{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:17:58Z","timestamp":1759742278505},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Szeged Open Access Fund","award":["4552"],"award-info":[{"award-number":["4552"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Benign foregut cysts usually develop in the thorax most of all in the mediastinum. Rare cases involving various abdominal organs, such as liver, stomach or pancreas have been previously published, mostly occurring in the retroperitoneum.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We herein present an adenocarcinoma of a foregut cyst involving the left side of the diaphragm, left lower lobe of the lung, and left lobe of the liver, successfully removed through multivisceral resection. In between drug holidays, postoperative oncological treatment has been ongoing for nearly 4\u00a0years. In terms of chemotherapy, FOLFOX 4 regime, capacitabine monotherapy and later on next generation sequencing has been attempted, although the patient refused the later treatment option. Despite multimodality (combined surgical and oncological) treatment, local- and later on loco-regional recurrence has been detected on follow-up staging, influencing further chemotherapy regime. Taking both the fairly unknown type of the tumor and uncertain response rate to oncological therapy into account, prolonged tumor pace with fairly stable general patient state was reached throughout the course of the disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Through surgical tumor resection, and postoperative chemotherapy the patient managed to maintain an acceptable quality of life without major symptoms during ongoing treatment. During our own case, with multiple organ involvement, multivisceral resection, with multimodality treatment had considerable effect in prolonging the lifespan of the patient.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-020-01005-1","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T13:04:06Z","timestamp":1607951046000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adenocarcinoma arising from a foregut cyst of the diaphragm: importance of multimodality treatment: a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Jozsef","family":"Furak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rieth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurel","family":"Ottlakan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Torday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Tiszlavicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyorgy","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"1005_CR1","first-page":"199","volume-title":"ESTS textbook of thoracic surgery","author":"P Mordant","year":"2015","unstructured":"Mordant P, Le Pimpec-Barthes F, Gangi A, et al. Tumours of the diaphragm. In: Kuzdzal J, editor., et al., ESTS textbook of thoracic surgery. Cracow: Medycyna Praktyczna; 2015. p. 199\u2013208."},{"key":"1005_CR2","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00247-003-1014-6","volume":"33","author":"J Esparza Esta\u00fan","year":"2003","unstructured":"Esparza Esta\u00fan J, Gonz\u00e1lez Alfageme A, S\u00e1enz BJ. Radiological appearance of diaphragmatic mesothelial cysts. Pediatr Radiol. 2003;33:855\u20138.","journal-title":"Pediatr Radiol"},{"key":"1005_CR3","first-page":"324","volume":"38","author":"FW Clark","year":"1886","unstructured":"Clark FW. Subpleural lipoma of diaphragm. Trans Path Soc Lond. 1886;38:324.","journal-title":"Trans Path Soc Lond"},{"key":"1005_CR4","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s002610000155","volume":"26","author":"M Froehner","year":"2001","unstructured":"Froehner M, Ockert D, Bunk A. Liposarcoma of the diaphragm: CT and sonographic appearances. Abdom Imaging. 2001;26:300\u20132.","journal-title":"Abdom Imaging"},{"key":"1005_CR5","doi-asserted-by":"crossref","unstructured":"Raney RB, Anderson JR, Andrassy RJ. Intergroup Rhabdomyosarcoma Study Group. Softtissue sarcomas of the diaphragm: a report from the Intergroup Rhabdomyosarcoma Study Group from 1972 to 1997. J Pediatr Hematol Oncol. 2000;22:510\u20134.","DOI":"10.1097\/00043426-200011000-00007"},{"key":"1005_CR6","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1055\/s-2007-959246","volume":"61","author":"S Kr\u00fcger","year":"2007","unstructured":"Kr\u00fcger S, Kratochwil C, Schumann C. Leiomyosarcoma of the diaphragm 20 years after resection of a diaphragmatic leiomyoma. Pneumologie. 2007;61:456\u20137.","journal-title":"Pneumologie"},{"key":"1005_CR7","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1055\/s-0036-1582256","volume":"64","author":"N Baldes","year":"2016","unstructured":"Baldes N, Schirren J. Primary and secondary tumors of the diaphragm. Thorac Cardiovasc Surg. 2016;64:641\u20136.","journal-title":"Thorac Cardiovasc Surg"},{"key":"1005_CR8","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1046\/j.1440-1827.1999.00869.x","volume":"49","author":"SM Sullivan","year":"1999","unstructured":"Sullivan SM, Okada S, Kudo M. A retroperitoneal bronchogenic cyst with malignant change. Pathol Int. 1999;49:338\u201341.","journal-title":"Pathol Int"},{"key":"1005_CR9","doi-asserted-by":"publisher","first-page":"387","DOI":"10.21037\/jgo.2017.01.04","volume":"8","author":"TH Au","year":"2017","unstructured":"Au TH, Wang K, Stenehjem D. Personalized and precision medicine: integrating genomics into treatment decisions in gastrointestinal malignancies. 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Wien Klin Wochenschr. 2013;125:283\u20137.","journal-title":"Wien Klin Wochenschr"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-020-01005-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12893-020-01005-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-020-01005-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T13:20:17Z","timestamp":1607952017000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-020-01005-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1005"],"URL":"https:\/\/doi.org\/10.1186\/s12893-020-01005-1","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"12 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethics approval and consent to participate were both obtained. Ethics approval has been granted by the Human Investigation Review Board of the University of Szeged, Faculty of Medicine, approval number: 4703. Written informed consent was obtained from patient\u2019s next of kin for publication of the manuscript, use of patient data and accompanying images.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from patient next of kin for publication of the manuscript and accompanying images. All authors confirm that written informed consent was obtained from family members of the patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"332"}}