{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:52:45Z","timestamp":1791489165197,"version":"4.3.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The aims of this study were to summarize the clinical presentation and histological results of 20 cases of complicated Meckel diverticulum (MD) who were presumed to have acute appendicitis before surgery, as well as to improve the diagnosis and treatment of complicated MD in children.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>We retrospectively reviewed the records of 20 complicated MD admitted to our institution who were preoperatively diagnosed with acute appendicitis from January 2012 to January 2019. Patients were divided into the perforated MD group and the Meckel\u2019s diverticulitis group. Patient demographics, clinical manifestations, laboratory data, auxiliary examinations, surgical methods, and the result of heterotopic tissue were recorded.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 20 cases of complicated MD (perforated or diverticulitis) were identified. Children were aged from 3 to 13 years, with a mean age of 7.75 years (median 7.75; range, 1\u201313 years). Perforated Meckel\u2019s diverticulum occurred in 5 of 20 (25%) cases. For perforated MD versus diverticulitis, no significant differences were found between age, time to intervention, length of hospital stay, and distance from the ileo-cecal valve. Heterotopic tissue was confirmed on histopathology in 75% of all patients, including 10 cases of gastric mucosa, 3 cases of coexistent gastric mucosa and pancreatic tissue, and 2 cases of pancreatic tissue. All patients underwent diverticulectomy or partial ileal resection under laparoscopy or laparotomy; two cases combined with appendectomy owing to slight inflammation of the appendix.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The most common presentation of symptomatic MD is painless rectal bleeding; however, it can present symptoms of acute abdomen mimicking acute appendicitis. The key point of diverticulectomy is to remove the ectopic mucosa completely.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-024-02323-4","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T13:03:04Z","timestamp":1706619784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Meckel\u2019s diverticulum mimicking acute appendicitis in children: a retrospective cohort study"],"prefix":"10.1186","volume":"24","author":[{"given":"Ling","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"2323_CR1","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.jpedsurg.2011.02.024","volume":"46","author":"KA Ruscher","year":"2011","unstructured":"Ruscher KA, Fisher JN, Hughes CD, et al. National trends in the surgical management of Meckel\u2019s diverticulum. J Pediatr Surg. 2011;46:893\u20136.","journal-title":"J Pediatr Surg"},{"issue":"suppl 3","key":"2323_CR2","first-page":"1167","volume":"55","author":"GL Stanescu","year":"2014","unstructured":"Stanescu GL, Plesea IE, Diaconu R, et al. Meckel\u2019s diverticulum in children, clinical and pathological aspects. Rom J Morphol Embryol. 2014;55(suppl 3):1167\u201370.","journal-title":"Rom J Morphol Embryol"},{"key":"2323_CR3","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/j.jpedsurg.2015.08.066","volume":"51","author":"H\u00d6 Gezer","year":"2016","unstructured":"Gezer H\u00d6, Temiz A, Ince E, Ezer SS, Hasbay B, Hi\u00e7s\u00f6nmez A, et al. Meckel diverticulum in children: evaluation of macroscopic appearance for guidance in subsequent surgery. J Pediatr Surg. 2016;51:1177\u201380.","journal-title":"J Pediatr Surg"},{"issue":"7\u20138","key":"2323_CR4","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1111\/ans.13516","volume":"88","author":"J Eisdorfer","year":"2018","unstructured":"Eisdorfer J, Zinkin NT, Rivadeneira DE. Meckel\u2019s diverticulitis: a rare cause of abdominal pain during pregnancy. ANZ J Surg. 2018;88(7\u20138):800\u20132.","journal-title":"ANZ J Surg"},{"key":"2323_CR5","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/01.sla.0000154270.14308.5f","volume":"241","author":"JJ Park","year":"2005","unstructured":"Park JJ, Wolff BG, Tollefson MK, et al. Meckel diverticulum: the Mayo Clinic experience with 1476 patients (1950\u20132002). 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Diverse presentations in pediatric Meckel\u2019s diverticulum: a review of 100 cases. Pediatr Neonatol. 2014;55:369\u201375.","journal-title":"Pediatr Neonatol"},{"issue":"9","key":"2323_CR9","doi-asserted-by":"publisher","first-page":"E379","DOI":"10.1111\/ans.14503","volume":"89","author":"WW Teng","year":"2019","unstructured":"Teng WW, Yeap BT, Azizan N, et al. Gangrenous giant Meckel\u2019s diverticulitis masquerading acute appendicitis: a surgical conundrum. ANZ J Surg. 2019;89(9):E379\u201380.","journal-title":"ANZ J Surg"},{"key":"2323_CR10","doi-asserted-by":"crossref","unstructured":"Kadian YS, Verma A, Rattan KN, Kajal P. Vitellointestinal duct anomalies in infancy. J Neonatal Surg. 2016; 3;5(3):30.","DOI":"10.21699\/jns.v5i3.351"},{"key":"2323_CR11","doi-asserted-by":"publisher","first-page":"776","DOI":"10.2967\/jnumed.107.040113","volume":"49","author":"G Mariani","year":"2008","unstructured":"Mariani G, Pauwels EK, AlSharif A, et al. 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Informed consent was obtained from the parents or legal guardians of all of the patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All study data were approved by the Ethics Committee of Hangzhou Children\u2019s Hospital.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics"}},{"value":"All authors have confirmed that this study did not involve animal subjects or tissue.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal ethics"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"40"}}