, Fisher J, Stone M, Wroblewski BM, Ingham E. Polyethylene particles of a \u2018critical size\u2019 are necessary for the induction of cytokines by macrophages in vitro. Biomaterials. 1998;19(24):2297\u2013302.","journal-title":"Biomaterials"},{"key":"1044_CR2","first-page":"95","volume":"258","author":"HG Willert","year":"1990","unstructured":"Willert HG, Bertram H, Buchhorn GH. Osteolysis in alloarthroplasty of the hip. The role of ultra-high molecular weight polyethylene wear particles. Clin Orthop Relat Res. 1990;258:95\u2013107.","journal-title":"Clin Orthop Relat Res"},{"issue":"9","key":"1044_CR3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00393-012-1042-4","volume":"71","author":"J Schaumburger","year":"2012","unstructured":"Schaumburger J, Winkler S, Handel M, Grifka J, Baier C. [Prosthesis loosening]. Z Rheumatol. 2012;71(9):785\u201397.","journal-title":"Z Rheumatol"},{"issue":"5","key":"1044_CR4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1089\/ten.teb.2012.0636","volume":"19","author":"R Lieder","year":"2013","unstructured":"Lieder R, Petersen PH, Sigurjonsson OE. Endotoxins-the Invisible Companion in Biomaterials Research. Tissue Eng Part B Rev. 2013;19(5):391\u2013402.","journal-title":"Tissue Eng Part B Rev"},{"issue":"2","key":"1044_CR5","first-page":"182","volume":"67","author":"NJ Hallab","year":"2009","unstructured":"Hallab NJ, Jacobs JJ. Biologic effects of implant debris. Bulletin NYU hosp JT Dis. 2009;67(2):182\u20138.","journal-title":"Bulletin NYU hosp JT Dis"},{"issue":"4","key":"1044_CR6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF00295957","volume":"54","author":"SM Horowitz","year":"1994","unstructured":"Horowitz SM, Rapuano BP, Lane JM, Burstein AH. The interaction of the macrophage and the osteoblast in the pathophysiology of aseptic loosening of joint replacements. Calcif Tissue Int. 1994;54(4):320\u20134.","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"1044_CR7","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1302\/0301-620X.80B5.8710","volume":"80","author":"M Lind","year":"1998","unstructured":"Lind M, Trindade MC, Yaszay B, Goodman SB, Smith RL. Effects of particulate debris on macrophage-dependent fibroblast stimulation in coculture. J Bone Joint Surg Br. 1998;80(5):924\u201330.","journal-title":"J Bone Joint Surg Br"},{"key":"1044_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.immunol.24.021605.090646","volume":"24","author":"MC Walsh","year":"2006","unstructured":"Walsh MC, Kim N, Kadono Y, Rho J, Lee SY, Lorenzo J, Choi Y. Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol. 2006;24:33\u201363.","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"1044_CR9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","volume":"15","author":"S Kwan Tat","year":"2004","unstructured":"Kwan Tat S, Padrines M, Theoleyre S, Heymann D, Fortun Y. IL-6, RANKL, TNF-alpha\/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev. 2004;15(1):49\u201360.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"1044_CR10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000360988","volume":"22","author":"H Jablonski","year":"2015","unstructured":"Jablonski H, Kauther MD, Bachmann HS, Jager M, Wedemeyer C. Calcitonin Gene-Related Peptide Modulates the Production of Pro-Inflammatory Cytokines Associated with Periprosthetic Osteolysis by THP-1 Macrophage-Like Cells. Neuroimmunomodulation. 2015;22(3):152\u201365.","journal-title":"Neuroimmunomodulation"},{"issue":"12","key":"1044_CR11","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1210\/endo.142.12.8536","volume":"142","author":"S Khosla","year":"2001","unstructured":"Khosla S. Minireview: the OPG\/RANKL\/RANK system. Endocrinology. 2001;142(12):5050\u20135.","journal-title":"Endocrinology"},{"issue":"3","key":"1044_CR12","doi-asserted-by":"crossref","first-page":"C529","DOI":"10.1152\/ajpcell.00354.2005","volume":"291","author":"I Villa","year":"2006","unstructured":"Villa I, Mrak E, Rubinacci A, Ravasi F, Guidobono F. CGRP inhibits osteoprotegerin production in human osteoblast-like cells via cAMP\/PKA-dependent pathway. Am J Physiol Cell Physiol. 2006;291(3):C529\u201337.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"1044_CR13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S8756-3282(01)00494-X","volume":"29","author":"J Cornish","year":"2001","unstructured":"Cornish J, Callon KE, Bava U, Kamona SA, Cooper GJ, Reid IR. Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development. Bone. 2001;29(2):162\u20138.","journal-title":"Bone"},{"issue":"3","key":"1044_CR14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0014-2999(00)00872-4","volume":"409","author":"I Villa","year":"2000","unstructured":"Villa I, Melzi R, Pagani F, Ravasi F, Rubinacci A, Guidobono F. Effects of calcitonin gene-related peptide and amylin on human osteoblast-like cells proliferation. Eur J Pharmacol. 2000;409(3):273\u20138.","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"1044_CR15","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/jcp.22266","volume":"225","author":"E Mrak","year":"2010","unstructured":"Mrak E, Guidobono F, Moro G, Fraschini G, Rubinacci A, Villa I. Calcitonin gene-related peptide (CGRP) inhibits apoptosis in human osteoblasts by beta-catenin stabilization. J Cell Physiol. 2010;225(3):701\u20138.","journal-title":"J Cell Physiol"},{"key":"1044_CR16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1749-799X-5-83","volume":"5","author":"J Xu","year":"2010","unstructured":"Xu J, Kauther MD, Hartl J, Wedemeyer C. Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-kappaB ligand expression in MG-63 osteoblast-like cells exposed to polyethylene particles. J Orthop Surg Res. 2010;5:83.","journal-title":"J Orthop Surg Res"},{"issue":"3","key":"1044_CR17","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1055\/s-2004-822589","volume":"142","author":"M Knoch von","year":"2004","unstructured":"von Knoch M, Sprecher C, Barden B, Saxler G, Loer F, Wimmer M. [Size and shape of commercially available polyethylene particles for in-vitro and in-vivo-experiments]. Z Orthop Ihre Grenzgeb. 2004;142(3):366\u201370.","journal-title":"Z Orthop Ihre Grenzgeb"},{"issue":"1","key":"1044_CR18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/jbm.a.32529","volume":"93","author":"RA Smith","year":"2010","unstructured":"Smith RA, Hallab NJ. In vitro macrophage response to polyethylene and polycarbonate-urethane particles. J Biomed Mater Res A. 2010;93(1):347\u201355.","journal-title":"J Biomed Mater Res A"},{"issue":"3","key":"1044_CR19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/00016470410001222","volume":"75","author":"B Baumann","year":"2004","unstructured":"Baumann B, Rader CP, Seufert J, Noth U, Rolf O, Eulert J, Jakob F. Effects of polyethylene and TiAlV wear particles on expression of RANK, RANKL and OPG mRNA. Acta Orthop Scand. 2004;75(3):295\u2013302.","journal-title":"Acta Orthop Scand"},{"issue":"6","key":"1044_CR20","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7150\/ijbs.6.525","volume":"6","author":"MD Kauther","year":"2010","unstructured":"Kauther MD, Xu J, Wedemeyer C. Alpha-calcitonin gene-related peptide can reverse the catabolic influence of UHMWPE particles on RANKL expression in primary human osteoblasts. Int J Biol Sci. 2010;6(6):525\u201336.","journal-title":"Int J Biol Sci"},{"key":"1044_CR21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-9255-8-4","volume":"8","author":"AL Blomkalns","year":"2011","unstructured":"Blomkalns AL, Stoll LL, Shaheen W, Romig-Martin SA, Dickson EW, Weintraub NL, Denning GM . Low level bacterial endotoxin activates two distinct signaling pathways in human peripheral blood mononuclear cells. J Inflamm (London, England). 2011;8:4.","journal-title":"J Inflamm (London, England)"},{"issue":"1","key":"1044_CR22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/CIRCRESAHA.110.218420","volume":"107","author":"P Wiesner","year":"2010","unstructured":"Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK et al. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010;107(1):56\u201365.","journal-title":"Circ Res"},{"issue":"4","key":"1044_CR23","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1186\/gb-2009-10-4-r41","volume":"10","author":"A Kubosaki","year":"2009","unstructured":"Kubosaki A, Tomaru Y, Tagami M, Arner E, Miura H, Suzuki T, Suzuki M, Suzuki H, Hayashizaki Y. Genome-wide investigation of in vivo EGR-1 binding sites in monocytic differentiation. Genome Biol. 2009;10(4):R41.","journal-title":"Genome Biol"},{"issue":"4","key":"1044_CR24","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1186\/gb-2009-10-4-r37","volume":"10","author":"J Fraser","year":"2009","unstructured":"Fraser J, Rousseau M, Shenker S, Ferraiuolo MA, Hayashizaki Y, Blanchette M, Dostie J. Chromatin conformation signatures of cellular differentiation. Genome Biol. 2009;10(4):R37.","journal-title":"Genome Biol"},{"issue":"9","key":"1044_CR25","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1096\/fj.00-0798com","volume":"15","author":"A Eckardstein Von","year":"2001","unstructured":"Von Eckardstein A, Langer C, Engel T, Schaukal I, Cignarella A, Reinhardt J, Lorkowski S, Li Z, Zhou X, Cullen P et al. ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages. FASEB J. 2001;15(9):1555\u201361.","journal-title":"FASEB J"},{"issue":"6","key":"1044_CR26","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/8756-3282(94)90305-0","volume":"15","author":"J Clover","year":"1994","unstructured":"Clover J, Gowen M. Are MG-63 and HOS TE85 human osteosarcoma cell lines representative models of the osteoblastic phenotype? Bone. 1994;15(6):585\u201391.","journal-title":"Bone"},{"issue":"4","key":"1044_CR27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method. Methods. 2001;25(4):402\u20138.","journal-title":"Methods"},{"key":"1044_CR28","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1038\/srep04745","volume":"4","author":"D Naskar","year":"2014","unstructured":"Naskar D, Nayak S, Dey T, Kundu SC. Non-mulberry silk fibroin influence osteogenesis and osteoblast-macrophage cross talk on titanium based surface. Sci Rep. 2014;4:4745.","journal-title":"Sci Rep"},{"key":"1044_CR29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00003086-199807000-00003","volume":"352","author":"J Lassus","year":"1998","unstructured":"Lassus J, Salo J, Jiranek WA, Santavirta S, Nevalainen J, Matucci-Cerinic M, Horak P, Konttinen Y. Macrophage activation results in bone resorption. Clin Orthop Relat Res. 1998;352:7\u201315.","journal-title":"Clin Orthop Relat Res"},{"issue":"5","key":"1044_CR30","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/term.535","volume":"7","author":"RP Pirraco","year":"2013","unstructured":"Pirraco RP, Reis RL, Marques AP. Effect of monocytes\/macrophages on the early osteogenic differentiation of hBMSCs. J Tissue Eng Regen Med. 2013;7(5):392\u2013400.","journal-title":"J Tissue Eng Regen Med"},{"issue":"33","key":"1044_CR31","doi-asserted-by":"crossref","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","volume":"285","author":"LJ Raggatt","year":"2010","unstructured":"Raggatt LJ, Partridge NC. Cellular and molecular mechanisms of bone remodeling. J Biol Chem. 2010;285(33):25103\u20138.","journal-title":"J Biol Chem"},{"issue":"2","key":"1044_CR32","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4049\/jimmunol.181.2.1232","volume":"181","author":"MK Chang","year":"2008","unstructured":"Chang MK, Raggatt LJ, Alexander KA, Kuliwaba JS, Fazzalari NL, Schroder K, Maylin ER, Ripoll VM, Hume DA, Pettit AR. Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J Immunol. 2008;181(2):1232\u201344.","journal-title":"J Immunol"},{"issue":"15","key":"1044_CR33","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.biomaterials.2008.02.011","volume":"29","author":"G Valles","year":"2008","unstructured":"Valles G, Gil-Garay E, Munuera L, Vilaboa N. Modulation of the cross-talk between macrophages and osteoblasts by titanium-based particles. Biomaterials. 2008;29(15):2326\u201335.","journal-title":"Biomaterials"},{"issue":"1","key":"1044_CR34","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/jor.20007","volume":"24","author":"A Rodrigo","year":"2006","unstructured":"Rodrigo A, Vall\u00e9s G, Salda\u00f1a L, Rodr\u00edguez M, Mart\u00ednez ME, Munuera L, Vilaboa N. Alumina particles influence the interactions of cocultured osteoblasts and macrophages. J Orthop Res. 2006;24(1):46\u201354.","journal-title":"J Orthop Res"},{"key":"1044_CR35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2474-10-57","volume":"10","author":"G Li","year":"2009","unstructured":"Li G, Wu P, Xu Y, Yu Y, Sun L, Zhu L, Ye D. The effect of Lipoxin A4 on the interaction between macrophage and osteoblast: possible role in the treatment of aseptic loosening. BMC Musculoskelet Disord. 2009;10:57.","journal-title":"BMC Musculoskelet Disord"},{"issue":"5","key":"1044_CR36","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S1357-2725(01)00147-9","volume":"34","author":"CE Evans","year":"2002","unstructured":"Evans CE. Bisphosphonates modulate the effect of macrophage-like cells on osteoblast. Int J Biochem Cell Biol. 2002;34(5):554\u201363.","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"1044_CR37","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0014-4827(92)90305-R","volume":"201","author":"ME Flores","year":"1992","unstructured":"Flores ME, Norgard M, Heinegard D, Reinholt FP, Andersson G. RGD-directed attachment of isolated rat osteoclasts to osteopontin, bone sialoprotein, and fibronectin. Exp Cell Res. 1992;201(2):526\u201330.","journal-title":"Exp Cell Res"},{"issue":"2","key":"1044_CR38","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0006-291X(92)90832-6","volume":"186","author":"K Tezuka","year":"1992","unstructured":"Tezuka K, Sato T, Kamioka H, Nijweide PJ, Tanaka K, Matsuo T, Ohta M, Kurihara N, Hakeda Y, Kumegawa M. Identification of osteopontin in isolated rabbit osteoclasts. Biochem Biophys Res Commun. 1992;186(2):911\u20137.","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"1044_CR39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0934-8832(11)80070-3","volume":"13","author":"J Chen","year":"1993","unstructured":"Chen J, Singh K, Mukherjee BB, Sodek J. Developmental expression of osteopontin (OPN) mRNA in rat tissues: evidence for a role for OPN in bone formation and resorption. Matrix. 1993;13(2):113\u201323.","journal-title":"Matrix"},{"issue":"1","key":"1044_CR40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1010011209064","volume":"2","author":"JE Aubin","year":"2001","unstructured":"Aubin JE. Regulation of osteoblast formation and function. Rev Endocr Metab Disord. 2001;2(1):81\u201394.","journal-title":"Rev Endocr Metab Disord"},{"issue":"8","key":"1044_CR41","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jbmr.5650050806","volume":"5","author":"M Weinreb","year":"1990","unstructured":"Weinreb M, Shinar D, Rodan GA. Different pattern of alkaline phosphatase, osteopontin, and osteocalcin expression in developing rat bone visualized by in situ hybridization. J Bone Miner Res. 1990;5(8):831\u201342.","journal-title":"J Bone Miner Res"},{"issue":"4","key":"1044_CR42","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1172\/JCI116755","volume":"92","author":"CM Giachelli","year":"1993","unstructured":"Giachelli CM, Bae N, Almeida M, Denhardt DT, Alpers CE, Schwartz SM. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J Clin Invest. 1993;92(4):1686\u201396.","journal-title":"J Clin Invest"},{"issue":"15","key":"1044_CR43","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1096\/fasebj.7.15.8262332","volume":"7","author":"DT Denhardt","year":"1993","unstructured":"Denhardt DT, Guo X. Osteopontin: a protein with diverse functions. FASEB J. 1993;7(15):1475\u201382.","journal-title":"FASEB J"},{"issue":"9","key":"1044_CR44","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1172\/JCI12980","volume":"107","author":"DT Denhardt","year":"2001","unstructured":"Denhardt DT, Noda M, O\u2019Regan AW, Pavlin D, Berman JS. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest. 2001;107(9):1055\u201361.","journal-title":"J Clin Invest"},{"issue":"2","key":"1044_CR45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200319190","volume":"112","author":"EM Gravallese","year":"2003","unstructured":"Gravallese EM. Osteopontin: a bridge between bone and the immune system. J Clin Invest. 2003;112(2):147\u20139.","journal-title":"J Clin Invest"},{"issue":"5","key":"1044_CR46","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/art.27400","volume":"62","author":"S Shimizu","year":"2010","unstructured":"Shimizu S, Okuda N, Kato N, Rittling SR, Okawa A, Shinomiya K, Muneta T, Denhardt DT, Noda M, Tsuji K et al. Osteopontin deficiency impairs wear debris-induced osteolysis via regulation of cytokine secretion from murine macrophages. Arthritis Rheum. 2010;62(5):1329\u201337.","journal-title":"Arthritis Rheum"},{"issue":"2","key":"1044_CR47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000323831","volume":"73","author":"J Kuczkowski","year":"2011","unstructured":"Kuczkowski J, Sakowicz-Burkiewicz M, Izycka-Swieszewska E, Mikaszewski B, Pawelczyk T. Expression of tumor necrosis factor-alpha, interleukin-1alpha, interleukin-6 and interleukin-10 in chronic otitis media with bone osteolysis. ORL J Otorhinolaryngol Relat Spec. 2011;73(2):93\u20139.","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"17","key":"1044_CR48","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1016\/j.biomaterials.2012.03.005","volume":"33","author":"SS Lee","year":"2012","unstructured":"Lee SS, Sharma AR, Choi BS, Jung JS, Chang JD, Park S, Salvati EA, Purdue EP, Song DK, Nam JS. The effect of TNFalpha secreted from macrophages activated by titanium particles on osteogenic activity regulated by WNT\/BMP signaling in osteoprogenitor cells. Biomaterials. 2012;33(17):4251\u201363.","journal-title":"Biomaterials"},{"issue":"12","key":"1044_CR49","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.exphem.2009.09.004","volume":"37","author":"J Kim","year":"2009","unstructured":"Kim J, Hematti P. Mesenchymal stem cell\u2013educated macrophages: A novel type of alternatively activated macrophages. Exp Hematol. 2009;37(12):1445\u201353.","journal-title":"Exp Hematol"},{"issue":"3","key":"1044_CR50","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/cpr.12030","volume":"46","author":"A Spano","year":"2013","unstructured":"Spano A, Barni S, Sciola L. PMA withdrawal in PMA-treated monocytic THP-1 cells and subsequent retinoic acid stimulation, modulate induction of apoptosis and appearance of dendritic cells. Cell Prolif. 2013;46(3):328\u201347.","journal-title":"Cell Prolif"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-016-1044-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T05:36:48Z","timestamp":1718516208000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/s12891-016-1044-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,4]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1044"],"URL":"https:\/\/doi.org\/10.1186\/s12891-016-1044-5","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,4]]},"article-number":"199"}}