{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:15:52Z","timestamp":1764494152904,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008092","name":"Jinhua Science and Technology Bureau","doi-asserted-by":"publisher","award":["2020-3-041-1"],"award-info":[{"award-number":["2020-3-041-1"]}],"id":[{"id":"10.13039\/501100008092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a high rate of new mutation and variable expression. Diffuse neurofibroma of the epidermis invading deeper organs is rare.We report a case of diffuse subcutaneous neurofibroma in the thoracoabdominal wall which had invaded the diaphragm and caused diaphragmatic eventration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We describe a patient with diffuse neurofibroma of the chest and abdomen who was admitted to the hospital due to sudden abdominal pain and a possible diaphragmatic hernia. We performed thoracotomy and found that the neurofibroma had invaded the diaphragm and caused diaphragmatic eventration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This occurrence has not been reported, and it shows that although neurofibromatosis is a benign disease, it still has the biological behavior of a malignant tumor and may cause a serious impact on and damage to other organs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-021-01258-4","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T12:02:51Z","timestamp":1621857771000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diffuse neurofibroma of the chest and abdominal wall invading the diaphragm leads to diaphragmatic eventration: case report"],"prefix":"10.1186","volume":"21","author":[{"given":"Xian-shuai","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-qian","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-2049","authenticated-orcid":false,"given":"Xian-guo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"1258_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1001\/jama.1997.03550010065042","volume":"278","author":"DH Gutmann","year":"1997","unstructured":"Gutmann DH, Aylsworth A, Carey JC, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA. 1997;278:51\u20137.","journal-title":"JAMA"},{"key":"1258_CR2","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1097\/PAS.0000000000000447","volume":"39","author":"IM Schaefer","year":"2015","unstructured":"Schaefer IM, Fletcher CD. Malignant peripheral nerve sheath tumor (MPNST) arising in diffuse type neurofibroma: clinicopathologic characterization in a series of 9 cases. Am J Surg Pathol. 2015;39:1234\u201341.","journal-title":"Am J Surg Pathol"},{"key":"1258_CR3","unstructured":"National Institutes of Health Consensus Development Conference Statement: neurofibromatosis. Bethesda, Md., USA, July 13\u201315, 1987. Neurofibromatosis. 1988;1(3):172\u20138."},{"issue":"5","key":"1258_CR4","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1093\/neuonc\/nov200","volume":"18","author":"JO Blakeley","year":"2016","unstructured":"Blakeley JO, Plotkin SR. Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis. NeuroOncology. 2016;18(5):624\u201338. https:\/\/doi.org\/10.1093\/neuonc\/nov200.","journal-title":"NeuroOncology"},{"key":"1258_CR5","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/B978-0-444-52891-9.00039-7","volume":"111","author":"BR Korf","year":"2013","unstructured":"Korf BR. Neurofibromatosis. Handb Clin Neurol. 2013;111:333\u201340. https:\/\/doi.org\/10.1016\/B978-0-444-52891-9.00039-7.","journal-title":"Handb Clin Neurol"},{"key":"1258_CR6","unstructured":"Messersmith L, Krauland K. Neurofibroma. 2020. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020 Jan. PMID: 30969529."},{"issue":"2","key":"1258_CR7","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/1346-8138.15194","volume":"47","author":"Y Ehara","year":"2020","unstructured":"Ehara Y, Koga M, Imafuku S, Yamamoto O, Yoshida Y. Distribution of diffuse plexiform neurofibroma on the body surface in patients with neurofibromatosis 1. J Dermatol. 2020;47(2):190\u20132. https:\/\/doi.org\/10.1111\/1346-8138.15194.","journal-title":"J Dermatol"},{"issue":"3","key":"1258_CR8","doi-asserted-by":"publisher","first-page":"582","DOI":"10.2214\/AJR.07.2589","volume":"190","author":"DS Hassell","year":"2008","unstructured":"Hassell DS, Bancroft LW, Kransdorf MJ, Peterson JJ, Berquist TH, Murphey MD, Fanburg-Smith JC. Imaging appearance of diffuse neurofibroma. AJR Am J Roentgenol. 2008;190(3):582\u20138. https:\/\/doi.org\/10.2214\/AJR.07.2589.","journal-title":"AJR Am J Roentgenol"},{"issue":"6","key":"1258_CR9","first-page":"54","volume":"65","author":"ES Pankratova","year":"2003","unstructured":"Pankratova ES, Chumachenko PA, Libiia\u012dnen TP, Mishakov NA, Klipova LN, Klishin AF, Mnikhovich MV. Diffuznaia ne\u012drofibroma s prorastaniem v spinno-mozgovo\u012d kanal i miagkie tkani grudno\u012d kletki [Diffuse neurofibroma invading the spinal cord channel and soft tissues of the chest]. Arkh Patol. 2003;65(6):54\u20136 (Russian).","journal-title":"Arkh Patol"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01258-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12893-021-01258-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01258-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T12:04:05Z","timestamp":1621857845000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-021-01258-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,24]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1258"],"URL":"https:\/\/doi.org\/10.1186\/s12893-021-01258-4","relation":{},"ISSN":["1471-2482"],"issn-type":[{"type":"electronic","value":"1471-2482"}],"subject":[],"published":{"date-parts":[[2021,5,24]]},"assertion":[{"value":"16 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study has been approval and consented by the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for personal or clinical details along with any identifying images to be published in this study was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author(s) declared no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"258"}}