{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:32:33Z","timestamp":1787020353567,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:00:00Z","timestamp":1615075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:00:00Z","timestamp":1615075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","award":["2017D01C287"],"award-info":[{"award-number":["2017D01C287"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Delirium is a common complication of hip surgery patients. It is necessary to investigate the epidemiological characteristics and related risk factors of delirium after hip fracture surgery, to provide evidence supports for the prevention and management of delirium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Hip fracture patients admitted to our hospital for surgical treatment from March 2018 to March 2020 were identified as participants. The characteristics and laboratory examinations in patients with and without postoperative delirium were compared and analyzed. Logistic regression analyses were conducted to ascertain the independent risk factors, and the area under the curve (AUC) were calculated to analyze the predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 568 postoperative patients with hip fracture were included, the incidence of delirium in postoperative patients with hip fracture was 14.44\u2009%. The preoperative albumin (OR 4.382, 2.501\u2009~\u20095.538), history of delirium (OR 2.197, 1.094\u2009~\u20093.253), TSH (OR1.245, 1.077\u2009~\u20091.638), the resting score on the first postoperative day (OR1.235, 0.944\u2009~\u20091.506) and age(OR1.185, 0.065\u2009~\u20091.814) were the independent risk factors for the postoperative delirium in patients with hip fracture(all p\u2009&lt;\u20090.05). The AUC of albumin, history of delirium, TSH, the resting score on the first postoperative day and age were 0.794, 0.754, 0.746, 0.721 and 0.689 respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of delirium in postoperative patients with hip fracture is rather high, especially for patients with old age and history of delirium. Monitoring albumin, TSH and resting score may be beneficial to the management of postoperative delirium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12891-021-04091-1","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T10:02:41Z","timestamp":1615111361000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The risk factors of postoperative delirium in patients with hip fracture: implication for clinical management"],"prefix":"10.1186","volume":"22","author":[{"given":"Weifang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,7]]},"reference":[{"issue":"1","key":"4091_CR1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s13018-019-1226-6","volume":"14","author":"O Guzon-Illescas","year":"2019","unstructured":"Guzon-Illescas O, Perez Fernandez E, Crespi Villarias N, Quiros Donate FJ, Pena M, Alonso-Blas C, Garcia-Vadillo A, Mazzucchelli R. Mortality after osteoporotic hip fracture: incidence, trends, and associated factors. J Orthop Surg Res. 2019;14(1):203.","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"4091_CR2","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/jgs.15661","volume":"67","author":"JS Albrecht","year":"2019","unstructured":"Albrecht JS, Al Kibria G, Gruber-Baldini A, Magaziner J. Risk of Mortality in Individuals with Hip Fracture and Traumatic Brain Injury. J Am Geriatr Soc. 2019;67(1):124\u20137.","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"4091_CR3","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1186\/s12891-018-2276-3","volume":"19","author":"L Mattisson","year":"2018","unstructured":"Mattisson L, Bojan A, Enocson A. Epidemiology, treatment and mortality of trochanteric and subtrochanteric hip fractures: data from the Swedish fracture register. BMC Musculoskelet Disord. 2018;19(1):369.","journal-title":"BMC Musculoskelet Disord"},{"issue":"2","key":"4091_CR4","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1080\/17453674.2018.1428436","volume":"89","author":"C Jantzen","year":"2018","unstructured":"Jantzen C, Madsen CM, Lauritzen JB, Jorgensen HL. Temporal trends in hip fracture incidence, mortality, and morbidity in Denmark from 1999 to 2012. Acta Orthop. 2018;89(2):170\u20136.","journal-title":"Acta Orthop"},{"key":"4091_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jclinane.2019.06.034","volume":"58","author":"PJ Lee","year":"2019","unstructured":"Lee PJ, Shorten GD. Delirium after hip fracture surgery. J Clin Anesth. 2019;58:119\u201320.","journal-title":"J Clin Anesth"},{"issue":"2","key":"4091_CR6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s40520-016-0541-6","volume":"29","author":"Y Yang","year":"2017","unstructured":"Yang Y, Zhao X, Dong T, Yang Z, Zhang Q, Zhang Y. Risk factors for postoperative delirium following hip fracture repair in elderly patients: a systematic review and meta-analysis. Aging Clin Exp Res. 2017;29(2):115\u201326.","journal-title":"Aging Clin Exp Res"},{"key":"4091_CR7","doi-asserted-by":"publisher","first-page":"421","DOI":"10.2147\/CIA.S115945","volume":"12","author":"CA Mosk","year":"2017","unstructured":"Mosk CA, Mus M, Vroemen JP, van der Ploeg T, Vos DI, Elmans LH, van der Laan L. Dementia and delirium, the outcomes in elderly hip fracture patients. Clin Interv Aging. 2017;12:421\u201330.","journal-title":"Clin Interv Aging"},{"issue":"1","key":"4091_CR8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00264-018-4132-3","volume":"43","author":"R Civinini","year":"2019","unstructured":"Civinini R, Paoli T, Cianferotti L, Cartei A, Boccaccini A, Peris A, Brandi ML, Rostagno C, Innocenti M. Functional outcomes and mortality in geriatric and fragility hip fractures-results of an integrated, multidisciplinary model experienced by the \u201cFlorence hip fracture unit. Int Orthop. 2019;43(1):187\u201392.","journal-title":"Int Orthop"},{"issue":"4","key":"4091_CR9","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1002\/gps.4655","volume":"32","author":"TO Smith","year":"2017","unstructured":"Smith TO, Cooper A, Peryer G, Griffiths R, Fox C, Cross J. Factors predicting incidence of post-operative delirium in older people following hip fracture surgery: a systematic review and meta-analysis. Int J Geriatr Psychiatry. 2017;32(4):386\u201396.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"2","key":"4091_CR10","doi-asserted-by":"publisher","first-page":"e190111","DOI":"10.1001\/jamanetworkopen.2019.0111","volume":"2","author":"B Ravi","year":"2019","unstructured":"Ravi B, Pincus D, Choi S, Jenkinson R, Wasserstein DN, Redelmeier DA. Association of Duration of Surgery With Postoperative Delirium Among Patients Receiving Hip Fracture Repair. JAMA Netw Open. 2019;2(2):e190111.","journal-title":"JAMA Netw Open"},{"issue":"12","key":"4091_CR11","doi-asserted-by":"publisher","first-page":"e020757","DOI":"10.1136\/bmjopen-2017-020757","volume":"8","author":"V Patel","year":"2018","unstructured":"Patel V, Champaneria R, Dretzke J, Yeung J. Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review. BMJ Open. 2018;8(12):e020757.","journal-title":"BMJ Open"},{"issue":"3","key":"4091_CR12","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/j.1532-5415.2005.53171.x","volume":"53","author":"L McNicoll","year":"2005","unstructured":"McNicoll L, Pisani MA, Ely EW, Gifford D, Inouye SK. Detection of delirium in the intensive care unit: comparison of confusion assessment method for the intensive care unit with confusion assessment method ratings. J Am Geriatr Soc. 2005;53(3):495\u2013500.","journal-title":"J Am Geriatr Soc"},{"issue":"21","key":"4091_CR13","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1056\/NEJMcp1611090","volume":"377","author":"M Bhandari","year":"2017","unstructured":"Bhandari M, Swiontkowski M. Management of Acute Hip Fracture. N Engl J Med. 2017;377(21):2053\u201362.","journal-title":"N Engl J Med"},{"issue":"2","key":"4091_CR14","doi-asserted-by":"publisher","first-page":"131","DOI":"10.5435\/JAAOS-D-14-00432","volume":"23","author":"KC Roberts","year":"2015","unstructured":"Roberts KC, Brox WT, Jevsevar DS, Sevarino K. Management of hip fractures in the elderly. J Am Acad Orthop Surg. 2015;23(2):131\u20137.","journal-title":"J Am Acad Orthop Surg"},{"issue":"Suppl 1","key":"4091_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/BOT.0000000000000562","volume":"30","author":"AG Sanzone","year":"2016","unstructured":"Sanzone AG. Current Challenges in Pain Management in Hip Fracture Patients. J Orthop Trauma. 2016;30(Suppl 1):1\u20135.","journal-title":"J Orthop Trauma"},{"issue":"4","key":"4091_CR16","doi-asserted-by":"publisher","first-page":"178","DOI":"10.11622\/smedj.2016071","volume":"57","author":"E Tay","year":"2016","unstructured":"Tay E. Hip fractures in the elderly: operative versus nonoperative management. Singapore Med J. 2016;57(4):178\u201381.","journal-title":"Singapore Med J"},{"key":"4091_CR17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2147\/CIA.S189760","volume":"14","author":"L de Jong","year":"2019","unstructured":"de Jong L, van Rijckevorsel V, Raats JW, Klem T, Kuijper TM, Roukema GR. Delirium after hip hemiarthroplasty for proximal femoral fractures in elderly patients: risk factors and clinical outcomes. Clin Interv Aging. 2019;14:427\u201335.","journal-title":"Clin Interv Aging"},{"issue":"2","key":"4091_CR18","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.injury.2018.10.034","volume":"50","author":"X Zhang","year":"2019","unstructured":"Zhang X, Tong DK, Ji F, Duan XZ, Liu PZ, Qin S, Xu KH, Di-Li XT. Predictive nomogram for postoperative delirium in elderly patients with a hip fracture. Injury. 2019;50(2):392\u20137.","journal-title":"Injury"},{"issue":"5\u20136","key":"4091_CR19","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1159\/000494754","volume":"46","author":"NB Halaas","year":"2018","unstructured":"Halaas NB, Blennow K, Idland AV, Wyller TB, Raeder J, Frihagen F, Staff AC, Zetterberg H, Watne LO. Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium. Dement Geriatr Cogn Disord. 2018;46(5\u20136):346\u201357.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"4","key":"4091_CR20","first-page":"250","volume":"38","author":"C Li","year":"2018","unstructured":"Li C, Bai S, Song X. Retrospective study on risk factors associated with postoperative delirium in elderly hip fracture patients. Chinese Journal of Orthopaedics. 2018;38(4):250\u20136.","journal-title":"Chinese Journal of Orthopaedics"},{"issue":"4","key":"4091_CR21","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1097\/01.CCM.0000119429.16055.92","volume":"32","author":"EB Milbrandt","year":"2004","unstructured":"Milbrandt EB, Deppen S, Harrison PL, Shintani AK, Speroff T, Stiles RA, Truman B, Bernard GR, Dittus RS, Ely EW. Costs associated with delirium in mechanically ventilated patients. Crit Care Med. 2004;32(4):955\u201362.","journal-title":"Crit Care Med"},{"key":"4091_CR22","doi-asserted-by":"publisher","first-page":"215145931881482","DOI":"10.1177\/2151459318814823","volume":"9","author":"A Arshi","year":"2018","unstructured":"Arshi A, Lai WC, Chen JB, Bukata SV, Stavrakis AI, Zeegen EN. Predictors and Sequelae of Postoperative Delirium in Geriatric Hip Fracture Patients. Geriatr Orthop Surg Rehabil. 2018;9:2151459318814823.","journal-title":"Geriatr Orthop Surg Rehabil"},{"issue":"4","key":"4091_CR23","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s11845-019-02011-w","volume":"188","author":"L Tao","year":"2019","unstructured":"Tao L, Xiaodong X, Qiang M, Jiao L, Xu Z. Prediction of postoperative delirium by comprehensive geriatric assessment among elderly patients with hip fracture. Ir J Med Sci. 2019;188(4):1311\u20135.","journal-title":"Ir J Med Sci"},{"issue":"1","key":"4091_CR24","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s13018-018-0897-8","volume":"13","author":"CG Wang","year":"2018","unstructured":"Wang CG, Qin YF, Wan X, Song LC, Li ZJ, Li H. Incidence and risk factors of postoperative delirium in the elderly patients with hip fracture. J Orthop Surg Res. 2018;13(1):186.","journal-title":"J Orthop Surg Res"},{"key":"4091_CR25","doi-asserted-by":"publisher","first-page":"115083","DOI":"10.1016\/j.bone.2019.115083","volume":"130","author":"B Abrahamsen","year":"2020","unstructured":"Abrahamsen B, Laursen HVB, Skjodt MK, Jensen MH, Vestergaard P. Age at hip fracture and life expectancy in Denmark - Secular trends over two decades. Bone. 2020;130:115083.","journal-title":"Bone"},{"issue":"1","key":"4091_CR26","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1080\/14397595.2018.1561351","volume":"30","author":"K Arai","year":"2020","unstructured":"Arai K, Suzuki N, Murayama T, Kondo N, Otsuka H, Koizumi M, Hosaka N, Fujikawa R, Yanabashi K, Sasage Y, et al. Age at the time of hip fracture in patients with rheumatoid arthritis is 4 years greater than it was 10 years before, but is still younger than that of the general population. Mod Rheumatol. 2020;30(1):64\u20139.","journal-title":"Mod Rheumatol"},{"key":"4091_CR27","doi-asserted-by":"crossref","unstructured":"Aamodt G, Renolen R, Omsland TK, Meyer HE, Rabanal KS, Sogaard AJ. Ethnic differences in risk of hip fracture in Norway: a NOREPOS study. Osteoporos Int 2020.","DOI":"10.1007\/s00198-020-05390-4"},{"issue":"3","key":"4091_CR28","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00198-019-05195-0","volume":"31","author":"ML Bouxsein","year":"2020","unstructured":"Bouxsein ML, Zysset P, Gluer CC, McClung M, Biver E, Pierroz DD, Ferrari SL, Target IOFWGoHBSaaT. Perspectives on the non-invasive evaluation of femoral strength in the assessment of hip fracture risk. Osteoporos Int. 2020;31(3):393\u2013408.","journal-title":"Osteoporos Int"},{"issue":"10","key":"4091_CR29","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1002\/gps.5139","volume":"34","author":"CJ Slor","year":"2019","unstructured":"Slor CJ, Witlox J, Adamis D, Jansen R, Houdijk APJ, van Gool WA, de Jonghe JFM, Eikelenboom P. The trajectory of C-reactive protein serum levels in older hip fracture patients with postoperative delirium. Int J Geriatr Psychiatry. 2019;34(10):1438\u201346.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"9","key":"4091_CR30","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/gps.4233","volume":"30","author":"ES Oh","year":"2015","unstructured":"Oh ES, Li M, Fafowora TM, Inouye SK, Chen CH, Rosman LM, Lyketsos CG, Sieber FE, Puhan MA. Preoperative risk factors for postoperative delirium following hip fracture repair: a systematic review. Int J Geriatr Psychiatry. 2015;30(9):900\u201310.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"3\u20134","key":"4091_CR31","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1159\/000443789","volume":"41","author":"KR Hov","year":"2016","unstructured":"Hov KR, Berg JP, Frihagen F, Raeder J, Hall R, Wyller TB, Watne LO. Blood-Cerebrospinal Fluid Barrier Integrity in Delirium Determined by Q-Albumin. Dement Geriatr Cogn Disord. 2016;41(3\u20134):192\u20138.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"40","key":"4091_CR32","first-page":"3235","volume":"98","author":"Y Yuan","year":"2018","unstructured":"Yuan Y, Han YZ, Ji XJ, Shi CM, Li ZQ, Zhou Y, Yang QG, Wang G, Guo XY. [Risk factors associated with delirium for patients with hip fracture under the orthogeriatric unit mode]. Zhonghua Yi Xue Za Zhi. 2018;98(40):3235\u20139.","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"1","key":"4091_CR33","doi-asserted-by":"publisher","first-page":"e01176","DOI":"10.1002\/brb3.1176","volume":"9","author":"QH Li","year":"2019","unstructured":"Li QH, Yu L, Yu ZW, Fan XL, Yao WX, Ji C, Deng F, Luo XZ, Sun JL. Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients. Brain Behav. 2019;9(1):e01176.","journal-title":"Brain Behav"},{"issue":"1","key":"4091_CR34","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s12888-016-1079-z","volume":"16","author":"JE Shin","year":"2016","unstructured":"Shin JE, Kyeong S, Lee JS, Park JY, Lee WS, Kim JJ, Yang KH. A personality trait contributes to the occurrence of postoperative delirium: a prospective study. BMC Psychiatry. 2016;16(1):371.","journal-title":"BMC Psychiatry"},{"issue":"7","key":"4091_CR35","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1111\/jgs.12885","volume":"62","author":"G Bellelli","year":"2014","unstructured":"Bellelli G, Mazzola P, Morandi A, Bruni A, Carnevali L, Corsi M, Zatti G, Zambon A, Corrao G, Olofsson B, et al. Duration of postoperative delirium is an independent predictor of 6-month mortality in older adults after hip fracture. J Am Geriatr Soc. 2014;62(7):1335\u201340.","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"4091_CR36","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s10140-016-1390-5","volume":"23","author":"GR Matcuk Jr","year":"2016","unstructured":"Matcuk GR Jr, Mahanty SR, Skalski MR, Patel DB, White EA, Gottsegen CJ. Stress fractures: pathophysiology, clinical presentation, imaging features, and treatment options. Emerg Radiol. 2016;23(4):365\u201375.","journal-title":"Emerg Radiol"},{"issue":"4","key":"4091_CR37","doi-asserted-by":"publisher","first-page":"e0214676","DOI":"10.1371\/journal.pone.0214676","volume":"14","author":"S Nomoto","year":"2019","unstructured":"Nomoto S, Kinno R, Ochiai H, Kubota S, Mori Y, Futamura A, Sugimoto A, Kuroda T, Yano S, Murakami H, et al. The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer\u2019s disease. PLoS One. 2019;14(4):e0214676.","journal-title":"PLoS One"},{"issue":"2","key":"4091_CR38","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/2151458513504215","volume":"4","author":"XW Ling","year":"2013","unstructured":"Ling XW, Howe TS, Koh JS, Wong MK, Ng AC. Preoperative thyroid dysfunction predicts 30-day postoperative complications in elderly patients with hip fracture. Geriatr Orthop Surg Rehabil. 2013;4(2):43\u20139.","journal-title":"Geriatr Orthop Surg Rehabil"},{"key":"4091_CR39","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/bs.vh.2017.05.005","volume":"106","author":"M Noda","year":"2018","unstructured":"Noda M. Thyroid Hormone in the CNS: Contribution of Neuron-Glia Interaction. Vitam Horm. 2018;106:313\u201331.","journal-title":"Vitam Horm"},{"issue":"6","key":"4091_CR40","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1093\/ajcn\/nqz244","volume":"110","author":"TB Shea","year":"2019","unstructured":"Shea TB. Choline and phosphatidylcholine may maintain cognitive performance by multiple mechanisms. Am J Clin Nutr. 2019;110(6):1268\u20139.","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"4091_CR41","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1093\/ajcn\/nqz148","volume":"110","author":"MPT Ylilauri","year":"2019","unstructured":"Ylilauri MPT, Voutilainen S, Lonnroos E, Virtanen HEK, Tuomainen TP, Salonen JT, Virtanen JK. Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2019;110(6):1416\u201323.","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"4091_CR42","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2174\/1567205012666150921100311","volume":"13","author":"BJ Strupp","year":"2016","unstructured":"Strupp BJ, Powers BE, Velazquez R, Ash JA, Kelley CM, Alldred MJ, Strawderman M, Caudill MA, Mufson EJ, Ginsberg SD. Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer\u2019s Disease. Curr Alzheimer Res. 2016;13(1):97\u2013106.","journal-title":"Curr Alzheimer Res"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-021-04091-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12891-021-04091-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-021-04091-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T10:03:56Z","timestamp":1615111436000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/s12891-021-04091-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,7]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4091"],"URL":"https:\/\/doi.org\/10.1186\/s12891-021-04091-1","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,7]]},"assertion":[{"value":"11 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Our study has been approved by the ethics committee of The First Affiliated hospital of XinJiang Medical University (2018101184).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"254"}}