{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:56:26Z","timestamp":1740135386292,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Gallbladder hemangioma is an exceptionally rare entity, with only ten cases reported in literature hitherto. The here described case is the first report of a gallbladder hemangioma coexisting with gallstones.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 76-year-old male was hospitalized following repeated episodes of epigastric pain. Patient\u2019s medical history included primary hypertension, type 2 diabetes mellitus, dyslipidemia, obesity and hyperuricemia. Physical examination revealed marked pain in the right hypochondriac region, and laboratory workup was notable for mildly elevated glycemia (125\u00a0mg\/dL) and pancreatic amylase (60\u00a0IU\/L). Abdominal ultrasound showed multiple gallstones, a thickened gallbladder wall and mild edema of the perivisceral adipose tissue as well as a hepatic angioma. During surgery, an incidental subserosal nodule of about 1\u00a0cm was detected within the gallbladder fundus. After surgery, the clinical course was uneventful and the patient was discharged. Histopathological examination of the subserosal nodule showed multiple dilated vascular channels within a sclerosing matrix, a finding consistent with a cavernous hemangioma. Diffuse chronic cholecystitis was also present.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Gallbladder hemangiomas represent a rare, likely underdiagnosed condition which can be undetected during the preoperative workup.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-022-01554-7","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:02:41Z","timestamp":1649203361000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First report of a gallbladder hemangioma coexisting with gallstones: a case report and literature review of a rare finding"],"prefix":"10.1186","volume":"22","author":[{"given":"Giulia","family":"Trucco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Chiusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Tandoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-7668","authenticated-orcid":false,"given":"Luca","family":"Bertero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"1554_CR1","volume-title":"Enzinger and Weiss\u2019s Soft tissue tumors","author":"J Goldblum","year":"2019","unstructured":"Goldblum J, Weiss S, Folpe AL. Enzinger and Weiss\u2019s Soft tissue tumors. 7th ed. Amsterdam: Elsevier; 2019.","edition":"7"},{"key":"1554_CR2","first-page":"851","volume":"6","author":"JW Zheng","year":"2013","unstructured":"Zheng JW, Zhang L, Zhou Q, Mai HM, Wang YA, Fan XD, et al. A practical guide to treatment of infantile hemangiomas of the head and neck. Int J Clin Exp Med. 2013;6:851\u201360.","journal-title":"Int J Clin Exp Med"},{"key":"1554_CR3","volume-title":"Harrison\u2019s principles of internal medicine","author":"LJ Jameson","year":"2018","unstructured":"Jameson LJ, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison\u2019s principles of internal medicine. New York: McGraw-Hill Education; 2018."},{"key":"1554_CR4","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1053\/j.gastro.2009.02.038","volume":"136","author":"JE Everhart","year":"2009","unstructured":"Everhart JE, Ruhl CE. Burden of digestive diseases in the United States Part III: liver, biliary tract, and pancreas. Gastroenterology. 2009;136:1134\u201344. https:\/\/doi.org\/10.1053\/j.gastro.2009.02.038.","journal-title":"Gastroenterology"},{"key":"1554_CR5","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1016\/j.transproceed.2015.04.059","volume":"47","author":"S Akbulut","year":"2015","unstructured":"Akbulut S, Karagul S, Ertugrul I, Aydin C, Yilmaz M, Yilmaz S. Histopathologic findings of cholecystectomy specimens in patients who underwent donor hepatectomy for living donor liver transplantation. Transplant Proc. 2015;47:1466\u20138. https:\/\/doi.org\/10.1016\/j.transproceed.2015.04.059.","journal-title":"Transplant Proc"},{"key":"1554_CR6","doi-asserted-by":"publisher","first-page":"534","DOI":"10.4240\/wjgs.v12.i12.534","volume":"12","author":"S Akbulut","year":"2020","unstructured":"Akbulut S, Demyati K, Ciftci F, Koc C, Tuncer A, Sahin E, et al. Ectopic liver tissue (choristoma) on the gallbladder: a comprehensive literature review. World J Gastrointest Surg. 2020;12:534\u201348. https:\/\/doi.org\/10.4240\/wjgs.v12.i12.534.","journal-title":"World J Gastrointest Surg"},{"key":"1554_CR7","doi-asserted-by":"publisher","unstructured":"Zimmermann A. Mesenchymal tumors of the gallbladder. Tumors and Tumor-Like Lesions Hepatobiliary Tract. Gen. Surg. Pathol., Cham: Springer International Publishing; 2017, p. 2779\u201399. https:\/\/doi.org\/10.1007\/978-3-319-26956-6_156.","DOI":"10.1007\/978-3-319-26956-6_156"},{"key":"1554_CR8","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1002\/cncr.33476","volume":"127","author":"G Ouyang","year":"2021","unstructured":"Ouyang G, Liu Q, Wu Y, Liu Z, Lu W, Li S, et al. The global, regional, and national burden of gallbladder and biliary tract cancer and its attributable risk factors in 195 countries and territories, 1990 to 2017: a systematic analysis for the Global Burden of Disease Study 2017. Cancer. 2021;127:2238\u201350. https:\/\/doi.org\/10.1002\/cncr.33476.","journal-title":"Cancer"},{"key":"1554_CR9","first-page":"535","volume":"61","author":"AA Arbab","year":"1967","unstructured":"Arbab AA, Brasfield R. Benign tumors of the gallbladder. Surgery. 1967;61:535\u201340.","journal-title":"Surgery"},{"key":"1554_CR10","first-page":"30","volume":"88","author":"JH Sewell","year":"1969","unstructured":"Sewell JH, Miron MA. Benign cavernous hemangioma of the gallbladder. Arch Pathol. 1969;88:30\u20131.","journal-title":"Arch Pathol"},{"key":"1554_CR11","first-page":"172","volume":"16","author":"JH Moffat","year":"1973","unstructured":"Moffat JH. Cavernous hemangioma of the gallbladder and liver. Can J Surg. 1973;16:172\u20135.","journal-title":"Can J Surg"},{"key":"1554_CR12","first-page":"325","volume":"42","author":"OR Cabrera","year":"1977","unstructured":"Cabrera OR, Hern\u00e1ndez Viruel JA, Colinabarranco M, Villa Fern\u00e1ndez A. A Visceral multiple angiomatosis. Clinical case and review of the literature. Prensa Med Mex. 1977;42:325\u201330.","journal-title":"Prensa Med Mex"},{"key":"1554_CR13","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/BF01885171","volume":"12","author":"WP Jones","year":"1987","unstructured":"Jones WP, Keller FS, Odrezin GT, Kelly DR. Venous hemangioma of the gallbladder. Gastrointest Radiol. 1987;12:319\u201321. https:\/\/doi.org\/10.1007\/BF01885171.","journal-title":"Gastrointest Radiol"},{"key":"1554_CR14","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.2214\/ajr.168.5.9129455","volume":"168","author":"H Furukawa","year":"1997","unstructured":"Furukawa H, Kanai Y, Mukai K, Yamasaki S. Arteriovenous hemangioma of the gallbladder: CT and pathologic findings. AJR Am J Roentgenol. 1997;168:1383. https:\/\/doi.org\/10.2214\/ajr.168.5.9129455.","journal-title":"AJR Am J Roentgenol"},{"key":"1554_CR15","first-page":"211","volume":"142","author":"M Mayorga","year":"1997","unstructured":"Mayorga M, Hernando M, Val-Bernal JF. Diffuse expansive cavernous hemangioma of the gallbladder. Gen Diagn Pathol. 1997;142:211\u20135.","journal-title":"Gen Diagn Pathol"},{"key":"1554_CR16","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1177\/030089160509100511","volume":"91","author":"A Crucitti","year":"2005","unstructured":"Crucitti A, La Greca A, Antinori A, Antonacci V, Magistrelli P. Cavernous hemangioma of the gallbladder. Case report and review of the literature. Tumori. 2005;91:432\u20135.","journal-title":"Tumori"},{"key":"1554_CR17","doi-asserted-by":"publisher","first-page":"431","DOI":"10.9738\/INTSURG-D-15-00015.1","volume":"101","author":"Y Akama","year":"2016","unstructured":"Akama Y, Mizuguchi Y, Mamada Y, Shimizu T, Kanda T, Nakamura Y, et al. A case of cavernous hemangioma of the gallbladder treated with single-incision laparoscopic cholecystectomy. Int Surg. 2016;101:431\u20136. https:\/\/doi.org\/10.9738\/INTSURG-D-15-00015.1.","journal-title":"Int Surg"},{"key":"1554_CR18","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1159\/000500079","volume":"13","author":"N Funamizu","year":"2019","unstructured":"Funamizu N, Nakabayashi Y. Cavernous hemangioma of the gallbladder masquerading as a carcinoma. Case Rep Gastroenterol. 2019;13:219\u201324. https:\/\/doi.org\/10.1159\/000500079.","journal-title":"Case Rep Gastroenterol"},{"key":"1554_CR19","unstructured":"National Institute for Health and Care Excellence. Gallstone disease: diagnosis and management 2014. https:\/\/www.nice.org.uk\/guidance\/cg188. Accessed 25 May 2021."},{"key":"1554_CR20","doi-asserted-by":"publisher","first-page":"681","DOI":"10.4103\/ijc.IJC_516_17","volume":"54","author":"S Patkar","year":"2017","unstructured":"Patkar S, Shinde RS, Kurunkar SR, Niyogi D, Shetty NS, Ramadwar M, et al. Radiological diagnosis alone risks overtreatment of benign disease in suspected gallbladder cancer: a word of caution in an era of radical surgery. Indian J Cancer. 2017;54:681\u20134. https:\/\/doi.org\/10.4103\/ijc.IJC_516_17.","journal-title":"Indian J Cancer"},{"key":"1554_CR21","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.3748\/wjg.v26.i22.2967","volume":"26","author":"MH Yu","year":"2020","unstructured":"Yu MH, Kim YJ, Park HS, Jung Sll. Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases. World J Gastroenterol. 2020;26:2967\u201386. https:\/\/doi.org\/10.3748\/wjg.v26.i22.2967.","journal-title":"World J Gastroenterol"},{"key":"1554_CR22","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1089\/lrb.2007.1014","volume":"5","author":"EI Chang","year":"2007","unstructured":"Chang EI, Chang EI, Thangarajah H, Hamou C, Gurtner GC. Hypoxia, hormones, and endothelial progenitor cells in hemangioma. Lymphat Res Biol. 2007;5:237\u201343. https:\/\/doi.org\/10.1089\/lrb.2007.1014.","journal-title":"Lymphat Res Biol"},{"key":"1554_CR23","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1001\/archdermatol.2010.1295","volume":"146","author":"BA Drolet","year":"2010","unstructured":"Drolet BA, Frieden IJ. Characteristics of infantile hemangiomas as clues to pathogenesis: does hypoxia connect the dots? Arch Dermatol. 2010;146:1295\u20139. https:\/\/doi.org\/10.1001\/archdermatol.2010.1295.","journal-title":"Arch Dermatol"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-022-01554-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12893-022-01554-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-022-01554-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:02:59Z","timestamp":1649203379000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-022-01554-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["1554"],"URL":"https:\/\/doi.org\/10.1186\/s12893-022-01554-7","relation":{},"ISSN":["1471-2482"],"issn-type":[{"type":"electronic","value":"1471-2482"}],"subject":[],"published":{"date-parts":[[2022,4,6]]},"assertion":[{"value":"20 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval was not required for single case reports. Written consent was obtained from the patient to publish the present case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent was obtained from the patient to publish the present case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"128"}}