{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:28:54Z","timestamp":1758706134711},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Young Medical Talents Training Program of Pudong Health Committee of Shanghai","award":["PWRq 2022-17"],"award-info":[{"award-number":["PWRq 2022-17"]}]},{"name":"\"Pu Jing Project\" of Shanghai Pudong Hospital","award":["PJ202004"],"award-info":[{"award-number":["PJ202004"]}]},{"name":"Outstanding Clinical Discipline Project of Shanghai Pudong","award":["PWYgy2021-04"],"award-info":[{"award-number":["PWYgy2021-04"]}]},{"name":"Project of Key Medical Discipline of Pudong Hospital of Fudan University","award":["Zdzk-04"],"award-info":[{"award-number":["Zdzk-04"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The characteristics and therapeutic potential of subtypes of bone marrow mesenchymal stem cells (BMSCs) are largely unknown. Also, the application of subpopulations of BMSCs in cartilage regeneration remains poorly characterized. The aim of this study was to explore the regenerative capacity of CD146-positive subpopulations of BMSCs for repairing cartilage defects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>CD146-positive BMSCs (CD146\u2009+\u2009BMSCs) were sorted by self-developed CD146-specific lipid magnetic spheres (CD146-LMS). Cell surface markers, viability, and proliferation were evaluated in vitro. CD146\u2009+\u2009BMSCs were subjected to in vitro chondrogenic induction and evaluated for chondrogenic properties by detecting mRNA and protein expression. The role of the CD146 subpopulation of BMSCs in cartilage damage repair was assessed by injecting CD146\u2009+\u2009BMSCs complexed with sodium alginate gel in the joints of a mouse cartilage defect model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The prepared CD146-LMS had an average particle size of 193.7\u2009\u00b1\u20095.24\u00a0nm, an average potential of 41.9\u2009\u00b1\u20096.21 mv, and a saturation magnetization intensity of 27.2 Am<jats:sup>2<\/jats:sup>\/kg, which showed good stability and low cytotoxicity. The sorted CD146\u2009+\u2009BMSCs highly expressed stem cell and pericyte markers with good cellular activity and cellular value-added capacity. Cartilage markers Sox9, Collagen II, and Aggrecan were expressed at both protein and mRNA levels in CD146\u2009+\u2009BMSCs cells after chondrogenic induction in vitro. In a mouse cartilage injury model, CD146\u2009+\u2009BMSCs showed better function in promoting the repair of articular cartilage injury.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The prepared CD146-LMS was able to sort out CD146\u2009+\u2009BMSCs efficiently, and the sorted subpopulation of CD146\u2009+\u2009BMSCs had good chondrogenic differentiation potential, which could efficiently promote the repair of articular cartilage injury, suggesting that the sorted CD146\u2009+\u2009BMSCs subpopulation is a promising seed cell for cartilage tissue engineering.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12891-024-07381-6","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T09:12:43Z","timestamp":1711962763000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Specific lipid magnetic sphere sorted CD146-positive bone marrow mesenchymal stem cells can better promote articular cartilage damage repair"],"prefix":"10.1186","volume":"25","author":[{"given":"Hanru","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lele","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengqing","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianghao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"7381_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.actbio.2021.12.006","volume":"140","author":"M Li","year":"2022","unstructured":"Li M, Yin H, Yan Z, Li H, Wu J, Wang Y, Wei F, Tian G, Ning C, Li H, Gao C, Fu L, Jiang S, Chen M, Sui X, Liu S, Chen Z, Guo Q. The immune microenvironment in cartilage injury and repair. Acta Biomater. 2022;140:23\u201342.","journal-title":"Acta Biomater"},{"key":"7381_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2017.01.036","volume":"57","author":"J Yang","year":"2017","unstructured":"Yang J, Zhang YS, Yue K, Khademhosseini A. Cell-laden hydrogels for osteochondral and cartilage tissue engineering. Acta Biomater. 2017;57:1\u201325.","journal-title":"Acta Biomater"},{"issue":"1","key":"7381_CR3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","volume":"11","author":"L He","year":"2020","unstructured":"He L, He T, Xing J, Zhou Q, Fan L, Liu C, Chen Y, Wu D, Tian Z, Liu B, Rong L. Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Res Ther. 2020;11(1):276.","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"7381_CR4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.joca.2021.10.009","volume":"30","author":"D Liu","year":"2022","unstructured":"Liu D, Cai ZJ, Yang YT, Lu WH, Pan LY, Xiao WF, Li YS. Mitochondrial quality control in cartilage damage and osteoarthritis: new insights and potential therapeutic targets. Osteoarthritis Cartilage. 2022;30(3):395\u2013405.","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"7381_CR5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3892\/mmr.2022.12615","volume":"25","author":"S Liu","year":"2022","unstructured":"Liu S, Deng Z, Chen K, Jian S, Zhou F, Yang Y, Fu Z, Xie H, Xiong J, Zhu W. Cartilage tissue engineering: from proinflammatory and anti-inflammatory cytokines to osteoarthritis treatments (Review). Mol Med Rep. 2022;25(3):99.","journal-title":"Mol Med Rep"},{"issue":"8","key":"7381_CR6","doi-asserted-by":"publisher","first-page":"232596712094531","DOI":"10.1177\/2325967120945313","volume":"8","author":"MJ Kraeutler","year":"2020","unstructured":"Kraeutler MJ, Aliberti GM, Scillia AJ, McCarty EC, Mulcahey MK. Microfracture versus drilling of articular cartilage defects: a systematic review of the basic science evidence. Orthop J Sports Med. 2020;8(8):2325967120945313.","journal-title":"Orthop J Sports Med"},{"issue":"19","key":"7381_CR7","doi-asserted-by":"publisher","first-page":"3984","DOI":"10.3390\/nu14193984","volume":"14","author":"Z Su","year":"2022","unstructured":"Su Z, Zong Z, Deng J, Huang J, Liu G, Wei B, Cui L, Li G, Zhong H, Lin S. Lipid metabolism in cartilage development, degeneration, and regeneration. Nutrients. 2022;14(19):3984.","journal-title":"Nutrients"},{"issue":"12","key":"7381_CR8","first-page":"4830","volume":"6","author":"W Wei","year":"2021","unstructured":"Wei W, Dai H. Articular cartilage and osteochondral tissue engineering techniques: recent advances and challenges. Bioact Mater. 2021;6(12):4830\u201355.","journal-title":"Bioact Mater"},{"issue":"9","key":"7381_CR9","doi-asserted-by":"publisher","first-page":"659","DOI":"10.2217\/rme-2022-0023","volume":"17","author":"B Bai","year":"2022","unstructured":"Bai B, Hou M, Hao J, Liu Y, Ji G, Zhou G. Research progress in seed cells for cartilage tissue engineering. Regen Med. 2022;17(9):659\u201375.","journal-title":"Regen Med"},{"key":"7381_CR10","doi-asserted-by":"publisher","first-page":"112491","DOI":"10.1016\/j.colsurfb.2022.112491","volume":"215","author":"Z Zhou","year":"2022","unstructured":"Zhou Z, Liu D. Mesenchymal stem cell-seeded porous tantalum-based biomaterial: a promising choice for promoting bone regeneration. Colloids Surf B Biointerfaces. 2022;215:112491.","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"3","key":"7381_CR11","doi-asserted-by":"publisher","first-page":"708","DOI":"10.3390\/ijms21030708","volume":"21","author":"DT Chu","year":"2020","unstructured":"Chu DT, Phuong TNT, Tien NLB, Tran DK, Thanh VV, Quang TL, Truong DT, Pham VH, Ngoc VTN, Chu-Dinh T, Kushekhar K. An update on the progress of isolation, culture, storage, and clinical application of human bone marrow mesenchymal stem\/stromal cells. Int J Mol Sci. 2020;21(3):708.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"7381_CR12","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.bbrc.2015.01.042","volume":"457","author":"R Hashimoto","year":"2015","unstructured":"Hashimoto R, Katoh Y, Miyamoto Y, Itoh S, Daida H, Nakazato Y, Okada T. Increased extracellular and intracellular Ca2+ lead to adipocyte accumulation in bone marrow stromal cells by different mechanisms. Biochem Biophys Res Commun. 2015;457(4):647\u201352.","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"7381_CR13","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41419-018-0279-5","volume":"9","author":"X Chen","year":"2018","unstructured":"Chen X, Liu Y, Ding W, Shi J, Li S, Liu Y, Wu M, Wang H. Mechanical stretch-induced osteogenic differentiation of human jaw bone marrow mesenchymal stem cells (hJBMMSCs) via inhibition of the NF-\u03baB pathway. Cell Death Dis. 2018;9(2):207.","journal-title":"Cell Death Dis"},{"issue":"24","key":"7381_CR14","doi-asserted-by":"publisher","first-page":"e1693","DOI":"10.21769\/BioProtoc.1693","volume":"5","author":"TD Bornes","year":"2015","unstructured":"Bornes TD, Jomha NM, Mulet-Sierra A, Adesida AB. Porous scaffold seeding and chondrogenic differentiation of BMSC-seeded scaffolds. Bio Protoc. 2015;5(24):e1693.","journal-title":"Bio Protoc"},{"issue":"1","key":"7381_CR15","first-page":"219","volume":"38","author":"NS Mohammad","year":"2022","unstructured":"Mohammad NS, Nazli R, Zafar H, Fatima S. Effects of lipid based multiple micronutrients supplement on the birth outcome of underweight pre-eclamptic women: a randomized clinical trial. Pak J Med Sci. 2022;38(1):219\u201326.","journal-title":"Pak J Med Sci"},{"key":"7381_CR16","doi-asserted-by":"publisher","first-page":"3187491","DOI":"10.1155\/2016\/3187491","volume":"2016","author":"V P\u00e9rez-Silos","year":"2016","unstructured":"P\u00e9rez-Silos V, Camacho-Morales A, Fuentes-Mera L. Mesenchymal stem cells subpopulations: application for orthopedic regenerative medicine. Stem Cells Int. 2016;2016:3187491.","journal-title":"Stem Cells Int"},{"issue":"15","key":"7381_CR17","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.7150\/ijbs.61950","volume":"17","author":"Z Wang","year":"2021","unstructured":"Wang Z, Li X, Yang J, Gong Y, Zhang H, Qiu X, Liu Y, Zhou C, Chen Y, Greenbaum J, Cheng L, Hu Y, Xie J, Yang X, Li Y, Schiller MR, Chen Y, Tan L, Tang SY, Shen H, Xiao HM, Deng HW. Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells. Int J Biol Sci. 2021;17(15):4192\u2013206.","journal-title":"Int J Biol Sci"},{"issue":"12","key":"7381_CR18","doi-asserted-by":"publisher","first-page":"e650","DOI":"10.1002\/ctm2.650","volume":"11","author":"Z Wang","year":"2021","unstructured":"Wang Z, Chai C, Wang R, Feng Y, Huang L, Zhang Y, Xiao X, Yang S, Zhang Y, Zhang X. Single-cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity. Clin Transl Med. 2021;11(12):e650.","journal-title":"Clin Transl Med"},{"issue":"9","key":"7381_CR19","doi-asserted-by":"publisher","first-page":"673","DOI":"10.5966\/sctm.2012-0053","volume":"1","author":"AW James","year":"2012","unstructured":"James AW, Zara JN, Corselli M, Askarinam A, Zhou AM, Hourfar A, Nguyen A, Megerdichian S, Asatrian G, Pang S, Stoker D, Zhang X, Wu B, Ting K, P\u00e9ault B, Soo C. An abundant perivascular source of stem cells for bone tissue engineering. Stem Cells Transl Med. 2012;1(9):673\u201384.","journal-title":"Stem Cells Transl Med"},{"issue":"8","key":"7381_CR20","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/stem.3196","volume":"38","author":"AC Bowles","year":"2020","unstructured":"Bowles AC, Kouroupis D, Willman MA, Perucca Orfei C, Agarwal A, Correa D. Signature quality attributes of CD146+ mesenchymal stem\/stromal cells correlate with high therapeutic and secretory potency. Stem Cells. 2020;38(8):1034\u201349.","journal-title":"Stem Cells"},{"key":"7381_CR21","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/1471-2474-15-322","volume":"15","author":"S Hagmann","year":"2014","unstructured":"Hagmann S, Frank S, Gotterbarm T, Dreher T, Eckstein V, Moradi B. Fluorescence activated enrichment of CD146+ cells during expansion of human bone-marrow derived mesenchymal stromal cells augments proliferation and GAG\/DNA content in chondrogenic media. BMC Musculoskelet Disord. 2014;15:322.","journal-title":"BMC Musculoskelet Disord"},{"issue":"17","key":"7381_CR22","doi-asserted-by":"publisher","first-page":"5105","DOI":"10.7150\/thno.33904","volume":"9","author":"X Li","year":"2019","unstructured":"Li X, Guo W, Zha K, Jing X, Wang M, Zhang Y, Hao C, Gao S, Chen M, Yuan Z, Wang Z, Zhang X, Shen S, Li H, Zhang B, Xian H, Zhang Y, Sui X, Qin L, Peng J, Liu S, Lu S, Guo Q. Enrichment of CD146+ adipose-derived stem cells in combination with articular cartilage extracellular matrix scaffold promotes cartilage regeneration. Theranostics. 2019;9(17):5105\u201321.","journal-title":"Theranostics"},{"issue":"4","key":"7381_CR23","doi-asserted-by":"publisher","first-page":"4048","DOI":"10.3390\/ijms24044048","volume":"24","author":"R Kunimatsu","year":"2023","unstructured":"Kunimatsu R, Rikitake K, Yoshimi Y, Putranti NAR, Hayashi Y, Tanimoto K. Bone differentiation ability of CD146-positive stem cells from human exfoliated deciduous teeth. Int J Mol Sci. 2023;24(4):4048.","journal-title":"Int J Mol Sci"},{"key":"7381_CR24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13287-016-0285-4","volume":"7","author":"CC Wu","year":"2016","unstructured":"Wu CC, Liu FL, Sytwu HK, Tsai CY, Chang DM. CD146+ mesenchymal stem cells display greater therapeutic potential than CD146- cells for treating collagen-induced arthritis in mice. Stem Cell Res Ther. 2016;7:23.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"7381_CR25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/jor.22731","volume":"33","author":"X Su","year":"2015","unstructured":"Su X, Zuo W, Wu Z, Chen J, Wu N, Ma P, Xia Z, Jiang C, Ye Z, Liu S, Liu J, Zhou G, Wan C, Qiu G. CD146 as a new marker for an increased chondroprogenitor cell sub-population in the later stages of osteoarthritis. J Orthop Res. 2015;33(1):84\u201391.","journal-title":"J Orthop Res"},{"issue":"3","key":"7381_CR26","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.3390\/ijms23031147","volume":"23","author":"W Liu","year":"2022","unstructured":"Liu W, Madry H, Cucchiarini M. Application of alginate hydrogels for next-generation articular cartilage regeneration. Int J Mol Sci. 2022;23(3):1147.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"7381_CR27","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1007\/s00167-013-2723-5","volume":"23","author":"H Dashtdar","year":"2015","unstructured":"Dashtdar H, Murali MR, Abbas AA, Suhaeb AM, Selvaratnam L, Tay LX, Kamarul T. PVA-chitosan composite hydrogel versus alginate beads as a potential mesenchymal stem cell carrier for the treatment of focal cartilage defects. Knee Surg Sports Traumatol Arthrosc. 2015;23(5):1368\u201377.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"12","key":"7381_CR28","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.joca.2008.04.013","volume":"16","author":"DR Seifer","year":"2008","unstructured":"Seifer DR, Furman BD, Guilak F, Olson SA, Brooks SC 3rd, Kraus VB. Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice. Osteoarthritis Cartilage. 2008;16(12):1532\u20138.","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"7381_CR29","doi-asserted-by":"publisher","first-page":"e0195326","DOI":"10.1371\/journal.pone.0195326","volume":"13","author":"X Cheng","year":"2018","unstructured":"Cheng X, Li K, Xu S, Li P, Yan Y, Wang G, Berman Z, Guo R, Liang J, Traore S, Yang X. Applying chlorogenic acid in an alginate scaffold of chondrocytes can improve the repair of damaged articular cartilage. PLoS One. 2018;13(4):e0195326.","journal-title":"PLoS One"},{"key":"7381_CR30","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.actbio.2021.12.034","volume":"141","author":"JM McKinney","year":"2022","unstructured":"McKinney JM, Pucha KA, Doan TN, Wang L, Weinstock LD, Tignor BT, Fowle KL, Levit RD, Wood LB, Willett NJ. Sodium alginate microencapsulation of human mesenchymal stromal cells modulates paracrine signaling response and enhances efficacy for treatment of established osteoarthritis. Acta Biomater. 2022;141:315\u201332.","journal-title":"Acta Biomater"},{"issue":"3","key":"7381_CR31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1067-1927.2004.012309.x","volume":"12","author":"M Ramallal","year":"2004","unstructured":"Ramallal M, Maneiro E, L\u00f3pez E, Fuentes-Boquete I, L\u00f3pez-Armada MJ, Fern\u00e1ndez-Sueiro JL, Galdo F, De Toro FJ, Blanco FJ. Xeno-implantation of pig chondrocytes into rabbit to treat localized articular cartilage defects: an animal model. Wound Repair Regen. 2004;12(3):337\u201345.","journal-title":"Wound Repair Regen"},{"key":"7381_CR32","doi-asserted-by":"publisher","first-page":"23076","DOI":"10.1038\/srep23076","volume":"6","author":"J Mak","year":"2016","unstructured":"Mak J, Jablonski CL, Leonard CA, Dunn JF, Raharjo E, Matyas JR, Biernaskie J, Krawetz RJ. Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model. Sci Rep. 2016;6:23076.","journal-title":"Sci Rep"},{"issue":"9","key":"7381_CR33","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.joca.2017.05.006","volume":"25","author":"H Katagiri","year":"2017","unstructured":"Katagiri H, Mendes LF, Luyten FP. Definition of a critical size osteochondral knee defect and its negative effect on the surrounding articular cartilage in the rat. Osteoarthritis Cartilage. 2017;25(9):1531\u201340.","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"7381_CR34","doi-asserted-by":"publisher","first-page":"5837","DOI":"10.1007\/s00167-023-07615-5","volume":"31","author":"A Bumberger","year":"2023","unstructured":"Bumberger A, Rupp MC, Lattermann C, Kleiner A, Niemeyer P. Increased risk of reoperation and failure to attain clinically relevant improvement following autologous chondrocyte implantation of the knee in female patients and individuals with previous surgeries: a time-to-event analysis based on the German cartilage registry (KnorpelRegister DGOU). Knee Surg Sports Traumatol Arthrosc. 2023;31(12):5837\u201347.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"12","key":"7381_CR35","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1177\/0363546511422220","volume":"39","author":"J Vanlauwe","year":"2011","unstructured":"Vanlauwe J, Saris DB, Victor J, Almqvist KF, Bellemans J, Luyten FP, TIG\/ACT\/01\/2000&EXT Study Group. Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters. Am J Sports Med. 2011;39(12):2566\u201374.","journal-title":"Am J Sports Med"},{"issue":"1","key":"7381_CR36","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3390\/ijms24010059","volume":"24","author":"P Wei","year":"2022","unstructured":"Wei P, Bao R. Intra-articular mesenchymal stem cell injection for knee osteoarthritis: mechanisms and clinical evidence. Int J Mol Sci. 2022;24(1):59.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"7381_CR37","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41413-022-00239-4","volume":"11","author":"X Du","year":"2023","unstructured":"Du X, Cai L, Xie J, Zhou X. The role of TGF-beta3 in cartilage development and osteoarthritis. Bone Res. 2023;11(1):2.","journal-title":"Bone Res"},{"issue":"10","key":"7381_CR38","doi-asserted-by":"publisher","first-page":"610","DOI":"10.21037\/atm-22-1715","volume":"10","author":"P Wang","year":"2022","unstructured":"Wang P, Zhang S, Meng Q, Zhu P, Yuan W. Treatment and application of stem cells from different sources for cartilage injury: a literature review. Ann Transl Med. 2022;10(10):610.","journal-title":"Ann Transl Med"},{"issue":"2","key":"7381_CR39","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/cbin.11256","volume":"44","author":"Y Liu","year":"2020","unstructured":"Liu Y, Li M, Yin Z, Zhou S, Qiu Y. SUMO-modified bone marrow mesenchymal stem cells promoted the repair of articular cartilage in rats. Cell Biol Int. 2020;44(2):560\u20138.","journal-title":"Cell Biol Int"},{"key":"7381_CR40","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.actbio.2021.12.011","volume":"140","author":"P Yuan","year":"2022","unstructured":"Yuan P, Li Z, Shao B, Zeng T, Wu X, Wang Y, Zhao Y, Wu W. Extracellular vesicles derived from starving BMSCs enhance survival of chondrocyte aggregates in grafts by attenuating chondrocyte apoptosis and enabling stable cartilage regeneration for craniofacial reconstruction. Acta Biomater. 2022;140:659\u201373.","journal-title":"Acta Biomater"},{"issue":"18","key":"7381_CR41","doi-asserted-by":"publisher","first-page":"11505","DOI":"10.1039\/D2RA00622G","volume":"12","author":"J Huang","year":"2022","unstructured":"Huang J, Wang Y, Zhou Y. Beneficial roles of the AhR ligand FICZ on the regenerative potentials of BMSCs and primed cartilage templates. RSC Adv. 2022;12(18):11505\u201316.","journal-title":"RSC Adv"},{"key":"7381_CR42","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.actbio.2022.03.056","volume":"145","author":"R Zuo","year":"2022","unstructured":"Zuo R, Liu J, Zhang Y, Zhang H, Li J, Wu J, Ji Y, Mao S, Li C, Zhou Y, Wu Y, Cai D, Sun Y, Zhang C. In situ regeneration of bone-to-tendon structures: comparisons between costal-cartilage derived stem cells and BMSCs in the rat model. Acta Biomater. 2022;145:62\u201376.","journal-title":"Acta Biomater"},{"issue":"4","key":"7381_CR43","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1359\/jbmr.2003.18.4.696","volume":"18","author":"S Shi","year":"2003","unstructured":"Shi S, Gronthos S. Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res. 2003;18(4):696\u2013704.","journal-title":"J Bone Miner Res"},{"issue":"4","key":"7381_CR44","doi-asserted-by":"publisher","first-page":"427","DOI":"10.5966\/sctm.2015-0109","volume":"5","author":"HJ Jin","year":"2016","unstructured":"Jin HJ, Kwon JH, Kim M, Bae YK, Choi SJ, Oh W, Yang YS, Jeon HB. Downregulation of melanoma cell adhesion molecule (MCAM\/CD146) accelerates cellular senescence in human umbilical cord blood-derived mesenchymal stem cells. Stem Cells Transl Med. 2016;5(4):427\u201339.","journal-title":"Stem Cells Transl Med"},{"issue":"24","key":"7381_CR45","doi-asserted-by":"publisher","first-page":"4002","DOI":"10.3390\/cells11244002","volume":"11","author":"C Le\u00f1ero","year":"2022","unstructured":"Le\u00f1ero C, Kaplan LD, Best TM, Kouroupis D. CD146+ Endometrial-derived mesenchymal stem\/stromal cell subpopulation possesses exosomal secretomes with strong immunomodulatory miRNA attributes. Cells. 2022;11(24):4002.","journal-title":"Cells"},{"key":"7381_CR46","doi-asserted-by":"publisher","first-page":"983059","DOI":"10.1155\/2013\/983059","volume":"2013","author":"WC Chen","year":"2013","unstructured":"Chen WC, Park TS, Murray IR, Zimmerlin L, Lazzari L, Huard J, P\u00e9ault B. Cellular kinetics of perivascular MSC precursors. Stem Cells Int. 2013;2013:983059.","journal-title":"Stem Cells Int"},{"issue":"5\u20136","key":"7381_CR47","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1089\/ten.tea.2017.0023","volume":"24","author":"CA Meyers","year":"2018","unstructured":"Meyers CA, Xu J, Zhang L, Asatrian G, Ding C, Yan N, Broderick K, Sacks J, Goyal R, Zhang X, Ting K, P\u00e9ault B, Soo C, James AW. Early immunomodulatory effects of implanted human perivascular stromal cells during bone formation. Tissue Eng Part A. 2018;24(5\u20136):448\u201357.","journal-title":"Tissue Eng Part A"},{"issue":"7","key":"7381_CR48","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.joca.2019.04.002","volume":"27","author":"S Wangler","year":"2019","unstructured":"Wangler S, Menzel U, Li Z, Ma J, Hoppe S, Benneker LM, Alini M, Grad S, Peroglio M. CD146\/MCAM distinguishes stem cell subpopulations with distinct migration and regenerative potential in degenerative intervertebral discs. Osteoarthritis Cartilage. 2019;27(7):1094\u2013105.","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"7381_CR49","doi-asserted-by":"publisher","first-page":"016601","DOI":"10.1088\/0034-4885\/78\/1\/016601","volume":"78","author":"BD Plouffe","year":"2015","unstructured":"Plouffe BD, Murthy SK, Lewis LH. Fundamentals and application of magnetic particles in cell isolation and enrichment: a review. Rep Prog Phys. 2015;78(1):016601.","journal-title":"Rep Prog Phys"},{"issue":"9","key":"7381_CR50","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1002\/term.2147","volume":"11","author":"AT Lauvrud","year":"2017","unstructured":"Lauvrud AT, Kelk P, Wiberg M, Kingham PJ. Characterization of human adipose tissue-derived stem cells with enhanced angiogenic and adipogenic properties. J Tissue Eng Regen Med. 2017;11(9):2490\u2013502.","journal-title":"J Tissue Eng Regen Med"},{"key":"7381_CR51","doi-asserted-by":"publisher","unstructured":"Mahajan KD, Nabar GM, Xue W, Anghelina M, Moldovan NI, Chalmers JJ, Winter JO. Mechanotransduction effects on endothelial cell proliferation via CD31 and VEGFR2: implications for immunomagnetic separation. Biotechnol J. 2017;12(9). https:\/\/doi.org\/10.1002\/biot.201600750.","DOI":"10.1002\/biot.201600750"},{"key":"7381_CR52","first-page":"501","volume":"20","author":"X Guo","year":"2022","unstructured":"Guo X, Ma Y, Min Y, Sun J, Shi X, Gao G, Sun L, Wang J. Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product. Bioact Mater. 2022;20:501\u201318.","journal-title":"Bioact Mater"},{"issue":"6","key":"7381_CR53","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1007\/s12015-023-10545-x","volume":"19","author":"F Ramzan","year":"2023","unstructured":"Ramzan F, Salim A, Khan I. Osteochondral tissue engineering dilemma: scaffolding trends in regenerative medicine. Stem Cell Rev Rep. 2023;19(6):1615\u201334.","journal-title":"Stem Cell Rev Rep"},{"key":"7381_CR54","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.ijbiomac.2022.01.054","volume":"203","author":"BN Singh","year":"2022","unstructured":"Singh BN, Nallakumarasamy A, Sinha S, Rastogi A, Mallick SP, Divakar S, Srivastava P. Generation of hybrid tissue engineered construct through embedding autologous chondrocyte loaded platelet rich plasma\/alginate based hydrogel in porous scaffold for cartilage regeneration. Int J Biol Macromol. 2022;203:389\u2013405.","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"7381_CR55","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3390\/gels9050430","volume":"9","author":"R Sharma","year":"2023","unstructured":"Sharma R, Malviya R, Singh S, Prajapati B. A critical review on classified excipient sodium-alginate-based hydrogels: modification, characterization, and application in soft tissue engineering. Gels. 2023;9(5):430.","journal-title":"Gels"},{"issue":"2","key":"7381_CR56","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1006\/bbrc.2001.6270","volume":"290","author":"GR Erickson","year":"2002","unstructured":"Erickson GR, Gimble JM, Franklin DM, Rice HE, Awad H, Guilak F. Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun. 2002;290(2):763\u20139.","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"7381_CR57","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11626-998-0094-x","volume":"34","author":"MB Aydelotte","year":"1998","unstructured":"Aydelotte MB, Thonar EJ, Mollenhauer J, Flechtenmacher J. Culture of chondrocytes in alginate gel: variations in conditions of gelation influence the structure of the alginate gel, and the arrangement and morphology of proliferating chondrocytes. In Vitro Cell Dev Biol Anim. 1998;34(2):123\u201330.","journal-title":"In Vitro Cell Dev Biol Anim"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-024-07381-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12891-024-07381-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-024-07381-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T10:05:48Z","timestamp":1711965948000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/s12891-024-07381-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["7381"],"URL":"https:\/\/doi.org\/10.1186\/s12891-024-07381-6","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]},"assertion":[{"value":"18 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the experimental procedures were carried out according to the guide for the Care and Use of Laboratory Animals and was approved by the Institutional Animal Care and Use Committee (NO:2023-QWJWRC-D-06). The study was carried out in compliance with the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"253"}}