{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:02:56Z","timestamp":1770040976482,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"DOI":"10.1186\/s12891-024-08213-3","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T10:16:41Z","timestamp":1735294601000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of aspirin in preventing venous thromboembolism after hip arthroplasty for femoral neck fracture: a noninferiority prospective cohort study"],"prefix":"10.1186","volume":"25","author":[{"given":"Yifan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyang","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"8213_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/BF01623184","volume":"2","author":"C Cooper","year":"1992","unstructured":"Cooper C, Campion G, Melton LJ. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2:285\u20139.","journal-title":"Osteoporos Int"},{"key":"8213_CR2","first-page":"675","volume":"106","author":"JD Schroeder","year":"2022","unstructured":"Schroeder JD, Turner SP, Buck E. Hip fractures: diagnosis and management. Am Fam Phys. 2022;106:675\u201383.","journal-title":"Am Fam Phys"},{"key":"8213_CR3","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/jbmr.4821","volume":"38","author":"C-W Sing","year":"2023","unstructured":"Sing C-W, Lin T-C, Bartholomew S, Bell JS, Bennett C, Beyene K, et al. Global epidemiology of hip fractures: secular trends in incidence rate, post-fracture treatment, and all-cause mortality. J Bone Min Res. 2023;38:1064\u201375. https:\/\/doi.org\/10.1002\/jbmr.4821.","journal-title":"J Bone Min Res"},{"key":"8213_CR4","doi-asserted-by":"publisher","first-page":"596","DOI":"10.5435\/00124635-200810000-00005","volume":"16","author":"RG Miyamoto","year":"2008","unstructured":"Miyamoto RG, Kaplan KM, Levine BR, Egol KA, Zuckerman JD. Surgical management of hip fractures: an evidence-based review of the literature. I: femoral neck fractures. J Am Acad Orthop Surg. 2008;16:596\u2013607.","journal-title":"J Am Acad Orthop Surg"},{"key":"8213_CR5","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1056\/NEJMcp1611090","volume":"377","author":"M Bhandari","year":"2017","unstructured":"Bhandari M, Swiontkowski M. Management of acute hip fracture. N Engl J Med. 2017;377:2053\u201362. https:\/\/doi.org\/10.1056\/NEJMcp1611090.","journal-title":"N Engl J Med"},{"key":"8213_CR6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s13018-018-0998-4","volume":"13","author":"Z-N Xia","year":"2018","unstructured":"Xia Z-N, Xiao K, Zhu W, Feng B, Zhang B-Z, Lin J, et al. Risk assessment and management of preoperative venous thromboembolism following femoral neck fracture. J Orthop Surg Res. 2018;13:291. https:\/\/doi.org\/10.1186\/s13018-018-0998-4.","journal-title":"J Orthop Surg Res"},{"key":"8213_CR7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3390\/prosthesis6030038","volume":"6","author":"M Sapienza","year":"2024","unstructured":"Sapienza M, Di Via D, Vaccalluzzo MS, Costarella L, Pavone V, Testa G. Comparative analysis of cemented and cementless straight-stem prostheses in hip replacement surgery for elderly patients: a mid-term follow-up study. Prosthesis. 2024;6:540\u201350.","journal-title":"Prosthesis"},{"key":"8213_CR8","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3928\/01477447-20100722-43","volume":"33","author":"VD Pellegrini","year":"2010","unstructured":"Pellegrini VD. DVT prophylaxis: better living through chemistry: affirms. Orthopedics. 2010;33:642. https:\/\/doi.org\/10.3928\/01477447-20100722-43.","journal-title":"Orthopedics"},{"issue":"6","key":"8213_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.arth.2009.06.002","volume":"24","author":"GA Brown","year":"2009","unstructured":"Brown GA. Venous thromboembolism prophylaxis after major orthopaedic surgery: a pooled analysis of randomized controlled trials. J Arthroplasty. 2009;24(6):77\u201383. https:\/\/doi.org\/10.1016\/j.arth.2009.06.002.","journal-title":"J Arthroplasty"},{"key":"8213_CR10","doi-asserted-by":"publisher","unstructured":"Falck-Ytter Y, Francis CW, Johanson NA, Curley C, Dahl OE, Schulman S et al. Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. 2012;141(2) Suppl:e278S-325S. https:\/\/doi.org\/10.1378\/chest.11-2404","DOI":"10.1378\/chest.11-2404"},{"key":"8213_CR11","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1530\/EOR-22-0053","volume":"7","author":"LC Singjie","year":"2022","unstructured":"Singjie LC, Halomoan R, Saleh I, Sumargono E, Kholinne E. Clinical effectiveness and safety of aspirin and other anticoagulants for venous thromboembolism prophylaxis after major orthopedic surgery: a systematic review and meta-analysis of randomized clinical trials. EFORT Open Rev. 2022;7:792\u20139. https:\/\/doi.org\/10.1530\/EOR-22-0053.","journal-title":"EFORT Open Rev"},{"key":"8213_CR12","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1097\/MCP.0b013e32833c3d3e","volume":"16","author":"JA Caprini","year":"2010","unstructured":"Caprini JA. Risk assessment as a guide to thrombosis prophylaxis. Curr Opin Pulm Med. 2010;16:448\u201352. https:\/\/doi.org\/10.1097\/MCP.0b013e32833c3d3e.","journal-title":"Curr Opin Pulm Med"},{"key":"8213_CR13","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/S0140-6736(04)16004-2","volume":"363","author":"SZ Goldhaber","year":"2004","unstructured":"Goldhaber SZ. Pulmonary embolism. Lancet. 2004;363:1295\u2013305.","journal-title":"Lancet"},{"key":"8213_CR14","doi-asserted-by":"publisher","first-page":"800","DOI":"10.7326\/0003-4819-158-11-201306040-00004","volume":"158","author":"DR Anderson","year":"2013","unstructured":"Anderson DR, Dunbar MJ, Bohm ER, Belzile E, Kahn SR, Zukor D, et al. Aspirin versus low-molecular-weight heparin for extended venous thromboembolism prophylaxis after total hip arthroplasty: a randomized trial. Ann Intern Med. 2013;158:800\u20136. https:\/\/doi.org\/10.7326\/0003-4819-158-11-201306040-00004.","journal-title":"Ann Intern Med"},{"key":"8213_CR15","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/CM9.0000000000001305","volume":"134","author":"Y Ren","year":"2021","unstructured":"Ren Y, Cao SL, Li Z, Luo T, Feng B, Weng XS. Comparable efficacy of 100\u00a0mg aspirin twice daily and Rivaroxaban for venous thromboembolism prophylaxis following primary total hip arthroplasty: a randomized controlled trial. Chin Med J (Engl). 2021;134:164\u201372. https:\/\/doi.org\/10.1097\/CM9.0000000000001305.","journal-title":"Chin Med J (Engl)"},{"key":"8213_CR16","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1093\/annonc\/mdz111","volume":"30","author":"C Ay","year":"2019","unstructured":"Ay C, Beyer-Westendorf J, Pabinger I. Treatment of cancer-associated venous thromboembolism in the age of direct oral anticoagulants. Ann Oncol. 2019;30:897\u2013907. https:\/\/doi.org\/10.1093\/annonc\/mdz111.","journal-title":"Ann Oncol"},{"key":"8213_CR17","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1016\/j.arth.2023.02.028","volume":"38","author":"AS Piple","year":"2023","unstructured":"Piple AS, Wang JC, Kang HP, Mills ES, Mayfield CK, Lieberman JR, et al. Safety and efficacy of Rivaroxaban in primary total hip and knee arthroplasty. J Arthroplasty. 2023;38:1613\u2013e16204. https:\/\/doi.org\/10.1016\/j.arth.2023.02.028.","journal-title":"J Arthroplasty"},{"key":"8213_CR18","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1001\/jama.2022.13416","volume":"328","author":"VS Sidhu","year":"2022","unstructured":"CRISTAL Study Group, Sidhu VS, Kelly T-L, Pratt N, Graves SE, Buchbinder R, et al. Effect of aspirin vs enoxaparin on symptomatic venous thromboembolism in patients undergoing hip or knee arthroplasty: the Cristal randomized trial. JAMA. 2022;328:719\u201327. https:\/\/doi.org\/10.1001\/jama.2022.13416.","journal-title":"JAMA"},{"key":"8213_CR19","doi-asserted-by":"publisher","first-page":"e2317838","DOI":"10.1001\/jamanetworkopen.2023.17838","volume":"6","author":"VS Sidhu","year":"2023","unstructured":"CRISTAL Study Group, Sidhu VS, Kelly TL, Pratt N, Graves SE, Buchbinder R, et al. Effect of aspirin vs enoxaparin on 90-day mortality in patients undergoing hip or knee arthroplasty: a secondary analysis of the Cristal Cluster randomized trial. JAMA Netw Open. 2023;6:e2317838. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.17838.","journal-title":"JAMA Netw Open"},{"key":"8213_CR20","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s13018-021-02274-z","volume":"16","author":"B Hu","year":"2021","unstructured":"Hu B, Jiang L, Tang H, Hu M, Yu J, Dai Z. Rivaroxaban versus aspirin in prevention of venous thromboembolism following total joint arthroplasty or hip fracture surgery: a meta-analysis. J Orthop Surg Res. 2021;16:135. https:\/\/doi.org\/10.1186\/s13018-021-02274-z.","journal-title":"J Orthop Surg Res"},{"key":"8213_CR21","doi-asserted-by":"publisher","first-page":"230949901989602","DOI":"10.1177\/2309499019896024:2309499019896024","volume":"28","author":"J Xu","year":"2020","unstructured":"Xu J, Kanagaratnam A, Cao JY, Chaggar GS, Bruce W. A comparison of aspirin against Rivaroxaban for venous thromboembolism prophylaxis after hip or knee arthroplasty: a meta-analysis. J Orthop Surg (Hong Kong). 2020;28:2309499019896024. https:\/\/doi.org\/10.1177\/2309499019896024:2309499019896024.","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"8213_CR22","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1001\/jamainternmed.2019.6108","volume":"180","author":"GS Matharu","year":"2020","unstructured":"Matharu GS, Kunutsor SK, Judge A, Blom AW, Whitehouse MR. Clinical effectiveness and safety of aspirin for venous thromboembolism prophylaxis after total hip and knee replacement: a systematic review and meta-analysis of randomized clinical trials. JAMA Intern Med. 2020;180:376\u201384. https:\/\/doi.org\/10.1001\/jamainternmed.2019.6108.","journal-title":"JAMA Intern Med"},{"key":"8213_CR23","doi-asserted-by":"publisher","first-page":"e2345883","DOI":"10.1001\/jamanetworkopen.2023.45883","volume":"6","author":"SJ Simon","year":"2023","unstructured":"Simon SJ, Patell R, Zwicker JI, Kazi DS, Hollenbeck BL. Venous thromboembolism in total hip and total knee arthroplasty. JAMA Netw Open. 2023;6:e2345883. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.45883.","journal-title":"JAMA Netw Open"},{"key":"8213_CR24","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1111\/os.12542","volume":"11","author":"Q Huang","year":"2019","unstructured":"Huang Q, Xing SX, Zeng Y, Si HB, Zhou ZK, Shen B. Comparison of the efficacy and safety of aspirin and Rivaroxaban following enoxaparin treatment for prevention of venous thromboembolism after hip fracture surgery. Orthop Surg. 2019;11:886\u201394. https:\/\/doi.org\/10.1111\/os.12542.","journal-title":"Orthop Surg"},{"key":"8213_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/s13018-020-01725-3","volume":"15","author":"Y Liu","year":"2020","unstructured":"Liu Y, Chen X, Zhang P, Jiang B. Comparing total hip arthroplasty and hemiarthroplasty for the treatment of displaced femoral neck fracture in the active elderly over 75 years old: a systematic review and meta-analysis of randomized control trials. J Orthop Surg Res. 2020;15:215. https:\/\/doi.org\/10.1186\/s13018-020-01725-3.","journal-title":"J Orthop Surg Res"},{"key":"8213_CR26","doi-asserted-by":"publisher","first-page":"6245","DOI":"10.26355\/eurrev_202110_26994","volume":"25","author":"JY Cai","year":"2021","unstructured":"Cai JY, Cui CM, Min MIN, Cao JK, Zhang YQ. Comparison between use of direct oral anticoagulants and aspirin for risk of thromboembolism complications in patients undergoing total knee and hip arthroplasty: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2021;25:6245\u201359. https:\/\/doi.org\/10.26355\/eurrev_202110_26994.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"8213_CR27","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1302\/0301-620X.99B11.BJJ-2017-0337.R2","volume":"99\u2013B","author":"I Azboy","year":"2017","unstructured":"Azboy I, Barrack R, Thomas AM, Haddad FS, Parvizi J. Aspirin and the prevention of venous thromboembolism following total joint arthroplasty: commonly asked questions. Bone Joint J. 2017;99\u2013B:1420\u201330. https:\/\/doi.org\/10.1302\/0301-620X.99B11.BJJ-2017-0337.R2.","journal-title":"Bone Joint J"},{"key":"8213_CR28","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/rth2.12325","volume":"4","author":"AR Folsom","year":"2020","unstructured":"Folsom AR, Wang W, Parikh R, Lutsey PL, Beckman JD, Cushman M, et al. Hematocrit and incidence of venous thromboembolism. Res Pract Thromb Haemost. 2020;4:422\u20138. https:\/\/doi.org\/10.1002\/rth2.12325.","journal-title":"Res Pract Thromb Haemost"},{"key":"8213_CR29","first-page":"1","volume-title":"PREEDY VR, PATEL V B. General methods in Biomarker Research and their applications","author":"WZ Abdullah","year":"2014","unstructured":"Abdullah WZ. Hemostatic biomarkers: future Prospect and ChallengesHaemostatic biomarkers. PREEDY VR, PATEL V B. General methods in Biomarker Research and their applications. Dordrecht: Springer Netherlands; 2014. pp. 1\u201315."},{"key":"8213_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23128","author":"JA Heit","year":"2012","unstructured":"Heit JA. Predicting the risk of venous thromboembolism recurrence. Am J Hematol. 2012;87(Suppl 1):S63\u201367. https:\/\/doi.org\/10.1002\/ajh.23128. Suppl 1 Suppl 1."},{"key":"8213_CR31","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/CORR.0000000000000613","volume":"477","author":"M Faour","year":"2019","unstructured":"Faour M, Piuzzi NS, Brigati DP, Klika AK, Mont MA, Barsoum WK, et al. No difference between low- and regular-dose aspirin for venous thromboembolism prophylaxis after THA. Clin Orthop Relat Res. 2019;477:396\u2013402. https:\/\/doi.org\/10.1097\/CORR.0000000000000613.","journal-title":"Clin Orthop Relat Res"},{"key":"8213_CR32","doi-asserted-by":"publisher","first-page":"1326224","DOI":"10.3389\/fphar.2023.1326224","volume":"14","author":"X Zheng","year":"2023","unstructured":"Zheng X, Nong L, Song Y, Han L, Zhang Y, Yin Q, et al. Comparison of efficacy and safety between aspirin and oral anticoagulants for venous thromboembolism prophylaxis after major orthopaedic surgery: a meta-analysis of randomized clinical trials. Front Pharmacol. 2023;14:1326224. https:\/\/doi.org\/10.3389\/fphar.2023.1326224.","journal-title":"Front Pharmacol"},{"key":"8213_CR33","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.arth.2022.02.008","volume":"37","author":"N Shohat","year":"2022","unstructured":"Shohat N, Goel R, Ludwick L, Parvizi J. Time to venous thromboembolism events following total hip arthroplasty: a comparison between aspirin and warfarin. J Arthroplasty. 2022;37:1198\u2013e12021. https:\/\/doi.org\/10.1016\/j.arth.2022.02.008.","journal-title":"J Arthroplasty"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-024-08213-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12891-024-08213-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-024-08213-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T11:03:35Z","timestamp":1735297415000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/s12891-024-08213-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["8213"],"URL":"https:\/\/doi.org\/10.1186\/s12891-024-08213-3","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]},"assertion":[{"value":"10 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of the Affiliated Hospital of Qingdao University (approval number: QYFYWZLL 28542). Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"1079"}}