{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:18:52Z","timestamp":1772165932141,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Huizhou Municipal Central Hospital key support research project Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In this study, we investigated the effect of preservation of the pulmonary branches of the vagus nerve during systematic dissection of mediastinal lymph nodes, when performing radical resection of lung cancer, on the postoperative complication rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical data for 80 patients who underwent three-dimensional thoracoscopic radical resection of lung cancer in the Department of Thoracic Surgery at Huizhou Municipal Central Hospital between 2020 and 2022 were analyzed. The patients were divided into two groups according to whether the pulmonary branches of the vagus nerve were retained during intraoperative carinal lymph node dissection. The operation time, time until first postoperative defecation, duration for which a chest tube was needed, total chest drainage volume, average pain intensity during the first 5 postoperative days, incidence of postoperative pneumonia, and postoperative length of stay were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no statistically significant difference in histological staging or in time until first postoperative defecation between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, there were significant differences in operation time, the duration for which a chest tube was needed, total chest drainage volume, average pain intensity during the first 5 postoperative days, white blood cell count and procalcitonin level on postoperative days 1 and 5, and postoperative length of stay between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preserving the pulmonary branches of the vagus nerve during carinal lymph node dissection when performing three-dimensional thoracoscopic radical resection of lung cancer can reduce the risk of postoperative complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12893-024-02347-w","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T11:02:13Z","timestamp":1707476533000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preservation of the pulmonary branches of the vagus nerve during three-dimensional thoracoscopic radical resection of lung cancer: a retrospective study"],"prefix":"10.1186","volume":"24","author":[{"given":"Wencong","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiantian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"issue":"6917","key":"2347_CR1","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/nature01321","volume":"420","author":"KJ Tracey","year":"2002","unstructured":"Tracey KJ. The inflammatory reflex[J]. Nature. 2002;420(6917):853\u20139.","journal-title":"Nature"},{"key":"2347_CR2","first-page":"117","volume":"39","author":"NLJ Song","year":"2012","unstructured":"Song NLJ, Bogdan M, Juan G, Rafael P, Yu J. The vagus nerve and pulmonary disease. Fudan Univ J Med Sci. 2012;39:117\u201322.","journal-title":"Fudan Univ J Med Sci"},{"issue":"2","key":"2347_CR3","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.athoracsur.2007.10.102","volume":"85","author":"SR DeMeester","year":"2008","unstructured":"DeMeester SR. New options for the therapy of Barrett\u2019s high-grade dysplasia and intramucosal adenocarcinoma: endoscopic mucosal resection and ablation versus vagal-sparing esophagectomy[J]. Ann Thorac Surg. 2008;85(2):747\u2013S750.","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"2347_CR4","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/joa.12366","volume":"227","author":"TJ Weijs","year":"2015","unstructured":"Weijs TJ, Ruurda JP, Luyer MD, et al. Topography and extent of pulmonary vagus nerve supply with respect to transthoracic oesophagectomy[J]. J Anat. 2015;227(4):431\u20139.","journal-title":"J Anat"},{"issue":"2","key":"2347_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.thorsurg.2011.01.006","volume":"21","author":"J Wang","year":"2011","unstructured":"Wang J, Li J, Liu G, et al. Nerves of the mediastinum[J]. Thorac Surg Clin. 2011;21(2):239\u201349.","journal-title":"Thorac Surg Clin"},{"key":"2347_CR6","unstructured":"Netter F. Netter\u2019s Atlas of Human Anatomy 6\/e - Professional Edition[J]. 2014."},{"issue":"2","key":"2347_CR7","first-page":"125","volume":"67","author":"H Akiyama","year":"1982","unstructured":"Akiyama H, Tsurumaru M, Kawamura T, et al. Esophageal stripping with preservation of the vagus nerve[J]. Int Surg. 1982;67(2):125\u20138.","journal-title":"Int Surg"},{"key":"2347_CR8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/B978-0-444-53491-0.00018-3","volume":"117","author":"SB Mazzone","year":"2013","unstructured":"Mazzone SB, Canning BJ. Autonomic neural control of the airways[J]. Handb Clin Neurol. 2013;117:215\u201328.","journal-title":"Handb Clin Neurol"},{"issue":"6","key":"2347_CR9","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s10753-013-9701-4","volume":"36","author":"C Chen","year":"2013","unstructured":"Chen C, Zhang Y, Du Z, et al. Vagal efferent fiber stimulation ameliorates pulmonary microvascular endothelial cell injury by downregulating inflammatory responses[J]. Inflammation. 2013;36(6):1567\u201375.","journal-title":"Inflammation"},{"issue":"9","key":"2347_CR10","doi-asserted-by":"publisher","first-page":"3816","DOI":"10.1007\/s00464-015-4683-y","volume":"30","author":"TJ Weijs","year":"2016","unstructured":"Weijs TJ, Ruurda JP, Luyer MD, et al. Preserving the pulmonary vagus nerve branches during thoracoscopic esophagectomy[J]. Surg Endosc. 2016;30(9):3816\u201322.","journal-title":"Surg Endosc"},{"key":"2347_CR11","unstructured":"Yu H. Li Gang,Tong Dongyi.Effect of bilateral cervical vagotomy on microglialactivation in spinal cordina rat model of persistent postoperative pain. J J Chin Physician January 2015 17 no.1:55\u20137."},{"issue":"2","key":"2347_CR12","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/SLA.0b013e3181dae411","volume":"252","author":"T Lubbers","year":"2010","unstructured":"Lubbers T, de Haan JJ, Luyer MD, et al. Cholecystokinin\/Cholecystokinin-1 receptor-mediated peripheral activation of the afferent vagus by enteral nutrients attenuates inflammation in rats[J]. Ann Surg. 2010;252(2):376\u201382.","journal-title":"Ann Surg"},{"issue":"31","key":"2347_CR13","doi-asserted-by":"publisher","first-page":"11008","DOI":"10.1073\/pnas.0803237105","volume":"105","author":"M Rosas-Ballina","year":"2008","unstructured":"Rosas-Ballina M, Ochani M, Parrish WR, et al. Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia[J]. Proc Natl Acad Sci U S A. 2008;105(31):11008\u201313.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"2347_CR14","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/nri2566","volume":"9","author":"KJ Tracey","year":"2009","unstructured":"Tracey KJ. Reflex control of immunity[J]. Nat Rev Immunol. 2009;9(6):418\u201328.","journal-title":"Nat Rev Immunol"},{"key":"2347_CR15","doi-asserted-by":"publisher","first-page":"17009","DOI":"10.1038\/celldisc.2017.9","volume":"3","author":"C Zhao","year":"2017","unstructured":"Zhao C, Yang X, Su EM, et al. Signals of vagal circuits engaging with AKT1 in alpha7 nAChR(+)CD11b(+) cells lessen E. Coli and LPS-induced acute inflammatory injury[J]. Cell Discov. 2017;3:17009.","journal-title":"Cell Discov"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-024-02347-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12893-024-02347-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-024-02347-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T11:04:45Z","timestamp":1707476685000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-024-02347-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2347"],"URL":"https:\/\/doi.org\/10.1186\/s12893-024-02347-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3328149\/v1","asserted-by":"object"}]},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,9]]},"assertion":[{"value":"5 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the ethics committee of Huizhou Municipal Central Hospital. All patients and their family members provided written informed consent before surgery.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"49"}}