{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:28:31Z","timestamp":1790659711899,"version":"4.1.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acute pancreatitis after liver resection is a rare but serious complication, and few cases have been described in the literature. Extended lymphadenectomy, and long ischemia due to the Pringle maneuver could be responsible of post-liver resection acute pancreatitis, but the exact causes of AP after hepatectomy remain unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Cases presentation<\/jats:title>\n                <jats:p>We report here three cases of AP after hepatectomy and we strongly hypothesize that this is due to the bile leakage white test. 502 hepatectomy were performed at our center and 3 patients (0.6%) experienced acute pancreatitis after LR and all of these three patients underwent the white test at the end of the liver resection. None underwent additionally lymphadenectomy to the liver resection. All patient had a white-test during the liver surgery. We identified distal implantation of the cystic duct in these three patients as a potential cause for acute pancreatitis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The white test is useful for detection of bile leakage after liver resection, but we do not recommend a systematic use after LR, because severe acute pancreatitis can be lethal for the patient, especially in case of distal cystic implantation which may facilitate reflux in the main pancreatic duct.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-021-01354-5","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T14:45:42Z","timestamp":1633358742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The white test for intraoperative screening of bile leakage: a potential trigger factor for acute pancreatitis after liver resection\u2014a case series"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-7280","authenticated-orcid":false,"given":"Sophie","family":"Chopinet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Bollon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Hak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Reydellet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ry","family":"Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farouk","family":"Tradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Gr\u00e9goire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Hardwigsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,2]]},"reference":[{"issue":"8","key":"1354_CR1","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1445-1433.2004.03113.x","volume":"74","author":"S Sathasivam","year":"2004","unstructured":"Sathasivam S, Ritchie A, Brooks AJ, Morris DL. Acute pancreatitis following liver resection: report of three fatal cases and a review of the literature. ANZ J Surg. 2004;74(8):643\u20135.","journal-title":"ANZ J Surg"},{"issue":"2","key":"1354_CR2","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1245\/s10434-018-6811-0","volume":"26","author":"F Ratti","year":"2019","unstructured":"Ratti F, Fiorentini G, Cipriani F, Paganelli M, Catena M, Aldrighetti L. Perioperative and long-term outcomes of laparoscopic versus open lymphadenectomy for biliary tumors: a propensity-score-based, case-matched analysis. Ann Surg Oncol. 2019;26(2):564\u201375.","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"1354_CR3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/j.1477-2574.2012.00580.x","volume":"15","author":"A Guillaud","year":"2013","unstructured":"Guillaud A, Pery C, Campillo B, Lourdais A, Sulpice L, Laurent S, et al. 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Surg Endosc. 2020;35:4134\u201342.","journal-title":"Surg Endosc"},{"issue":"1","key":"1354_CR6","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S1072-7515(00)00261-1","volume":"191","author":"J Belghiti","year":"2000","unstructured":"Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg. 2000;191(1):38\u201346.","journal-title":"J Am Coll Surg"},{"issue":"12","key":"1354_CR7","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1001\/archsurg.135.12.1395","volume":"135","author":"M Ijichi","year":"2000","unstructured":"Ijichi M, Takayama T, Toyoda H, Sano K, Kubota K, Makuuchi M. Randomized trial of the usefulness of a bile leakage test during hepatic resection. Arch Surg. 2000;135(12):1395\u2013400.","journal-title":"Arch Surg"},{"issue":"2","key":"1354_CR8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S1665-2681(19)30777-X","volume":"14","author":"R Linke","year":"2015","unstructured":"Linke R, Ulrich F, Bechstein WO, Schnitzbauer AA. The white-test helps to reduce biliary leakage in liver resection: a systematic review and meta-analysis. Ann Hepatol. 2015;14(2):161\u20137.","journal-title":"Ann Hepatol"},{"issue":"1","key":"1354_CR9","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/00000658-200001000-00018","volume":"231","author":"ST Fan","year":"2000","unstructured":"Fan ST, Lo CM, Liu CL. Technical refinement in adult-to-adult living donor liver transplantation using right lobe graft. Ann Surg. 2000;231(1):126\u201331.","journal-title":"Ann Surg"},{"key":"1354_CR10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.asjsur.2020.04.001","volume":"44","author":"U Tuysuz","year":"2020","unstructured":"Tuysuz U, Aktas H, Bat\u0131 IB, Em\u0131roglu R. The role of Intraoperative cholangiography (IOC) and methylene blue tests in reducing bile leakage after living donor hepatectomies. Asian J Surg. 2020;44:147\u201352.","journal-title":"Asian J Surg"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01354-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12893-021-01354-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-021-01354-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T14:58:03Z","timestamp":1633359483000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-021-01354-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,2]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1354"],"URL":"https:\/\/doi.org\/10.1186\/s12893-021-01354-5","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,2]]},"assertion":[{"value":"30 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case series has been approved by the ethical committee Sud M\u00e9diterran\u00e9e 2 (Sainte-Marguerite hospital, Marseille)","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patients included in this study or the patient\u2019s next to kin have provided written informed consent for publication of the cases.All the authors gave their consent for the publication of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"356"}}