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Baseline predictors were: age decade; sex; BMI\u2009\u2265\u200925; physical exam knee effusion; crepitus; malalignment; quadriceps atrophy; flexion; flexion contracture; Kellgren-Lawrence (KL) x-ray grade (0\/1\/2\/3+); WOMAC pain \u226525; WOMAC stiffness \u226525; self-reported knee swelling; and knee OA diagnosis (no\/probable\/definite). Depression and anxiety, cutoffs 5+ and 7+ respectively, were measured via the Hospital Anxiety and Depression Scale. We fit logistic models at each cycle using multivariable models selected via lowest Akaike\u2019s information criterion.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Baseline depression model: sex (female OR\u2009=\u20090.27; 0.10, 0.76) and KL grade (KL 1 OR\u2009=\u20094.21; 1.31, 13.48). Three-year depression model: KL grade (KL 1 OR\u2009=\u200918.92; 1.73, 206.25). Seven-year depression model: WOMAC stiffness \u226525 (OR\u2009=\u20093.49; 1.02, 11.94) and flexion contracture \u22651 degree (OR\u2009=\u20090.23; 0.07, 0.81). Baseline anxiety model: knee swelling (OR\u2009=\u20094.11; 1.51, 11.13) and age (50\u201359 vs. 40\u201349 OR\u2009=\u20090.31 [0.11, 0.85]; 60\u201369 OR\u2009=\u20090.07 [0.01, 0.42]). Three-year anxiety model: WOMAC stiffness \u226525 (OR\u2009=\u20095.80; 1.23, 27.29) and KL grade (KL 1 OR\u2009=\u20096.25; 1.04, 37.65). Seven-year anxiety model: sex (female OR\u2009=\u20092.71; 0.87, 8.46).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Specific knee OA-related manifestations predict depression and anxiety cross-sectionally, 3\u2009years in the future, and for depression, 7\u2009years in the future. This information may prove useful to clinicians in helping to identify patients most at risk of present or future depression and anxiety, thus facilitating preemptive discussions that may help counter that risk.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12891-020-03496-8","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T12:02:47Z","timestamp":1594900967000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Specific manifestations of knee osteoarthritis predict depression and anxiety years in the future: Vancouver Longitudinal Study of Early Knee Osteoarthritis"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-278X","authenticated-orcid":false,"given":"Eric C.","family":"Sayre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Esdaile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek A.","family":"Kopec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anona","family":"Thorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savvas","family":"Nicolaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda","family":"Cibere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"3496_CR1","first-page":"386","volume":"34","author":"JA Kopec","year":"2007","unstructured":"Kopec JA, Rahman MM, Berthelot JM, Le Petit C, Aghajanian J, Sayre EC, et al. 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The study was conducted in accordance with the Declaration of Helsinki and was approved by the Clinical Research Ethics Board, University of British Columbia with approval number #H09\u201302046.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Ali Guermazi is President of Boston Imaging Core Lab, LLC, and consultant to AstraZeneca, TissueGene, Roche, Galapagos, Merck Serono and Pfizer. No other authors have competing interests to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"467"}}