{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:06:24Z","timestamp":1774890384134,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"S&T Program of Chengde","award":["202109A052"],"award-info":[{"award-number":["202109A052"]}]},{"name":"S&T Program of Chengde","award":["202109A052"],"award-info":[{"award-number":["202109A052"]}]},{"name":"S&T Program of Chengde","award":["202109A052"],"award-info":[{"award-number":["202109A052"]}]},{"name":"S&T Program of Chengde","award":["202109A052"],"award-info":[{"award-number":["202109A052"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To evaluate the association of preoperative vitamin D levels with postoperative hypocalcaemia after total thyroidectomy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The medical records of patients who underwent total thyroidectomy between May 2020 and January 2022 and who had a documented preoperative serum 25-hydroxyvitamin D (25-OHD) concentration were retrospectively reviewed. Vitamin D levels were categorized into four groups: &lt;10 ng\/mL (severe vitamin D deficiency), 10\u201320 ng\/mL (vitamin D deficiency), 20\u201330 ng\/mL (vitamin D insufficiency), and &gt;\u200930 ng\/mL (vitamin D sufficiency). Multivariate logistic regression was performed to analyse the association of vitamin D levels with the risk of hypocalcaemia after controlling for potential confounding factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 196 patients were included in this study. Of these, 47 (24.0%) had preoperative 25-OHD\u2009&lt;\u200910 ng\/mL, 62 (31.6%) had 25-OHD of 10\u201320 ng\/mL, 51 (26.0%) had 25-OHD of 20\u201330 ng\/mL and the remaining 36 (18.4%) had 25-OHD\u2009&gt;\u200930 ng\/mL. The incidence of postoperative hypocalcemia was highest in the group of patients with severe vitamin D deficiency (42.6% and 23.4% for postoperative laboratory and symptomatic hypocalcaemia, respectively), followed by the group with vitamin D deficiency (29.0% and 16.1%), the group with vitamin D insufficiency (19.6% and 5.9%) and the group with vitamin D sufficiency (5.6% and 2.8%). Multivariate logistic regression indicated that the odds of postoperative laboratory hypocalcaemia for patients with severe vitamin D deficiency and vitamin D deficiency were 13.20 times (95% CI: 2.69\u201364.79, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and 6.32 times (95% CI: 1.32\u201330.28, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) greater than for those with vitamin D sufficiency, respectively; while the odds of symptomatic hypocalcaemia for patients with severe vitamin D deficiency was 10.18 times (95% CI: 1.14\u201390.86, <jats:italic>P<\/jats:italic>\u2009=\u20090.04) greater than for those with vitamin D sufficiency.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Preoperative vitamin D deficiency (&lt;\u200920 ng\/mL), especially severe vitamin D deficiency (&lt;\u200910 ng\/mL), is an independent predictive factor of postoperative hypocalcaemia after total thyroidectomy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12891-022-05977-4","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T06:02:27Z","timestamp":1671688947000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preoperative vitamin D level is significantly associated with hypocalcemia after total thyroidectomy"],"prefix":"10.1186","volume":"23","author":[{"given":"Yantao","family":"Qi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"issue":"3","key":"5977_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1001\/jamaoto.2019.4193","volume":"146","author":"RH Liu","year":"2020","unstructured":"Liu RH, Razavi CR, Chang HY, Tufano RP, Eisele DW, Gourin CG, Russell JO. Association of Hypocalcemia and Magnesium Disorders with Thyroidectomy in commercially insured patients. JAMA Otolaryngol Head Neck Surg. 2020;146(3):237\u201346.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"4","key":"5977_CR2","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1056\/NEJMcp0803050","volume":"359","author":"D Shoback","year":"2008","unstructured":"Shoback D. Clinical practice. Hypoparathyroidism. N Engl J Med. 2008;359(4):391\u2013403.","journal-title":"N Engl J Med"},{"issue":"3","key":"5977_CR3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1590\/1516-3180.2018.0336140319","volume":"137","author":"GB Carvalho","year":"2019","unstructured":"Carvalho GB, Giraldo LR, Lira RB, Macambira IBM, Tapia MA, Kohler HF, Novoa JA, Kowalski LP. Preoperative vitamin D deficiency is a risk factor for postoperative hypocalcemia in patients undergoing total thyroidectomy: retrospective cohort study. Sao Paulo Med J. 2019;137(3):241\u20137.","journal-title":"Sao Paulo Med J"},{"key":"5977_CR4","doi-asserted-by":"publisher","first-page":"614089","DOI":"10.3389\/fonc.2020.614089","volume":"10","author":"Y Qin","year":"2020","unstructured":"Qin Y, Sun W, Wang Z, Dong W, He L, Zhang T, Zhang H. A Meta-analysis of risk factors for transient and permanent Hypocalcemia after total thyroidectomy. Front Oncol. 2020;10:614089.","journal-title":"Front Oncol"},{"issue":"1","key":"5977_CR5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00423-019-01748-3","volume":"404","author":"G Manzini","year":"2019","unstructured":"Manzini G, Malhofer F, Weber T. Can preoperative vitamin D deficiency predict postoperative hypoparathyroidism following thyroid surgery? 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All procedures involving human participants were performed in accordance with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Because this was a retrospective study, informed consent was not required by the Ethical Committee of The Affiliated Hospital of Chengde Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1118"}}