{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:29:56Z","timestamp":1794353396513,"version":"4.9.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To indicate whether combined topical and intravenous (IV) administration of tranexamic acid (TXA) could further reduce the blood loss after surgery for adolescent idiopathic scoliosis (AIS) compared with IV-TXA alone.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ninety AIS patients who underwent posterior spinal fusion were prospectively randomized to combined group (IV\u2009+\u2009topical- TXA group) and IV-TXA alone group. TXA was infused at a loading dose of 1\u2009g from the beginning of the surgery with a maintenance dose of 10\u2009mg\/kg\/h until the wound was closed. In the combined group, 2\u2009g TXA was injected retrogradely through a drain, while an equivalent amount of normal saline was injected in the IV-TXA alone group. The drain tube was clamped for 2\u2009h in both groups. The amount of wound drainage and transfusion rates were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The drainage volume and duration of drain were significantly lower in the combined group compared with that in the IV-TXA alone group (372.0\u2009\u00b1\u2009129.7\u2009mL vs. 545.2\u2009\u00b1\u2009207.7\u2009mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001;64.7\u2009\u00b1\u200913.9\u2009h vs. 82.0\u2009\u00b1\u200912.5\u2009h, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Postoperative length of hospital stay was also significantly shorter in the combined group (6.5\u2009\u00b1\u20091.51\u2009days vs. 7.95\u2009\u00b1\u20091.44\u2009days, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Transfusion and complication rates were comparable between the two groups .<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>IV injection of TXA combined with retrograde injection of TXA into a drain and clamping it for 2\u2009h could further reduce the total volume of drainage in AIS patients who underwent spinal fusion surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Chinese Clinical Trial Registry: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.chictr.org.cn\/showproj.aspx?proj=40214\">ChiCTR1900024177<\/jats:ext-link>, Registered 29 June 2019, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\/showproj.aspx?proj=40214\">http:\/\/www.chictr.org.cn\/showproj.aspx?proj=40214<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12891-021-04562-5","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T05:02:32Z","timestamp":1628485352000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Combined topical and intravenous administration of tranexamic acid further reduces postoperative blood loss in adolescent idiopathic scoliosis patients undergoing spinal fusion surgery: a randomized controlled trial"],"prefix":"10.1186","volume":"22","author":[{"given":"Yulei","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingdu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"issue":"18","key":"4562_CR1","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1097\/BRS.0000000000000439","volume":"39","author":"JD Koerner","year":"2014","unstructured":"Koerner JD, Patel A, Zhao C, et al. 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Informed consent was obtained from parent and\/or legal guardian for subjects are under 16. All methods were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients signed written informed consent forms prior to commencing the study for the publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author(s) declare(s) that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"663"}}