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The present study aims to explore the relationship of\n                      <jats:italic>ESR1<\/jats:italic>\n                      polymorphism rs2234693 and rs9340799 with PMO risk in a Chinese Han population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PMO patients and healthy controls were recruited from gynecology department. DNA of all participants were extracted from the peripheral blood samples and genotyped by Mass Array method. A meta-analysis of case control studies was also conducted to further elucidate the relationship of polymorphism with PMO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results revealed that there were no associations of rs2234693 with PMO. However, GG genotype of rs9340799 was associated with a higher risk of PMO (OR\u2009=\u20091.51, 95%CI:1.08\u20134.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), even adjusting for risk factors (OR\u2009=\u20091.83, 95%CI: 1.12\u20135.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Logistic regression analysis showed that dominant model was associated with a higher risk of PMO (OR\u2009=\u20092.07, 95%CI: 1.02\u20135.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) after correcting the risk factors (OR\u2009=\u20092.14, 95%CI:1.12\u20135.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04); In addition, the Meta-analysis results revealed that both two polymorphisms were not associated with PMO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In conclusion,\n                      <jats:italic>ESR1<\/jats:italic>\n                      polymorphism rs9340799 was associated with PMO. However, well designed studies with larger sample sizes are required to further elucidate the associations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12891-020-03359-2","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T15:03:44Z","timestamp":1591196624000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of ESR1 polymorphism rs2234693 and rs9340799 with postmenopausal osteoporosis in a Chinese population"],"prefix":"10.1186","volume":"21","author":[{"given":"Jin","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"issue":"3","key":"3359_CR1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1056\/NEJMcp1513724","volume":"374","author":"DM Black","year":"2016","unstructured":"Black DM, Rosen CJ. 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All participants in this study were provided with explanations via face-to-face interpretation and a written informed consent was obtained before inclusion.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"346"}}