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However, hidden blood loss (HBL) caused by this procedure is usually disregarded. This study aimed to investigate the amount of HBL and its influencing factors after MIPTSF in thoracolumbar fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between October 2017 and December 2020, a total of 146 patients (106 males and 40 females, age range 21\u201359\u00a0years) were retrospectively examined, and their clinical and radiological data were recorded and analyzed. The Pearson or Spearman correlation analysis was used to investigate an association between patient\u2019s characteristics and HBL. Multivariate linear regression analysis was performed to elucidate the related clinical or radiological factors of HBL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A substantial amount of HBL (164.00\u2009\u00b1\u2009112.02\u00a0ml, 40.65% of total blood loss (TBL)) occurred after transpedicular screw internal fixation. Multivariate linear regression analysis revealed that HBL was positively associated with TBL (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), percentage of vertebral height loss (VHL) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), percentage of vertebral height restoration (VHR) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), numbers of fractured vertebrae (<jats:italic>P<\/jats:italic>\u2009=\u2009.013), and numbers of fixed vertebral segments (<jats:italic>P<\/jats:italic>\u2009=\u2009.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A large amount of HBL was incurred in patients undergoing MIPTSF in thoracolumbar fracture. More importantly, TBL, percentage of VHL, percentage of VHR, the numbers of fractured vertebrae and fixed vertebral segments were independent risk factors for HBL.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12891-022-05938-x","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T09:19:44Z","timestamp":1667812784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hidden blood loss and its influencing factors after minimally invasive percutaneous transpedicular screw fixation in thoracolumbar fracture"],"prefix":"10.1186","volume":"23","author":[{"given":"Xin","family":"Yue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianze","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"5938_CR1","doi-asserted-by":"crossref","unstructured":"Kim D.Y, et al. 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This report does not contain any personal information that could lead to the identification of the patient(s) and\/or volunteers. This study was performed in accordance with relevant guidelines and regulations and all participants provided written informed consent to participate in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"959"}}