{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:34:44Z","timestamp":1771040084590,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The newly designed cervical disc prosthesis, Pretic-I, had been finished its limited clinical use for over 5\u2009years. At a short-term follow-up of 2\u2009years, we obtained satisfactory clinical results. The long-term clinical efficacy and safety of Pretic-I will now be analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Peri-operative parameters included intra-operative blood loss, operation time, off-bed time. Clinical parameters included visual analogue scale (VAS) for arm and neck, neck disability index (NDI), and Japanese Orthopaedic Association (JOA) score. Radiological parameters included C2\u20137 Cobb angle, Shell angle, and the range of motion (ROM) of C2\u20137, functional segment unit (FSU), and adjacent FSU. The CDA-related complications included adjacent segment degeneration (ASDeg), adjacent segment disease (ASDis), heterotopic ossification (HO), prosthesis subsidence, prosthesis displacement, and dysphagia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total 64 patients from two independent centers received a single-level CDA with Discover (<jats:italic>n<\/jats:italic>\u2009=\u200932) and Pretic-I (<jats:italic>n<\/jats:italic>\u2009=\u200932), and all of patients finished a 5-year follow-up. There\u2019re no significant differences between two groups in peri-operative parameters. The clinical parameters improved greatly in Pretic-I group (<jats:italic>p<\/jats:italic>&lt;0.0001), and there\u2019s no statistical difference from Discover group. Furthermore, Pretic-I could slightly improve the cervical curvature (15.08\u2009\u00b1\u200911.75 to 18.00\u2009\u00b1\u200910.61, <jats:italic>p<\/jats:italic>\u2009=\u20090.3079) and perfectly maintain the Shell angle (3.03\u2009\u00b1\u20093.68 to 2.23\u2009\u00b1\u20094.10, <jats:italic>p<\/jats:italic>\u2009=\u20090.1988), cervical ROM (52.48\u2009\u00b1\u200914.31 to 53.30\u2009\u00b1\u200911.71, <jats:italic>p<\/jats:italic>\u2009=\u20090.8062) and FSU ROM (12.20\u2009\u00b1\u20094.52 to 10.73\u2009\u00b1\u20094.45, <jats:italic>p<\/jats:italic>\u2009=\u20090.2002). The incidence of high-grade HO (Grade III-IV) at the final follow-up was significantly lower in Pretic-I group than in Discover group (12.50% vs. 34.38%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0389, Statistical Power\u2009=\u200995.36%). The incidences of other CDA-related complications in Pretic-I group were also well-accepted, comparable to the Discover group, without significant differences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CDA with Pretic-I demonstrated a well-accepted and sustained clinical outcome, with a significantly lower incidence of high-grade HO. This newly designed prosthesis is expected to become an alternative choice for cervical disc prosthesis in the future.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12891-021-04813-5","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T10:02:44Z","timestamp":1637748164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pretic-I was a safe and effective artificial cervical disc prosthesis--a retrospective and comparative study with 5-year follow-up"],"prefix":"10.1186","volume":"22","author":[{"given":"Yingjun","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"issue":"4","key":"4813_CR1","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s00586-016-4655-5","volume":"26","author":"S Zou","year":"2017","unstructured":"Zou S, Gao J, Xu B, Lu X, Han Y, Meng H. 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All of the 64 patients gave informed consent and agreed to participate in the study.\u2019<b>Guideline statement<\/b>All experiments were performed in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"981"}}