{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T23:16:44Z","timestamp":1773703004948,"version":"3.50.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401606"],"award-info":[{"award-number":["81401606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400862"],"award-info":[{"award-number":["81400862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010013","name":"Science Foundation for Excellent Youth Scholars of Sichuan University","doi-asserted-by":"publisher","award":["2015SU04A15"],"award-info":[{"award-number":["2015SU04A15"]}],"id":[{"id":"10.13039\/501100010013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2019HXFH056"],"award-info":[{"award-number":["2019HXFH056"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Neuroblastoma is the most common malignant extracranial solid tumor in pediatrics patients. Intraoperative hyperthermia is extremely rare in patients with neuroblastoma and can cause a series of complications. Here, we represent a case of neuroblastoma accompanied by hyperthermia during anesthesia, and propose a rational explanation and management options.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>The patient had gait disturbance and sitting-related pain without fever. Magnetic resonance imaging revealed a soft tissue mass located in the right posterior mediastinum, paravertebral space and canalis vertebralis. Serum tumor marker screening showed that the patient had increased epinephrine, norepinephrine and neuron specific enolase levels, with an increased 24\u00a0hour urine vanillylmandelic acid level. Intraspinal tumor resection was conducted. The temperature of the patient rapidly arose to 40.1\u2009\u00b0C over 10 minutes when waiting for tracheal extubation. The arterial gas analysis results indicated malignant hyperthermia was less likely, and dantrolene was not administered. Physical cooling methods were used, and the temperature dropped to 38.6\u00a0\u2103. The trachea was successfully extubated. Histological results confirmed the diagnosis of neuroblastoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Hyperthermia during anesthesia is a serious adverse event. Catecholamines secreted from neuroblatoma cells can lead to hypermetabolism and hyperthermia. Surgeons and anesthesiologists should be aware of the possibility of hyperthermia in patients with neuroblastoma.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-021-01124-3","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T03:02:32Z","timestamp":1614913352000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hyperthermia in a pediatric patient with neuroblastoma during anesthesia: a case report"],"prefix":"10.1186","volume":"21","author":[{"given":"Chuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-9660","authenticated-orcid":false,"given":"Yi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"1124_CR1","first-page":"e1470-7","volume":"121","author":"J Li","year":"2008","unstructured":"Li J, Thompson TD, Miller JW, Pollack LA, Stewart SL. Cancer incidence among children and adolescents in the United States, 2001\u20132003. Pediatrics. 2008;121:e1470-7.","journal-title":"Pediatrics"},{"key":"1124_CR2","doi-asserted-by":"publisher","first-page":"37730","DOI":"10.18632\/oncotarget.17146","volume":"8","author":"WG He","year":"2017","unstructured":"He WG, Yan Y, Tang W, Cai R, Ren G. Clinical and biological features of neuroblastic tumors: A comparison of neuroblastoma and ganglioneuroblastoma. Oncotarget. 2017;8:37730\u20139.","journal-title":"Oncotarget"},{"key":"1124_CR3","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1055\/s-0038-1648231","volume":"44","author":"M Levi","year":"2018","unstructured":"Levi M. Hemostasis and thrombosis in extreme temperatures (Hypo- and Hyperthermia). Semin Thromb Hemost. 2018;44:651\u20135.","journal-title":"Semin Thromb Hemost"},{"key":"1124_CR4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s13054-016-1376-4","volume":"20","author":"EJ Walter","year":"2016","unstructured":"Walter EJ, Carraretto M. The neurological and cognitive consequences of hyperthermia. Crit Care. 2016;20:199.","journal-title":"Crit Care"},{"key":"1124_CR5","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1111\/j.1460-9592.2006.01878.x","volume":"16","author":"JF Mayhew","year":"2006","unstructured":"Mayhew JF. Intraoperative hyperthermia in a child with neuroblastoma. Paediatr Anaesth. 2006;16:890\u20131.","journal-title":"Paediatr Anaesth"},{"key":"1124_CR6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.jpedsurg.2018.09.004","volume":"54","author":"EA Newman","year":"2019","unstructured":"Newman EA, Abdessalam S, Aldrink JH, Austin M, Heaton TE, Bruny J, et al. Update on neuroblastoma. J Pediatr Surg. 2019;54:383\u20139.","journal-title":"J Pediatr Surg"},{"key":"1124_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ejca.2019.01.014","volume":"111","author":"IRN Verly","year":"2019","unstructured":"Verly IRN, Leen R, Meinsma JR, Hooijer GKJ, Savci-Heijink CD, van Nes J, et al. Catecholamine excretion profiles identify clinical subgroups of neuroblastoma patients. Eur J Cancer. 2019;111:21\u20139.","journal-title":"Eur J Cancer"},{"key":"1124_CR8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/00000542-197601000-00008","volume":"44","author":"GA Gronert","year":"1976","unstructured":"Gronert GA, Theye RA. Halothane-induced porcine malignant hyperthermia: metabolic and hemodynamic changes. Anesthesiology. 1976;44:36\u201343.","journal-title":"Anesthesiology"},{"key":"1124_CR9","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.mehy.2019.02.020","volume":"124","author":"X Xu","year":"2019","unstructured":"Xu X. Magnesium sulfate\u2014an effective agent could delay the progression of fulminant malignant hyperthermia. Med Hypotheses. 2019;124:118\u201320.","journal-title":"Med Hypotheses"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01124-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12893-021-01124-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01124-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T15:02:58Z","timestamp":1614956578000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-021-01124-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1124"],"URL":"https:\/\/doi.org\/10.1186\/s12893-021-01124-3","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"assertion":[{"value":"25 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We confirm that written consent to publish this information was obtained from parents of the study participant, and a copy of the consent is available for the journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"112"}}