{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:19:13Z","timestamp":1773933553122,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T00:00:00Z","timestamp":1613865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T00:00:00Z","timestamp":1613865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>During clinical practice we have noticed that some patients with hyperthyroidism have finer skin with less wrinkles, pores, and spots after thyroidectomy, and the improvement can be observed within a few weeks after the operation. However, there is no evidence or study in the literature to proof this finding.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Aim and objective<\/jats:title>\n                <jats:p>This study was designed to evaluate and quantify the skin characters of patients with hyperthyroidism before and after thyroidectomy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material and methods<\/jats:title>\n                <jats:p>This is a prospective study to include patients with hyperthyroidism who received total thyroidectomy between March 1st, 2018 and February 28th, 2019. The patients received blood test for T4 and TSH analysis and VISIA measurements for skin texture quantification, at the preoperative stage, three, and six months postoperatively. A total of 8 patients were included. Repeated measurement was used to determine the lab data and VISIA measurement changes before and after the operation. Mauchly\u2019s sphericity test was performed to determine whether the violation of sphericity occurs, and the Greenhouse\u2013Geisser correction was used when the violation of sphericity occurs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All the patients were female and generally healthy without systemic medical disease except the hyperthyroidism. The T4 and TSH levels were not significantly different before and after the thyroidectomy. In terms of the skin character measurements, the wrinkles, texture, pores, UV spots, and brown spots were not improved after thyroidectomy. A trend of improvement in spots, red area, and porphyrin was noted, although not statistically significant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Surgical removal of the thyroid gland in patients with hyperthyroidism does not improve the skin quality and texture in examinations via the VISIA system.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-021-01108-3","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T08:03:15Z","timestamp":1613894595000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigate the improvement of facial skin texture with the VISIA system after total thyroidectomy"],"prefix":"10.1186","volume":"21","author":[{"given":"Spencer C. H.","family":"Kuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faye","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Yu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Chen","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Hua","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,21]]},"reference":[{"issue":"10047","key":"1108_CR1","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S0140-6736(16)00278-6","volume":"388","author":"S De Leo","year":"2016","unstructured":"De Leo S, Lee SY, Braverman LE. Hyperthyroidism. Lancet (London, England). 2016;388(10047):906\u201318.","journal-title":"Lancet (London, England)"},{"issue":"3","key":"1108_CR2","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/cen.12816","volume":"84","author":"B Goichot","year":"2016","unstructured":"Goichot B, Caron P, Landron F, Bouee S. Clinical presentation of hyperthyroidism in a large representative sample of outpatients in France: relationships with age, aetiology and hormonal parameters. Clin Endocrinol. 2016;84(3):445\u201351.","journal-title":"Clin Endocrinol"},{"issue":"2","key":"1108_CR3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.emc.2013.12.001","volume":"32","author":"D Devereaux","year":"2014","unstructured":"Devereaux D, Tewelde SZ. Hyperthyroidism and thyrotoxicosis. 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Transl Pediatr. 2017;6(4):300\u201312.","journal-title":"Transl Pediatr"},{"issue":"11","key":"1108_CR6","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/BF03348807","volume":"15","author":"MJ van Soestbergen","year":"1992","unstructured":"van Soestbergen MJ, van der Vijver JC, Graafland AD. Recurrence of hyperthyroidism in multinodular goiter after long-term drug therapy: a comparison with Graves\u2019 disease. J Endocrinol Invest. 1992;15(11):797\u2013800.","journal-title":"J Endocrinol Invest"},{"issue":"11","key":"1108_CR7","first-page":"1312","volume":"13","author":"A Goldsberry","year":"2014","unstructured":"Goldsberry A, Hanke CW, Hanke KE. VISIA system: a possible tool in the cosmetic practice. JDD. 2014;13(11):1312\u20134.","journal-title":"JDD"},{"issue":"57\u201378","key":"1108_CR8","first-page":"55","volume":"61","author":"WM Ord","year":"1878","unstructured":"Ord WM. On Myxoedema, a term proposed to be applied to an essential condition in the \u201cCretinoid\u201d Affection occasionally observed in Middle-aged Women. Med Chir Trans. 1878;61(57\u201378):55.","journal-title":"Med Chir Trans"},{"issue":"5","key":"1108_CR9","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1097\/MED.0b013e328357b45e","volume":"19","author":"JD Safer","year":"2012","unstructured":"Safer JD. Thyroid hormone action on skin. Curr Opin Endocrinol Diabetes Obes. 2012;19(5):388\u201393.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"3","key":"1108_CR10","first-page":"680","volume":"76","author":"M Weiss","year":"1993","unstructured":"Weiss M, Milman B, Rosen B, Zimlichman R. Quantitation of thyroid hormone effect on skin perfusion by laser Doppler flowmetry. 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J Invest Dermatol. 1977;68(5):299\u2013301.","journal-title":"J Invest Dermatol"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01108-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12893-021-01108-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01108-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T08:03:20Z","timestamp":1613894600000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-021-01108-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,21]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1108"],"URL":"https:\/\/doi.org\/10.1186\/s12893-021-01108-3","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,21]]},"assertion":[{"value":"28 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the institutional review board (IRB) of the Kaohsiung Chang Gung Memorial Hospital, with the reference number of 201800309B0 and conformed to the ethical guidelines of the 1975 Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"94"}}