{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:57:07Z","timestamp":1754110627170},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Appendiceal inversion with neoplasia in adults is an extremely rare event with a reported incidence of &lt;\u20090.01%. Preoperative diagnosis is very important for surgical treatment; however, it is very difficult to be exact.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>The patient was a 60-year-old woman with complaints of intermittent abdominal pain. Computed tomography and colonoscopy revealed a cecal mass, which was diagnosed as a tubulovillous adenoma in the preoperative colonoscopic biopsy. At surgery, the appendix was found to be completely inverted into the cecum. The cecum was partially resected, and surgical pathology examination confirmed a tubulovillous adenoma of the appendix with local high-grade intraepithelial neoplasia.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Although preoperative diagnosis of appendiceal inversion with neoplasia may be often difficult due to its non-specific symptoms, clinicians should consider this disease entity when they encounter an intraluminal protruding cecal mass without visualization of the normal appendix on CT and colonoscopy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12893-019-0632-3","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T14:03:25Z","timestamp":1573481005000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Complete appendiceal inversion with local high-grade intraepithelial neoplasia in an adult female: a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Xinlu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongsheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,11]]},"reference":[{"key":"632_CR1","first-page":"265","volume":"14","author":"DC Collins","year":"1963","unstructured":"Collins DC. 71,000 human appendix specimens. A final report, summarizing forty Years' study. Am J Proctol. 1963;14:265\u201381.","journal-title":"Am J Proctol"},{"issue":"1","key":"632_CR2","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.amjsurg.2008.08.023","volume":"198","author":"CI Chaar","year":"2009","unstructured":"Chaar CI, Wexelman B, Zuckerman K, Longo W. Intussusception of the appendix: comprehensive review of the literature. Am J Surg. 2009;198(1):122\u20138.","journal-title":"Am J Surg"},{"issue":"9","key":"632_CR3","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ijscr.2012.04.019","volume":"3","author":"SA Laalim","year":"2012","unstructured":"Laalim SA, Toughai I, Benjelloun el B, Majdoub KH, Mazaz K. Appendiceal intussusception to the cecum caused by mucocele of the appendix: laparoscopic approach. Int J Surg Case Rep. 2012;3(9):445\u20137.","journal-title":"Int J Surg Case Rep"},{"issue":"2","key":"632_CR4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/BF02586780","volume":"22","author":"S Holck","year":"1979","unstructured":"Holck S, Wolff M. Intussusception with incarceration of a cystadenoma of the appendix: case report and review of the complications of appendiceal adenomas. Dis Colon Rectum. 1979;22(2):133\u20138.","journal-title":"Dis Colon Rectum"},{"issue":"1","key":"632_CR5","first-page":"55","volume":"31","author":"Hemakini","year":"2010","unstructured":"Hemakini, Kaur H, Khadilkar U, Rau AR, Rao HT, Tantry BV. \"the inside out appendix\"--report of 2 cases. Trop Gastroenterol. 2010;31(1):55\u20136.","journal-title":"Trop Gastroenterol"},{"issue":"5","key":"632_CR6","first-page":"1161","volume":"22","author":"A Bergnach","year":"1967","unstructured":"Bergnach A. On the invagination of the appendix vermiformis (presentation of a clinical case). Il Friuli medico. 1967;22(5):1161\u20138.","journal-title":"Il Friuli medico"},{"issue":"1","key":"632_CR7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12893-018-0380-9","volume":"18","author":"BS Park","year":"2018","unstructured":"Park BS, Shin DH, Kim DI, Son GM, Kim HS. Appendiceal intussusception requiring an ileocecectomy: a case report and comment on the optimal surgery. BMC Surg. 2018;18(1):48.","journal-title":"BMC Surg"},{"issue":"162","key":"632_CR8","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/bjs.18004016203","volume":"40","author":"I Forshall","year":"1953","unstructured":"Forshall I. Intussusception of the vermiform appendix with a report of seven cases in children. Br J Surg. 1953;40(162):305\u201312.","journal-title":"Br J Surg"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-019-0632-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12893-019-0632-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-019-0632-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:30:11Z","timestamp":1604968211000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-019-0632-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,11]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["632"],"URL":"https:\/\/doi.org\/10.1186\/s12893-019-0632-3","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,11]]},"assertion":[{"value":"24 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The case report was exempt from review by the Ethics Committee of the First Affiliated Hospital of Dalian Medical University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"A written informed consent was obtained from the patient for the publication of this case report and accompanying images. And the consent for publication is available for review by the editor of the journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The datasets used and\/or analysed during the current study available from the corresponding author on reasonable request. All authors declared that they have no conflict of interest. JZ is an assistant editor on the BMC Series, but is not an Assistant Editor on BMC surgery and had no role in the editorial process of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"168"}}