{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:18:33Z","timestamp":1767183513286,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T00:00:00Z","timestamp":1570838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T00:00:00Z","timestamp":1570838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Government","award":["Institutional grant"],"award-info":[{"award-number":["Institutional grant"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The development of total knee replacement (TKR) implant designs aims to improve outcome regarding pain, function, joint stiffness, instability, patellar problems, and ultimately wear of the implant. Recently, two major orthopaedic implant manufacturers launched a new generation of TKR implants which, according to the manufacturers, provide improved functional outcome. However, the benefits of these new TKR designs claimed by the manufacturers in terms of improved functional outcome still lack scientific documentation. The present randomized controlled trial has been designed to compare three fixed bearing, cemented cruciate-retaining (CR) designs; one of the new personalized TKR design with two conventional TKR designs with the main emphasis being on functional outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study is a prospective, double-blinded, randomized, single-center intervention trial. A total of 240 patients will be recruited to participate in a parallel-group study at Coxa Hospital for Joint Replacement, Tampere, Finland. We will compare the short-term functional outcome of TKR performed with a novel personalized TKR design (Persona CR, Zimmer, Warsaw, IN, USA) against TKRs performed with two conventional designs (PFC CR, DePuy, Warsaw, IN, USA and Nexgen CR, Zimmer, Warsaw, IN, USA). In total, 80 patients will be randomized in each of the three study arms. The primary outcome in this study is the Oxford Knee Score (OKS), which is a validated patient-reported outcome measure (PROM). Secondary outcome measures include the Forgotten Joint Score, the 15D, the UCLA activity score, and the VAS pain scale. The results will be analyzed after 2-year follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This paper presents a prospective, randomized, single-center trial study protocol. It provides details of patient randomization, PROMs, follow-up, methods of analysis of the material, and publication plan. An important aspect that will be considered in the study will be the economic effects of the novel designs as they are substantially more expensive, and the benefits of the added costs remain unknown. In addition, it is especially important to carry out evaluative studies in independent centers that are not biased by the interests of the manufacturers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>Retrospectively registered, November, 2017,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>Identifier:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03339557?term=NCT03339557&amp;rank=1\">NCT03339557<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12891-019-2830-7","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T23:04:34Z","timestamp":1570835074000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Functional outcome of total knee replacement: a study protocol for a prospective, double-blinded, parallel-group randomized, clinical controlled trial of novel, personalized and conventional implants"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1785-5174","authenticated-orcid":false,"given":"T.","family":"Irmola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kangas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Eskelinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Niemel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Huhtala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. M.","family":"Mattila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Moilanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,12]]},"reference":[{"issue":"5","key":"2830_CR1","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2106\/00004623-200405000-00012","volume":"86","author":"O Ethgen","year":"2004","unstructured":"Ethgen O, Bruyere O, Richy F, Dardennes C, Reginster J. Health-related quality of life in total hip and total knee arthroplasty: a qualitative and systematic review of the literature. J Bone Joint Surg. 2004;86(5):963\u201374. https:\/\/doi.org\/10.2106\/00004623-200405000-00012 .","journal-title":"J Bone Joint Surg"},{"issue":"17","key":"2830_CR2","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1056\/NEJMoa1505467","volume":"373","author":"ST Skou","year":"2015","unstructured":"Skou ST, Roos EM, Laursen MB, Rathleff MS, Arendt-Nielsen L, Simonsen O, et al. A randomized controlled trial of total knee replacement. N Engl J Med. 2015;373(17):1597\u2013606. https:\/\/doi.org\/10.1056\/NEJMoa1505467 .","journal-title":"N Engl J Med"},{"issue":"9","key":"2830_CR3","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.joca.2018.04.014","volume":"26","author":"ST Skou","year":"2018","unstructured":"Skou ST, Roos EM, Laursen MB, Rathleff MS, Arendt-Nielsen L, Rasmussen S, et al. Total knee replacement and non-surgical treatment of knee osteoarthritis: 2-year outcome from two parallel randomized controlled trials. Osteoarthr Cartil. 2018;26(9):1170\u201380. https:\/\/doi.org\/10.1016\/j.joca.2018.04.014 .","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"2830_CR4","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1080\/17453670610013501","volume":"78","author":"P R\u00e4s\u00e4nen","year":"2007","unstructured":"R\u00e4s\u00e4nen P, Paavolainen P, Sintonen H, Koivisto A, Blom M, Ryyn\u00e4nen O, et al. Effectiveness of hip or knee replacement surgery in terms of quality-adjusted life years and costs. Acta Orthop. 2007;78(1):108\u201315. https:\/\/doi.org\/10.1080\/17453670610013501 .","journal-title":"Acta Orthop"},{"issue":"1","key":"2830_CR5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1302\/0301-620X.95B1.29835","volume":"95-B","author":"PJ Jenkins","year":"2013","unstructured":"Jenkins PJ, Clement ND, Hamilton DF, Gaston P, Patton JT, Howie CR. Predicting the cost-effectiveness of total hip and knee replacement: a health economic analysis. Bone Joint J. 2013;95-B(1):115\u201321. https:\/\/doi.org\/10.1302\/0301-620X.95B1.29835 .","journal-title":"Bone Joint J"},{"issue":"4","key":"2830_CR6","doi-asserted-by":"publisher","first-page":"780","DOI":"10.2106\/00004623-200704000-00012","volume":"89","author":"S Kurtz","year":"2007","unstructured":"Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89(4):780\u20135. https:\/\/doi.org\/10.2106\/00004623-200704000-00012 .","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"2830_CR7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11999-009-1119-9","volume":"468","author":"R Bourne","year":"2010","unstructured":"Bourne R, Chesworth B, Davis A, Mahomed N, Charron K. Patient satisfaction after total knee arthroplasty: who is satisfied and who is not? Clin Orthop Relat Res. 2010;468(1):57\u201363. https:\/\/doi.org\/10.1007\/s11999-009-1119-9 .","journal-title":"Clin Orthop Relat Res"},{"issue":"9","key":"2830_CR8","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1302\/0301-620X.92B9.24394","volume":"92","author":"CEH Scott","year":"2010","unstructured":"Scott CEH, Howie CR, MacDonald D, Biant LC. Predicting dissatisfaction following total knee replacement: a prospective study of 1217 patients. J Bone Joint Surg. 2010;92(9):1253\u20138. https:\/\/doi.org\/10.1302\/0301-620X.92B9.24394 .","journal-title":"J Bone Joint Surg"},{"issue":"1","key":"2830_CR9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000435","volume":"2","author":"AD Beswick","year":"2012","unstructured":"Beswick AD, Wylde V, Gooberman-Hill R, Blom A, Dieppe P. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients. BMJ Open. 2012;2(1):e000435. https:\/\/doi.org\/10.1136\/bmjopen-2011-000435 .","journal-title":"BMJ Open"},{"key":"2830_CR10","doi-asserted-by":"publisher","DOI":"10.13140\/RG.2.2.27578.08649","volume-title":"National Joint Replacement Registry","author":"Aust Orthopaedic Assoc","year":"2017","unstructured":"Aust Orthopaedic Assoc. National Joint Replacement Registry. Hip, Knee & Shoulder Arthroplasty 2017 Annual Report; 2017. https:\/\/doi.org\/10.13140\/RG.2.2.27578.08649 ."},{"key":"2830_CR11","volume-title":"NJR 14th annual report 2017","author":"National Joint Registry fo England, Wales","year":"2017","unstructured":"National Joint Registry fo England, Wales. NJR 14th annual report 2017; 2017."},{"key":"2830_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2016.12.006","volume-title":"Nasjonalt register for Leddproteser annual report","author":"Norwegian National Unit on Arthroplasty","year":"2017","unstructured":"Norwegian National Unit on Arthroplasty. Nasjonalt register for Leddproteser annual report. 2017;70(6); doi: https:\/\/doi.org\/10.1016\/j.rec.2016.12.006 ."},{"key":"2830_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2012.08.011","volume-title":"The New Zealand joint registry","author":"New Zealand Orhtopedic Association","year":"2017","unstructured":"New Zealand Orhtopedic Association. The New Zealand joint registry; 2017. https:\/\/doi.org\/10.1016\/j.fcl.2012.08.011 ."},{"key":"2830_CR14","unstructured":"Robertsson O, Lidgren L, Sundberg M, W-Dahl A. The Swedish Knee Arthroplasty Register Annual Report 2017. 2017."},{"key":"2830_CR15","volume-title":"ODEP statement","author":"Anonymous","year":"2015","unstructured":"Anonymous. ODEP statement. 2015. http:\/\/www.odep.org.uk\/ODEPProcess\/ODEPStatement.aspx . Accessed 11 Dec 2018."},{"issue":"2","key":"2830_CR16","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.joca.2013.11.001","volume":"22","author":"K Giesinger","year":"2014","unstructured":"Giesinger K, Hamilton DF, Jost B, Holzner B, Giesinger JM. Comparative responsiveness of outcome measures for total knee arthroplasty osteoarthritis and cartilage \/ OARS. Osteoarthr Res Soc. 2014;22(2):184\u20139. https:\/\/doi.org\/10.1016\/j.joca.2013.11.001 .","journal-title":"Osteoarthr Res Soc"},{"issue":"11","key":"2830_CR17","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1302\/0301-620X.94B11.30081","volume":"94","author":"DF Hamilton","year":"2012","unstructured":"Hamilton DF, Gaston P, Simpson AH. R WIs patient reporting of physical function accurate following total knee replacement? J Bone Joint Surg. 2012;94(11):1506\u201310. https:\/\/doi.org\/10.1302\/0301-620X.94B11.30081 .","journal-title":"J Bone Joint Surg"},{"issue":"1","key":"2830_CR18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1302\/0301-620X.80B1.7859","volume":"80","author":"J Dawson","year":"1998","unstructured":"Dawson J, Fitzpatrick R, Murray D, Carr A. Questionnaire on the perceptions of patients about total knee replacement. J Bone Joint Surg. 1998;80(1):63\u20139. https:\/\/doi.org\/10.1302\/0301-620X.80B1.7859 .","journal-title":"J Bone Joint Surg"},{"issue":"5","key":"2830_CR19","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3109\/07853890109002086","volume":"33","author":"H Sintonen","year":"2001","unstructured":"Sintonen H. The 15D instrument of health-related quality of life: properties and applications. Ann Med. 2001;33(5):328\u201336. https:\/\/doi.org\/10.3109\/07853890109002086 .","journal-title":"Ann Med"},{"issue":"8","key":"2830_CR20","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/S0883-5403(98)90195-4","volume":"13","author":"CA Zahiri","year":"1998","unstructured":"Zahiri CA, Schmalzried TP, Szuszczewicz ES, Amstutz HC. Assessing activity in joint replacement patients. J Arthroplasty. 1998;13(8):890\u20135. https:\/\/doi.org\/10.1016\/S0883-5403(98)90195-4 .","journal-title":"J Arthroplasty"},{"issue":"3","key":"2830_CR21","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.arth.2011.06.035","volume":"27","author":"H Behrend","year":"2012","unstructured":"Behrend H, Giesinger K, Giesinger JM, Kuster MS. The \"forgotten joint\" as the ultimate goal in joint arthroplasty. J Arthroplasty. 2012;27(3):430. https:\/\/doi.org\/10.1016\/j.arth.2011.06.035 .","journal-title":"J Arthroplasty"},{"issue":"1","key":"2830_CR22","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.arth.2013.04.024","volume":"29","author":"E Thienpont","year":"2014","unstructured":"Thienpont E, Opsomer G, Koninckx A, Houssiau F. Joint awareness in different types of knee arthroplasty evaluated with the forgotten joint score. J Arthroplasty. 2014;29(1):48\u201351. https:\/\/doi.org\/10.1016\/j.arth.2013.04.024 .","journal-title":"J Arthroplasty"},{"issue":"5","key":"2830_CR23","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.arth.2013.09.035","volume":"29","author":"J Klit","year":"2014","unstructured":"Klit J, Jacobsen S, Rosenlund S, Sonne-Holm S, Troelsen A. Total knee arthroplasty in younger patients evaluated by alternative outcome measures. J Arthroplasty. 2014;29(5):912\u20137. https:\/\/doi.org\/10.1016\/j.arth.2013.09.035 .","journal-title":"J Arthroplasty"},{"issue":"8","key":"2830_CR24","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1302\/0301-620X.94B8.28786","volume":"94","author":"PN Baker","year":"2012","unstructured":"Baker PN, Deehan DJ, Lees D, Jameson S, Avery PJ, Gregg PJ, et al. The effect of surgical factors on early patient-reported outcome measures (PROMS) following total knee replacement. J Bone Joint Surg. 2012;94(8):1058\u201366. https:\/\/doi.org\/10.1302\/0301-620X.94B8.28786 .","journal-title":"J Bone Joint Surg"},{"issue":"4","key":"2830_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059500","volume":"8","author":"JC Keurentjes","year":"2013","unstructured":"Keurentjes JC, Fiocco M, So-Osman C, Onstenk R, Gemert K-V, Ankie WMM, et al. Patients with severe radiographic osteoarthritis have a better prognosis in physical functioning after hip and knee replacement: a cohort-study. PLoS One. 2013;8(4):e59500. https:\/\/doi.org\/10.1371\/journal.pone.0059500 .","journal-title":"PLoS One"},{"issue":"11 Suppl A","key":"2830_CR26","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1302\/0301-620X.95B11.32835","volume":"95-B","author":"KR Berend","year":"2013","unstructured":"Berend KR, Lombardi J, Adams JB. Which total knee replacement implant should I pick? Correcting the pathology: the role of knee bearing designs. Bone Joint J. 2013;95-B(11 Suppl A):129\u201332. https:\/\/doi.org\/10.1302\/0301-620X.95B11.32835 .","journal-title":"Bone Joint J"},{"issue":"9","key":"2830_CR27","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1302\/0301-620X.95B9.30386","volume":"95-B","author":"P van der Voort","year":"2013","unstructured":"van der Voort P, Pijls BG, Nouta KA, Valstar ER, Jacobs WCH, Nelissen RG, et al. A systematic review and meta-regression of mobile-bearing versus fixed-bearing total knee replacement in 41 studies. Bone Joint J. 2013;95-B(9):1209\u201316. https:\/\/doi.org\/10.1302\/0301-620X.95B9.30386 .","journal-title":"Bone Joint J"},{"issue":"8","key":"2830_CR28","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1007\/s00167-014-3145-8","volume":"22","author":"R Becker","year":"2014","unstructured":"Becker R, Hirschmann M, Karlsson J. Does implant design and surgical technique improve the clinical outcome in total knee arthroplasty? Knee Surg Sports Traumatol Arthrosc. 2014;22(8):1716\u20138. https:\/\/doi.org\/10.1007\/s00167-014-3145-8 .","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"2830_CR29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11999-014-3713-8","volume":"473","author":"R Nunley","year":"2015","unstructured":"Nunley R, Nam D, Berend K, Lombardi A, Dennis D, Della Valle C, et al. New Total knee arthroplasty designs: do young patients notice? Clin Orthop Relat Res. 2015;473(1):101\u20138. https:\/\/doi.org\/10.1007\/s11999-014-3713-8 .","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"2830_CR30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jclinepi.2014.08.009","volume":"68","author":"DJ Beard","year":"2015","unstructured":"Beard DJ, Harris K, Dawson J, Doll H, Murray DW, Carr AJ, et al. Meaningful changes for the Oxford hip and knee scores after joint replacement surgery. J Clin Epidemiol. 2015;68(1):73\u20139. https:\/\/doi.org\/10.1016\/j.jclinepi.2014.08.009 .","journal-title":"J Clin Epidemiol"},{"key":"2830_CR31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1749-799X-9-7","volume":"9","author":"MJ Piepers","year":"2014","unstructured":"Piepers MJ, van Hove RP, van den Bekerom MPJ, Nolte PA. Do refinements to original designs improve outcome of total knee replacement? A retrospective cohort study. J Orthop Surg Res. 2014;9:7. https:\/\/doi.org\/10.1186\/1749-799X-9-7 .","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"2830_CR32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12891-016-1001-3","volume":"17","author":"MG Thomsen","year":"2016","unstructured":"Thomsen MG, Latifi R, Kallemose T, Husted H, Troelsen A. Does knee awareness differ between different knee arthroplasty prostheses? A matched, case-control, cross-sectional study. BMC Musculoskelet Disord. 2016;17(1):141. https:\/\/doi.org\/10.1186\/s12891-016-1001-3 .","journal-title":"BMC Musculoskelet Disord"},{"key":"2830_CR33","doi-asserted-by":"publisher","unstructured":"Reito A, Jarvisto A, Jamsen E, Skytta E, Remes V, Huhtala H, et al. Translation and validation of the 12-item Oxford knee score for use in Finland. BMC Musculoskelet Disord. 2017;18. https:\/\/doi.org\/10.1186\/s12891-017-1405-8 .","DOI":"10.1186\/s12891-017-1405-8"},{"issue":"8","key":"2830_CR34","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1302\/0301-620X.89B8.19424","volume":"89","author":"DW Murray","year":"2007","unstructured":"Murray DW, Fitzpatrick R, Rogers K, Pandit H, Beard DJ, Carr AJ, et al. The use of the Oxford hip and knee scores. J Bone Joint Surg. British volume. 2007;89(8):1010\u20134. https:\/\/doi.org\/10.1302\/0301-620X.89B8.19424 .","journal-title":"J Bone Joint Surg"},{"issue":"9","key":"2830_CR35","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1016\/j.arth.2016.02.035","volume":"31","author":"H Behrend","year":"2016","unstructured":"Behrend H, Zdravkovic V, Giesinger J, Giesinger K. Factors predicting the forgotten joint score after Total knee arthroplasty. J Arthroplasty. 2016;31(9):1927\u201332. https:\/\/doi.org\/10.1016\/j.arth.2016.02.035 .","journal-title":"J Arthroplasty"},{"issue":"3","key":"2830_CR36","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3109\/17453674.2016.1156934","volume":"87","author":"MG Thomsen","year":"2016","unstructured":"Thomsen MG, Latifi R, Kallemose T, Barfod KW, Husted H, Troelsen A. Good validity and reliability of the forgotten joint score in evaluating the outcome of total knee arthroplasty. Acta Orthop. 2016;87(3):280\u20135. https:\/\/doi.org\/10.3109\/17453674.2016.1156934 .","journal-title":"Acta Orthop"},{"issue":"3","key":"2830_CR37","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s11136-014-0787-4","volume":"24","author":"S Alanne","year":"2015","unstructured":"Alanne S, Roine RP, R\u00e4s\u00e4nen P, Vainiola T, Sintonen H. Estimating the minimum important change in the 15D scores. Qual Life Res. 2015;24(3):599\u2013606. https:\/\/doi.org\/10.1007\/s11136-014-0787-4 .","journal-title":"Qual Life Res"},{"key":"2830_CR38","doi-asserted-by":"crossref","unstructured":"Insall JN, Binazzi R, Soudry M, Mestriner LA. Total knee arthroplasty. Clin Orthop Relat Res. 1985;(192):13\u201322.","DOI":"10.1097\/00003086-198501000-00003"},{"key":"2830_CR39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00003086-198501000-00004","volume":"192","author":"DS Hungerford","year":"1985","unstructured":"Hungerford DS, Krackow KA. Total joint arthroplasty of the knee. Clin Orthop Relat Res. 1985;192:23\u201333.","journal-title":"Clin Orthop Relat Res"},{"issue":"6","key":"2830_CR40","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1007\/s11999-011-2171-9","volume":"470","author":"M Peltola","year":"2012","unstructured":"Peltola M, Malmivaara A, Paavola M. Introducing a knee Endoprosthesis model increases risk of early revision surgery. Clin Orthop Relat Res. 2012;470(6):1711\u20137. https:\/\/doi.org\/10.1007\/s11999-011-2171-9 .","journal-title":"Clin Orthop Relat Res"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-019-2830-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12891-019-2830-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-019-2830-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T14:54:58Z","timestamp":1664636098000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/s12891-019-2830-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,12]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2830"],"URL":"https:\/\/doi.org\/10.1186\/s12891-019-2830-7","relation":{},"ISSN":["1471-2474"],"issn-type":[{"type":"electronic","value":"1471-2474"}],"subject":[],"published":{"date-parts":[[2019,10,12]]},"assertion":[{"value":"5 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the Regional Ethics Committee of Pirkanmaa Hospital District (Approval number: R15053). All participants will provide informed written consent to participate.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors have completed the ICMJE uniform disclosure form atand declare: no support from any organization for the submitted work. The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"443"}}