{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:33:51Z","timestamp":1787020431798,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perforated peptic ulcer disease is a surgical emergency with a high morbidity and mortality. The socio-demographic characteristic and the factors associated with morbidity and mortality seems to differ between the developed and developing world. This is the first a prospective cohort study in Ethiopia designed to analyze pattern and outcome of patients with perforated peptic ulcer disease in four teaching hospitals affiliated with SOM, CHS of Addis Ababa University.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This is a prospective cohort study of patients operated for perforated peptic ulcer disease from June 1, 2018 to May 31, 2019 in four teaching hospital affiliated to department of surgery of SOM, CHS of Addis Ababa university.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>A total of 97 patients were operated in a year. 86.6% were males with a male to female ratio of 6.5:1. The age group 21\u201330 were most affected constituting 42.3% of all patients. Mean age is 31.9, Median of 27, age ranges from 16 to 76. Alcohol use (45.4%) and previous history of ulcer disease (75.3%) were the most prevalent risk factors.33% were smokers. Abdominal was present in all and most presented within 48\u2009h (79.4%). 85.6% had pneumo\u2009=\u2009peritoneum in an x-ray at presentation. Size of the perforation is 10\u2009mm or less in 81.3%. 91(93.8%) had anterior first part duodenum perforation. Repair with pedicled omental patch was done in 65 (67.1%) patients. Age, duration of presentation, hypotension at presentation, size of perforation, degree of peritoneal contamination were found to be the significant factors for morbidity and mortality. Major morbidities were observed in 16 (16.5%) and mortality occurred in 3 (3.1%) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Perforation of peptic ulcer disease here occurs in the young. Age, duration of presentation, hypotension at presentation, size of perforation, degree of peritoneal contamination were found to be the significant factors for morbidity and mortality. Morbidity and mortality rate of 16.5 and 3.1% observed here are quite acceptable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12893-020-00796-7","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T10:03:46Z","timestamp":1592215426000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pattern and outcome of perforated peptic ulcer disease patient in four teaching hospitals in Addis Ababa, Ethiopia: a prospective cohort multicenter study"],"prefix":"10.1186","volume":"20","author":[{"given":"Jatani Arero","family":"Bupicha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-4193","authenticated-orcid":false,"given":"Hailu Wondimu","family":"Gebresellassie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abebe","family":"Alemayehu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"796_CR1","volume-title":"Epidemiology and etiology of peptic ulcer disease","author":"NB Vakil","year":"2018","unstructured":"Vakil NB. In: Feldman M, editor. Epidemiology and etiology of peptic ulcer disease; 2018. Available from: Epidemiology and etiology of peptic ulcer disease - UpToDate."},{"key":"796_CR2","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/S0140-6736(15)00276-7","volume":"386","author":"K S\u00f8reide","year":"2015","unstructured":"S\u00f8reide K, Thorsen K, Harrison EM, Bingener J, M\u00f8ller MH, Ohene-yeboah M, et al. Perforated peptic ulcer. Lancet. 2015;386:1288\u201398.","journal-title":"Lancet."},{"key":"796_CR3","doi-asserted-by":"crossref","unstructured":"Kang JY, Elders A, Majee AD, Ll JDM, Bardhan KD. Recent trends in hospital admissions and mortality rates for peptic ulcer in Scotland 1982\u20132002. Aliment Pharmacol Ther Recent trends Hosp admissions Mortal rates peptic ulcer Scotl 1982\u20132002 J Y KANG*, A ELDERS ,AMAJEED\u00e0,J DMAXWELL* &K DBARDHAN\u00a7 *Department. 2006;24(1):65\u201379.","DOI":"10.1111\/j.1365-2036.2006.02960.x"},{"key":"796_CR4","doi-asserted-by":"publisher","unstructured":"Gebresellassie HW, Tamerat G. Audit of surgical services in a teaching hospital in Addis Ababa , Ethiopia. BMC Res Notes. 20191\u20135. Available from. https:\/\/doi.org\/10.1186\/s13104-019-4709-y.","DOI":"10.1186\/s13104-019-4709-y"},{"issue":"2","key":"796_CR5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4314\/ecajs.v23i2.2","volume":"23","author":"G Tamrat","year":"2018","unstructured":"Tamrat G, Osman M, Deyessa N, Taye M, Lett R, Bekele A. Delay of emergency surgical interventions in Ethiopia : patient and health system factors. 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J Gastrointest Surg. 2016;20(4):840\u201350.","journal-title":"J Gastrointest Surg"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-020-00796-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12893-020-00796-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-020-00796-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:17:20Z","timestamp":1696231040000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-020-00796-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["796"],"URL":"https:\/\/doi.org\/10.1186\/s12893-020-00796-7","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,15]]},"assertion":[{"value":"3 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval were obtained from the department of surgery\u2019s research and publication committee as well as the school of medicine of CHS of AAU in a letter dated April 12, 2018. Written consent to participate were obtained from each patient.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The department of surgery as well as the school encourage publication of research works. All the participants gave a written consent for their personal and clinical details.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no competing interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"135"}}