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Open reduction and internal fixation (ORIF) were used to treat 14 patients with humeral shaft fractures as the control group (ORIF group). The two groups were fixed with a locking compression plate (LCP) or LCP\u2009+\u2009multi-directional locking screw system (MDLS). The incision length, intraoperative blood loss, intraoperative fluoroscopy time, operation time, length of hospital stay, fracture healing time, QuickDASH score and Constant score were observed and compared between the two groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fourteen patients were enrolled in each group. The incision length (7.79\u2009\u00b1\u20092.39\u00a0cm), intraoperative blood loss (96.07\u2009\u00b1\u200914.96\u00a0mL), operative time (110.57\u2009\u00b1\u200921.90\u00a0min), hospital stay (6.29\u2009\u00b1\u20091.49\u00a0days) and fracture healing time (14.94\u2009\u00b1\u20090.99\u00a0weeks) in the MIPO group were all lower than those in the ORIF group, and the difference was statistically significant for each parameter (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The intraoperative fluoroscopy time (20.07\u2009\u00b1\u20093.22) in the MIPO group was significantly higher than that in the ORIF group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There were no significant differences in age (<jats:italic>P<\/jats:italic>\u2009=\u20090.078), QuickDASH score (<jats:italic>P<\/jats:italic>\u2009=\u20090.074) or Constant score (<jats:italic>P<\/jats:italic>\u2009=\u20090.293) between the two groups and no postoperative complications occurred in any of the patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The anteromedial approach MIPO technique has the advantages of less trauma, less bleeding, low risk of nerve injury and high rate of fracture healing. It is one of the most effective methods for the treatment of middle and middle\u2013distal humeral shaft fractures.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-021-01347-4","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T02:06:31Z","timestamp":1632362791000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of humeral shaft fractures: a new minimally-invasive plate osteosynthesis versus open reduction and internal fixation: a case control study"],"prefix":"10.1186","volume":"21","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanxin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"issue":"4","key":"1347_CR1","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1016\/j.jse.2017.10.028","volume":"27","author":"GF Updegrove","year":"2018","unstructured":"Updegrove GF, Mourad W, Abboud JA. 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Written informed consent was obtained from each patient prior to the study. All authors certify that the methods were carried out in accordance with relevant guidelines and regulations. All authors certify that the patients gave informed consent and agreed to participate in our study. All authors certify that all patients provided a signed informed consent prior to the operation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"349"}}