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This aim of the study is to identify factors associated with a clinically meaningful placebo response in patients with hand OA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This post-hoc analysis of two double-blind, placebo-controlled, randomized trials (RCTs) investigating the efficacy of GCSB-5 or diacerein as treatments for hand OA analyzed the efficacy of a placebo. Clinical and laboratory factors associated with a clinically meaningful response, defined as an improvement in the Australian\/Canadian Osteoarthritis Hand Index (AUSCAN) pain score\u2009&gt;\u200910 at 4\u2009weeks relative to baseline, were identified.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean improvement in the AUSCAN pain score was \u2212\u20096.0\u2009\u00b1\u200920.3, with marked variation between 143 hand OA patients (range: \u2212\u200976.4 to 33.2). A clinically meaningful improvement was observed in 54 (37.8%) patients. Placebo responders had worse AUSCAN pain scores (55.7\u2009\u00b1\u200919.7 vs. 43.6\u2009\u00b1\u200921.6, <jats:italic>p<\/jats:italic>\u00a0=\u20090.001) and a worse AUSCAN stiffness (68.2\u2009\u00b1\u200920.5 vs. 57.5\u2009\u00b1\u200924.5, <jats:italic>p<\/jats:italic>\u00a0=\u20090.008) at baseline than non-responders. Improvements in pain correlated with the baseline pain level (Pearson <jats:italic>r<\/jats:italic>\u00a0=\u2009\u2212\u2009427, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Structural joint changes such as tender, swollen, enlarged, or deformed joint counts did not differ between placebo responders and non-responders. In a multivariable analysis, only baseline AUSCAN pain was associated with a clinically meaningful placebo response (OR: 1.054, 95% CI [1.019\u20131.089], <jats:italic>p<\/jats:italic>\u00a0=\u20090.002).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>High levels of pain at baseline are predictive of a clinically meaningful placebo response in patients with hand OA. Further studies are needed to optimize and utilize the benefit of placebo responses in patients with hand OA.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12891-021-04089-9","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T13:03:43Z","timestamp":1614863023000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of a placebo response in patients with hand osteoarthritis: post-hoc analysis of two randomized controlled trials"],"prefix":"10.1186","volume":"22","author":[{"given":"Jin Kyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Han","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kichul","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Jong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Wook","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-1208","authenticated-orcid":false,"given":"Eun Bong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"issue":"6","key":"4089_CR1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.semarthrit.2009.03.001","volume":"39","author":"L Kalichman","year":"2010","unstructured":"Kalichman L, Hernandez-Molina G. 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Institutional review boards of all participating centers approved the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"EBL has acted as a consultant to Pfizer and research grants from GC Pharma Korea and Handok inc. The other authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"244"}}