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Patients\u2019 characteristics and defect causes were evaluated. Treatment recommendations (TR) of MDT meetings and subsequent implementation were reviewed (cohort with implementation of TR versus cohort with non-implementation of TR), and factors associated with non-adherence to recommendations were statistically analyzed using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-one patients (41 male) with a mean age of 54\u00a0years were presented in 27 MDT meetings. Most of the patients (70%) suffered from reconstructive challenging or combined bone- and soft tissue defects, primarily located at the lower extremity (88%). Large skeletal defects, chronic osteomyelitis, and multi-fragmented fractures were present in 65% of cases. Forty-five percent of the patients suffered from peripheral vascular disease, necessitating surgical optimization. Of the 51 MDT decisions, 40 were implemented (78%; (32\/40) limb salvage versus 22%; (8\/40) limb amputation). Limb salvage was successfully achieved in 91% (29\/32) of the cases. Failed limb salvages were due to flap failure (33%; 1\/3), recurring periprosthetic joint infections (66%; 2\/3) and concomitant reconstructive failure. Patients who underwent limb amputation, as recommended, showed proper stump healing and regained mobility with a prosthesis. Overall the MDT treatment plan was effective in 92.5% (37\/40) of the patients, who adhered to the MDT treatment recommendation. In eleven patients (22%; 11\/51), the MDT treatment was not implemented. MDT decisions were less likely to be implemented, if amputation was recommended (p\u2009=\u20090.029).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MDT meetings represent a valid tool to formulate individualized treatment plans, avoiding limb amputation in most patients with severe extremity defects. Recommendation for limb amputation is less likely to be implemented than plans for limb salvage.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial registration:<\/jats:italic>\n                      Retrospectively registered\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12893-021-01169-4","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T05:02:51Z","timestamp":1616994171000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Multidisciplinary team meetings for patients with complex extremity defects: a retrospective analysis of treatment recommendations and prognostic factors for non-implementation"],"prefix":"10.1186","volume":"21","author":[{"given":"Dimitra","family":"Kotsougiani-Fischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Warszawski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Gruetzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Hirche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Kneser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"1169_CR1","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2020.1773670","author":"SCM Van Den Heuvel","year":"2020","unstructured":"Van Den Heuvel SCM, Winters HAH, Ultee KH, Zijlstra-Koenrades N, Sakkers RJB. 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