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The trials that evaluated the safety of 6% hydroxyethyl starch (HES) 130\/0.4 in cardiac surgical patients were inconsistent. It is necessary to compare the efficacy and safety of albumin and 6% HES (130\/0.4).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>We searched for the randomized controlled clinical trials that compared human albumin with 6% HES (130\/0.4) in cardiac surgery in PubMed, Cochrane, and Embase.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Ten studies involved a total of 1567 patients were included in our meta-analysis. For the efficiency, there was no difference in total volume of infusion between compared groups [P\u2009=\u20090.64, Fixed Effect Model (FEM): standardized mean difference (SMD)\u2009=\u20090.04, 95% confidence interval (CI) (\u2212\u00a00.12, 0.20)]. As for safety, the albumin show more risk than hydroxyethyl starch 130\/0.4 in blood loss [P\u2009=\u20090.02, FEM: SMD: 0.22, 95% CI (0.03, 0.41)]. There was no difference in the frequency of transfusions (P\u2009=\u20090.20, RR\u2009=\u20091.11; 95% CI (0.95, 1.27)) between the two groups. No difference was observed for the days in intensive care unit [P\u2009=\u20090.05, FEM: SMD\u2009=\u2009\u2212\u00a00.18, 95% CI (\u2212\u00a00.36, 0.00)], and the days in hospital [P\u2009=\u20090.32, FEM: SMD\u2009=\u2009\u2212\u00a00.11, 95% CI (\u2212\u00a00.32, 0.10)]. Furthermore, both the incidence of AKI, RRT, and mortality were comparable in the two groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study provided evidence that the 6% HES (130\/0.4) might be the substitute for HA, which reduced the economic burden for patients with cardiac surgery. However, the effect of 6% HES (130\/0.4) and HA on AKI still needs to be further studied.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-021-01340-x","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T12:04:18Z","timestamp":1631448258000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The comparison of albumin and 6% hydroxyethyl starches (130\/0.4) in cardiac surgery: a meta-analysis of randomized controlled clinical trials"],"prefix":"10.1186","volume":"21","author":[{"given":"Ling","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"1340_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1352-z","author":"JB O\u2019Neal","year":"2016","unstructured":"O\u2019Neal JB, Shaw AD, Billings FT. 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