{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T11:10:17Z","timestamp":1741864217026,"version":"3.38.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Central High level Hospital Clinical Research Special Foundation of Peking Union Medical College Hospital","award":["2022-PUMCH-B-131"],"award-info":[{"award-number":["2022-PUMCH-B-131"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"DOI":"10.1186\/s12891-025-08473-7","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T10:10:35Z","timestamp":1741687835000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of the current status and characteristics of osteoporosis in adult hemophilia patients based on high-resolution peripheral quantitative computed tomography: a case control study"],"prefix":"10.1186","volume":"26","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingnan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"issue":"1","key":"8473_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41572-021-00278-x","volume":"7","author":"E Berntorp","year":"2021","unstructured":"Berntorp E, Fischer K, Hart DP, Mancuso ME, Stephensen D, Shapiro AD, Blanchette V. Haemophilia Nat Rev Dis Primers. 2021;7(1):45.","journal-title":"Haemophilia Nat Rev Dis Primers"},{"issue":"Suppl 6","key":"8473_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/hae.13449","volume":"24","author":"LFD van Vulpen","year":"2018","unstructured":"van Vulpen LFD, Holstein K, Martinoli C. Joint disease in haemophilia: Pathophysiology, pain and imaging. Haemophilia. 2018;24(Suppl 6):44\u20139.","journal-title":"Haemophilia"},{"issue":"2","key":"8473_CR3","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1365-2516.2008.01963.x","volume":"15","author":"G Gerstner","year":"2009","unstructured":"Gerstner G, Damiano ML, Tom A, Worman C, Schultz W, Recht M, Stopeck AT. Prevalence and risk factors associated with decreased bone mineral density in patients with haemophilia. Haemophilia. 2009;15(2):559\u201365.","journal-title":"Haemophilia"},{"issue":"5","key":"8473_CR4","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/hae.13814","volume":"25","author":"SH Tuan","year":"2019","unstructured":"Tuan SH, Hu LY, Sun SF, Huang WY, Chen GB, Li MH, Liou IH. Risk of osteoporotic fractures as a consequence of haemophilia: A nationwide population-based cohort study. Haemophilia. 2019;25(5):876\u201384.","journal-title":"Haemophilia"},{"issue":"3","key":"8473_CR5","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/hae.14540","volume":"28","author":"MJ Petkovic","year":"2022","unstructured":"Petkovic MJ, Tran HA, Ebeling PR, Zengin A. Osteoporosis management and falls prevention in patients with haemophilia: Review of haemophilia guidelines. Haemophilia. 2022;28(3):388\u201396.","journal-title":"Haemophilia"},{"issue":"6","key":"8473_CR6","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1210\/jc.2011-3045","volume":"97","author":"NB Watts","year":"2012","unstructured":"Watts NB, Adler RA, Bilezikian JP, Drake MT, Eastell R, Orwoll ES, Finkelstein JS, Endocrine S. Osteoporosis in men: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(6):1802\u201322.","journal-title":"J Clin Endocrinol Metab"},{"key":"8473_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bone.2018.05.005","volume":"113","author":"HA Fink","year":"2018","unstructured":"Fink HA, Langsetmo L, Vo TN, Orwoll ES, Schousboe JT, Ensrud KE. Osteoporotic Fractures in Men Study G: Association of High-resolution Peripheral Quantitative Computed Tomography (HR-pQCT) bone microarchitectural parameters with previous clinical fracture in older men: The Osteoporotic Fractures in Men (MrOS) study. Bone. 2018;113:49\u201356.","journal-title":"Bone"},{"issue":"6","key":"8473_CR8","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1002\/jbmr.3105","volume":"32","author":"E Sornay-Rendu","year":"2017","unstructured":"Sornay-Rendu E, Boutroy S, Duboeuf F, Chapurlat RD. Bone Microarchitecture Assessed by HR-pQCT as Predictor of Fracture Risk in Postmenopausal Women: The OFELY Study. J Bone Miner Res. 2017;32(6):1243\u201351.","journal-title":"J Bone Miner Res"},{"issue":"3","key":"8473_CR9","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/jbmr.3901","volume":"35","author":"N Mikolajewicz","year":"2020","unstructured":"Mikolajewicz N, Bishop N, Burghardt AJ, Folkestad L, Hall A, Kozloff KM, Lukey PT, Molloy-Bland M, Morin SN, Offiah AC, et al. HR-pQCT Measures of Bone Microarchitecture Predict Fracture: Systematic Review and Meta-Analysis. J Bone Miner Res. 2020;35(3):446\u201359.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"8473_CR10","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1111\/hae.13591","volume":"24","author":"P Xafaki","year":"2018","unstructured":"Xafaki P, Balanika A, Pergantou H, Papakonstantinou O, Platokouki H. Impact of target joint and FVIII inhibitor omicronn bone properties in children with haemophilia A: A peripheral quantitative computed tomography study. Haemophilia. 2018;24(5):800\u20136.","journal-title":"Haemophilia"},{"issue":"13","key":"8473_CR11","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1182\/blood-2014-10-602060","volume":"125","author":"A Lee","year":"2015","unstructured":"Lee A, Boyd SK, Kline G, Poon MC. Premature changes in trabecular and cortical microarchitecture result in decreased bone strength in hemophilia. Blood. 2015;125(13):2160\u20133.","journal-title":"Blood"},{"key":"8473_CR12","unstructured":"Thrombosis, Hemostasis Group HSoCMA, Hemophilia Treatment Center Collaborative Network of C: Consensus of Chinese expert on the diagnosis and treatment of hemophilia (version 2017). Chinese J Hematol\u00a02017, 38(5):364\u2013370."},{"issue":"6","key":"8473_CR13","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.bone.2008.08.106","volume":"43","author":"EM Lewiecki","year":"2008","unstructured":"Lewiecki EM, Gordon CM, Baim S, Leonard MB, Bishop NJ, Bianchi ML, Kalkwarf HJ, Langman CB, Plotkin H, Rauch F, et al. International Society for Clinical Densitometry 2007 Adult and Pediatric Official Positions. Bone. 2008;43(6):1115\u201321.","journal-title":"Bone"},{"issue":"11","key":"8473_CR14","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1002\/jbmr.4116","volume":"35","author":"F Yu","year":"2020","unstructured":"Yu F, Xu Y, Hou Y, Lin Y, Jiajue R, Jiang Y, Wang O, Li M, Xing X, Zhang L, et al. Age-, Site-, and Sex-Specific Normative Centile Curves for HR-pQCT-Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population. J Bone Miner Res. 2020;35(11):2159\u201370.","journal-title":"J Bone Miner Res"},{"issue":"9","key":"8473_CR15","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s00198-020-05438-5","volume":"31","author":"DE Whittier","year":"2020","unstructured":"Whittier DE, Boyd SK, Burghardt AJ, Paccou J, Ghasem-Zadeh A, Chapurlat R, Engelke K, Bouxsein ML. Guidelines for the assessment of bone density and microarchitecture in vivo using high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2020;31(9):1607\u201327.","journal-title":"Osteoporos Int"},{"issue":"1","key":"8473_CR16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00277-009-0759-x","volume":"89","author":"O Katsarou","year":"2010","unstructured":"Katsarou O, Terpos E, Chatzismalis P, Provelengios S, Adraktas T, Hadjidakis D, Kouramba A, Karafoulidou A. Increased bone resorption is implicated in the pathogenesis of bone loss in hemophiliacs: correlations with hemophilic arthropathy and HIV infection. Ann Hematol. 2010;89(1):67\u201374.","journal-title":"Ann Hematol"},{"issue":"1","key":"8473_CR17","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1186\/s12891-023-06795-y","volume":"24","author":"D Wu","year":"2023","unstructured":"Wu D, Shen S. Osteoporosis and associated risk factors in patients with severe hemophilia A: a case-control study from China. BMC Musculoskelet Disord. 2023;24(1):657.","journal-title":"BMC Musculoskelet Disord"},{"issue":"6","key":"8473_CR18","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/ajh.20877","volume":"82","author":"AP Nair","year":"2007","unstructured":"Nair AP, Jijina F, Ghosh K, Madkaikar M, Shrikhande M, Nema M. Osteoporosis in young haemophiliacs from western India. Am J Hematol. 2007;82(6):453\u20137.","journal-title":"Am J Hematol"},{"issue":"5","key":"8473_CR19","doi-asserted-by":"publisher","first-page":"e315","DOI":"10.1111\/hae.13836","volume":"25","author":"O Ekinci","year":"2019","unstructured":"Ekinci O, Demircioglu S, Dogan A, Merter M, Yildiz S, Demir C. Decreased bone mineral density and associated factors in severe haemophilia A patients: A case-control study. Haemophilia. 2019;25(5):e315\u201321.","journal-title":"Haemophilia"},{"issue":"7","key":"8473_CR20","doi-asserted-by":"publisher","first-page":"e259","DOI":"10.1097\/MPH.0b013e3181e8cd40","volume":"32","author":"A Christoforidis","year":"2010","unstructured":"Christoforidis A, Economou M, Papadopoulou E, Kazantzidou E, Gompakis N, Athanassiou-Metaxa M. Bone status of children with hemophilia A assessed with quantitative ultrasound sonography (QUS) and dual energy X-ray absorptiometry (DXA). J Pediatr Hematol Oncol. 2010;32(7):e259\u2013263.","journal-title":"J Pediatr Hematol Oncol"},{"issue":"5","key":"8473_CR21","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nrrheum.2014.23","volume":"10","author":"P Geusens","year":"2014","unstructured":"Geusens P, Chapurlat R, Schett G, Ghasem-Zadeh A, Seeman E, de Jong J, van den Bergh J. High-resolution in vivo imaging of bone and joints: a window to microarchitecture. Nat Rev Rheumatol. 2014;10(5):304\u201313.","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"8473_CR22","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1530\/EJE-18-0711","volume":"180","author":"H Yang","year":"2019","unstructured":"Yang H, Yan K, Yuping X, Zhang Q, Wang L, Gong F, Zhu H, Xia W, Pan H. Bone microarchitecture and volumetric bone density impairment in young male adults with childhood-onset growth hormone deficiency. Eur J Endocrinol. 2019;180(2):145\u201353.","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"8473_CR23","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jocd.2018.07.009","volume":"23","author":"L Cui","year":"2020","unstructured":"Cui L, Xu Y, Xu Q, Jiang Y, Wang O, Li M, Xing X, Xia W. Atypical Femoral Fracture Associated With Overuse of Bisphosphonate Evaluated by High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT). J Clin Densitom. 2020;23(2):329\u201334.","journal-title":"J Clin Densitom"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-025-08473-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12891-025-08473-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-025-08473-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:27:18Z","timestamp":1741861638000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/s12891-025-08473-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8473"],"URL":"https:\/\/doi.org\/10.1186\/s12891-025-08473-7","relation":{},"ISSN":["1471-2474"],"issn-type":[{"type":"electronic","value":"1471-2474"}],"subject":[],"published":{"date-parts":[[2025,3,11]]},"assertion":[{"value":"2 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Medical Ethics Committee of Peking Union Medical College Hospital, Beijing, China and was conducted in accordance with the Helsinki Declaration. A written informed consent was obtained from each patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have read and approved the final manuscript and consent to its publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"242"}}