{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:14:08Z","timestamp":1788200048809,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Nerve conduction study (NCS) is the only useful test for objective assessment of carpal tunnel syndrome (CTS). However, the relationship between pre- and postoperative NCS and clinical outcomes was unclear. This study aimed to determine whether pre- and postoperative (6\u2009months) NCS could predict patient-oriented and motor outcomes (6 and 12\u2009months postoperatively) in patients with CTS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>Of the 85 patients with CTS, 107 hands were analyzed from March 2011 to March 2020. All patients underwent open carpal tunnel release and were examined using the disabilities of the arm, shoulder and hand (DASH) questionnaire and grip strength (GS) preoperatively and 6 and 12\u2009months postoperatively. Moreover, NCS was examined preoperatively and 6\u2009months postoperatively. Distal motor latency (DML) and sensory conduction velocity (SCV) were the parameters used for NCS. The correlation coefficient between NCS and DASH or GS was calculated. A receiver operating characteristic curve was utilized to determine the NCS threshold value to predict DASH and GS improvement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The average scores of GS preoperatively and 6 and 12\u2009months postoperatively were 21.3, 22.3, and 22.8, respectively. On the other hand, the average scores of DASH preoperatively and 6 and 12\u2009months postoperatively were 28.8, 18.3, and 12.2, respectively. The average NCS scores (DML and SCV) preoperatively\/6\u2009months postoperatively were 7.3\/5.4 and 27.8\/36.7, respectively. Preoperative NCS did not correlate with DASH and GS. Postoperative SCV correlated with the change in grip strength (6\u201312\u2009months, <jats:italic>r<\/jats:italic>\u2009=\u20090.67; 0\u201312\u2009months, <jats:italic>r<\/jats:italic>\u2009=\u20090.60) and DASH (0\u201312\u2009months, <jats:italic>r<\/jats:italic>\u2009=\u20090.77). Moreover, postoperative DML correlated with the change in DASH (6\u201312\u2009months, <jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u20090.33; 0\u201312\u2009months, <jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u20090.59). The prediction for the improvement of GS\/DASH achieved a sensitivity of 50.0%\/66.7% and a specificity of 100%\/100%, at an SCV cutoff score of 38.5\/45.0 or above. The prediction for improvement of GS\/DASH achieved a sensitivity of 83.3%\/66.7% and a specificity of 100%\/66.7% at a DML cutoff score of 4.4\/4.4 or below.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>NCS at 6\u2009months postoperatively can be used to predict the improvement of clinical outcome after 6\u2009months postoperatively in patients with CTS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12891-021-04771-y","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T16:53:01Z","timestamp":1634403181000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Relationship between clinical outcomes and nerve conduction studies before and after surgery in patients with carpal tunnel syndrome"],"prefix":"10.1186","volume":"22","author":[{"given":"Masato","family":"Ise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Shimamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masuo","family":"Senda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,16]]},"reference":[{"issue":"2","key":"4771_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1001\/jama.282.2.153","volume":"282","author":"I Atroshi","year":"1999","unstructured":"Atroshi I, Gummesson C, Johnsson R, Ornstein E, Ranstam J, Rosen I. Prevalence of carpal tunnel syndrome in a general population. JAMA. 1999;282(2):153\u20138.","journal-title":"JAMA"},{"issue":"4","key":"4771_CR2","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0895-4356(92)90038-O","volume":"45","author":"MC de Krom","year":"1992","unstructured":"de Krom MC, Knipschild PG, Kester AD, Thijs CT, Boekkooi PF, Spaans F. Carpal tunnel syndrome: prevalence in the general population. J Clin Epidemiol. 1992;45(4):373\u20136.","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"4771_CR3","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1142\/S2424835520500356","volume":"25","author":"S Hashimoto","year":"2020","unstructured":"Hashimoto S, Ikegami S, Nishimura H, Uchiyama S, Takahashi J, Kato H. Prevalence and risk factors of carpal tunnel syndrome in Japanese aged 50 to 89 years. J Hand Surg Asian Pac Vol. 2020;25(3):320\u20137.","journal-title":"J Hand Surg Asian Pac Vol"},{"issue":"481","key":"4771_CR4","first-page":"670","volume":"52","author":"R Jordan","year":"2002","unstructured":"Jordan R, Carter T, Cummins C. A systematic review of the utility of electrodiagnostic testing in carpal tunnel syndrome. Br J Gen Pract. 2002;52(481):670\u20133.","journal-title":"Br J Gen Pract"},{"issue":"4","key":"4771_CR5","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/(SICI)1097-4598(199904)22:4<497::AID-MUS11>3.0.CO;2-T","volume":"22","author":"H You","year":"1999","unstructured":"You H, Simmons Z, Freivalds A, Kothari MJ, Naidu SH. Relationships between clinical symptom severity scales and nerve conduction measures in carpal tunnel syndrome. Muscle Nerve. 1999;22(4):497\u2013501.","journal-title":"Muscle Nerve"},{"issue":"7","key":"4771_CR6","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1002\/mus.1091","volume":"24","author":"JD Bland","year":"2001","unstructured":"Bland JD. Do nerve conduction studies predict the outcome of carpal tunnel decompression? Muscle Nerve. 2001;24(7):935\u201340.","journal-title":"Muscle Nerve"},{"issue":"3","key":"4771_CR7","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s11552-012-9429-x","volume":"7","author":"D Louie","year":"2012","unstructured":"Louie D, Earp B, Blazar P. Long-term outcomes of carpal tunnel release: a critical review of the literature. Hand (N Y). 2012;7(3):242\u20136.","journal-title":"Hand (N Y)"},{"issue":"6","key":"4771_CR8","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.jhsa.2016.04.003","volume":"41","author":"CA Goldfarb","year":"2016","unstructured":"Goldfarb CA. The clinical practice guideline on carpal tunnel syndrome and workers\u2019 compensation. J Hand Surg Am. 2016;41(6):723\u20135.","journal-title":"J Hand Surg Am"},{"issue":"6","key":"4771_CR9","first-page":"500","volume":"7","author":"J Kimura","year":"1983","unstructured":"Kimura J. Electrodiagnosis in diseases of nerve and muscle: principles and practice. Muscle Nerve. 1983;7(6):500\u20131.","journal-title":"Muscle Nerve"},{"issue":"3","key":"4771_CR10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1136\/jnnp.34.3.243","volume":"34","author":"F Buchthal","year":"1971","unstructured":"Buchthal F, Rosenfalck A. Sensory conduction from digit to palm and from palm to wrist in the carpal tunnel syndrome. J Neurol Neurosurg Psychiatry. 1971;34(3):243\u201352.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"4771_CR11","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00776-005-0917-5","volume":"10","author":"T Imaeda","year":"2005","unstructured":"Imaeda T, Toh S, Nakao Y, Nishida J, Hirata H, Ijichi M, et al. Validation of the Japanese Society for Surgery of the Hand version of the Disability of the Arm, Shoulder, and Hand questionnaire. J Orthop Sci. 2005;10(4):353\u20139.","journal-title":"J Orthop Sci"},{"issue":"1","key":"4771_CR12","doi-asserted-by":"publisher","first-page":"30","DOI":"10.2519\/jospt.2014.4893","volume":"44","author":"F Franchignoni","year":"2014","unstructured":"Franchignoni F, Vercelli S, Giordano A, Sartorio F, Bravini E, Ferriero G. Minimal clinically important difference of the disabilities of the arm, shoulder and hand outcome measure (DASH) and its shortened version (QuickDASH). J Orthop Sports Phys Ther. 2014;44(1):30\u20139.","journal-title":"J Orthop Sports Phys Ther"},{"issue":"3","key":"4771_CR13","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/CND.0b013e31822b19a5","volume":"13","author":"YL Lo","year":"2012","unstructured":"Lo YL, Lim SH, Fook-Chong S, Lum SY, Teoh LC, Yong FC. Outcome prediction value of nerve conduction studies for endoscopic carpal tunnel surgery. J Clin Neuromuscul Dis. 2012;13(3):153\u20138.","journal-title":"J Clin Neuromuscul Dis"},{"issue":"5","key":"4771_CR14","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/art.24396","volume":"61","author":"JS Roy","year":"2009","unstructured":"Roy JS, MacDermid JC, Woodhouse LJ. Measuring shoulder function: a systematic review of four questionnaires. Arthritis Rheum. 2009;61(5):623\u201332.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"4771_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/rnj.196","volume":"42","author":"JH Villafa\u00f1e","year":"2017","unstructured":"Villafa\u00f1e JH, Valdes K, Bertozzi L, Negrini S. Minimal clinically important difference of grip and pinch strength in women with thumb carpometacarpal osteoarthritis when compared to healthy subjects. Rehabil Nurs. 2017;42(3):139\u201345.","journal-title":"Rehabil Nurs"},{"issue":"4","key":"4771_CR16","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00701-019-03839-y","volume":"161","author":"F De Kleermaeker","year":"2019","unstructured":"De Kleermaeker F, Meulstee J, Bartels R, Verhagen WIM. Long-term outcome after carpal tunnel release and identification of prognostic factors. Acta Neurochir. 2019;161(4):663\u201371.","journal-title":"Acta Neurochir"},{"issue":"1","key":"4771_CR17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1388-2457(01)00704-0","volume":"113","author":"F Giannini","year":"2002","unstructured":"Giannini F, Cioni R, Mondelli M, Padua R, Gregori B, D'Amico P, et al. A new clinical scale of carpal tunnel syndrome: validation of the measurement and clinical-neurophysiological assessment. Clin Neurophysiol. 2002;113(1):71\u20137.","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"4771_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00776-008-1290-y","volume":"14","author":"T Itsubo","year":"2009","unstructured":"Itsubo T, Uchiyama S, Momose T, Yasutomi T, Imaeda T, Kato H. Electrophysiological responsiveness and quality of life (QuickDASH, CTSI) evaluation of surgically treated carpal tunnel syndrome. J Orthop Sci. 2009;14(1):17\u201323.","journal-title":"J Orthop Sci"},{"issue":"3","key":"4771_CR19","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1054\/jhsb.2002.0762","volume":"27","author":"N Heybeli","year":"2002","unstructured":"Heybeli N, Kutluhan S, Demirci S, Kerman M, Mumcu EF. Assessment of outcome of carpal tunnel syndrome: a comparison of electrophysiological findings and a self-administered Boston questionnaire. J Hand Surg Br. 2002;27(3):259\u201364.","journal-title":"J Hand Surg Br"},{"key":"4771_CR20","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s12891-016-1046-3","volume":"17","author":"C Conzen","year":"2016","unstructured":"Conzen C, Conzen M, R\u00fcbsamen N, Mikolajczyk R. Predictors of the patient-centered outcomes of surgical carpal tunnel release - a prospective cohort study. BMC Musculoskelet Disord. 2016;17:190.","journal-title":"BMC Musculoskelet Disord"},{"issue":"8","key":"4771_CR21","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1002\/1097-4598(200008)23:8<1280::AID-MUS20>3.0.CO;2-Y","volume":"23","author":"JD Bland","year":"2000","unstructured":"Bland JD. A neurophysiological grading scale for carpal tunnel syndrome. Muscle Nerve. 2000;23(8):1280\u20133.","journal-title":"Muscle Nerve"},{"issue":"6","key":"4771_CR22","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/S0363-5023(09)91050-4","volume":"17","author":"WB Nolan 3rd","year":"1992","unstructured":"Nolan WB 3rd, Alkaitis D, Glickel SZ, Snow S. Results of treatment of severe carpal tunnel syndrome. J Hand Surg Am. 1992;17(6):1020\u20133.","journal-title":"J Hand Surg Am"},{"issue":"2","key":"4771_CR23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jhsb.2003.10.010","volume":"29","author":"JR Greenslade","year":"2004","unstructured":"Greenslade JR, Mehta RL, Belward P, Warwick DJ. Dash and Boston questionnaire assessment of carpal tunnel syndrome outcome: what is the responsiveness of an outcome questionnaire? J Hand Surg Br. 2004;29(2):159\u201364.","journal-title":"J Hand Surg Br"},{"issue":"2","key":"4771_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3233\/NRE-182589","volume":"44","author":"A Yoshida","year":"2019","unstructured":"Yoshida A, Kurimoto S, Iwatsuki K, Saeki M, Nishizuka T, Nakano T, et al. Upper extremity disability is associated with pain intensity and grip strength in women with bilateral idiopathic carpal tunnel syndrome. NeuroRehabilitation. 2019;44(2):199\u2013205.","journal-title":"NeuroRehabilitation"},{"issue":"5","key":"4771_CR25","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S0363-5023(89)80091-7","volume":"14","author":"H Gellman","year":"1989","unstructured":"Gellman H, Kan D, Gee V, Kuschner SH, Botte MJ. Analysis of pinch and grip strength after carpal tunnel release. J Hand Surg Am. 1989;14(5):863\u20134.","journal-title":"J Hand Surg Am"},{"issue":"1","key":"4771_CR26","first-page":"21","volume":"70","author":"M Bednarski","year":"2005","unstructured":"Bednarski M, Zyluk A, Zyluk B. Changes of grip and pinch strength after carpal tunnel release. Chir Narzadow Ruchu Ortop Pol. 2005;70(1):21\u20136.","journal-title":"Chir Narzadow Ruchu Ortop Pol"},{"issue":"9","key":"4771_CR27","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1097\/00007611-199209000-00009","volume":"85","author":"VL Young","year":"1992","unstructured":"Young VL, Logan SE, Fernando B, Grasse P, Seaton M, Young AE. Grip strength before and after carpal tunnel decompression. South Med J. 1992;85(9):897\u2013900.","journal-title":"South Med J"},{"issue":"3","key":"4771_CR28","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1007\/s11999-014-3835-z","volume":"473","author":"ET Sayegh","year":"2015","unstructured":"Sayegh ET, Strauch RJ. Open versus endoscopic carpal tunnel release: a meta-analysis of randomized controlled trials. Clin Orthop Relat Res. 2015;473(3):1120\u201332.","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"4771_CR29","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1080\/10803548.2018.1462915","volume":"26","author":"GK Singh","year":"2020","unstructured":"Singh GK, Srivastava S. Grip strength of occupational workers in relation to carpal tunnel syndrome and individual factors. Int J Occup Saf Ergon. 2020;26(2):296\u2013302.","journal-title":"Int J Occup Saf Ergon"},{"issue":"8","key":"4771_CR30","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1177\/1753193411410155","volume":"36","author":"RA Pensy","year":"2011","unstructured":"Pensy RA, Burke FD, Bradley MJ, Dubin NH, Wilgis EF. A 6-year outcome of patients who cancelled carpal tunnel surgery. J Hand Surg Eur Vol. 2011;36(8):642\u20137.","journal-title":"J Hand Surg Eur Vol"},{"key":"4771_CR31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2474-4-9","volume":"4","author":"I Atroshi","year":"2003","unstructured":"Atroshi I, Gummesson C, Johnsson R, Ornstein E. Diagnostic properties of nerve conduction tests in population-based carpal tunnel syndrome. BMC Musculoskelet Disord. 2003;4:9.","journal-title":"BMC Musculoskelet Disord"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-021-04771-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12891-021-04771-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-021-04771-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T22:05:26Z","timestamp":1634421926000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/s12891-021-04771-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,16]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4771"],"URL":"https:\/\/doi.org\/10.1186\/s12891-021-04771-y","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,16]]},"assertion":[{"value":"21 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was designed as a single-center retrospective cohort study and was approved by the Ethic Committee of Okayama University Hospital (approval No. K2009\u2013006). All methods were carried out in accordance with guidelines and regulations of Okayama University Hospital.We have obtained informed consent in the form of opt-out on the web-site from patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"882"}}