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median age 71.00\u00a0years [range, 41\u201394\u00a0years]) or aseptic loosening (30 female, 32 male; median age 68.50\u00a0years [range, 34\u201385\u00a0years]). Patient demographic data were compared, and the relative sensitivity and specificity of preoperative GLB, ESR, CRP, NLR, and A\/G values as predictors of PJI diagnosis were assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Median globulin levels in the PJI and aseptic groups were 31.700\u00a0g\/L (interquartile range [IQR], 28.400\u201435.300) and 26.600\u00a0g\/L (IQR, 24.375\u201430.550), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The median A\/G values in the PJI and aseptic groups were 1.150 (IQR, 0.960\u20141.255) and 1.510 (IQR, 1.265\u20141.670), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The median NLR values in the PJI and aseptic groups were 2.510 (IQR, 1.900\u20143.335) and 1.850 (IQR, 1.425 to 2.362), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The median ESR values in the PJI and aseptic groups were 53.000\u00a0mm\/h (IQR, 35.000\u201476.500) and 16.000\u00a0mm\/h (IQR, 7.000\u201433.000), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Median CRP levels in the PJI and aseptic groups were 24.890\u00a0mg\/L (IQR, 10.595\u201454.095) and 2.245\u00a0mg\/L (IQR, 0.865\u20148.6075), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Area under the receiver operating characteristic (ROC) curve (AUC) values for CRP, ESR, GLB, A\/G, and NLR were 0.841 (95% confidence interval, 0.761\u20130.903), 0.850 (0.771\u20130.910), 0.747 (0.658\u20130.824), 0.779 (0.692\u20130.851), and 0.708 (0.616\u20130.789), respectively. When GLB\u2009&gt;\u200926.6\u00a0g\/L, A\/G\u2009&lt;\u20091.32, and NLR\u2009&gt;\u20092.1 were utilized as threshold values to diagnose PJI, GLB and A\/G were found to exhibit superior sensitivity (90.57%, 81.13%) to that observed for CRP (71.70%) and ESR (79.25%), but the specificity of these two metrics (GLB: 51.61%, A\/G: 72.58%) was significantly reduced relative to that for CRP (87.10%) or ESR (75.81%). ROC analyses further revealed that NLR did not exhibit significant advantages in sensitivity (73.58%) or specificity (70.97%) relative to CRP or ESR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Globulin levels, NLR values, and A\/G values do not outperform ESR or CRP levels when used to diagnose PJI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12891-022-05357-y","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:22:28Z","timestamp":1651296148000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Albumin to Globulin ratio, Neutrophil to Lymphocyte ratio, and Globulin levels do not outperform ESR or CRP when diagnosing periprosthetic joint infection"],"prefix":"10.1186","volume":"23","author":[{"given":"Jing-bo","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"issue":"10","key":"5357_CR1","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1016\/j.arth.2014.07.005","volume":"29","author":"JZ Liu","year":"2014","unstructured":"Liu JZ, et al. 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