{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:19:22Z","timestamp":1783549162027,"version":"3.55.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age-dependent male osteoporosis remains a poorly studied medical problem despite its significance. It is estimated that at least 1 of 5 men will suffer from osteoporotic consequences. Given that multiple mechanisms are involved in the process of senescence, much attention has been given to compounds with polymodal actions. To challenge such a health problem, we tested here the therapeutic potential of resveratrol in male osteoporosis. We also studied the possible molecular mechanisms that may underlie resveratrol effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty male Wistar albino rats were used in the present study. Rats were divided (10\/group) into: control (3\u20134\u2009months old weighing 150\u2013200\u2009g receiving vehicle), aged (18\u201320\u2009months old, weighing 350\u2013400\u2009g and receiving vehicle), and resveratrol treated aged (18\u201320\u2009months old, weighing 350\u2013400\u2009g and receiving resveratrol 20\u2009mg\/kg\/day for 6\u2009weeks) groups. Assessment of serum calcium, phosphate, bone specific alkaline phosphatase, inflammatory cytokines, oxidative stress markers, and rat femur gene expression of FoxO1, SIRT1, RANKL and OPG proteins was carried out. Histopathological assessment of different levels of rat femur was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age-dependent osteoporosis resulted in significant increase in serum levels of phosphate, bone specific alkaline phosphatase, hsCRP, IL-1\u03b2, IL-6, TNF-\u03b1, MDA, NO, and RANKL gene expression. However, there was significant decrease in serum level of GSH, and gene expression of FoxO1, SIRT1 and OPG. Osteoporotic changes were seen in femur epiphysis, metaphysis and diaphysis. Resveratrol restored significantly age-dependent osteoporotic changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We concluded that resveratrol can play an important role in the prevention of male osteoporosis. Resveratrol can counter the molecular changes in male osteoporosis via anti-inflammatory, anti-oxidant and gene modifying effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12891-020-03389-w","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T10:02:56Z","timestamp":1591956176000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Activation of FoxO1\/SIRT1\/RANKL\/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis"],"prefix":"10.1186","volume":"21","author":[{"given":"Omnia","family":"Ameen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania I.","family":"Yassien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-7238","authenticated-orcid":false,"given":"Yahya M.","family":"Naguib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"issue":"6","key":"3389_CR1","first-page":"569","volume":"94","author":"NIH","year":"2001","unstructured":"NIH. NIH consensus development panel on osteoporosis prevention, diagnosis, and therapy, March 7\u201329, 2000: highlights of the conference. Southern Med J. 2001;94(6):569\u201373.","journal-title":"Southern Med J"},{"issue":"3","key":"3389_CR2","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/14656566.2018.1428559","volume":"19","author":"L Gennari","year":"2018","unstructured":"Gennari L, Bilezikian JP. New and developing pharmacotherapy for osteoporosis in men. Exp Opin Pharmacother. 2018;19(3):253\u201364.","journal-title":"Exp Opin Pharmacother"},{"issue":"7529","key":"3389_CR3","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1136\/bmj.38643.663843.55","volume":"331","author":"JJ Roche","year":"2005","unstructured":"Roche JJ, Wenn RT, Sahota O, Moran CG. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ. 2005;331(7529):1374.","journal-title":"BMJ"},{"issue":"4","key":"3389_CR4","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00198-004-1694-2","volume":"16","author":"LS Orsini","year":"2005","unstructured":"Orsini LS, Rousculp MD, Long SR, Wang S. Health care utilization and expenditures in the United States: a study of osteoporosis-related fractures. Osteoporos Int. 2005;16(4):359\u201371.","journal-title":"Osteoporos Int"},{"issue":"12","key":"3389_CR5","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17(12):1726\u201333.","journal-title":"Osteoporos Int"},{"key":"3389_CR6","doi-asserted-by":"publisher","first-page":"907689","DOI":"10.1155\/2015\/907689","volume":"2015","author":"P D\u2019Amelio","year":"2015","unstructured":"D\u2019Amelio P, Isaia GC. Male Osteoporosis in the Elderly. Int J Endocrinol. 2015;2015:907689.","journal-title":"Int J Endocrinol"},{"issue":"4","key":"3389_CR7","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.beem.2013.04.010","volume":"27","author":"M Laurent","year":"2013","unstructured":"Laurent M, Gielen E, Claessens F, Boonen S, Vanderschueren D. Osteoporosis in older men: recent advances in pathophysiology and treatment. Best Pract Res. 2013;27(4):527\u201339.","journal-title":"Best Pract Res"},{"issue":"5","key":"3389_CR8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1089\/rej.2014.1551","volume":"17","author":"IF Tresguerres","year":"2014","unstructured":"Tresguerres IF, Tamimi F, Eimar H, Barralet J, Torres JS, Blanco L, Tresguerres JA. Resveratrol as anti-aging therapy for age-related bone loss. Rejuvenat Res. 2014;17(5):439\u201345.","journal-title":"Rejuvenat Res"},{"issue":"Suppl 2","key":"3389_CR9","first-page":"S86","volume":"10","author":"DW Sommerfeldt","year":"2001","unstructured":"Sommerfeldt DW, Rubin CT. Biology of bone and how it orchestrates the form and function of the skeleton. Eur Spine J. 2001;10(Suppl 2):S86\u201395.","journal-title":"Eur Spine J"},{"issue":"1","key":"3389_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000166209","volume":"55","author":"P Pietschmann","year":"2009","unstructured":"Pietschmann P, Rauner M, Sipos W, Kerschan-Schindl K. Osteoporosis: an age-related and gender-specific disease--a mini-review. Gerontology. 2009;55(1):3\u201312.","journal-title":"Gerontology"},{"issue":"5","key":"3389_CR11","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1359\/jbmr.1998.13.5.763","volume":"13","author":"BL Riggs","year":"1998","unstructured":"Riggs BL, Khosla S, Melton LJ 3rd. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res. 1998;13(5):763\u201373.","journal-title":"J Bone Miner Res"},{"key":"3389_CR12","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","volume":"908","author":"C Franceschi","year":"2000","unstructured":"Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann New York Acad Sci. 2000;908:244\u201354.","journal-title":"Ann New York Acad Sci"},{"issue":"1","key":"3389_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1172\/JCI116179","volume":"91","author":"S Tanaka","year":"1993","unstructured":"Tanaka S, Takahashi N, Udagawa N, Tamura T, Akatsu T, Stanley ER, Kurokawa T, Suda T. Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J Clin Invest. 1993;91(1):257\u201363.","journal-title":"J Clin Invest"},{"issue":"6","key":"3389_CR14","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1172\/JCI117606","volume":"94","author":"R Kitazawa","year":"1994","unstructured":"Kitazawa R, Kimble RB, Vannice JL, Kung VT, Pacifici R. Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J Clin Invest. 1994;94(6):2397\u2013406.","journal-title":"J Clin Invest"},{"issue":"5066","key":"3389_CR15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1126\/science.1621100","volume":"257","author":"RL Jilka","year":"1992","unstructured":"Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. 1992;257(5066):88\u201391.","journal-title":"Science"},{"issue":"5","key":"3389_CR16","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1111\/j.1474-9726.2010.00616.x","volume":"9","author":"RL Jilka","year":"2010","unstructured":"Jilka RL, Almeida M, Ambrogini E, Han L, Roberson PK, Weinstein RS, Manolagas SC. Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration. Aging Cell. 2010;9(5):851\u201367.","journal-title":"Aging Cell"},{"issue":"3","key":"3389_CR17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1210\/er.2009-0024","volume":"31","author":"SC Manolagas","year":"2010","unstructured":"Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocrine Rev. 2010;31(3):266\u2013300.","journal-title":"Endocrine Rev"},{"issue":"4","key":"3389_CR18","doi-asserted-by":"publisher","first-page":"e35712","DOI":"10.1371\/journal.pone.0035712","volume":"7","author":"M Shakibaei","year":"2012","unstructured":"Shakibaei M, Shayan P, Busch F, Aldinger C, Buhrmann C, Lueders C, Mobasheri A. Resveratrol mediated modulation of Sirt-1\/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. PloS one. 2012;7(4):e35712.","journal-title":"PloS one"},{"issue":"5","key":"3389_CR19","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1017\/S0007114513003115","volume":"111","author":"H Zhao","year":"2014","unstructured":"Zhao H, Li X, Li N, Liu T, Liu J, Li Z, Xiao H, Li J. Long-term resveratrol treatment prevents ovariectomy-induced osteopenia in rats without hyperplastic effects on the uterus. British J Nutr. 2014;111(5):836\u201346.","journal-title":"British J Nutr"},{"issue":"1","key":"3389_CR20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00774-010-0187-y","volume":"29","author":"C Habold","year":"2011","unstructured":"Habold C, Momken I, Ouadi A, Bekaert V, Brasse D. Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension. J Bone Mineral Metabol. 2011;29(1):15\u201322.","journal-title":"J Bone Mineral Metabol"},{"issue":"1","key":"3389_CR21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s00774-013-0469-2","volume":"32","author":"SM Durbin","year":"2015","unstructured":"Durbin SM, Jackson JR, Ryan MJ, Gigliotti JC, Alway SE, Tou JC. Resveratrol supplementation preserves long bone mass, microstructure, and strength in hindlimb-suspended old male rats. J Bone Mineral Metabol. 2015;32(1):38\u201347.","journal-title":"J Bone Mineral Metabol"},{"issue":"1","key":"3389_CR22","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12894-019-0534-9","volume":"19","author":"DF El Agamy","year":"2019","unstructured":"El Agamy DF, Naguib YM. CoQ10 ameliorates monosodium glutamate-induced alteration in detrusor activity and responsiveness in rats via anti-inflammatory, anti-oxidant and channel inhibiting mechanisms. BMC Urol. 2019;19(1):103.","journal-title":"BMC Urol"},{"issue":"12","key":"3389_CR23","doi-asserted-by":"publisher","first-page":"5871","DOI":"10.3390\/nu6125871","volume":"6","author":"AMC Lee","year":"2014","unstructured":"Lee AMC, Shandala T, Nguyen L, Muhlhausler BS, Chen K-M, Howe PR, Xian CJ. Effects of resveratrol supplementation on bone growth in young rats and microarchitecture and remodeling in ageing rats. Nutrients. 2014;6(12):5871\u201387.","journal-title":"Nutrients"},{"issue":"1","key":"3389_CR24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13098-020-00546-y","volume":"12","author":"SM Motawea","year":"2020","unstructured":"Motawea SM, Noreldin RI, Naguib YM. Potential therapeutic effects of endothelial cells trans-differentiated from Wharton\u00e2\u20ac\u2122s Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model. Diabetol Metabol Syndrome. 2020;12(1):40.","journal-title":"Diabetol Metabol Syndrome"},{"issue":"1","key":"3389_CR25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12958-020-0563-y","volume":"18","author":"NI Rizk","year":"2020","unstructured":"Rizk NI, Rizk MS, Mohamed AS, Naguib YM. Attenuation of sleep deprivation dependent deterioration in male fertility parameters by vitamin C. Reprod Biol Endocrinol. 2020;18(1):2.","journal-title":"Reprod Biol Endocrinol"},{"key":"3389_CR26","first-page":"1707","volume":"35","author":"T Goldschlager","year":"2010","unstructured":"Goldschlager T, Abdelkader A, Kerr J, Boundy I, Jenkin G. Undecalcified bone preparation for histology, histomorphometry and fluorochrome analysis. J Visual Exp. 2010;35:1707.","journal-title":"J Visual Exp"},{"issue":"5","key":"3389_CR27","first-page":"5032","volume":"14","author":"X Wang","year":"2017","unstructured":"Wang X, Chen L, Peng W. Protective effects of resveratrol on osteoporosis via activation of the SIRT1-NF-kappaB signaling pathway in rats. Exp Ther Med. 2017;14(5):5032\u20138.","journal-title":"Exp Ther Med"},{"issue":"2","key":"3389_CR28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S8756-3282(01)00483-5","volume":"29","author":"L Wang","year":"2001","unstructured":"Wang L, Banu J, McMahan CA, Kalu DN. Male rodent model of age-related bone loss in men. Bone. 2001;29(2):141\u20138.","journal-title":"Bone"},{"issue":"6","key":"3389_CR29","first-page":"624","volume":"4","author":"P Sengupta","year":"2013","unstructured":"Sengupta P. The laboratory rat: relating its age with human\u2019s. Int J Prevent Med. 2013;4(6):624\u201330.","journal-title":"Int J Prevent Med"},{"key":"3389_CR30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1749-6632.2010.05843.x","volume":"1215","author":"G Petrovski","year":"2011","unstructured":"Petrovski G, Gurusamy N, Das DK. Resveratrol in cardiovascular health and disease. Ann New York Acad Sci. 2011;1215:22\u201333.","journal-title":"Ann New York Acad Sci"},{"issue":"11","key":"3389_CR31","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.jnutbio.2015.05.009","volume":"26","author":"L Zhao","year":"2015","unstructured":"Zhao L, Wang Y, Wang Z, Xu Z, Zhang Q, Yin M. Effects of dietary resveratrol on excess-iron-induced bone loss via antioxidative character. J Nutr Biochem. 2015;26(11):1174\u201382.","journal-title":"J Nutr Biochem"},{"key":"3389_CR32","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s40520-014-0296-x","volume":"27","author":"K Mukaiyama","year":"2015","unstructured":"Mukaiyama K, Kamimura M, Uchiyama S, Ikegami S, Nakamura Y, Kato H. Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turnover. Aging Clin Exp Res. 2015;27:413\u20138.","journal-title":"Aging Clin Exp Res"},{"key":"3389_CR33","doi-asserted-by":"publisher","first-page":"781","DOI":"10.2147\/IJWH.S145191","volume":"9","author":"BD Pardhe","year":"2017","unstructured":"Pardhe BD, Pathak S, Bhetwal A, Ghimire S, Shakya S, Khanal PR, Marahatta SB. Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal. Int J Womens Health. 2017;9:781\u20138.","journal-title":"Int J Womens Health"},{"issue":"11","key":"3389_CR34","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1007\/s00467-012-2175-z","volume":"27","author":"MG Penido","year":"2012","unstructured":"Penido MG, Alon US. Phosphate homeostasis and its role in bone health. Pediatr Nephrol. 2012;27(11):2039\u201348.","journal-title":"Pediatr Nephrol"},{"issue":"12","key":"3389_CR35","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1093\/abbs\/gmu103","volume":"46","author":"J Feng","year":"2014","unstructured":"Feng J, Liu S, Ma S, Zhao J, Zhang W, Qi W, Cao P, Wang Z, Lei W. Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-kappaB signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2014;46(12):1024\u201333.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"3389_CR36","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00223-016-0130-x","volume":"99","author":"MJ Ornstrup","year":"2016","unstructured":"Ornstrup MJ, Harsl\u00f8f T, S\u00f8rensen L, Stenkj\u00e6r L, Langdahl BL, Pedersen SB. Resveratrol Increases Osteoblast Differentiation In Vitro Independently of Inflammation. Calcified Tissue Int. 2016;99:155\u201363.","journal-title":"Calcified Tissue Int"},{"issue":"10","key":"3389_CR37","doi-asserted-by":"publisher","first-page":"4295","DOI":"10.1210\/endo.142.10.8437","volume":"142","author":"PJ Kostenuik","year":"2001","unstructured":"Kostenuik PJ, Capparelli C, Morony S, Adamu S, Shimamoto G, Shen V, Lacey DL, Dunstan CR. OPG and PTH-(1\u201334) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats. Endocrinology. 2001;142(10):4295\u2013304.","journal-title":"Endocrinology"},{"key":"3389_CR38","doi-asserted-by":"publisher","first-page":"6","DOI":"10.4061\/2011\/293808","volume":"2011","author":"RY Lau","year":"2011","unstructured":"Lau RY, Guo X. A review on current osteoporosis research: with special focus on disuse bone loss. J Osteoporosis. 2011;2011:6.","journal-title":"J Osteoporosis"},{"key":"3389_CR39","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/nyas.12840","volume":"1348","author":"JC Tou","year":"2015","unstructured":"Tou JC. Evaluating resveratrol as a therapeutic bone agent: preclinical evidence from rat models of osteoporosis. Ann New York Acad Sci. 2015;1348:75\u201385.","journal-title":"Ann New York Acad Sci"},{"issue":"5","key":"3389_CR40","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.jbiomech.2014.12.007","volume":"48","author":"J Klein-Nulend","year":"2014","unstructured":"Klein-Nulend J, van Oers RFM, Bakker AD, Bacabac RG. Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis. J Biomech. 2014;48(5):855\u201365.","journal-title":"J Biomech"},{"issue":"11","key":"3389_CR41","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.prp.2004.10.003","volume":"200","author":"G Motomura","year":"2005","unstructured":"Motomura G, Yamamoto T, Miyanishi K, Yamashita A, Sueishi K, Iwamoto Y. Bone marrow fat-cell enlargement in early steroid-induced osteonecrosis\u2014a histomorphometric study of autopsy cases. Pathol Res Pract. 2005;200(11):807\u201311.","journal-title":"Pathol Res Pract"},{"key":"3389_CR42","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/j.1600-079X.2008.00606.x","volume":"45","author":"RA Kireev","year":"2008","unstructured":"Kireev RA, Tresguerres ACF, Garcia C, Ariznavarreta C, Vara E, Tresguerres JAF. Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro-inflammatory damage. J Pineal Res. 2008;45:394\u2013402.","journal-title":"J Pineal Res"},{"key":"3389_CR43","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrd3669","volume":"11","author":"K Redlich","year":"2012","unstructured":"Redlich K, Smolen JS. Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov. 2012;11:234.","journal-title":"Nat Rev Drug Discov"},{"key":"3389_CR44","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1007\/s00223-010-9393-9","volume":"87","author":"KH Baek","year":"2010","unstructured":"Baek KH, Oh KW, Lee WY, Lee SS, Kim MK, Kwon HS, Rhee EJ, Han JH, Song KH, Cha BY, et al. Association of Oxidative stress with postmenopausal Osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures. Calcified Tissue Int. 2010;87:226\u201335.","journal-title":"Calcified Tissue Int"},{"issue":"9","key":"3389_CR45","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.bcp.2006.06.017","volume":"72","author":"G Gloire","year":"2006","unstructured":"Gloire G, Dejardin E, Piette J. Extending the nuclear roles of I\u00ce\u00b0B kinase subunits. Biochem Pharmacol. 2006;72(9):1081\u20139.","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"3389_CR46","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.intimp.2004.08.008","volume":"5","author":"XL Bi","year":"2005","unstructured":"Bi XL, Yang JY, Dong YX, Wang JM, Cui YH, Ikeshima T, Zhao YQ, Wu CF. Resveratrol inhibits nitric oxide and TNF-\u00ce\u2009\u00b1\u2009production by lipopolysaccharide-activated microglia. Int Immunopharmacol. 2005;5(1):185\u201393.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"3389_CR47","doi-asserted-by":"publisher","first-page":"209","DOI":"10.11138\/ccmbm\/2017.14.1.209","volume":"14","author":"V Domazetovic","year":"2017","unstructured":"Domazetovic V, Marcucci G, Iantomasi T, Brandi ML, Vincenzini MT. Oxidative stress in bone remodeling: role of antioxidants. Clin Cases Mineral Bone Metabol. 2017;14(2):209\u201316.","journal-title":"Clin Cases Mineral Bone Metabol"},{"issue":"6","key":"3389_CR48","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.bbadis.2014.10.003","volume":"1852","author":"JC Tou","year":"2015","unstructured":"Tou JC. Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy. Biochimica et Biophysica Acta Mol Basis Dis. 2015;1852(6):1186\u201394.","journal-title":"Biochimica et Biophysica Acta Mol Basis Dis"},{"issue":"2","key":"3389_CR49","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.bone.2012.11.038","volume":"54","author":"RL Jilka","year":"2013","unstructured":"Jilka RL, Noble B, Weinstein RS. Osteocyte Apoptosis. Bone. 2013;54(2):264\u201371.","journal-title":"Bone"},{"key":"3389_CR50","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00223-015-9961-0","volume":"96","author":"F Fontani","year":"2015","unstructured":"Fontani F, Marcucci G, Iantomasi T, Brandi ML, Vincenzini MT. Glutathione, N-acetylcysteine and Lipoic Acid Down-Regulate Starvation-Induced Apoptosis, RANKL\/OPG Ratio and Sclerostin in Osteocytes: Involvement of JNK and ERK1\/2 Signalling. Calcified Tissue Int. 2015;96:335\u201346.","journal-title":"Calcified Tissue Int"},{"key":"3389_CR51","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1038\/ncomms4773","volume":"5","author":"SM Bartell","year":"2014","unstructured":"Bartell SM, Kim H-N, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, et al. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H(2)O(2) accumulation. Nat Commun. 2014;5:3773.","journal-title":"Nat Commun"},{"issue":"1","key":"3389_CR52","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/nyas.13433","volume":"1403","author":"YT Chin","year":"2017","unstructured":"Chin YT, Cheng GY, Shih YJ, Lin CY, Lin SJ, Lai HY, Whang-Peng J, Chiu HC, Lee SY, Fu E, et al. Therapeutic applications of resveratrol and its derivatives on periodontitis. Ann New York Acad Sci. 2017;1403(1):101\u20138.","journal-title":"Ann New York Acad Sci"},{"issue":"5","key":"3389_CR53","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/acel.12220","volume":"13","author":"EM Mercken","year":"2014","unstructured":"Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, et al. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell. 2014;13(5):787\u201396.","journal-title":"Aging Cell"},{"issue":"9","key":"3389_CR54","doi-asserted-by":"publisher","first-page":"e46364","DOI":"10.1371\/journal.pone.0046364","volume":"7","author":"H Yang","year":"2012","unstructured":"Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, Leung S, Zhong Z, Zhao H, Sweitzer S, et al. SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-\u00ce\u00b0B Activity. PLoS One. 2012;7(9):e46364.","journal-title":"PLoS One"},{"key":"3389_CR55","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00441-013-1750-3","volume":"355","author":"I Titorencu","year":"2014","unstructured":"Titorencu I, Pruna V, Jinga VV, Simionescu M. Osteoblast ontogeny and implications for bone pathology: an overview. Cell Tissue Res. 2014;355:23\u201333.","journal-title":"Cell Tissue Res"},{"issue":"8","key":"3389_CR56","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1590\/1414-431X20132903","volume":"46","author":"L Cao","year":"2013","unstructured":"Cao L, Liu C, Wang F, Wang H. SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-\u00ce\u00b0B pathway. Brazil J Med Biol Res. 2013;46(8):659\u201369.","journal-title":"Brazil J Med Biol Res"},{"issue":"9","key":"3389_CR57","doi-asserted-by":"publisher","first-page":"e73875","DOI":"10.1371\/journal.pone.0073875","volume":"8","author":"YS Hori","year":"2013","unstructured":"Hori YS, Kuno A, Hosoda R, Horio Y. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PLoS One. 2013;8(9):e73875.","journal-title":"PLoS One"},{"issue":"2","key":"3389_CR58","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cmet.2010.01.001","volume":"11","author":"M-T Rached","year":"2010","unstructured":"Rached M-T, Kode A, Xu L, Yoshikawa Y, Paik J-H, DePinho RA, Kousteni S. FOXO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab. 2010;11(2):147.","journal-title":"Cell Metab"},{"issue":"12","key":"3389_CR59","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1093\/abbs\/gmu103","volume":"46","author":"J Feng","year":"2018","unstructured":"Feng J, Liu S, Ma S, Zhao J, Zhang W, Qi W, Cao P, Wang Z, Lei W. Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-\u00ce\u00b0B signaling pathway. Acta Biochimica et Biophysica Sinica. 2018;46(12):1024\u201333.","journal-title":"Acta Biochimica et Biophysica Sinica"},{"issue":"2","key":"3389_CR60","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.cmet.2009.12.009","volume":"11","author":"E Ambrogini","year":"2010","unstructured":"Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L, Goellner J, Weinstein RS, Jilka RL, O\u2019Brien CA, et al. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010;11(2):136\u201346.","journal-title":"Cell Metab"},{"issue":"Suppl 1","key":"3389_CR61","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1186\/ar2167","volume":"9","author":"M McClung","year":"2007","unstructured":"McClung M. Role of RANKL inhibition in osteoporosis. Arthritis Res Ther. 2007;9(Suppl 1):S3.","journal-title":"Arthritis Res Ther"},{"key":"3389_CR62","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/46303","volume":"402","author":"Y-Y Kong","year":"1999","unstructured":"Kong Y-Y, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 1999;402:304.","journal-title":"Nature"},{"key":"3389_CR63","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/1529-0131(200002)43:2<259::AID-ANR4>3.0.CO;2-W","volume":"43","author":"H Takayanagi","year":"2000","unstructured":"Takayanagi H, Iizuka H, Juji T, Nakagawa T, Yamamoto A, Miyazaki T, Koshihara Y, Oda H, Nakamura K, Tanaka S. Involvement of receptor activator of nuclear factor \u00ce\u00b0B ligand\/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheumatism. 2000;43:259\u201369.","journal-title":"Arthritis Rheumatism"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-020-03389-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12891-020-03389-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-020-03389-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T19:21:27Z","timestamp":1623439287000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/s12891-020-03389-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,12]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["3389"],"URL":"https:\/\/doi.org\/10.1186\/s12891-020-03389-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-16952\/v1","asserted-by":"object"}]},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,12]]},"assertion":[{"value":"4 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethical Committee of the Faculty of Medicine, Menoufia University, Egypt.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No conflict of interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"375"}}