{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:55:51Z","timestamp":1775246151554,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3H1651"],"award-info":[{"award-number":["CMRPG3H1651"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To evaluate the use of a human fibrin glue (Tisseel) for minor bleeding control and approximation of ovarian defect during transvaginal natural orifice ovarian cystectomy (TNOOC) of benign and non-endometriotic ovarian tumors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 125 women with benign and non-endometriotic ovarian tumors who underwent TNOOC between May 2011 and January 2020: 54 with the aid of Tisseel and 71 with traditional suture for hemostasis and approximation of ovarian defect. Surgical outcomes such as length of surgery, operative blood loss, postoperative pain score, and postoperative hospital stay were recorded. Before and immediately (10\u00a0days) and at 6\u00a0months after the procedure, serum anti-M\u00fcllerian hormone (AMH) levels were also determined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Complete hemostasis and approximation of ovarian defect were achieved in all cases. No significant difference was noted in the operating time, operative blood loss, postoperative pain scores after 12, 24 and 48\u00a0h, length of postoperative stay, and baseline AMH levels between the two groups. The operation did not have a negative effect on the immediate and 6-month postoperative AMH levels in the suture group. However, the decline in the AMH levels was significant immediately after surgery in the Tisseel group, nevertheless, no significant difference was noted in the AMH levels at 6\u00a0months (3.3 <jats:italic>vs.<\/jats:italic> 1.7\u00a0mg\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.042, adjusted <jats:italic>p<\/jats:italic>\u2009=\u20090.210).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The use of Tisseel in TNOOC of benign and non-endometriotic ovarian tumors without suturing the ovarian tissue is clinically safe and feasible.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-021-01061-1","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T11:04:06Z","timestamp":1611227046000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Use of human fibrin glue (Tisseel) versus suture during transvaginal natural orifice ovarian cystectomy of benign and non-endometriotic ovarian tumor: a retrospective comparative study"],"prefix":"10.1186","volume":"21","author":[{"given":"Yu-Ying","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Shan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan-Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Bin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy Hsuan","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Yun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5730-6551","authenticated-orcid":false,"given":"Chin-Jung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"1061_CR1","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1046\/j.1469-0705.1999.13050345.x","volume":"13","author":"C Borgfeldt","year":"1999","unstructured":"Borgfeldt C, Andolf E. Transvaginal sonographic ovarian findings in a random sample of women 25\u201340 years old. Ultrasound Obstet Gynecol. 1999;13:345\u201350.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1061_CR2","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1056\/NEJMra041842","volume":"351","author":"SA Cannistra","year":"2004","unstructured":"Cannistra SA. Cancer of the ovary. N Engl J Med. 2004;351:2519\u201329.","journal-title":"N Engl J Med"},{"key":"1061_CR3","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.ogc.2011.09.003","volume":"38","author":"C Nezhat","year":"2011","unstructured":"Nezhat C, Cho J, King LP, Hajhosseini B, Nezhat F. Laparoscopic management of adnexal masses. Obstet Gynecol Clin North Am. 2011;38:663\u20136.","journal-title":"Obstet Gynecol Clin North Am"},{"key":"1061_CR4","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.tjog.2013.10.008","volume":"52","author":"MP Wu","year":"2013","unstructured":"Wu MP, Wu CJ, Long CY, Ho CH, Huang KH, Chu CC, Chou CY. Surgical trends for benign ovarian tumors among hospitals of different accreditation levels: an 11-year nationwide population-based descriptive study in Taiwan. Taiwan J Obstet Gynecol. 2013;52:498\u2013504.","journal-title":"Taiwan J Obstet Gynecol"},{"key":"1061_CR5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/S1074-3804(05)60552-X","volume":"8","author":"L Mettler","year":"2001","unstructured":"Mettler L, Jacobs V, Brandenburg K, Jonat W, Semm K. Laparoscopic management of 641 adnexal tumors in Kiel. Germany J Am Assoc Gynecol Laparosc. 2001;8:74\u201382.","journal-title":"Germany J Am Assoc Gynecol Laparosc"},{"key":"1061_CR6","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1089\/lap.2009.0085","volume":"19","author":"CJ Wang","year":"2009","unstructured":"Wang CJ, Chao A, Lai CH, Huang SY, Lee CL, Soong YK. Laparoscopically assisted vaginal ovarian cystectomy for clinically diagnosed benign large ovarian masses. J Laparoendosc Adv Surg Tech A. 2009;19:623\u20138.","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"1061_CR7","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.jmig.2012.04.001","volume":"19","author":"KH Ahn","year":"2012","unstructured":"Ahn KH, Song JY, Kim SH, Lee KW, Kim T. Transvaginal single-port natural orifice transluminal endoscopic surgery for benign uterine adnexal pathologies. J Minim Invasive Gynecol. 2012;19:631\u20135.","journal-title":"J Minim Invasive Gynecol"},{"key":"1061_CR8","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jmig.2019.04.009","volume":"27","author":"YT Huang","year":"2020","unstructured":"Huang YT, Yang LY, Pan YB, Huang HY, Wu KY, Wang CJ, Weng CH. Learning curve analysis of transvaginal natural orifice adnexal surgery. J Minim Invasive Gynecol. 2020;27:489\u201397.","journal-title":"J Minim Invasive Gynecol"},{"key":"1061_CR9","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.tjog.2017.04.013","volume":"56","author":"YC Li","year":"2017","unstructured":"Li YC, Ku FC, Kuo HH, Tseng HJ, Wang CJ. Transvaginal endoscopic surgery-assisted versus conventional laparoscopic adnexectomy (TVEA vs CLA): a propensity-matched study and literature review. Taiwan J Obstet Gynecol. 2017;56:336\u201341.","journal-title":"Taiwan J Obstet Gynecol."},{"key":"1061_CR10","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s00464-015-4315-6","volume":"30","author":"CJ Wang","year":"2016","unstructured":"Wang CJ, Wu PY, Kuo HH, Yu HT, Huang CY, Tseng HT. Natural orifice transluminal endoscopic surgery-assisted versus laparoscopic ovarian cystectomy (NAOC vs LOC): a case-matched study. Surg Endosc. 2016;30:1227\u201334.","journal-title":"Surg Endosc."},{"key":"1061_CR11","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1111\/jog.12108","volume":"39","author":"YS Yang","year":"2013","unstructured":"Yang YS, Hur MH, Oh KY, Kim SY. Transvaginal natural orifice transluminal endoscopic surgery for adnexal masses. J Obstet Gynaecol Res. 2013;39:1604\u20139.","journal-title":"J Obstet Gynaecol Res"},{"key":"1061_CR12","doi-asserted-by":"publisher","first-page":"863","DOI":"10.2165\/00003495-199958050-00010","volume":"58","author":"CJ Dunn","year":"1999","unstructured":"Dunn CJ, Goa KL. Fibrin sealant: a review of its use in surgery and endoscopy. Drugs. 1999;58:863\u201386.","journal-title":"Drugs"},{"key":"1061_CR13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.tjog.2017.04.014","volume":"56","author":"YC Liu","year":"2017","unstructured":"Liu YC, Li YC, Kuo HH, Wang CJ, Wu KY. The use of fibrin sealant (Tisseel) in laparoscopic excision of ovarian endometrioma. Taiwan J Obstet Gynecol. 2017;56:342\u20135.","journal-title":"Taiwan J Obstet Gynecol"},{"key":"1061_CR14","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ygyno.2007.08.085","volume":"108","author":"GH Eltabbakh","year":"2008","unstructured":"Eltabbakh GH, Charboneau AM, Eltabbakh NG. Laparoscopic surgery for large benign ovarian cysts. Gynecol Oncol. 2008;108:72\u20136.","journal-title":"Gynecol Oncol"},{"issue":"3 Suppl","key":"1061_CR15","doi-asserted-by":"publisher","first-page":"S33","DOI":"10.1016\/j.pain.2010.11.005","volume":"152","author":"TJ Brennan","year":"2011","unstructured":"Brennan TJ. Pathophysiology of postoperative pain. Pain. 2011;152(3 Suppl):S33-40.","journal-title":"Pain"},{"key":"1061_CR16","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.jpain.2008.02.004","volume":"9","author":"B Carvalho","year":"2008","unstructured":"Carvalho B, Clark DJ, Angst MS. Local and systemic release of cytokines, nerve growth factor, prostaglandin E2, and substance P in incisional wounds and serum following cesarean delivery. J Pain. 2008;9:650\u20137.","journal-title":"J Pain"},{"key":"1061_CR17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.4293\/108680813X13693422519875","volume":"18","author":"B Xu","year":"2014","unstructured":"Xu B, Liu Y, Ying X, Fan Z. Transvaginal endoscopic surgery for tubal ectopic pregnancy. JSLS. 2014;18:76\u201382.","journal-title":"JSLS"},{"key":"1061_CR18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13048-014-0108-0","volume":"7","author":"Y Chen","year":"2014","unstructured":"Chen Y, Pei H, Chang Y, Chen M, Wang H, Xie H, Yao S. The impact of endometrioma and laparoscopic cystectomy on ovarian reserve and the exploration of related factors assessed by serum anti-Mullerian hormone: a prospective cohort study. J Ovarian Res. 2014;7:108.","journal-title":"J Ovarian Res"},{"issue":"589","key":"1061_CR19","first-page":"e1","volume":"215","author":"LR Goodman","year":"2016","unstructured":"Goodman LR, Goldberg JM, Flyckt RL, Gupta M, Harwalker J, Falcone T. Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. Am J Obstet Gynecol. 2016;215(589):e1\u20136.","journal-title":"Am J Obstet Gynecol"},{"key":"1061_CR20","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/ijgo.12884","volume":"146","author":"M Kostrzewa","year":"2019","unstructured":"Kostrzewa M, Wilczynski JR, Glowacka E, Zyla M, Szyllo K, Stachowiak G. One-year follow-up of ovarian reserve by three methods in women after laparoscopic cystectomy for endometrioma and benign ovarian cysts. Int J Gynaecol Obstet. 2019;146:350\u20136.","journal-title":"Int J Gynaecol Obstet"},{"key":"1061_CR21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jmig.2004.12.019","volume":"12","author":"L Muzii","year":"2005","unstructured":"Muzii L, Angioli R, Zullo M, Panici PB. The unexpected ovarian malignancy found during operative laparoscopy: incidence, management, and implications for prognosis. J Minim Invasive Gynecol. 2005;12:81\u20139; quiz 90\u20131.","journal-title":"J Minim Invasive Gynecol."},{"key":"1061_CR22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6839","author":"D Timmerman","year":"2010","unstructured":"Timmerman D, Ameye L, Fischerova D, Epstein E, Melis GB, Guerriero S, et al. Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group. BMJ. 2010. https:\/\/doi.org\/10.1136\/bmj.c6839.","journal-title":"BMJ"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01061-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12893-021-01061-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01061-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T11:13:46Z","timestamp":1611227626000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-021-01061-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1061"],"URL":"https:\/\/doi.org\/10.1186\/s12893-021-01061-1","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]},"assertion":[{"value":"31 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was given by the Institutional Review Board of the Chang Gung Memorial Hospital, Taoyuan, Taiwan on 6 April 2020, reference number 202000474B0. The consent to participate from the patients was waived by The Institutional Review Board of the Chang Gung Memorial Hospital due to the retrospective and non-interventional nature of the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All the authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"49"}}