{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:58:59Z","timestamp":1785243539178,"version":"3.55.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81702651"],"award-info":[{"award-number":["81702651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M611313"],"award-info":[{"award-number":["2017M611313"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20170520018JH and 20190201225JC"],"award-info":[{"award-number":["20170520018JH and 20190201225JC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>In this study, we aimed to compare the kinetics of intact parathyroid hormone (iPTH) during the perioperative period of endoscopic thyroidectomy via bilateral areola approach (ETBAA) in the same period, following a traditional open thyroidectomy approach (OTA).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We conducted a prospective observational study of patients who were undergoing thyroidectomy and level VI clearance. Patients who had been affected by papillary thyroid cancer (PTC) were stratified into three groups: those eligible for endoscopic treatment (ETBAA); patients who were eligible for ETBAA but had opted for OTA (OTA-L); and patients who were not suitable for endoscopic intervention (OTA-H). A process for locating parathyroid glands was utilized to stratify gland dissection laboriousness. In Type A, the gland is firmly fixed to thyroid gland. This type can be sub-classified into three subtypes. A1: the parathyroid gland is attached to the inherent thyroid capsule. A2: the gland is partially embedded in the thyroid gland. A3: the gland is located in the thyroid tissue. Type B is defined as a gland which is separated from the thyroid gland. The iPTH was sampled at wound closure.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>There were 100 patients in each group. We found a significant difference between the ETBAA and OTA-H groups for type A2, as well as a loss of parathyroid glands and a number of parathyroid transplantation procedures. The endoscopic group was treated during an earlier stage of thyroid cancer. The iPTH profile of each group decreased, although this was the most consistent in the OTA-H group. A comparison of ETBAA with OTA-L demonstrates that the iPTH level change is similar.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>There is no advantage of endoscopic treatment for preserving parathyroid function.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12893-019-0656-8","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T16:04:04Z","timestamp":1576080244000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of parathyroid hormone kinetics in endoscopic thyroidectomy via bilateral areola with open thyroidectomy"],"prefix":"10.1186","volume":"19","author":[{"given":"Daqi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianlorenzo","family":"Dionigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofeng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8348-4933","authenticated-orcid":false,"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"issue":"5","key":"656_CR1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.amjsurg.2013.01.038","volume":"206","author":"MT Juli\u00e1n","year":"2013","unstructured":"Juli\u00e1n MT, Balibrea JM, Granada ML, Moreno P, Alastru\u00e9 A, Puig-Domingo M, Lucas A. Intact parathyroid hormone measurement at 24 hours after thyroid surgery as predictor of parathyroid function at long term. Am J Surg. 2013;206(5):783\u20139. https:\/\/doi.org\/10.1016\/j.amjsurg.2013.01.038 Epub 2013 Jul 5. PubMed PMID: 23835208.2.","journal-title":"Am J Surg"},{"issue":"6","key":"656_CR2","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.jamcollsurg.2007.06.298","volume":"205","author":"JP Noordzij","year":"2007","unstructured":"Noordzij JP, Lee SL, Bernet VJ, Payne RJ, Cohen SM, McLeod IK, Hier MP, Black MJ, Kerr PD, Richards ML, Lo CY, Raffaelli M, Bellantone R, Lombardi CP, Cohen JI, Dietrich MS. Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies. J Am Coll Surg. 2007;205(6):748\u201354 Epub 2007 Sep 18. PubMed PMID: 18035257.","journal-title":"J Am Coll Surg"},{"issue":"6","key":"656_CR3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.2310\/7070.2003.13985","volume":"32","author":"RJ Payne","year":"2003","unstructured":"Payne RJ, Hier MP, Tamilia M, Young J, MacNamara E, Black MJ. Postoperative parathyroid hormone level as a predictor of post-thyroidectomy hypocalcemia. J Otolaryngol. 2003;32(6):362\u20137 PubMed PMID: 14967080.","journal-title":"J Otolaryngol"},{"issue":"3","key":"656_CR4","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.otohns.2005.02.021","volume":"133","author":"RJ Payne","year":"2005","unstructured":"Payne RJ, Tewfik MA, Hier MP, Tamilia M, Mac Namara E, Young J, Black MJ. Benefits resulting from 1- and 6-hour parathyroid hormone and calcium levels after thyroidectomy. Otolaryngol Head Neck Surg. 2005;133(3):386\u201390 PubMed PMID: 16143187.","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"656_CR5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.2310\/7070.2005.34505","volume":"34","author":"RJ Payne","year":"2005","unstructured":"Payne RJ, Hier MP, C\u00f4t\u00e9 V, Tamilia M, MacNamara E, Black MJ. Postoperative parathyroid hormone levels in conjunction with corrected calcium values as a predictor of post-thyroidectomy hypocalcemia: review of outcomes 1 year after the implementation of a new protocol. J Otolaryngol. 2005;34(5):323\u20137 PubMed PMID: 16181594.6.","journal-title":"J Otolaryngol"},{"key":"656_CR6","doi-asserted-by":"publisher","first-page":"78","DOI":"10.5935\/1808-8694.20120012","volume":"78","author":"AJ Graciano","year":"2012","unstructured":"Graciano AJ, Chone CT, Fischer CA. Applicability of immediate, late or serial intact parathyroid hormone measurement following total thyroidectomy. Braz J Otorhinolaryngol. 2012;78:78\u201382. https:\/\/doi.org\/10.5935\/1808-8694.20120012.","journal-title":"Braz J Otorhinolaryngol"},{"issue":"4","key":"656_CR7","doi-asserted-by":"publisher","first-page":"594","DOI":"10.5812\/ijem.3462","volume":"10","author":"Y Yano","year":"2012","unstructured":"Yano Y, Masaki C, Sugino K, Nagahama M, Kitagawa W, Sibuya H, Ito K. Serum intact parathyroid hormone level after total thyroidectomy or total thyroidectomy plus lymph node dissection for thyroid nodules: report from 296 surgical cases. Int J Endocrinol Metab. 2012;10(4):594\u20138. https:\/\/doi.org\/10.5812\/ijem.3462 Epub 2012 Sep 30. 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Parathyroid hormone: an early predictor of symptomatic hypocalcemia after total thyroidectomy. Arq Bras Endocrinol Metabol. 2012;56(3):168\u201372 PubMed PMID: 22666731.10.","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"3","key":"656_CR10","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3349\/ymj.2013.54.3.637","volume":"54","author":"JP Kim","year":"2013","unstructured":"Kim JP, Park JJ, Son HY, Kim RB, Kim HY, Woo SH. Effectiveness of an i-PTH measurement in predicting post thyroidectomy hypocalcemia: prospective controlled study. Yonsei Med J. 2013;54(3):637\u201342. https:\/\/doi.org\/10.3349\/ymj.2013.54.3.637 PubMed PMID: 23549808; PubMed Central PMCID: PMC3635650.","journal-title":"Yonsei Med J"},{"key":"656_CR11","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1007\/s00268-012-1561-9","volume":"36","author":"BH Lang","year":"2012","unstructured":"Lang BH, Yih PC, Ng KK. A prospective evaluation of quick intraoperative parathyroid hormone assay at the time of skin closure in predicting clinically relevant hypocalcemia after thyroidectomy. World J Surg. 2012;36:1300\u20136. https:\/\/doi.org\/10.1007\/s00268-012-1561-9.","journal-title":"World J Surg"},{"issue":"1","key":"656_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016;26(1):1\u2013133. https:\/\/doi.org\/10.1089\/thy.2015.0020 Review. 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World J Surg. 2019;43(11):2829\u201341. https:\/\/doi.org\/10.1007\/s00268-019-05092-x PubMed PMID: 31367782.","journal-title":"World J Surg"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-019-0656-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12893-019-0656-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-019-0656-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:39:25Z","timestamp":1607560765000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-019-0656-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["656"],"URL":"https:\/\/doi.org\/10.1186\/s12893-019-0656-8","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"28 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in studies involving human participants were in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards, while the protocol was approved by the ethics committee of China-Japan Union Hospital of Jilin University (see protocol n. 2012-wjw-004). Informed consent of written was obtained from all individual participants included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"190"}}